MA27795A1 - Derives d'amine cycliques, procedes de preparation de ceux-ci et compositions pharmaceutiques les contenant - Google Patents

Derives d'amine cycliques, procedes de preparation de ceux-ci et compositions pharmaceutiques les contenant

Info

Publication number
MA27795A1
MA27795A1 MA28584A MA28584A MA27795A1 MA 27795 A1 MA27795 A1 MA 27795A1 MA 28584 A MA28584 A MA 28584A MA 28584 A MA28584 A MA 28584A MA 27795 A1 MA27795 A1 MA 27795A1
Authority
MA
Morocco
Prior art keywords
same
processes
pharmaceutical compositions
compositions containing
cyclic amine
Prior art date
Application number
MA28584A
Other languages
English (en)
Inventor
Giuseppe Alvaro
Luca Arista
Francesca Cardullo
Adamo Lucilla D
Aldo Feriani
Riccardo Giovannini
Catia Seri
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of MA27795A1 publication Critical patent/MA27795A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Anesthesiology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Dérivés d'aminés cycliques, procédés pour leur préparation et compositions pharmaceutiques les contenant Un composé de formule (I) dans laquelle R représente un radical choisi entre les radicaux i) , ii) , iii) et iv) , oé les substituants R1, R2, R3, R4, R5, R6, R7 et les indices m, n et p sont tels que définis dans la description ; ou ses sels et produits de solvatation pharmaceutiquement acceptables ; des procédés pour leur préparation ; des compositions pharmaceutiques les contenant ; et leur utilisation dans le traitement d'affections à médiation par des tachykinines et/ou par inhibition sélective de la protéine transporteur de réabsorption de sérotonine.
MA28584A 2003-05-09 2005-11-08 Derives d'amine cycliques, procedes de preparation de ceux-ci et compositions pharmaceutiques les contenant MA27795A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0310724.0A GB0310724D0 (en) 2003-05-09 2003-05-09 Chemical compounds

Publications (1)

Publication Number Publication Date
MA27795A1 true MA27795A1 (fr) 2006-03-01

Family

ID=9957781

Family Applications (1)

Application Number Title Priority Date Filing Date
MA28584A MA27795A1 (fr) 2003-05-09 2005-11-08 Derives d'amine cycliques, procedes de preparation de ceux-ci et compositions pharmaceutiques les contenant

Country Status (21)

Country Link
US (2) US20070073061A1 (fr)
EP (1) EP1622871A1 (fr)
JP (1) JP4684221B2 (fr)
KR (1) KR20060009313A (fr)
CN (1) CN100534983C (fr)
AR (1) AR044269A1 (fr)
AU (1) AU2004235967B2 (fr)
BR (1) BRPI0410154A (fr)
CA (1) CA2524894A1 (fr)
EG (1) EG24668A (fr)
GB (1) GB0310724D0 (fr)
IS (1) IS8164A (fr)
MA (1) MA27795A1 (fr)
MX (1) MXPA05012096A (fr)
MY (1) MY140027A (fr)
NO (1) NO20055835L (fr)
NZ (1) NZ543068A (fr)
RU (1) RU2392270C2 (fr)
TW (1) TWI332499B (fr)
WO (1) WO2004099143A1 (fr)
ZA (1) ZA200508339B (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0412865D0 (en) 2004-06-09 2004-07-14 Glaxo Group Ltd Chemical compounds
US7844037B2 (en) 2005-08-08 2010-11-30 Palm, Inc. Method and device for enabling message responses to incoming phone calls
EP2094692B1 (fr) * 2006-11-01 2012-11-28 Bristol-Myers Squibb Company Modulateurs du récepteur des glucocorticoïdes et de l'activité ap-1 et/ou nf-kappab et leur utilisation
EP2331505A2 (fr) * 2008-09-01 2011-06-15 NeuroSearch A/S Nouveaux dérivés de piperidine-4-acetamide et utilisation de ceux-ci en tant qu'inhibiteurs du recaptage des neurotransmetteurs monoamines
ES2672099T3 (es) 2011-07-04 2018-06-12 Irbm - Science Park S.P.A. Antagonistas del receptor NK-1 para el tratamiento de la neovascularización corneal
CN106187999A (zh) * 2015-05-04 2016-12-07 复旦大学 取代哌啶类化合物及其制备方法和用途
KR20240019754A (ko) 2021-03-23 2024-02-14 바이오에이지 랩스, 인코포레이티드 Nlrp3 인플라마좀의 억제제
WO2023147468A1 (fr) 2022-01-28 2023-08-03 BioAge Labs, Inc. Inhibiteurs de n-oxyde de l'inflammasome nlrp3

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US309720A (en) * 1884-12-23 William p
NL262366A (fr) * 1960-03-14
GB1356117A (en) * 1970-12-16 1974-06-12 Searle & Co 1-3-cyano-3,3-diphenylpropyl-4-phenylpiperidine-4-carboxylic acid derivatives
US5635510A (en) * 1993-05-06 1997-06-03 Merrell Pharmaceuticals Inc. Substituted pyrrolidin-3-yl-alkyl-piperidines
DE19603767A1 (de) * 1996-02-02 1997-08-07 Hoechst Ag Pyrrolidinpropionsäurederivate mit bradykinin-antagonistischer Wirkung
US6020347A (en) * 1997-11-18 2000-02-01 Merck & Co., Inc. 4-substituted-4-piperidine carboxamide derivatives
WO1999025685A1 (fr) * 1997-11-18 1999-05-27 Merck & Co., Inc. Derives de 4-piperidine carboxamides 4-substitues
US6423519B1 (en) * 1998-07-15 2002-07-23 Gpc Biotech Inc. Compositions and methods for inhibiting fungal growth
CA2443672C (fr) * 2001-04-12 2011-03-29 Pharmacopeia, Inc. Aryl et biaryl piperidines utilisees en tant qu'antagonistes de la mch
JP2005510563A (ja) * 2001-11-26 2005-04-21 シェーリング　コーポレイション 肥満およびｃｎｓ障害の処置のためのピペリジン系ｍｃｈアンタゴニスト
TW200403058A (en) * 2002-04-19 2004-03-01 Bristol Myers Squibb Co Heterocyclo inhibitors of potassium channel function
US20060128752A1 (en) * 2002-07-03 2006-06-15 Giuseppe Alvaro Chemical compounds

Also Published As

Publication number Publication date
EG24668A (en) 2010-04-11
EP1622871A1 (fr) 2006-02-08
US20090192194A1 (en) 2009-07-30
AU2004235967A1 (en) 2004-11-18
BRPI0410154A (pt) 2006-05-16
MXPA05012096A (es) 2006-02-08
TW200510309A (en) 2005-03-16
RU2005138315A (ru) 2007-06-20
RU2392270C2 (ru) 2010-06-20
KR20060009313A (ko) 2006-01-31
US20070073061A1 (en) 2007-03-29
WO2004099143A1 (fr) 2004-11-18
ZA200508339B (en) 2006-10-25
JP4684221B2 (ja) 2011-05-18
GB0310724D0 (en) 2003-06-11
JP2006525975A (ja) 2006-11-16
MY140027A (en) 2009-11-30
AR044269A1 (es) 2005-09-07
NZ543068A (en) 2009-07-31
CN1819995A (zh) 2006-08-16
CN100534983C (zh) 2009-09-02
NO20055835L (no) 2006-02-07
AU2004235967B2 (en) 2008-10-23
IS8164A (is) 2005-12-01
TWI332499B (en) 2010-11-01
NO20055835D0 (no) 2005-12-08
CA2524894A1 (fr) 2004-11-18

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