HUP0401949A2 - 4-Imidazolin-2-on-származékok - Google Patents

4-Imidazolin-2-on-származékok

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Publication number
HUP0401949A2
HUP0401949A2 HU0401949A HUP0401949A HUP0401949A2 HU P0401949 A2 HUP0401949 A2 HU P0401949A2 HU 0401949 A HU0401949 A HU 0401949A HU P0401949 A HUP0401949 A HU P0401949A HU P0401949 A2 HUP0401949 A2 HU P0401949A2
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HU
Hungary
Prior art keywords
optionally substituted
group
hydrogen atom
alkyl group
meaning
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HU0401949A
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English (en)
Inventor
Akira Kubo
Ritsuo Imashiro
Hiroaki Sakurai
Hidetaka Miyoshi
Akihito Ogasawara
Hajime Hiramatsu
Original Assignee
Tanabe Seiyaku Co., Ltd.
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Application filed by Tanabe Seiyaku Co., Ltd. filed Critical Tanabe Seiyaku Co., Ltd.
Publication of HUP0401949A2 publication Critical patent/HUP0401949A2/hu
Publication of HUP0401949A3 publication Critical patent/HUP0401949A3/hu

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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
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Abstract

A találmány tárgya egy (I) általános képletű vegyület - a képletben G1jelentése adott esetben halogénatommal vagy alkoxicsoporttalhelyettesített alkilcsoport vagy (101) általános képletű csoport, ahola B gyűrű jelentése benzolgyűrű, naftalingyűrű, monociklusos vagybiciklusos aromás heterogyűrű vagy egy cikloalkán, amelyek mindegyikeadott esetben helyettesített lehet, és W jelentése vegyértékkötés vagyadott esetben helyettesített alkilénlánc, Q1 és O2 azonos vagykülönböző, jelentésük hidrogénatom, halogénatom, és/vagy alkilcsoport,n értéke 0, 1, 2, 3 vagy 4, R1 jelentése hidrogénatom, adott esetbenhelyettesített alkilcsoport, adott esetben helyettesítettcikloalkilcsoport, adott esetben helyettesített fenilcsoport vagyadott esetben helyettesített heterogyűrűs csoport, Z1, Z2, Z3 és Z4azonos vagy különböző, jelentésük -CH= vagy -N=, azzal a megkötéssel,hogy 3 vagy több Z1, Z2, Z3 és Z4 helyettesítő egyidejűleg nem lehetnitrogénatom, G2 jelentése hidrogénatom, -NR3R4, -OR5, -SR5, -COR6, -CHR7R8 vagy heterogyűrűs csoport, valamint a fenti vegyületekgyógyászati szempontból elfogadható sói. Ó
HU0401949A 2001-10-22 2002-10-22 4-imidazolin-2-one derivatives HUP0401949A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2001324029 2001-10-22
JP2002263680 2002-09-10
PCT/JP2002/010937 WO2003035638A1 (fr) 2001-10-22 2002-10-22 Composes de 4-imidazolin-2-one

Publications (2)

Publication Number Publication Date
HUP0401949A2 true HUP0401949A2 (hu) 2005-01-28
HUP0401949A3 HUP0401949A3 (en) 2009-07-28

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HU0401949A HUP0401949A3 (en) 2001-10-22 2002-10-22 4-imidazolin-2-one derivatives

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EP (1) EP1439174B1 (hu)
JP (1) JP4432492B2 (hu)
KR (1) KR100742058B1 (hu)
CN (1) CN100402521C (hu)
AT (1) ATE550332T1 (hu)
BR (1) BR0213465A (hu)
CA (1) CA2461100C (hu)
HU (1) HUP0401949A3 (hu)
IL (2) IL160874A0 (hu)
MX (1) MXPA04003729A (hu)
MY (1) MY147948A (hu)
NO (1) NO20042010L (hu)
PH (1) PH12009500610A1 (hu)
PL (1) PL210470B1 (hu)
TW (1) TWI329642B (hu)
WO (1) WO2003035638A1 (hu)

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MY143245A (en) * 2004-04-28 2011-04-15 Mitsubishi Tanabe Pharma Corp 4- 2-(cycloalkylamino)pyrimidin-4-yl-(phenyl)-imidazolin-2-one derivatives as p38 map-kinase inhibitors for the treatment of inflammatory diseases
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EP1951679B1 (en) * 2005-08-18 2015-02-18 Synta Pharmaceuticals Corp. Imidazole compounds that modulate hsp90 activity
JP2007145819A (ja) * 2005-10-28 2007-06-14 Tanabe Seiyaku Co Ltd 医薬組成物
CN101130539B (zh) * 2007-09-26 2012-05-30 浙江大学 吲哚取代咪唑啉-2-酮类衍生物及其制备方法和用途
DE102009043260A1 (de) 2009-09-28 2011-04-28 Merck Patent Gmbh Pyridinyl-imidazolonderivate
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WO2017151409A1 (en) 2016-02-29 2017-09-08 University Of Florida Research Foundation, Incorporated Chemotherapeutic methods

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MXPA04003729A (es) 2004-07-23
CA2461100C (en) 2009-12-01
WO2003035638A1 (fr) 2003-05-01
IL160874A0 (en) 2004-08-31
PL210470B1 (pl) 2012-01-31
EP1439174A1 (en) 2004-07-21
JPWO2003035638A1 (ja) 2005-02-10
JP4432492B2 (ja) 2010-03-17
ATE550332T1 (de) 2012-04-15
IL160874A (en) 2012-05-31
HUP0401949A3 (en) 2009-07-28
CA2461100A1 (en) 2003-05-01
CN100402521C (zh) 2008-07-16
NO20042010L (no) 2004-07-09
CN1571781A (zh) 2005-01-26
BR0213465A (pt) 2004-11-09
EP1439174B1 (en) 2012-03-21
PL369287A1 (en) 2005-04-18
KR100742058B1 (ko) 2007-07-23
TWI329642B (en) 2010-09-01
KR20040047942A (ko) 2004-06-05
EP1439174A4 (en) 2004-12-22
MY147948A (en) 2013-02-15

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