EA201790207A1 - Новые замещенные пиримидиновые соединения - Google Patents

Новые замещенные пиримидиновые соединения

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Publication number
EA201790207A1
EA201790207A1 EA201790207A EA201790207A EA201790207A1 EA 201790207 A1 EA201790207 A1 EA 201790207A1 EA 201790207 A EA201790207 A EA 201790207A EA 201790207 A EA201790207 A EA 201790207A EA 201790207 A1 EA201790207 A1 EA 201790207A1
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EA
Eurasian Patent Office
Prior art keywords
pyrimidine compounds
substituted pyrimidine
new substituted
medicines
indices
Prior art date
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EA201790207A
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English (en)
Other versions
EA201790207A8 (ru
Inventor
Антонио Нарди
Флориан Якоб
Инго Конетцки
Тобиас Кран
Кристиан Хесслингер
Робин Додеман
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Грюненталь Гмбх
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Publication of EA201790207A1 publication Critical patent/EA201790207A1/ru
Publication of EA201790207A8 publication Critical patent/EA201790207A8/ru

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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems

Abstract

Изобретение относится к новым замещенным пиримидиновым соединениям общей формулы (I)в которой химические группировки, заместители, переменные и индексы имеют значения, определенные в описании, и к их применению в качестве лекарственных средств, в частности в качестве лекарственных средств для лечения состояний и заболеваний, которые можно лечить путем ингибирования фермента ФДЭ4.
EA201790207A 2014-07-16 2015-07-16 Новые замещенные пиримидиновые соединения EA201790207A8 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14002452 2014-07-16
PCT/EP2015/001476 WO2016008593A1 (en) 2014-07-16 2015-07-16 Novel substituted pyrimidine compounds

Publications (2)

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EA201790207A1 true EA201790207A1 (ru) 2017-07-31
EA201790207A8 EA201790207A8 (ru) 2018-06-29

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EA201790207A EA201790207A8 (ru) 2014-07-16 2015-07-16 Новые замещенные пиримидиновые соединения

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US (2) US9540349B2 (ru)
EP (2) EP3169681A1 (ru)
JP (1) JP6738795B2 (ru)
KR (1) KR20170029614A (ru)
CN (1) CN107074812B (ru)
AR (1) AR101196A1 (ru)
AU (1) AU2015291478B2 (ru)
BR (1) BR112017000821A2 (ru)
CA (1) CA2955070A1 (ru)
CL (1) CL2017000104A1 (ru)
CO (1) CO2017001528A2 (ru)
EA (1) EA201790207A8 (ru)
EC (1) ECSP17010238A (ru)
IL (1) IL250022B (ru)
MX (1) MX2017000524A (ru)
PE (1) PE20170120A1 (ru)
TW (1) TW201609707A (ru)
WO (1) WO2016008593A1 (ru)

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WO2018234354A1 (en) 2017-06-20 2018-12-27 Grünenthal GmbH NOVEL SUBSTITUTED 3-INDOLE AND 3-INDAZOLE COMPOUNDS AS PHOSPHODIESTERASE INHIBITORS
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AR101196A1 (es) 2016-11-30
JP2017520602A (ja) 2017-07-27
AU2015291478B2 (en) 2019-04-04
JP6738795B2 (ja) 2020-08-12
ECSP17010238A (es) 2017-03-31
BR112017000821A2 (pt) 2017-12-05
CL2017000104A1 (es) 2017-08-04
CN107074812B (zh) 2020-08-21
WO2016008593A1 (en) 2016-01-21
US20160016937A1 (en) 2016-01-21
US9540349B2 (en) 2017-01-10
AU2015291478A1 (en) 2017-03-09
EA201790207A8 (ru) 2018-06-29
US10189854B2 (en) 2019-01-29
CO2017001528A2 (es) 2017-05-10
CN107074812A (zh) 2017-08-18
CA2955070A1 (en) 2016-01-21
EP3169681A1 (en) 2017-05-24
IL250022B (en) 2019-10-31
IL250022A0 (en) 2017-03-30
TW201609707A (zh) 2016-03-16
MX2017000524A (es) 2017-05-01
EP3527561A1 (en) 2019-08-21
PE20170120A1 (es) 2017-03-30
KR20170029614A (ko) 2017-03-15
US20170066776A1 (en) 2017-03-09

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