JOP20190278A1 - مركبات 5، 6-ثنائية الحلقة مندمجة وتركيبات لعلاج الأمراض الطفيلية - Google Patents

مركبات 5، 6-ثنائية الحلقة مندمجة وتركيبات لعلاج الأمراض الطفيلية

Info

Publication number
JOP20190278A1
JOP20190278A1 JOP/2019/0278A JOP20190278A JOP20190278A1 JO P20190278 A1 JOP20190278 A1 JO P20190278A1 JO P20190278 A JOP20190278 A JO P20190278A JO P20190278 A1 JOP20190278 A1 JO P20190278A1
Authority
JO
Jordan
Prior art keywords
fused
compositions
treatment
parasitic diseases
bicyclic compounds
Prior art date
Application number
JOP/2019/0278A
Other languages
English (en)
Inventor
Valentina Molteni
Advait Suresh Nagle
Shuyi Pearly Ng
Fang Liang
Jan Jiricek
Jeffrey M Smith
Yongping Xie
Maxim Ratnikov
Isabelle K Lerario
Xiaodong Liu
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of JOP20190278A1 publication Critical patent/JOP20190278A1/ar

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/417—Imidazole-alkylamines, e.g. histamine, phentolamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

يقدم الاختراع الحالي مركب بالصيغة (I) أو ملح مقبول صيدلانياً منه؛ صورة I طريقة لتصنيع المركبات وفقاً للاختراع، واستخداماتها العلاجية. يقدم الاختراع الحالي أيضاً توليفة من عوامل علاجية فعّالة وتركيبة صيدلانية.
JOP/2019/0278A 2017-05-31 2017-06-16 مركبات 5، 6-ثنائية الحلقة مندمجة وتركيبات لعلاج الأمراض الطفيلية JOP20190278A1 (ar)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762513211P 2017-05-31 2017-05-31
US201762581919P 2017-11-06 2017-11-06

Publications (1)

Publication Number Publication Date
JOP20190278A1 true JOP20190278A1 (ar) 2019-11-28

Family

ID=62749123

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2019/0278A JOP20190278A1 (ar) 2017-05-31 2017-06-16 مركبات 5، 6-ثنائية الحلقة مندمجة وتركيبات لعلاج الأمراض الطفيلية

Country Status (26)

Country Link
US (2) US11384078B2 (ar)
EP (1) EP3630771B1 (ar)
JP (1) JP7187490B2 (ar)
KR (1) KR20200010275A (ar)
CN (1) CN110678468B (ar)
AR (1) AR111826A1 (ar)
AU (1) AU2018276190B2 (ar)
BR (1) BR112019024804A2 (ar)
CA (1) CA3060990A1 (ar)
CL (1) CL2019003467A1 (ar)
CO (1) CO2019013254A2 (ar)
CR (1) CR20190545A (ar)
CU (1) CU24543B1 (ar)
DO (1) DOP2019000299A (ar)
EC (1) ECSP19084722A (ar)
ES (1) ES2927207T3 (ar)
IL (1) IL270927B (ar)
JO (1) JOP20190278A1 (ar)
MA (1) MA50495A (ar)
MX (1) MX2019014321A (ar)
PE (1) PE20201148A1 (ar)
PH (1) PH12019502652A1 (ar)
RU (1) RU2738647C1 (ar)
TW (1) TW201902894A (ar)
UY (1) UY37745A (ar)
WO (1) WO2018220531A1 (ar)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JOP20190278A1 (ar) * 2017-05-31 2019-11-28 Novartis Ag مركبات 5، 6-ثنائية الحلقة مندمجة وتركيبات لعلاج الأمراض الطفيلية
WO2021209269A1 (en) * 2020-04-17 2021-10-21 Dsm Ip Assets B.V. A process for preparation of substituted enamine compounds
EP4155302A4 (en) * 2020-06-23 2023-11-22 Shanghai Meiyue Biotech Development Co., Ltd. METHOD FOR PREPARING A CONDENSED PYRAZOLE-TYPE COMPOUND

