HUP0103460A2 - Vírusellenes hatású indolszármazékok és a vegyületeket tartalmazó gyógyszerkészítmények - Google Patents

Vírusellenes hatású indolszármazékok és a vegyületeket tartalmazó gyógyszerkészítmények

Info

Publication number
HUP0103460A2
HUP0103460A2 HU0103460A HUP0103460A HUP0103460A2 HU P0103460 A2 HUP0103460 A2 HU P0103460A2 HU 0103460 A HU0103460 A HU 0103460A HU P0103460 A HUP0103460 A HU P0103460A HU P0103460 A2 HUP0103460 A2 HU P0103460A2
Authority
HU
Hungary
Prior art keywords
group
optionally substituted
indole derivatives
hydrogen atom
pharmaceutical compositions
Prior art date
Application number
HU0103460A
Other languages
English (en)
Inventor
Toshio Fujishita
Tomokazu Yoshinaga
Original Assignee
Shionogi & Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi & Co., Ltd. filed Critical Shionogi & Co., Ltd.
Publication of HUP0103460A2 publication Critical patent/HUP0103460A2/hu
Publication of HUP0103460A3 publication Critical patent/HUP0103460A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/22—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an aralkyl radical attached to the ring nitrogen atom

Abstract

A találmány tárgyát az integráz inhibitor hatású, így vírusellenes,különösen HIV-ellenes hatóanyagként hasznosítható általános képletűindolszármazékok - amely képletben előnyösen R1 hidrogénatom vagyadott esetben szubsztituált aril-szulfonilcsoport R2 hidrogénatom,adott esetben szubsztituált aril- vagy aralkilcsoport; R3, R4, R5 ésR6 hidrogén- vagy halogénatom; X hidroxi- vagy adott esetbenszubsztituált aminocsoport; és Y -COOR általános képletű csoport (aholR hidrogénatom vagy észtert képező csoport) vagy adott esetbenszubsztituált heteroarilcsoport - és gyógyszerészetileg elfogadhatósóik vagy hidrátjaik, valamint ezeket hatóanyagként tartalmazógyógyszerkészítmények képezik. Ó
HU0103460A 1998-03-26 1999-03-26 Indole derivatives with antiviral activity and pharmaceutical compositions containing them HUP0103460A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP7820398 1998-03-26
PCT/JP1999/001547 WO1999050245A1 (fr) 1998-03-26 1999-03-26 Derives d'indole exerçant une activite antivirale

Publications (2)

Publication Number Publication Date
HUP0103460A2 true HUP0103460A2 (hu) 2002-01-28
HUP0103460A3 HUP0103460A3 (en) 2002-11-28

Family

ID=13655476

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0103460A HUP0103460A3 (en) 1998-03-26 1999-03-26 Indole derivatives with antiviral activity and pharmaceutical compositions containing them

Country Status (17)

Country Link
US (3) US6333323B1 (hu)
EP (1) EP1069111A4 (hu)
JP (1) JP3794469B2 (hu)
KR (1) KR20010041705A (hu)
CN (1) CN1142909C (hu)
AU (1) AU752005B2 (hu)
BR (1) BR9909146A (hu)
CA (1) CA2326166A1 (hu)
HU (1) HUP0103460A3 (hu)
ID (1) ID26031A (hu)
IL (1) IL137974A0 (hu)
NO (1) NO317423B1 (hu)
NZ (1) NZ506435A (hu)
PL (1) PL343249A1 (hu)
RU (1) RU2217421C2 (hu)
WO (1) WO1999050245A1 (hu)
ZA (1) ZA200004047B (hu)

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Also Published As

Publication number Publication date
RU2217421C2 (ru) 2003-11-27
JP3794469B2 (ja) 2006-07-05
BR9909146A (pt) 2000-12-05
US20020019434A1 (en) 2002-02-14
IL137974A0 (en) 2001-10-31
ZA200004047B (en) 2001-04-25
ID26031A (id) 2000-11-16
KR20010041705A (ko) 2001-05-25
NZ506435A (en) 2002-08-28
EP1069111A4 (en) 2001-06-06
AU2958199A (en) 1999-10-18
WO1999050245A1 (fr) 1999-10-07
CN1142909C (zh) 2004-03-24
US6716605B2 (en) 2004-04-06
US20030181499A1 (en) 2003-09-25
NO317423B1 (no) 2004-10-25
US6333323B1 (en) 2001-12-25
CN1294580A (zh) 2001-05-09
AU752005B2 (en) 2002-09-05
US6506787B2 (en) 2003-01-14
EP1069111A1 (en) 2001-01-17
HUP0103460A3 (en) 2002-11-28
PL343249A1 (en) 2001-07-30
NO20004787D0 (no) 2000-09-25
CA2326166A1 (en) 1999-10-07
NO20004787L (no) 2000-11-27

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