EA201692270A1 - Производные нафтиридиндиона - Google Patents

Производные нафтиридиндиона

Info

Publication number
EA201692270A1
EA201692270A1 EA201692270A EA201692270A EA201692270A1 EA 201692270 A1 EA201692270 A1 EA 201692270A1 EA 201692270 A EA201692270 A EA 201692270A EA 201692270 A EA201692270 A EA 201692270A EA 201692270 A1 EA201692270 A1 EA 201692270A1
Authority
EA
Eurasian Patent Office
Prior art keywords
naftyridindione
derivatives
compound
substituents
medicine
Prior art date
Application number
EA201692270A
Other languages
English (en)
Other versions
EA030374B1 (ru
Inventor
Юрген Райнхардт
Нико ШМИДЕБЕРГ
Карстен Шпанка
Original Assignee
Новартис Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Новартис Аг filed Critical Новартис Аг
Publication of EA201692270A1 publication Critical patent/EA201692270A1/ru
Publication of EA030374B1 publication Critical patent/EA030374B1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/16—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Изобретение относится к соединению формулы (I')или его соли, где заместители определены в описании; к его получению, его применению в качестве лекарственного средства и к лекарственным средствам, содержащим это соединение.
EA201692270A 2014-06-03 2015-06-02 Производные нафтиридиндиона EA030374B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14170976 2014-06-03
PCT/IB2015/054174 WO2015186063A1 (en) 2014-06-03 2015-06-02 Naphthyridinedione derivatives

Publications (2)

Publication Number Publication Date
EA201692270A1 true EA201692270A1 (ru) 2017-03-31
EA030374B1 EA030374B1 (ru) 2018-07-31

Family

ID=50841689

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201692270A EA030374B1 (ru) 2014-06-03 2015-06-02 Производные нафтиридиндиона

Country Status (28)

Country Link
US (2) US10138232B2 (ru)
EP (1) EP3152209B1 (ru)
JP (2) JP6343034B2 (ru)
KR (1) KR101905295B1 (ru)
CN (1) CN106459043B (ru)
AP (1) AP2016009545A0 (ru)
AR (1) AR100706A1 (ru)
AU (2) AU2015270125B2 (ru)
BR (1) BR112016027383A8 (ru)
CA (1) CA2950724A1 (ru)
CL (1) CL2016003081A1 (ru)
CR (1) CR20160565A (ru)
CU (1) CU24438B1 (ru)
EA (1) EA030374B1 (ru)
EC (1) ECSP16096831A (ru)
ES (1) ES2731802T3 (ru)
GT (1) GT201600252A (ru)
IL (1) IL248773B (ru)
MX (1) MX2016015856A (ru)
MY (1) MY178379A (ru)
PE (1) PE20170086A1 (ru)
PH (2) PH12016502293A1 (ru)
SG (1) SG11201609209YA (ru)
SV (1) SV2016005331A (ru)
TN (1) TN2016000490A1 (ru)
TW (1) TWI688565B (ru)
UY (1) UY36150A (ru)
WO (1) WO2015186063A1 (ru)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015186061A1 (en) * 2014-06-03 2015-12-10 Novartis Ag Pyridopyrimidinedione derivatives
JP6560257B2 (ja) * 2014-06-03 2019-08-14 ノバルティス アーゲー ピリミド［４，５−ｂ］キノリン−４，５（３Ｈ，１０Ｈ）−ジオン誘導体
TN2016000490A1 (en) 2014-06-03 2018-04-04 Novartis Ag Naphthyridinedione derivatives.
WO2019225625A1 (ja) * 2018-05-23 2019-11-28 京都薬品工業株式会社 リードスルー誘導剤およびその医薬用途
WO2020022375A1 (ja) 2018-07-24 2020-01-30 ソニーセミコンダクタソリューションズ株式会社 半導体装置

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JP2884170B2 (ja) 1989-08-24 1999-04-19 株式会社フジモト・ブラザーズ ５−デアザフラビン系化合物を有効成分とする制癌剤
JP2989871B2 (ja) * 1989-08-30 1999-12-13 大日本製薬株式会社 三環式化合物
DE4035479A1 (de) 1990-11-08 1992-05-14 Basf Ag Substituierte pyrido (2,3-d)pyrimidin-2,4(1h,3h)-dione
US5908930A (en) 1995-03-15 1999-06-01 Pfizer Inc. 5,10-dihydropyrimdo 4,5-b!quinolin-4(1H)-one tyrosine kinase inhibitors
US6016875A (en) * 1998-02-10 2000-01-25 Case Corporation Gain adaptation control for hydraulic systems
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WO2004006906A2 (en) 2002-07-15 2004-01-22 Combinatorx, Incorporated Methods for the treatment of neoplasms
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TN2016000490A1 (en) 2014-06-03 2018-04-04 Novartis Ag Naphthyridinedione derivatives.
JP6560257B2 (ja) 2014-06-03 2019-08-14 ノバルティス アーゲー ピリミド［４，５−ｂ］キノリン−４，５（３Ｈ，１０Ｈ）−ジオン誘導体
WO2015186061A1 (en) 2014-06-03 2015-12-10 Novartis Ag Pyridopyrimidinedione derivatives

Also Published As

Publication number Publication date
PH12016502293B1 (en) 2017-02-13
CN106459043B (zh) 2018-12-28
CU20160182A7 (es) 2017-03-03
MX2016015856A (es) 2017-04-25
CL2016003081A1 (es) 2017-06-09
PH12016502293A1 (en) 2017-02-13
BR112016027383A8 (pt) 2021-07-20
SG11201609209YA (en) 2016-12-29
EP3152209B1 (en) 2019-03-20
EA030374B1 (ru) 2018-07-31
CU24438B1 (es) 2019-09-04
GT201600252A (es) 2018-12-18
ES2731802T3 (es) 2019-11-19
US20150344476A1 (en) 2015-12-03
PE20170086A1 (es) 2017-03-17
JP2018138609A (ja) 2018-09-06
SV2016005331A (es) 2018-08-20
KR101905295B1 (ko) 2018-10-05
US20190248784A1 (en) 2019-08-15
IL248773B (en) 2019-12-31
TN2016000490A1 (en) 2018-04-04
CA2950724A1 (en) 2015-12-10
CN106459043A (zh) 2017-02-22
US10138232B2 (en) 2018-11-27
PH12018501709A1 (en) 2019-08-14
JP6343034B2 (ja) 2018-06-13
BR112016027383A2 (pt) 2017-08-15
CR20160565A (es) 2017-03-10
UY36150A (es) 2016-01-29
IL248773A0 (en) 2017-01-31
AU2018200421A1 (en) 2018-02-08
AP2016009545A0 (en) 2016-11-30
AU2015270125A1 (en) 2016-11-24
TW201625610A (zh) 2016-07-16
ECSP16096831A (es) 2018-04-30
TWI688565B (zh) 2020-03-21
MY178379A (en) 2020-10-09
AU2015270125B2 (en) 2017-10-19
JP2017516821A (ja) 2017-06-22
AR100706A1 (es) 2016-10-26
KR20160148679A (ko) 2016-12-26
EP3152209A1 (en) 2017-04-12
WO2015186063A1 (en) 2015-12-10

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