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10053275A1 (de) * 2000-10-27 2002-05-02 Dresden Arzneimittel Neue 7-Azaindole, deren Verwendung als Inhibitoren der Phosphodiesterase 4 und Verfahren zu deren Herstellung
DE602004029145D1 (de) 2003-02-27 2010-10-28 Palau Pharma Sa Pyrazolopyridin-derivate
BR102012004142A2 (pt) 2011-02-25 2015-04-07 Dow Agrosciences Llc Composições pesticidas e processos relacionados às mesmas
WO2013067302A1 (en) * 2011-11-04 2013-05-10 Glaxosmithkline Intellectual Property (No. 2) Limited Method of treatment
WO2013106254A1 (en) * 2012-01-11 2013-07-18 Dow Agrosciences Llc Pesticidal compositions and processes related thereto
EP2925757B1 (en) 2012-11-19 2017-10-04 Novartis AG Compounds and compositions for the treatment of parasitic diseases
UY35400A (es) * 2013-03-15 2014-10-31 Novartis Ag Compuestos y composiciones para el tratamiento de enfermedades parasitarias
US9186361B2 (en) * 2013-03-15 2015-11-17 Novartis Ag Compounds and compositions for the treatment of parasitic diseases
AU2014364565B2 (en) * 2013-12-19 2017-06-15 Novartis Ag [1,2,4]triazolo[1,5-a]pyrimidine derivatives as protozoan proteasome inhibitors for the treatment of parasitic diseases such as leishmaniasis
CN107207497A (zh) 2014-12-02 2017-09-26 拜耳作物科学股份公司 作为害虫防治剂的双环化合物
CN112679467A (zh) 2015-03-11 2021-04-20 Fmc公司 杂环取代的二环唑杀有害生物剂
EP3303336A1 (en) * 2015-05-29 2018-04-11 GlaxoSmithKline Intellectual Property Development Limited Imidazo[1,2-b][1,2,4]triazine derivatives as antiparasitic agents
WO2017025416A1 (en) * 2015-08-07 2017-02-16 Glaxosmithkline Intellectual Property Development Limited Compounds
BR112018072549A2 (pt) * 2016-05-03 2019-02-19 Bayer Pharma Aktiengesellschaft derivados de sulfonamida aromática
JOP20190278A1 (ar) * 2017-05-31 2019-11-28 Novartis Ag مركبات 5، 6-ثنائية الحلقة مندمجة وتركيبات لعلاج الأمراض الطفيلية

Also Published As

Publication number Publication date
AU2018276190B2 (en) 2020-05-14
EP3630771B1 (en) 2022-06-29
UY37745A (es) 2019-01-02
US20200109142A1 (en) 2020-04-09
CN110678468B (zh) 2022-07-29
MA50495A (fr) 2021-04-28
US20220324863A1 (en) 2022-10-13
US11384078B2 (en) 2022-07-12
WO2018220531A1 (en) 2018-12-06
IL270927B (en) 2022-01-01
CA3060990A1 (en) 2018-12-06
KR20200010275A (ko) 2020-01-30
CO2019013254A2 (es) 2020-01-17
JP7187490B2 (ja) 2022-12-12
IL270927A (en) 2020-01-30
MX2019014321A (es) 2020-02-05
AR111826A1 (es) 2019-08-21
ECSP19084722A (es) 2019-12-27
PH12019502652A1 (en) 2020-07-13
EP3630771A1 (en) 2020-04-08
CU24543B1 (es) 2021-08-06
RU2738647C1 (ru) 2020-12-15
JP2020521775A (ja) 2020-07-27
BR112019024804A2 (pt) 2020-06-09
CU20190095A7 (es) 2020-10-20
DOP2019000299A (es) 2019-12-15
PE20201148A1 (es) 2020-10-26
ES2927207T3 (es) 2022-11-03
AU2018276190A1 (en) 2019-11-07
CN110678468A (zh) 2020-01-10
TW201902894A (zh) 2019-01-16
CR20190545A (es) 2020-01-15
CL2019003467A1 (es) 2020-03-13

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