CL2020001062A1 - Sulfonas y sulfóxidos bicíclicos y métodos de uso de los mismos. - Google Patents
Sulfonas y sulfóxidos bicíclicos y métodos de uso de los mismos.Info
- Publication number
- CL2020001062A1 CL2020001062A1 CL2020001062A CL2020001062A CL2020001062A1 CL 2020001062 A1 CL2020001062 A1 CL 2020001062A1 CL 2020001062 A CL2020001062 A CL 2020001062A CL 2020001062 A CL2020001062 A CL 2020001062A CL 2020001062 A1 CL2020001062 A1 CL 2020001062A1
- Authority
- CL
- Chile
- Prior art keywords
- methods
- sulfoxides
- compounds
- sulfones
- bicyclic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
SE PROPORCIONAN COMPUESTOS QUE TIENEN LA FÓRMULA GENERAL I: EN LA QUE R1, R B1, RB2, N, P, Q, EL ANILLO A Y EL ANILLO B SON COMO SE DESCRIBEN EN EL PRESENTE DOCUMENTO, COMPOSICIONES FARMACÉUTICAS QUE INCLUYEN LOS COMPUESTOS Y MÉTODOS PARA USAR LOS COMPUESTOS. LOS COMPUESTOS DE FÓRMULA (I) SON INHIBIDORES DE LA QUINASA RIP1 Y, POR LO TANTO, SON ÚTILES EN EL TRATAMIENTO DE TRASTORNOS INFLAMATORIOS, NEURODEGENERATIVOS Y DE OTRO TIPO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762579392P | 2017-10-31 | 2017-10-31 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2020001062A1 true CL2020001062A1 (es) | 2020-08-21 |
Family
ID=64051580
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2020001062A CL2020001062A1 (es) | 2017-10-31 | 2020-04-20 | Sulfonas y sulfóxidos bicíclicos y métodos de uso de los mismos. |
Country Status (21)
Country | Link |
---|---|
US (2) | US11072617B2 (es) |
EP (1) | EP3704097B1 (es) |
JP (1) | JP2021501183A (es) |
KR (1) | KR20200083515A (es) |
CN (1) | CN111278809A (es) |
AR (1) | AR113811A1 (es) |
AU (1) | AU2018360270A1 (es) |
BR (1) | BR112020008446A2 (es) |
CA (1) | CA3078688A1 (es) |
CL (1) | CL2020001062A1 (es) |
CO (1) | CO2020003475A2 (es) |
CR (1) | CR20200168A (es) |
IL (1) | IL273847A (es) |
MA (1) | MA50503A (es) |
MX (1) | MX2020003451A (es) |
PE (1) | PE20211247A1 (es) |
PH (1) | PH12020550537A1 (es) |
RU (1) | RU2020115915A (es) |
SG (1) | SG11202002877RA (es) |
TW (1) | TW201922748A (es) |
WO (1) | WO2019086494A1 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP6890179B2 (ja) | 2016-12-02 | 2021-06-18 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 二環式アミド化合物及びその使用方法 |
US11098058B2 (en) | 2017-07-14 | 2021-08-24 | Genentech, Inc. | Bicyclic ketone compounds and methods of use thereof |
TW202214617A (zh) | 2020-06-02 | 2022-04-16 | 法商賽諾菲公司 | 作為ripk1抑制劑之異㗁唑啶及其用途 |
TW202340182A (zh) | 2021-11-11 | 2023-10-16 | 美商健臻公司 | 做為ripk1抑制劑之異㗁唑啶及其用途 |
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DE1620508A1 (de) | 1965-07-23 | 1969-09-18 | Thomae Gmbh Dr K | Verfahren zur Herstellung neuer 4,5,6,7-Tetrahydrothiazolo-[5,4-c]-pyridine |
US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
US3948903A (en) | 1972-12-15 | 1976-04-06 | Parke, Davis & Company | Substituted N-(1,2-dihydro-2-oxonicotinyl)-cephalexins and -cephaloglycins |
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EP0102324A3 (de) | 1982-07-29 | 1984-11-07 | Ciba-Geigy Ag | Lipide und Tenside in wässriger Phase |
