AR067060A1 - Derivados de guanina policiclicos y sus metodos de uso - Google Patents
Derivados de guanina policiclicos y sus metodos de usoInfo
- Publication number
- AR067060A1 AR067060A1 ARP080102611A ARP080102611A AR067060A1 AR 067060 A1 AR067060 A1 AR 067060A1 AR P080102611 A ARP080102611 A AR P080102611A AR P080102611 A ARP080102611 A AR P080102611A AR 067060 A1 AR067060 A1 AR 067060A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- aryl
- heterocycloalkyl
- alkylene
- groups
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Obesity (AREA)
- Immunology (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Physical Education & Sports Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Se refiere a derivados de guanina policíclicos, composiciones que comprenden los derivados de guanina policíclicos y los métodos de uso de los derivados de guanina policíclicos para tratar el dolor o una enfermedad inflamatoria. Reivindicacion 1: Un compuesto que tiene la formula (1) o una sal, solvato, éster o prodroga farmacéuticamente aceptable de los mismos, en donde: R1 es alquilo C1-6 o alquilo-alquilen-O-C1-6; R2 es alquilo, arilo, -alquilen-arilo, heterocicloalquilo o heteroarilo, cualquiera de las cuales puede estar opcionalmente sustituido por R5; R3 es alquilo, -alquilen-arilo, cicloalquilo, -alquilen-cicloalquilo o -alquileno-heterocicloalquilo, en donde un grupo arilo, cicloalquilo o heterocicloalquilo puede estar opcionalmente sustituido con R7; Cada aparicion de R4 es independientemente H o alquilo C1-6, o ambos grupos R4 junto con el átomo de C al cual están unidos, se juntan para formar un grupo cicloalquilo de 3 a 7 miembros, que se puede opcionalmente con un anillo e benceno; R5 representa de 1 a 3 grupos, cada uno se selecciono independientemente de alquenilo, alquinilo, arilo, heterocicloalquilo, heteroarilo, halo, -CN, -C(O)OR6, -C(O)R6, -C(O)N(R6)2, -S(O)2NHR6, -OH, -Oalquilo, haloalquilo, -Ohaloalquilo y -NHC(O)N(R6)2, donde un grupo arilo, heterocicloalquilo o heteroarilo puede estar opcionalmente sustituido con hasta 3 grupos, cada uno independientemente seleccionado de alquilo C1-6, halo, -C(O)OR6 y -C(O)N(R6)2; cada aparicion de R6 es independientemente H, alquilo C1-6, arilo o heterocicloalquilo, en donde un grupo arilo o heterocicloalquilo puede estar opcionalmente sustituido con hasta 3 grupos, cada uno independientemente seleccionado de alquilo, -Oalquilo, halo, -CN, haloalquilo, -alquilen-C(O)N(R8)2, -C(O)N(R8)2, -C(O)OR8, heterocicloalquil-C(O)-, alquil-C(O) o -N(R8)2; R7 representa de 1 a 3 grupos, cada uno independientemente seleccionado de alquilo C1-6, halo, arilo, -N(R8)2, -C(O)OR8, C(O)N(R8)2 y haloalquilo; y cada aparicion de R8 es independientemente H, alquilo C1-6 o arilo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94545207P | 2007-06-21 | 2007-06-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR067060A1 true AR067060A1 (es) | 2009-09-30 |
Family
ID=40186205
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP080102611A AR067060A1 (es) | 2007-06-21 | 2008-06-19 | Derivados de guanina policiclicos y sus metodos de uso |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US8349858B2 (es) |
| EP (1) | EP2170896A2 (es) |
| JP (1) | JP2010530427A (es) |
