HUP0303494A2 - Bakteriális giráz inhibitorokat tartalmazó gyógyszerkészítmények és alkalmazásaik - Google Patents

Bakteriális giráz inhibitorokat tartalmazó gyógyszerkészítmények és alkalmazásaik

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Publication number
HUP0303494A2
HUP0303494A2 HU0303494A HUP0303494A HUP0303494A2 HU P0303494 A2 HUP0303494 A2 HU P0303494A2 HU 0303494 A HU0303494 A HU 0303494A HU P0303494 A HUP0303494 A HU P0303494A HU P0303494 A2 HUP0303494 A2 HU P0303494A2
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HU
Hungary
Prior art keywords
bacterial
compositions containing
membered ring
ring containing
containing bacterial
Prior art date
Application number
HU0303494A
Other languages
English (en)
Inventor
Michael C. Badia
Paul Charifson
Anne-Laure Grillot
Yusheng Liao
Dean Stamos
Martin Trudeau
Original Assignee
Vertex Pharmaceuticals Incorporated
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharmaceuticals Incorporated filed Critical Vertex Pharmaceuticals Incorporated
Publication of HUP0303494A2 publication Critical patent/HUP0303494A2/hu
Publication of HUP0303494A3 publication Critical patent/HUP0303494A3/hu

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    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/42—Oxazoles
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    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
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Abstract

A találmány az általános képletű vegyületekre - ahol Z -O- vagy =N-R4 W =N- vagy =C-Ra; Ra hidrogén- vagy halogénatom, -CF3, R7, -OR7 vagy -N (R7) 2; R1 adott esetben szubsztituált aril-vagy heteroaril-gyűrű, vagy R2-vel együtt kondenzált 5-8 tagú, 0-2=N-, -O- vagy S- hetoeroatmot tartalmazó gyűrűt képezhet: R2 és R3egymástól függetlenül halogénatom, cianocsoport vagy egyéb,diszubsztituált amino- vagy karboxiszármazék-csoport, vagy együttkondenzált 5-8 tagú, 0-2 =N-, -O- vagy -S- hetoeroatmot tartalmazógyűrűt képezhetnek; R5 különféle összetett szubsztituens lehet - vagy gyógyszerészetileg elfogadható sóira és prodrugjairavonatkozik, amelyek baktérium giráz aktivitást gátló hatást mutatnak,és biológiai minták baktériumtartalmának csökkentésére, valamintemlősökben, elsősorban emberben bakteriális fertőzések megelőzésére,illetve kezelésére alkalmas gyógyszerkészítmények előállításáraalkalmazhatók. Ó
HU0303494A 2000-12-15 2001-12-12 Parmaceutical compositions containing bacterial gyrase inhibitors and uses thereof HUP0303494A3 (en)

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CA2433197A1 (en) 2002-08-08
MY138797A (en) 2009-07-31
AR054963A1 (es) 2007-08-01
AU2006201397B2 (en) 2009-10-01
JP5196660B2 (ja) 2013-05-15
ATE375983T1 (de) 2007-11-15
BR0116216A (pt) 2004-08-17
DE60131015T2 (de) 2008-07-10
RU2262932C2 (ru) 2005-10-27
US7414046B2 (en) 2008-08-19
IL156031A0 (en) 2003-12-23
US20030119868A1 (en) 2003-06-26
ATE443052T1 (de) 2009-10-15
WO2002060879A2 (en) 2002-08-08
JP2004518684A (ja) 2004-06-24
AU2006201397A1 (en) 2006-04-27
RU2003121398A (ru) 2005-02-10
JP2009102449A (ja) 2009-05-14
JP4516272B2 (ja) 2010-08-04
KR20030061855A (ko) 2003-07-22
HUP0303494A3 (en) 2009-08-28
CO7250441A2 (es) 2015-04-30
AP2003002824A0 (en) 2003-09-30
NZ526241A (en) 2007-01-26
CA2433197C (en) 2009-11-24
MXPA03005298A (es) 2003-10-06
US20040043989A1 (en) 2004-03-04
US6632809B2 (en) 2003-10-14
DK1341769T3 (da) 2008-01-28
CN1266138C (zh) 2006-07-26
DE60139964D1 (de) 2009-10-29
CN1481368A (zh) 2004-03-10
NO20032668D0 (no) 2003-06-12
EP1557410A2 (en) 2005-07-27
WO2002060879A3 (en) 2003-03-27
SI1341769T1 (sl) 2008-02-29
PT1341769E (pt) 2007-12-31
NO20032668L (no) 2003-06-12
NO327312B1 (no) 2009-06-08
HK1061851A1 (en) 2004-10-08
USRE40245E1 (en) 2008-04-15
EP1341769A2 (en) 2003-09-10
ES2331250T3 (es) 2009-12-28
IL156031A (en) 2011-11-30
DE60131015D1 (de) 2007-11-29
PL362691A1 (en) 2004-11-02
KR100944645B1 (ko) 2010-03-04
EP1557410B1 (en) 2009-09-16
EP1341769B1 (en) 2007-10-17
ES2294046T3 (es) 2008-04-01
CY1107854T1 (el) 2013-06-19
EP1557410A3 (en) 2006-04-26

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