US4544545A (en) | 1983-06-20 | 1985-10-01 | Trustees University Of Massachusetts | Liposomes containing modified cholesterol for organ targeting |
HUT35524A (en) | 1983-08-02 | 1985-07-29 | Hoechst Ag | Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance |
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US5004697A (en) | 1987-08-17 | 1991-04-02 | Univ. Of Ca | Cationized antibodies for delivery through the blood-brain barrier |
US5268164A (en) | 1990-04-23 | 1993-12-07 | Alkermes, Inc. | Increasing blood-brain barrier permeability with permeabilizer peptides |
US5112596A (en) | 1990-04-23 | 1992-05-12 | Alkermes, Inc. | Method for increasing blood-brain barrier permeability by administering a bradykinin agonist of blood-brain barrier permeability |
EP0652775B1 (en) | 1992-07-27 | 2000-04-19 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES | Targeting of liposomes to the blood-brain barrier |
US6080772A (en) * | 1995-06-07 | 2000-06-27 | Sugen, Inc. | Thiazole compounds and methods of modulating signal transduction |
JP2002512628A (ja) | 1997-06-13 | 2002-04-23 | スージェン・インコーポレーテッド | タンパク質チロシン酵素関連の細胞信号伝達を調節するための新規ヘテロアリール化合物 |
WO2001058869A2 (en) | 2000-02-11 | 2001-08-16 | Bristol-Myers Squibb Company | Cannabinoid receptor modulators, their processes of preparation, and use of cannabinoid receptor modulators in treating respiratory and non-respiratory diseases |
US6514221B2 (en) | 2000-07-27 | 2003-02-04 | Brigham And Women's Hospital, Inc. | Blood-brain barrier opening |
WO2002017930A2 (en) | 2000-08-30 | 2002-03-07 | The Board Of Trustees Of The Leland Stanford Junior University | Glucocorticoid blocking agents for increasing blood-brain barrier permeability |
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DE10121982B4 (de) | 2001-05-05 | 2008-01-24 | Lts Lohmann Therapie-Systeme Ag | Nanopartikel aus Protein mit gekoppeltem Apolipoprotein E zur Überwindung der Blut-Hirn-Schranke und Verfahren zu ihrer Herstellung |
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EP1572113B1 (en) | 2002-08-26 | 2017-05-17 | Takeda Pharmaceutical Company Limited | Calcium receptor modulating compound and use thereof |
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ATE410161T1 (de) | 2003-05-02 | 2008-10-15 | Elan Pharm Inc | 4-bromo-5-(2-chloro-benzoylamino)-1h-pyrazol-3- carbonsäureamid-derivate und verwandte verbindungen als bradykinin b1 rezeptor antagonisten zur behandlung von entzündlichen erkrankungen |
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MX2014013407A (es) | 2012-05-22 | 2014-11-26 | Hoffmann La Roche | Dipiridilaminas sustituidas y uso de las mismas. |
MX2015009270A (es) | 2013-01-18 | 2015-10-30 | Hoffmann La Roche | Pirazoles sustituidos en posicion 3 y uso de los mismos como inhibidores de la cinasa cremallera de leucinas dual (dlk). |
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CN106573006A (zh) | 2014-08-21 | 2017-04-19 | 葛兰素史密斯克莱知识产权发展有限公司 | 作为药物的rip1激酶抑制剂杂环酰胺 |