| KR (1) | KR20100023040A (es) |
| AR (1) | AR067060A1 (es) |
| AU (1) | AU2008269177A1 (es) |
| BR (1) | BRPI0812909A2 (es) |
| CA (1) | CA2691194A1 (es) |
| CL (1) | CL2008001835A1 (es) |
| CO (1) | CO6251257A2 (es) |
| EC (1) | ECSP099822A (es) |
| IL (1) | IL202754A0 (es) |
| MX (1) | MX2010000098A (es) |
| PE (1) | PE20090418A1 (es) |
| RU (1) | RU2010101611A (es) |
| TW (1) | TW200911817A (es) |
| WO (1) | WO2009002423A2 (es) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011079000A1 (en) * | 2009-12-22 | 2011-06-30 | Schering Corporation | DERIVATIVES OF 7,8-DIHYDRO-1H-IMIDAZO[2,1-b]PURIN-4(5H)-ONE AND METHODS OF USE THEREOF |
| EP2648517B1 (en) * | 2010-12-06 | 2015-08-05 | Merck Sharp & Dohme Corp. | Tricyclic heterocycles useful as dipeptidyl peptidase-iv inhibitors |
| TWI589576B (zh) | 2011-07-15 | 2017-07-01 | 諾華公司 | 氮雜－雙環二芳基醚之鹽類及製造彼等或其前驅物之方法 |
| EP2797933B1 (en) * | 2011-12-30 | 2017-08-16 | Dow AgroSciences LLC | Methods of forming 4-chloro-2-fluoro-3-substituted-phenylboronic acid pinacol esters and methods of using the same |
| KR102154104B1 (ko) * | 2013-01-28 | 2020-09-09 | 인코젠 쎄라퓨틱스 프라이빗 리미티드 | 로플루밀라스트 n- 옥사이드의 흡입에 의한 자가면역, 호흡 및 염증성 장애의 치료방법 |
| US9040534B2 (en) | 2013-03-14 | 2015-05-26 | Janssen Pharmaceutica Nv | [1,2,4]triazolo[4,3-a]pyrazines as P2X7 modulators |
| US9604982B2 (en) | 2013-03-14 | 2017-03-28 | Janssen Pharmaceutica Nv | P2X7 modulators |
| JO3509B1 (ar) | 2013-03-14 | 2020-07-05 | Janssen Pharmaceutica Nv | معدلات p2x7 |
| TWI599567B (zh) | 2013-03-14 | 2017-09-21 | 健生藥品公司 | Ｐ２ｘ７調節劑 |
| US10150766B2 (en) | 2014-09-12 | 2018-12-11 | Janssen Pharmaceutica Nv | P2X7 modulators |
| KR102059333B1 (ko) | 2015-04-24 | 2019-12-26 | 시오노기 앤드 컴파니, 리미티드 | 6원 헤테로환 유도체 및 그를 함유하는 의약 조성물 |
| AU2017345923B2 (en) * | 2016-10-17 | 2021-11-11 | Shionogi & Co., Ltd. | Bicyclic nitrogenated heterocyclic derivative and pharmaceutical composition containing same |
| EP3856179A1 (en) | 2018-09-28 | 2021-08-04 | Janssen Pharmaceutica N.V. | Monoacylglycerol lipase modulators |
| MX2021003737A (es) | 2018-09-28 | 2021-05-14 | Janssen Pharmaceutica Nv | Moduladores de monoacilglicerol lipasa. |
| JP2022550767A (ja) | 2019-09-30 | 2022-12-05 | ヤンセン ファーマシューティカ エヌ．ベー． | 放射線標識されたｍｇｌ ｐｅｔリガンド |
| US11891387B2 (en) | 2020-03-26 | 2024-02-06 | Janssen Pharmaceutica Nv | Monoacylglycerol lipase modulators |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0119372A1 (en) | 1983-03-21 | 1984-09-26 | Svecia Silkscreen Maskiner AB | Conveying device using a number of rollers |
| ZA914727B (en) | 1990-06-21 | 1992-03-25 | Schering Corp | Polycyclic guanine derivatives |
| AU681875B2 (en) * | 1993-02-26 | 1997-09-11 | Schering Corporation | 2-benzyl-polycyclic guanine derivatives and process for preparing them |
| JPH10501122A (ja) | 1994-05-27 | 1998-02-03 | グラクソ、グループ、リミテッド | Ｐ▲下２ｘ▼レセプター（プリノセプターファミリー） |
| US5856129A (en) | 1996-10-30 | 1999-01-05 | Incyte Pharmaceuticals, Inc. | DNA encoding a human purinoceptor |
| WO1999055901A2 (en) | 1998-04-30 | 1999-11-04 | Abbott Laboratories | Screening assay for identifying human purinoreceptor ligands |
| IL155317A0 (en) | 2000-10-13 | 2003-11-23 | Bristol Myers Squibb Co | Methods for detecting modulators of ion channels using thallium (i) sensitive assays |
