HUP0301336A2 - Réztartalmú amin-oxidázok inhibitorai és alkalmazásuk gyógyszerkészítmények előállítására - Google Patents
Réztartalmú amin-oxidázok inhibitorai és alkalmazásuk gyógyszerkészítmények előállításáraInfo
- Publication number
- HUP0301336A2 HUP0301336A2 HU0301336A HUP0301336A HUP0301336A2 HU P0301336 A2 HUP0301336 A2 HU P0301336A2 HU 0301336 A HU0301336 A HU 0301336A HU P0301336 A HUP0301336 A HU P0301336A HU P0301336 A2 HUP0301336 A2 HU P0301336A2
- Authority
- HU
- Hungary
- Prior art keywords
- optionally substituted
- alkyl
- aralkyl
- hydrogen atom
- containing amine
- Prior art date
Links
- 102000016893 Amine Oxidase (Copper-Containing) Human genes 0.000 title abstract 2
- 108010028700 Amine Oxidase (Copper-Containing) Proteins 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 5
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000001589 carboacyl group Chemical group 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical group [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 abstract 1
- 102100027159 Membrane primary amine oxidase Human genes 0.000 abstract 1
- 101710132836 Membrane primary amine oxidase Proteins 0.000 abstract 1
- 125000003435 aroyl group Chemical group 0.000 abstract 1
- 150000001805 chlorine compounds Chemical group 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- OAKJQQAXSVQMHS-UHFFFAOYSA-N hydrazine Substances NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 abstract 1
- -1 hydrazine compound Chemical class 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-M iodide Chemical group [I-] XMBWDFGMSWQBCA-UHFFFAOYSA-M 0.000 abstract 1
- 229940006461 iodide ion Drugs 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 125000005346 substituted cycloalkyl group Chemical group 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/131—Amines acyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/15—Oximes (>C=N—O—); Hydrazines (>N—N<); Hydrazones (>N—N=) ; Imines (C—N=C)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Rheumatology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurology (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Vascular Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
A találmány tárgya (I) vagy (II) általános képletű hidrazin vegyület,annak racemátja, izomerje, gyógyászatilag elfogadható szolvátja,hidrátja vagy sója - ahol a képletben R1 jelentése hidrogénatom, 1-4szénatomos alkil-, aralkil-, 2-5 szénatomos alkanoil-, aroil- vagyheteroaroilcsoport, R2 jelentése hidrogénatom, vagy adott esetbenhelyettesített 1-4 szénatomos alkil-, adott esetben helyettesítettcikloalkil- vagy adott esetben helyettesített aralkilcsoport; R3-R6 -amelyek lehetnek azonosak vagy különbözőek - jelentése hidrogénatom,adott esetben helyettesített 1-4 szénatomos alkil-, adott esetbenhelyettesített aralkil-, adott esetben helyettesített fenil- vagyadott esetben helyettesített heteroarilcsoport, R1 és R2 jelentéselehet adott esetben helyettesített heterociklus, R2 és R3 jelentéselehet adott esetben helyettesített heterociklus, R3 és R5 jelentéselehet egy telített, adott esetben helyettesített karbociklus, R7jelentése hidrogénatom, 1-4 szénatomos alkil-, 2-5 szénatomosalkanoil- vagy aralkilcsoport, R8 jelentése 1-4 szénatomos alkil- vagyaralkilcsoport, n értéke 1, 2 vagy 3, X jelentése klorid-, bromid-,jodid-ion vagy R2-szulfát, ahol a képletben R2 jelentése a fentiekbenmeghatározott alkalmazása réztartalmú amin-oxidáz (SSAO) gátlásáraszolgáló gyógyászati készítmény előállítására. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21634100P | 2000-07-05 | 2000-07-05 | |