EP3268373B1 (en) | 2015-03-09 | 2022-04-27 | F. Hoffmann-La Roche AG | Tricyclic dlk inhibitors and uses thereof |
TWI763630B (zh) | 2015-07-02 | 2022-05-11 | 瑞士商赫孚孟拉羅股份公司 | 雙環內醯胺及其使用方法 |
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JP6890179B2 (ja) | 2016-12-02 | 2021-06-18 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 二環式アミド化合物及びその使用方法 |
US11072607B2 (en) | 2016-12-16 | 2021-07-27 | Genentech, Inc. | Inhibitors of RIP1 kinase and methods of use thereof |
US11098058B2 (en) | 2017-07-14 | 2021-08-24 | Genentech, Inc. | Bicyclic ketone compounds and methods of use thereof |
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-
2018
- 2018-10-30 JP JP2020524177A patent/JP2021501183A/ja active Pending
- 2018-10-30 WO PCT/EP2018/079772 patent/WO2019086494A1/en active Application Filing
- 2018-10-30 RU RU2020115915A patent/RU2020115915A/ru unknown
- 2018-10-30 TW TW107138469A patent/TW201922748A/zh unknown
- 2018-10-30 US US16/175,206 patent/US11072617B2/en active Active
- 2018-10-30 CA CA3078688A patent/CA3078688A1/en active Pending
- 2018-10-30 AU AU2018360270A patent/AU2018360270A1/en active Pending
- 2018-10-30 CR CR20200168A patent/CR20200168A/es unknown
- 2018-10-30 MX MX2020003451A patent/MX2020003451A/es unknown
- 2018-10-30 SG SG11202002877RA patent/SG11202002877RA/en unknown
- 2018-10-30 BR BR112020008446-8A patent/BR112020008446A2/pt not_active Application Discontinuation
- 2018-10-30 EP EP18796020.8A patent/EP3704097B1/en active Active
- 2018-10-30 MA MA050503A patent/MA50503A/fr unknown
- 2018-10-30 KR KR1020207015138A patent/KR20200083515A/ko not_active Application Discontinuation
- 2018-10-30 CN CN201880070578.0A patent/CN111278809A/zh active Pending
- 2018-10-30 PE PE2020000353A patent/PE20211247A1/es unknown
- 2018-10-30 AR ARP180103157A patent/AR113811A1/es unknown
-
2020
- 2020-03-25 CO CONC2020/0003475A patent/CO2020003475A2/es unknown
- 2020-04-06 IL IL273847A patent/IL273847A/en unknown
- 2020-04-20 CL CL2020001062A patent/CL2020001062A1/es unknown
- 2020-04-30 PH PH12020550537A patent/PH12020550537A1/en unknown
-
2021
- 2021-06-06 US US17/340,082 patent/US20230002391A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
AU2018360270A1 (en) | 2020-03-26 |
AR113811A1 (es) | 2020-06-10 |
CO2020003475A2 (es) | 2020-04-24 |
WO2019086494A1 (en) | 2019-05-09 |
CR20200168A (es) | 2020-07-12 |
IL273847A (en) | 2020-05-31 |
US20190127382A1 (en) | 2019-05-02 |
US11072617B2 (en) | 2021-07-27 |
MX2020003451A (es) | 2020-08-03 |
CA3078688A1 (en) | 2019-05-09 |
EP3704097B1 (en) | 2023-10-25 |
CN111278809A (zh) | 2020-06-12 |
PE20211247A1 (es) | 2021-07-13 |
US20230002391A1 (en) | 2023-01-05 |
SG11202002877RA (en) | 2020-04-29 |
PH12020550537A1 (en) | 2021-03-22 |
TW201922748A (zh) | 2019-06-16 |
MA50503A (fr) | 2020-09-09 |
BR112020008446A2 (pt) | 2020-12-29 |
EP3704097C0 (en) | 2023-10-25 |
RU2020115915A3 (es) | 2022-05-06 |
RU2020115915A (ru) | 2021-12-01 |
JP2021501183A (ja) | 2021-01-14 |
KR20200083515A (ko) | 2020-07-08 |
EP3704097A1 (en) | 2020-09-09 |
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