CU20160182A7 - Compuestos derivados de 1,6 naftiridina-diona activos como supresores de mutación sin sentido - Google Patents
Compuestos derivados de 1,6 naftiridina-diona activos como supresores de mutación sin sentidoInfo
- Publication number
- CU20160182A7 CU20160182A7 CUP2016000182A CU20160182A CU20160182A7 CU 20160182 A7 CU20160182 A7 CU 20160182A7 CU P2016000182 A CUP2016000182 A CU P2016000182A CU 20160182 A CU20160182 A CU 20160182A CU 20160182 A7 CU20160182 A7 CU 20160182A7
- Authority
- CU
- Cuba
- Prior art keywords
- naftiridine
- diona
- assets
- compounds derived
- sense
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 230000035772 mutation Effects 0.000 title 1
- 108020004485 Nonsense Codon Proteins 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 230000037434 nonsense mutation Effects 0.000 abstract 2
- KVOHQTLDEXUTGJ-UHFFFAOYSA-N 1,6-naphthyridine-2,3-dione Chemical compound O=C1C(N=C2C=CN=CC2=C1)=O KVOHQTLDEXUTGJ-UHFFFAOYSA-N 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000001629 suppression Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/16—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurology (AREA)
- Pulmonology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La invención se refiere a compuestos derivados de 1,6-naftiridina-diona de fórmula (I'): ESPACIO PARA FÓRMULA o a una sal del mismo, activos como supresores de mutación sin sentido, en donde los sustituyentes son como se definen en el Capítulo Descriptivo; a su preparación, a su uso como un medicamento, y a los medicamentos que lo comprenden. La ventaja de los compuestos de la invención es que promueven la lectura de traducción teniendo valores de AC50 para la supresión de la mutación sin sentido entre 0,4 y 22 uM.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14170976 | 2014-06-03 | ||
| PCT/IB2015/054174 WO2015186063A1 (en) | 2014-06-03 | 2015-06-02 | Naphthyridinedione derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CU20160182A7 true CU20160182A7 (es) | 2017-03-03 |
| CU24438B1 CU24438B1 (es) | 2019-09-04 |
Family
ID=50841689
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CU2016000182A CU24438B1 (es) | 2014-06-03 | 2015-06-02 | Compuestos derivados de 1,6 naftiridina-diona activos como supresores de mutación sin sentido |
Country Status (28)
| Country | Link |
|---|---|
| US (2) | US10138232B2 (es) |
| EP (1) | EP3152209B1 (es) |
| JP (2) | JP6343034B2 (es) |
| KR (1) | KR101905295B1 (es) |
| CN (1) | CN106459043B (es) |
| AP (1) | AP2016009545A0 (es) |
| AR (1) | AR100706A1 (es) |
| AU (2) | AU2015270125B2 (es) |
| BR (1) | BR112016027383A8 (es) |
| CA (1) | CA2950724A1 (es) |
| CL (1) | CL2016003081A1 (es) |
| CR (1) | CR20160565A (es) |
| CU (1) | CU24438B1 (es) |
| EA (1) | EA030374B1 (es) |
| EC (1) | ECSP16096831A (es) |
| ES (1) | ES2731802T3 (es) |
| GT (1) | GT201600252A (es) |
| IL (1) | IL248773B (es) |
| MX (1) | MX374245B (es) |
| MY (1) | MY178379A (es) |
| PE (1) | PE20170086A1 (es) |
| PH (2) | PH12016502293B1 (es) |
| SG (1) | SG11201609209YA (es) |
| SV (1) | SV2016005331A (es) |
| TN (1) | TN2016000490A1 (es) |
| TW (1) | TWI688565B (es) |
| UY (1) | UY36150A (es) |
| WO (1) | WO2015186063A1 (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015186062A1 (en) | 2014-06-03 | 2015-12-10 | Novartis Ag | PYRIMIDO[4,5-b]QUINOLINE-4,5(3H,10H)-DIONE DERIVATIVES |
| EP3152207B1 (en) | 2014-06-03 | 2019-05-08 | Novartis AG | Pyridopyrimidinedione derivatives as suppressors of non-sens mutations |
| CA2950724A1 (en) | 2014-06-03 | 2015-12-10 | Novartis Ag | Naphthyridinedione derivatives |
| WO2019225625A1 (ja) * | 2018-05-23 | 2019-11-28 | 京都薬品工業株式会社 | リードスルー誘導剤およびその医薬用途 |
| KR102719696B1 (ko) | 2018-07-24 | 2024-10-21 | 소니 세미컨덕터 솔루션즈 가부시키가이샤 | 반도체 장치 |
| KR20240070637A (ko) * | 2021-09-30 | 2024-05-21 | 캐러웨이 테라퓨틱스, 인크. | Trpml의 조정제, 그의 조성물 및 사용 방법 |
| WO2024161623A1 (ja) * | 2023-02-03 | 2024-08-08 | 株式会社 RINAT Imaging | リードスルー薬、リードスルー用組み合わせ剤及び核酸プローブの使用 |
| CN117756607A (zh) * | 2023-12-01 | 2024-03-26 | 陕西煤业化工技术研究院有限责任公司 | 一种二甲酚馏分异构化生产高值二甲酚的工艺及系统 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2884170B2 (ja) | 1989-08-24 | 1999-04-19 | 株式会社フジモト・ブラザーズ | ５−デアザフラビン系化合物を有効成分とする制癌剤 |
| JP2989871B2 (ja) * | 1989-08-30 | 1999-12-13 | 大日本製薬株式会社 | 三環式化合物 |
| DE4035479A1 (de) | 1990-11-08 | 1992-05-14 | Basf Ag | Substituierte pyrido (2,3-d)pyrimidin-2,4(1h,3h)-dione |
| WO1996028444A1 (en) | 1995-03-15 | 1996-09-19 | Pfizer Inc. | 5,10-DIHYDROPYRIMIDO[4,5-b]QUINOLIN-4(1H)-ONE TYROSINE KINASE INHIBITORS |
| US6016875A (en) * | 1998-02-10 | 2000-01-25 | Case Corporation | Gain adaptation control for hydraulic systems |
| US6468990B1 (en) | 1999-05-17 | 2002-10-22 | Queen's University At Kingston | Method of inhibiting binding of nerve growth factor to p75 NTR receptor |
| WO2004078163A2 (en) | 2003-02-28 | 2004-09-16 | Transform Pharmaceuticals, Inc. | Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen |
| WO2004006906A2 (en) | 2002-07-15 | 2004-01-22 | Combinatorx, Incorporated | Methods for the treatment of neoplasms |
| EP4101846B1 (en) | 2003-04-11 | 2023-08-02 | PTC Therapeutics, Inc. | 1,2,4-oxadiazole benzoic acid compounds and their use for nonsense suppression and the treatment of disease |
| US8354427B2 (en) | 2004-06-24 | 2013-01-15 | Vertex Pharmaceutical Incorporated | Modulators of ATP-binding cassette transporters |
| CA2881078C (en) * | 2004-06-24 | 2018-10-02 | Vertex Pharmaceuticals Incorporated | Modulators of atp-binding cassette transporters |
| CN101076332A (zh) * | 2004-10-13 | 2007-11-21 | Ptc医疗公司 | 吡唑或三唑化合物及其用于制备治疗体细胞突变相关疾病的药物的用途 |
| HUE031643T2 (en) | 2006-04-03 | 2017-07-28 | Technion Res & Dev Foundation | New aminoglycosides and their applications in the treatment of genetic disorders |
| US20080090845A1 (en) | 2006-08-23 | 2008-04-17 | Neurogen Corporation | Haloalkyl-substituted pyrimidinone derivatives |
| CN101687883B (zh) | 2007-05-25 | 2012-05-23 | 沃泰克斯药物股份有限公司 | 囊性纤维化跨膜传导调节因子的调节剂 |
| AU2008345225A1 (en) | 2007-12-21 | 2009-07-09 | University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
| EP2422817A1 (en) | 2010-07-29 | 2012-02-29 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Flavin-nucleic acid ligand conjugates |
| JP5877200B2 (ja) | 2010-08-05 | 2016-03-02 | ユニヴェルシテ ドゥ ドロワ エ サンテ ドゥ リール | ナンセンス突然変異による疾患の治療に有用な化合物及びその化合物を含む医薬組成物 |
| MX363437B (es) | 2012-12-13 | 2019-03-22 | Novartis Ag | Pirimido-4,5-b]-quinolina-4,5 (3h,10h)-dionas como supresoras de mutacion sin sentido. |
| EP3152207B1 (en) | 2014-06-03 | 2019-05-08 | Novartis AG | Pyridopyrimidinedione derivatives as suppressors of non-sens mutations |
| CA2950724A1 (en) | 2014-06-03 | 2015-12-10 | Novartis Ag | Naphthyridinedione derivatives |
| WO2015186062A1 (en) | 2014-06-03 | 2015-12-10 | Novartis Ag | PYRIMIDO[4,5-b]QUINOLINE-4,5(3H,10H)-DIONE DERIVATIVES |
-
2015
- 2015-06-02 CA CA2950724A patent/CA2950724A1/en not_active Abandoned
- 2015-06-02 AU AU2015270125A patent/AU2015270125B2/en not_active Ceased
- 2015-06-02 EP EP15731121.8A patent/EP3152209B1/en active Active
- 2015-06-02 CN CN201580029417.3A patent/CN106459043B/zh not_active Expired - Fee Related
- 2015-06-02 SG SG11201609209YA patent/SG11201609209YA/en unknown
- 2015-06-02 WO PCT/IB2015/054174 patent/WO2015186063A1/en not_active Ceased
- 2015-06-02 TW TW104117848A patent/TWI688565B/zh not_active IP Right Cessation
- 2015-06-02 MY MYPI2016704068A patent/MY178379A/en unknown
- 2015-06-02 EA EA201692270A patent/EA030374B1/ru not_active IP Right Cessation