| PCT/FI2001/000638 WO2002002090A2 (en) | 2000-07-05 | 2001-07-04 | Inhibitors of copper-containing amine oxidases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0301336A2 true HUP0301336A2 (hu) | 2003-08-28 |
| HUP0301336A3 HUP0301336A3 (en) | 2005-04-28 |
Family
ID=22806663
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0301336A HUP0301336A3 (en) | 2000-07-05 | 2001-07-04 | Inhibitors of copper-containing amine oxidases and their use for preparation of pharmaceutical compositions |
| HU0301625A HUP0301625A3 (en) | 2000-07-05 | 2001-07-04 | 1,3,4-oxadiazine-compounds as inhibitors of copper-containing amine oxidases, process for their preparation and their use for preparation of pharmaceutical compositions |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0301625A HUP0301625A3 (en) | 2000-07-05 | 2001-07-04 | 1,3,4-oxadiazine-compounds as inhibitors of copper-containing amine oxidases, process for their preparation and their use for preparation of pharmaceutical compositions |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US6624202B2 (hu) |
| EP (2) | EP1313718A2 (hu) |
| JP (2) | JP2004501962A (hu) |
| CN (2) | CN1450997A (hu) |
| AU (3) | AU2001282162A1 (hu) |
| CA (2) | CA2414807A1 (hu) |
| HU (2) | HUP0301336A3 (hu) |
| IL (2) | IL153766A0 (hu) |
| NO (2) | NO20026283L (hu) |
| NZ (2) | NZ523463A (hu) |
| PL (2) | PL360374A1 (hu) |
| RU (2) | RU2003103291A (hu) |
| WO (2) | WO2002002090A2 (hu) |
| ZA (2) | ZA200300064B (hu) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUP0301336A3 (en) | 2000-07-05 | 2005-04-28 | Biotie Therapies Corp | Inhibitors of copper-containing amine oxidases and their use for preparation of pharmaceutical compositions |
| US6982286B2 (en) | 2001-07-12 | 2006-01-03 | Biotie Therapies Corp. | Carbocyclic hydrazino inhibitors of copper-containing amine oxidases |
| CA2514573A1 (en) * | 2003-01-27 | 2004-08-12 | Astellas Pharma Inc. | Thiazole derivatives and their use as vap-1 inhibitors |
| CA2520957C (en) * | 2003-03-31 | 2013-08-06 | Sucampo Ag | Method for treating vascular hyperpermeable disease |
| JP2007509605A (ja) | 2003-05-26 | 2007-04-19 | バイオティ セラピーズ コーポレイション | 結晶性タンパク質ｖａｐ−１その用途 |
| FI20031927A0 (fi) * | 2003-12-31 | 2003-12-31 | Faron Pharmaceuticals Oy | Terapeuttisesti vaikuttavia aineita ja niiden käyttö |
| EP1708711B1 (en) † | 2004-01-30 | 2010-03-17 | Faron Pharmaceuticals OY | Compositions useful especially for treatment or prevention of metabolic syndrome |
| FI20040136A0 (fi) * | 2004-01-30 | 2004-01-30 | Faron Pharmaceuticals Oy | Erityisesti diabeetikoille soveltuvia koostumuksia |
| US8119651B2 (en) | 2004-01-30 | 2012-02-21 | Biotie Therapies Corp. | Compositions useful especially for treatment or prevention of metabolic syndrome |
| FI20040270A0 (fi) * | 2004-02-20 | 2004-02-20 | Biotie Therapies Oyj | Kuparia sisältävien amiinioksidaasien imhibiittoreina käyttökelpoiset hydratsinoalkoholijohdannaiset |
| CA2575411A1 (en) * | 2004-07-27 | 2006-02-02 | Astellas Pharma Inc. | Thiazole derivatives having vap-1 inhibitory activity |