| US20020182646A1 (en) | 2001-04-30 | 2002-12-05 | Ke Huazhu | Methods and products for identifying modulators of P2X7 receptor activity, and their use in the treatment of skeletal disorders |
| US6969719B2 (en) * | 2001-08-28 | 2005-11-29 | Schering Corporation | Polycyclic guanine phosphodiesterase V inhibitors |
| US20050123925A1 (en) | 2002-11-15 | 2005-06-09 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of tumor |
| US20050238650A1 (en) | 2002-04-17 | 2005-10-27 | Genentech, Inc. | Compositions and methods for the treatment of tumor of hematopoietic origin |
| MXPA04004370A (es) * | 2001-11-09 | 2004-08-11 | Schering Corp | Derivados policiclicos de guanina inhibidores de fosfodiesterasa v. |
| US7560243B2 (en) | 2003-04-21 | 2009-07-14 | Wisconsin Alumni Research Foundation | White blood cell functional assay |
| GB0323147D0 (en) | 2003-10-03 | 2003-11-05 | Medical Res Council | Improvements in or relating to concentration of intracellular agents |
| JP2008542385A (ja) | 2005-05-31 | 2008-11-27 | ダスカ サイエンティフィック コーポレーション | 神経損傷の抑制 |
| WO2007115192A2 (en) | 2006-03-31 | 2007-10-11 | Abbott Laboratories | P2x7 antagonists to treat affective disorders |
-
2008
- 2008-06-18 CA CA2691194A patent/CA2691194A1/en not_active Abandoned
- 2008-06-18 AU AU2008269177A patent/AU2008269177A1/en not_active Abandoned
- 2008-06-18 US US12/663,727 patent/US8349858B2/en not_active Expired - Fee Related
- 2008-06-18 RU RU2010101611/04A patent/RU2010101611A/ru not_active Application Discontinuation
- 2008-06-18 JP JP2010513236A patent/JP2010530427A/ja not_active Withdrawn
- 2008-06-18 EP EP08768585A patent/EP2170896A2/en not_active Withdrawn
- 2008-06-18 WO PCT/US2008/007592 patent/WO2009002423A2/en active Application Filing
- 2008-06-18 PE PE2008001040A patent/PE20090418A1/es not_active Application Discontinuation
- 2008-06-18 MX MX2010000098A patent/MX2010000098A/es not_active Application Discontinuation
- 2008-06-18 KR KR1020107001339A patent/KR20100023040A/ko not_active Application Discontinuation
- 2008-06-18 BR BRPI0812909-6A2A patent/BRPI0812909A2/pt not_active Application Discontinuation
- 2008-06-19 CL CL2008001835A patent/CL2008001835A1/es unknown
- 2008-06-19 TW TW097122895A patent/TW200911817A/zh unknown
- 2008-06-19 AR ARP080102611A patent/AR067060A1/es not_active Application Discontinuation
-
2009
- 2009-12-15 IL IL202754A patent/IL202754A0/en unknown
- 2009-12-17 CO CO09144826A patent/CO6251257A2/es not_active Application Discontinuation
- 2009-12-21 EC EC2009009822A patent/ECSP099822A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL202754A0 (en) | 2010-06-30 |
| EP2170896A2 (en) | 2010-04-07 |
| ECSP099822A (es) | 2010-01-29 |
| MX2010000098A (es) | 2010-04-21 |
| WO2009002423A2 (en) | 2008-12-31 |
| US8349858B2 (en) | 2013-01-08 |
| PE20090418A1 (es) | 2009-04-18 |
| US20110065738A1 (en) | 2011-03-17 |
| TW200911817A (en) | 2009-03-16 |
| KR20100023040A (ko) | 2010-03-03 |
| BRPI0812909A2 (pt) | 2014-12-09 |
| AU2008269177A1 (en) | 2008-12-31 |
| CO6251257A2 (es) | 2011-02-21 |
| WO2009002423A3 (en) | 2009-04-23 |
| CL2008001835A1 (es) | 2008-12-26 |
| JP2010530427A (ja) | 2010-09-09 |
| CA2691194A1 (en) | 2008-12-31 |
| RU2010101611A (ru) | 2011-07-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |