CL2018003135A1 - Derivados aromáticos de sulfonamida. - Google Patents
Derivados aromáticos de sulfonamida.Info
- Publication number
- CL2018003135A1 CL2018003135A1 CL2018003135A CL2018003135A CL2018003135A1 CL 2018003135 A1 CL2018003135 A1 CL 2018003135A1 CL 2018003135 A CL2018003135 A CL 2018003135A CL 2018003135 A CL2018003135 A CL 2018003135A CL 2018003135 A1 CL2018003135 A1 CL 2018003135A1
- Authority
- CL
- Chile
- Prior art keywords
- sulfonamide
- aromatic derivatives
- compounds
- aromatic
- pharmaceutical
- Prior art date
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
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- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
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- C07C311/17—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
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- C07C311/38—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton
- C07C311/39—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
- C07C311/40—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
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- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
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Abstract
SULFONAMIDAS AROMÁTICAS SUSTITUIDAS DE LA FÓRMULA (I), COMPOSICIONES FARMACÉUTICAS Y COMBINACIONES QUE COMPRENDEN DICHOS COMPUESTOS Y EL USO DE DICHOS COMPUESTOS PARA ELABORAR UNA COMPOSICIÓN FARMACÉUTICA PARA EL TRATAMIENTO O LA PROFILAXIS DE UNA ENFERMEDAD.
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PT3458443T (pt) | 2016-05-03 | 2020-11-05 | Bayer Pharma AG | Derivados de sulfonamida aromática |
WO2018080859A1 (en) * | 2016-10-24 | 2018-05-03 | E. I. Du Pont De Nemours And Company | Fungicidal oxadiazoles |
WO2018104307A1 (en) * | 2016-12-09 | 2018-06-14 | Bayer Pharma Aktiengesellschaft | Aromatic sulfonamide derivatives and their use as anatagon i sts or negative allosteric modulators of p2x4 |
WO2018210729A1 (en) * | 2017-05-18 | 2018-11-22 | Bayer Pharma Aktiengesellschaft | Aromatic sulfonamide derivatives as antagonists or negative allosteric modulators of p2x4 receptor |
JOP20190278A1 (ar) * | 2017-05-31 | 2019-11-28 | Novartis Ag | مركبات 5، 6-ثنائية الحلقة مندمجة وتركيبات لعلاج الأمراض الطفيلية |
EA202091028A1 (ru) * | 2017-10-29 | 2020-09-09 | Байер Акциенгезельшафт | Ароматические сульфонамидные производные для лечения ишемического инсульта |
CN112638879A (zh) | 2018-08-31 | 2021-04-09 | 泽农医药公司 | 杂芳基取代的磺酰胺化合物及其作为治疗剂的用途 |
WO2021104486A1 (zh) * | 2019-11-29 | 2021-06-03 | 武汉朗来科技发展有限公司 | 一种含苯环的化合物及其应用 |
CN113082023B (zh) * | 2019-12-23 | 2024-03-01 | 武汉朗来科技发展有限公司 | P2x3抑制剂和p2x4抑制剂的药物组合及其应用 |
US20230118751A1 (en) * | 2019-12-30 | 2023-04-20 | Wuhan Ll Science And Technology Development Co., Ltd. | Fused ring compound and application thereof |
WO2022002859A1 (en) | 2020-06-30 | 2022-01-06 | Bayer Aktiengesellschaft | Substituted n-phenylacetamides having p2x4 receptor antagonistic activity |
JP2023533496A (ja) | 2020-06-30 | 2023-08-03 | バイエル アクチェンゲゼルシャフト | 特定の眼疾患を治療するためのp2x4受容体拮抗活性を有するn-フェニルアセトアミドの使用 |
CN111743864B (zh) * | 2020-08-05 | 2022-04-01 | 牡丹江医学院 | 一种体育外伤喷雾剂及其制备方法 |
WO2022049253A1 (en) | 2020-09-07 | 2022-03-10 | Bayer Aktiengesellschaft | Substituted n-heteroaryl-n-pyridinylacetamides as p2x4 modulators |
TW202239748A (zh) * | 2021-01-27 | 2022-10-16 | 大陸商武漢朗來科技發展有限公司 | 芳香化合物、其製備方法及應用 |
WO2022186133A1 (ja) | 2021-03-01 | 2022-09-09 | 日本農薬株式会社 | スルホンアミド基を有する縮合複素環化合物又はその塩類及び該化合物若しくはその塩類を含有する農園芸用殺虫剤又は動物用の外部若しくは内部寄生虫防除剤並びにそれらの使用方法 |
US11878269B2 (en) | 2022-03-17 | 2024-01-23 | International Business Machines Corporation | Cyclopropeneimines for capture and transfer of carbon dioxide |
WO2023190826A1 (ja) * | 2022-03-31 | 2023-10-05 | 学校法人 高崎健康福祉大学 | 偽アレルギー反応に伴う症状の予防若しくは抑制又は治療用の医薬組成物 |
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AU2011254242B2 (en) | 2010-05-17 | 2015-10-29 | Incozen Therapeutics Pvt. Ltd. | Novel 3,5-disubstitued-3H-imidazo[4,5-b]pyridine and 3,5- disubstitued -3H-[1,2,3]triazolo[4,5-b] pyridine compounds as modulators of protein kinases |
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EP3010474A1 (en) | 2013-06-21 | 2016-04-27 | L'oreal | Process for dyeing in the presence of oxidation bases comprising at least one sulfonic, sulfonamide, sulfone, amid or acid group and a metal catalyst, device and ready-to-use composition |
WO2015005468A1 (ja) | 2013-07-12 | 2015-01-15 | 日本ケミファ株式会社 | P2x4受容体拮抗剤 |
CA2921200C (en) | 2013-07-12 | 2021-07-13 | Nippon Chemiphar Co., Ltd. | Diazepinyl derivatives and compositions therof useful as p2x4 receptor antagonist |
WO2015088565A1 (en) | 2013-12-13 | 2015-06-18 | Sunovion Pharmaceuticals Inc. | P2x4 receptor modulating compounds and methods of use thereof |
WO2015088564A1 (en) | 2013-12-13 | 2015-06-18 | Sunovion Pharmaceuticals Inc. | P2x4 receptor modulating compounds |
JP2018528159A (ja) * | 2015-06-10 | 2018-09-27 | バイエル・ファルマ・アクティエンゲゼルシャフト | 芳香族スルホンアミド誘導体 |
CN109414454A (zh) | 2016-05-03 | 2019-03-01 | 加莱拉实验室有限责任公司 | 用于癌症治疗的组合疗法 |
PT3458443T (pt) * | 2016-05-03 | 2020-11-05 | Bayer Pharma AG | Derivados de sulfonamida aromática |
US9988367B2 (en) | 2016-05-03 | 2018-06-05 | Bayer Pharma Aktiengesellschaft | Amide-substituted pyridinyltriazole derivatives and uses thereof |
WO2018104307A1 (en) * | 2016-12-09 | 2018-06-14 | Bayer Pharma Aktiengesellschaft | Aromatic sulfonamide derivatives and their use as anatagon i sts or negative allosteric modulators of p2x4 |
WO2018104305A1 (en) * | 2016-12-09 | 2018-06-14 | Bayer Pharma Aktiengesellschaft | Field of application of the invention |
WO2018210729A1 (en) * | 2017-05-18 | 2018-11-22 | Bayer Pharma Aktiengesellschaft | Aromatic sulfonamide derivatives as antagonists or negative allosteric modulators of p2x4 receptor |
EA202091028A1 (ru) * | 2017-10-29 | 2020-09-09 | Байер Акциенгезельшафт | Ароматические сульфонамидные производные для лечения ишемического инсульта |
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