EA201600434A1 - Применение производных бензимидазолпролина - Google Patents

Применение производных бензимидазолпролина

Info

Publication number
EA201600434A1
EA201600434A1 EA201600434A EA201600434A EA201600434A1 EA 201600434 A1 EA201600434 A1 EA 201600434A1 EA 201600434 A EA201600434 A EA 201600434A EA 201600434 A EA201600434 A EA 201600434A EA 201600434 A1 EA201600434 A1 EA 201600434A1
Authority
EA
Eurasian Patent Office
Prior art keywords
benzimidazolproline
derivatives
application
compounds
relates
Prior art date
Application number
EA201600434A
Other languages
English (en)
Other versions
EA029725B1 (ru
Inventor
Кристоф Босс
Катерине Роч
Кристине Брочи
Маркус Гуде
Бибиа Хайдманн
Франсуа Женк
Тьерри Зифферлен
Мишель Штайнер
Джоди Т. Уилльямс
Original Assignee
Актелион Фармасьютиклз Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Актелион Фармасьютиклз Лтд. filed Critical Актелион Фармасьютиклз Лтд.
Publication of EA201600434A1 publication Critical patent/EA201600434A1/ru
Publication of EA029725B1 publication Critical patent/EA029725B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Настоящее изобретение относится к соединениям формулы (I)где Arи Arимеют значения, как указано в описании, и к их применению в качестве лекарственных средств для лечения вечерней спутанности. Изобретение также относится к приготовлению таких соединений и их фармацевтически приемлемых солей.
EA201600434A 2013-12-04 2014-12-03 Применение производных бензимидазолпролина EA029725B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IB2013060630 2013-12-04
PCT/IB2014/066548 WO2015083094A1 (en) 2013-12-04 2014-12-03 Use of benzimidazole-proline derivatives

Publications (2)

Publication Number Publication Date
EA201600434A1 true EA201600434A1 (ru) 2016-11-30
EA029725B1 EA029725B1 (ru) 2018-05-31

Family

ID=52347368

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201600434A EA029725B1 (ru) 2013-12-04 2014-12-03 Применение производных бензимидазолпролина

Country Status (29)

Country Link
US (1) US9914721B2 (ru)
EP (1) EP3077391B1 (ru)
JP (1) JP6421185B2 (ru)
KR (1) KR102330133B1 (ru)
CN (1) CN105873921B (ru)
AU (1) AU2014358766B2 (ru)
CA (1) CA2930053A1 (ru)
CL (1) CL2016001349A1 (ru)
CY (1) CY1121089T1 (ru)
DK (1) DK3077391T3 (ru)
EA (1) EA029725B1 (ru)
ES (1) ES2696708T3 (ru)
HK (1) HK1225734B (ru)
HR (1) HRP20181710T1 (ru)
HU (1) HUE040555T2 (ru)
IL (1) IL245914B (ru)
LT (1) LT3077391T (ru)
MA (1) MA39165A1 (ru)
MX (1) MX366642B (ru)
MY (1) MY179605A (ru)
PH (1) PH12016500985B1 (ru)
PL (1) PL3077391T3 (ru)
PT (1) PT3077391T (ru)
SA (1) SA516371253B1 (ru)
SI (1) SI3077391T1 (ru)
TR (1) TR201815342T4 (ru)
UA (1) UA116053C2 (ru)
WO (1) WO2015083094A1 (ru)
ZA (1) ZA201604502B (ru)

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Also Published As

Publication number Publication date
KR20160093686A (ko) 2016-08-08
HUE040555T2 (hu) 2019-03-28
EP3077391B1 (en) 2018-08-15
HK1225734B (zh) 2017-09-15
PL3077391T3 (pl) 2019-01-31
ES2696708T3 (es) 2019-01-17
SA516371253B1 (ar) 2018-07-24
UA116053C2 (uk) 2018-01-25
MY179605A (en) 2020-11-11
PT3077391T (pt) 2018-11-26
CY1121089T1 (el) 2019-12-11
NZ721697A (en) 2021-09-24
PH12016500985A1 (en) 2016-06-20
MA39165A1 (fr) 2017-10-31
IL245914B (en) 2019-09-26
TR201815342T4 (tr) 2018-11-21
MX366642B (es) 2019-07-17
US20170001985A1 (en) 2017-01-05
AU2014358766B2 (en) 2019-01-17
JP2016539157A (ja) 2016-12-15
JP6421185B2 (ja) 2018-11-07
US9914721B2 (en) 2018-03-13
DK3077391T3 (en) 2018-10-22
IL245914A0 (en) 2016-08-02
CA2930053A1 (en) 2015-06-11
LT3077391T (lt) 2018-10-25
KR102330133B1 (ko) 2021-11-23
CL2016001349A1 (es) 2017-01-27
HRP20181710T1 (hr) 2018-12-28
AU2014358766A1 (en) 2016-07-21
EP3077391A1 (en) 2016-10-12
PH12016500985B1 (en) 2016-06-20
CN105873921B (zh) 2019-03-15
SI3077391T1 (sl) 2018-11-30
CN105873921A (zh) 2016-08-17
MX2016007313A (es) 2016-09-07
ZA201604502B (en) 2019-07-31
EA029725B1 (ru) 2018-05-31
WO2015083094A1 (en) 2015-06-11

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