| EP1791835A2 (en) * | 2004-09-09 | 2007-06-06 | Astellas Pharma Inc. | Thiazole derivatives having vap-1 inhibitory activity |
| JP4140630B2 (ja) * | 2005-11-10 | 2008-08-27 | Ｔｄｋ株式会社 | 磁気ヘッドアセンブリ及び磁気ヘッドアセンブリの製造方法 |
| US20080058922A1 (en) * | 2006-08-31 | 2008-03-06 | Cardiac Pacemakers, Inc. | Methods and devices employing vap-1 inhibitors |
| US8636995B2 (en) * | 2006-08-31 | 2014-01-28 | Cardiac Pacemakers, Inc. | Methods and devices to regulate stem cell homing |
| US8372399B2 (en) * | 2006-08-31 | 2013-02-12 | Cardiac Pacemakers, Inc. | Bispecific antibodies and agents to enhance stem cell homing |
| FI20061156A0 (fi) | 2006-12-27 | 2006-12-27 | Elina Kivi | Uusia peptidejä |
| US20090170770A1 (en) * | 2007-11-06 | 2009-07-02 | Ali Hafezi-Moghadam | Methods and compositions for treating conditions associated with angiogenesis using a vascular adhesion protein-1 (vap 1) inhibitor |
| JP2011504485A (ja) | 2007-11-21 | 2011-02-10 | ファーマクシス リミテッド | Ｓｓａｏ／ｖａｐ−１のハロアリルアミン阻害剤およびその用途 |
| TWI437986B (zh) | 2008-01-31 | 2014-05-21 | R Tech Ueno Ltd | 噻唑衍生物及使用該衍生物作為ｖａｐ－１抑制劑之用途 |
| TWI490214B (zh) | 2008-05-30 | 2015-07-01 | 艾德克 上野股份有限公司 | 苯或噻吩衍生物及該等作為ｖａｐ－１抑制劑之用途 |
| US8906642B2 (en) | 2008-09-03 | 2014-12-09 | Universitat Autonoma De Barcelona | Methods and compositions for the treatment and diagnosis of haemorrhagic conversion |
| RU2400233C1 (ru) | 2009-07-07 | 2010-09-27 | Общество с ограниченной ответственностью "Вирфарм" | Способ лечения заболеваний печени различного генеза |
| UA112154C2 (uk) | 2009-09-08 | 2016-08-10 | Біоті Терапіс Корп. | Застосування повністю людського анти-vap-1-антитіла для лікування фіброзних станів |
| AU2010296420A1 (en) | 2009-09-16 | 2012-03-22 | Astellas Pharma Inc. | Glycine compound |
| RU2010145439A (ru) | 2010-11-08 | 2012-05-20 | Виктор Вениаминович Тец (RU) | Средство для лечения поражений печени, вызванных воздействием химических или биологических агентов |
| FI20115234A0 (fi) | 2011-03-08 | 2011-03-08 | Biotie Therapies Corp | Uusia pyridatsinoni- ja pyridoniyhdisteitä |
| HUE034860T2 (hu) | 2011-03-15 | 2018-03-28 | Astellas Pharma Inc | Guanidin vegyület |
| AU2014279863A1 (en) | 2013-06-12 | 2016-01-28 | Proximagen Limited | New therapeutic uses of enzyme inhibitors |
| EP3131539B1 (en) | 2014-04-15 | 2018-12-05 | Pécsi Tudományegyetem | Semicarbazide-sensitive amine oxidase inhibitors for use as analgesics in traumatic neuropathy and neurogenic inflammation |
| WO2015189534A1 (en) | 2014-06-12 | 2015-12-17 | Proximagen Limited | Vap-1 inhibitors for treating muscular dystrophy |
| RU2595868C1 (ru) | 2015-03-27 | 2016-08-27 | Виктор Вениаминович Тец | Лекарственное средство с гепатопротекторной активностью |
| JP2018076236A (ja) | 2015-06-05 | 2018-05-17 | 株式会社アールテック・ウエノ | がんを処置するための医薬組成物 |
| JP2019502672A (ja) | 2015-12-07 | 2019-01-31 | ベネボレンタイ ケンブリッジ リミティド | 疼痛の治療のためのｖａｐ−１阻害剤 |
| CN109810041B (zh) * | 2017-11-21 | 2023-08-15 | 药捷安康(南京)科技股份有限公司 | 卤代烯丙基胺类ssao/vap-1抑制剂及其应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3377345A (en) * | 1966-09-23 | 1968-04-09 | Dow Chemical Co | Substituted 3, 4, 5, 6-tetrahydro-2h-1, 3, 4-oxadiazin-2-one compounds and method ofpreparation thereof |
| US3486916A (en) | 1966-12-22 | 1969-12-30 | William A Cordon | Cement mixes and the production of articles therefrom |