- 2015-06-02 ES ES15731121T patent/ES2731802T3/es active Active
- 2015-06-02 CU CU2016000182A patent/CU24438B1/es unknown
- 2015-06-02 TN TN2016000490A patent/TN2016000490A1/en unknown
- 2015-06-02 AR ARP150101737A patent/AR100706A1/es unknown
- 2015-06-02 MX MX2016015856A patent/MX374245B/es active IP Right Grant
- 2015-06-02 PE PE2016002514A patent/PE20170086A1/es unknown
- 2015-06-02 CR CR20160565A patent/CR20160565A/es unknown
- 2015-06-02 BR BR112016027383A patent/BR112016027383A8/pt active Search and Examination
- 2015-06-02 JP JP2016570886A patent/JP6343034B2/ja not_active Expired - Fee Related
- 2015-06-02 US US14/728,613 patent/US10138232B2/en active Active
- 2015-06-02 AP AP2016009545A patent/AP2016009545A0/en unknown
- 2015-06-02 KR KR1020167033550A patent/KR101905295B1/ko not_active Expired - Fee Related
- 2015-06-03 UY UY0001036150A patent/UY36150A/es not_active Application Discontinuation
-
2016
- 2016-11-06 IL IL248773A patent/IL248773B/en active IP Right Grant
- 2016-11-17 PH PH12016502293A patent/PH12016502293B1/en unknown
- 2016-11-30 CL CL2016003081A patent/CL2016003081A1/es unknown
- 2016-12-02 SV SV2016005331A patent/SV2016005331A/es unknown
- 2016-12-02 GT GT201600252A patent/GT201600252A/es unknown
- 2016-12-28 EC ECIEPI201696831A patent/ECSP16096831A/es unknown
-
2018
- 2018-01-18 AU AU2018200421A patent/AU2018200421A1/en not_active Withdrawn
- 2018-05-17 JP JP2018095248A patent/JP2018138609A/ja active Pending
- 2018-08-13 PH PH12018501709A patent/PH12018501709A1/en unknown
- 2018-10-10 US US16/156,447 patent/US20190248784A1/en not_active Abandoned
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DOP2020000102A (es) | Compuestos útiles para inhibir a cdk7 | |
| CR20160564A (es) | Dinucleótidos cíclicos como moduladores de sting | |
| NI201700020A (es) | Compuestos de aminopirimidinilo como inhibidores de jak | |
| DOP2016000085A (es) | Amino-heteroaril-benzamidas como inhibidores de cinasa | |
| CL2018003135A1 (es) | Derivados aromáticos de sulfonamida. | |
| EA201691857A1 (ru) | Соединения, применимые в качестве иммуномодуляторов | |
| EA201890052A1 (ru) | Регуляторы nrf2 | |
| MX2016001480A (es) | Formulacion de inhibidores de syk. | |
| CO2018000589A2 (es) | Oxiesteroles y composiciones farmacéuticas que los contienen | |
| CU24438B1 (es) | Compuestos derivados de 1,6 naftiridina-diona activos como supresores de mutación sin sentido | |
| AR101995A1 (es) | COMPUESTOS ANTAGONISTAS DE INTEGRINA avb6 | |
| CU20150061A7 (es) | PIRIMIDO-[4,5-b]-QUINOLINA-4,5(3H,10H)-DIONAS COMO SUPRESORAS DE MUTACIÓN SIN SENTIDO | |
| EA201692526A1 (ru) | Замещенные [1,2,4]триазольные соединения | |
| CO7101239A2 (es) | Composiciones derivadas de la quitosana | |
| GT201500247A (es) | Imidazopiridazinas sustituidas | |
| MX381970B (es) | Derivado de sulfonamida y composición farmacéutica que contiene el mismo. | |
| EA201791219A1 (ru) | Антибактериальные композиции, имеющие широкий спектр активности | |
| EA201890532A1 (ru) | Новые аннелированные бензамиды | |
| EA201890534A1 (ru) | Новые аннелированные феноксиацетамиды | |
| CL2016002677A1 (es) | Compuestos heteroaromáticos y su uso como ligandos de dopamina d1. | |
| AR101806A1 (es) | Derivados de 1-acetil-4-amino-1,2,3,4-tetrahidroquinolina, composición farmacéutica que los comprende y su uso en el tratamiento de afecciones mediadas por un inhibidor de bromodominio | |
| EA201890828A1 (ru) | Оптимизированная таблетка с высокой дозой активного соединения, содержащая месалазин | |
| SV2016005293A (es) | Compuestos de azol amido-sustituidos como inhibidores de tnks1 y/o tnks2 | |
| BR112017002852A2 (pt) | compostos de azetidiniloxifenilpirrolidina | |
| DOP2019000021A (es) | Derivado de triazolopirazinona útil como un inhibidor de pde1 humana |