| SE320311B (hu) | 1968-07-15 | 1970-02-02 | Mo Och Domsjoe Ab | |
| EP0639972A1 (en) * | 1992-05-15 | 1995-03-01 | University Of Saskatchewan | Method for preventing endothelium damage in mammals and for alleviating pain associated with gout and arthritis |
| US5413634A (en) | 1993-08-06 | 1995-05-09 | Arco Chemical Technology, L.P. | Cement composition |
| CA2117585C (en) | 1993-09-14 | 2001-06-05 | Edward T. Shawl | Cement composition |
| WO1996006058A1 (en) | 1994-08-25 | 1996-02-29 | W.R. Grace & Co.-Conn. | Shrinkage reduction cement composition |
| US5618344A (en) | 1995-03-06 | 1997-04-08 | W. R. Grace & Co.-Conn. | Cement composition |
| US5603760A (en) | 1995-09-18 | 1997-02-18 | W. R. Grace & Co.-Conn. | Cement admixture capable of inhibiting drying shrinkage and method of using same |
| US5556460A (en) | 1995-09-18 | 1996-09-17 | W.R. Grace & Co.-Conn. | Drying shrinkage cement admixture |
| HUP0301336A3 (en) | 2000-07-05 | 2005-04-28 | Biotie Therapies Corp | Inhibitors of copper-containing amine oxidases and their use for preparation of pharmaceutical compositions |
-
2001
- 2001-07-04 HU HU0301336A patent/HUP0301336A3/hu unknown
- 2001-07-04 IL IL15376601A patent/IL153766A0/xx unknown
- 2001-07-04 WO PCT/FI2001/000638 patent/WO2002002090A2/en not_active Application Discontinuation
- 2001-07-04 AU AU2001282162A patent/AU2001282162A1/en not_active Abandoned
- 2001-07-04 EP EP01960764A patent/EP1313718A2/en not_active Withdrawn
- 2001-07-04 CN CN01815101A patent/CN1450997A/zh active Pending
- 2001-07-04 EP EP01960763A patent/EP1301495A2/en not_active Withdrawn
- 2001-07-04 JP JP2002506712A patent/JP2004501962A/ja not_active Withdrawn
- 2001-07-04 RU RU2003103291/04A patent/RU2003103291A/ru not_active Application Discontinuation
- 2001-07-04 IL IL15376701A patent/IL153767A0/xx unknown
- 2001-07-04 AU AU8216301A patent/AU8216301A/xx active Pending
- 2001-07-04 AU AU2001282163A patent/AU2001282163B2/en not_active Ceased
- 2001-07-04 CA CA002414807A patent/CA2414807A1/en not_active Abandoned
- 2001-07-04 NZ NZ523463A patent/NZ523463A/en unknown
- 2001-07-04 RU RU2003103286/15A patent/RU2003103286A/ru not_active Application Discontinuation
- 2001-07-04 HU HU0301625A patent/HUP0301625A3/hu unknown
- 2001-07-04 JP JP2002507795A patent/JP2004502682A/ja not_active Withdrawn
- 2001-07-04 PL PL36037401A patent/PL360374A1/xx not_active Application Discontinuation
- 2001-07-04 CA CA002414799A patent/CA2414799A1/en not_active Abandoned
- 2001-07-04 NZ NZ523464A patent/NZ523464A/en unknown
- 2001-07-04 PL PL36035301A patent/PL360353A1/xx not_active Application Discontinuation
- 2001-07-04 CN CN01815102A patent/CN1450998A/zh active Pending
- 2001-07-04 WO PCT/FI2001/000637 patent/WO2002002541A2/en not_active Application Discontinuation
- 2001-07-05 US US09/898,003 patent/US6624202B2/en not_active Expired - Fee Related
-
2002
- 2002-12-30 NO NO20026283A patent/NO20026283L/no not_active Application Discontinuation
- 2002-12-30 NO NO20026282A patent/NO20026282L/no not_active Application Discontinuation
-
2003
- 2003-01-03 ZA ZA200300064A patent/ZA200300064B/en unknown
- 2003-01-03 ZA ZA200300063A patent/ZA200300063B/en unknown
- 2003-07-21 US US10/622,581 patent/US20040106654A1/en not_active Abandoned
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