CU24516B1 - Derivados aromáticos de sulfonamida útiles como medicamentos contra enfermedades asociadas con dolor - Google Patents
Derivados aromáticos de sulfonamida útiles como medicamentos contra enfermedades asociadas con dolorInfo
- Publication number
- CU24516B1 CU24516B1 CU2018000137A CU20180137A CU24516B1 CU 24516 B1 CU24516 B1 CU 24516B1 CU 2018000137 A CU2018000137 A CU 2018000137A CU 20180137 A CU20180137 A CU 20180137A CU 24516 B1 CU24516 B1 CU 24516B1
- Authority
- CU
- Cuba
- Prior art keywords
- pain
- aromatic derivatives
- formula
- associated diseases
- useful
- Prior art date
Links
- 208000002193 Pain Diseases 0.000 title abstract 7
- 201000010099 disease Diseases 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title abstract 2
- 229940124530 sulfonamide Drugs 0.000 title abstract 2
- 150000003456 sulfonamides Chemical class 0.000 title abstract 2
- 230000036407 pain Effects 0.000 abstract 6
- 201000009273 Endometriosis Diseases 0.000 abstract 2
- 206010061218 Inflammation Diseases 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 201000011510 cancer Diseases 0.000 abstract 2
- 230000004054 inflammatory process Effects 0.000 abstract 2
- 210000000278 spinal cord Anatomy 0.000 abstract 2
- 208000000450 Pelvic Pain Diseases 0.000 abstract 1
- 201000002661 Spondylitis Diseases 0.000 abstract 1
- 230000001154 acute effect Effects 0.000 abstract 1
- 206010003246 arthritis Diseases 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 210000004556 brain Anatomy 0.000 abstract 1
- 208000029028 brain injury Diseases 0.000 abstract 1
- 230000001684 chronic effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000000302 ischemic effect Effects 0.000 abstract 1
- 201000006417 multiple sclerosis Diseases 0.000 abstract 1
- 230000003961 neuronal insult Effects 0.000 abstract 1
- 230000002981 neuropathic effect Effects 0.000 abstract 1
- 208000011580 syndromic disease Diseases 0.000 abstract 1
Classifications
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
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- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
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Abstract
<p>La presente invención se refiere a derivados aromáticos de sulfonamidas de fórmula (I)</p> <p>ESPACIO PARA FÓRMULA </p> <p>donde R1, R2, R3, R4, R5 R2c, R2b son como se definen en las reivindicaciones. Dichos compuestos de fórmula (I) son útiles como medicamentos contra enfermedades asociadas con dolor, tal como: dolor o daño neuronal e inflamación en el cerebro o médula espinal o artritis o síndromes de espondilitis (agudo y crónico), dolor inducido por inflamación, dolor neuropático, dolor pélvico, dolor asociado con cáncer, dolor asociado con endometriosis y endometriosis, cáncer, esclerosis múltiple, médula espinal o lesión cerebral isquémica.</p>
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UA122819C2 (uk) * | 2016-05-03 | 2021-01-06 | Байєр Фарма Акцієнгезелльшафт | Ароматичні сульфонамідні похідні |
EP3529246B1 (en) * | 2016-10-24 | 2023-10-18 | FMC Corporation | Oxadiazoles having fungicidal activity |
WO2018104307A1 (en) * | 2016-12-09 | 2018-06-14 | Bayer Pharma Aktiengesellschaft | Aromatic sulfonamide derivatives and their use as anatagon i sts or negative allosteric modulators of p2x4 |
WO2018210729A1 (en) * | 2017-05-18 | 2018-11-22 | Bayer Pharma Aktiengesellschaft | Aromatic sulfonamide derivatives as antagonists or negative allosteric modulators of p2x4 receptor |
JOP20190278A1 (ar) * | 2017-05-31 | 2019-11-28 | Novartis Ag | مركبات 5، 6-ثنائية الحلقة مندمجة وتركيبات لعلاج الأمراض الطفيلية |
MA50448A (fr) * | 2017-10-29 | 2020-09-02 | Bayer Ag | Dérivés sulfonamides aromatiques pour le traitement d'un accident cérébral ischémique |
EP3844150A1 (en) | 2018-08-31 | 2021-07-07 | Xenon Pharmaceuticals Inc. | Heteroaryl-substituted sulfonamide compounds and their use as therapeutic agents |
CA3159689A1 (en) * | 2019-11-29 | 2021-06-03 | Jun LOU | Compound containing an ortho-condensed heterocycle and its use as a p2x4 antagonist |
CN113082023B (zh) * | 2019-12-23 | 2024-03-01 | 武汉朗来科技发展有限公司 | P2x3抑制剂和p2x4抑制剂的药物组合及其应用 |
WO2021136238A1 (zh) * | 2019-12-30 | 2021-07-08 | 武汉朗来科技发展有限公司 | 一种稠环化合物及其应用 |
BR112022023376A2 (pt) | 2020-06-30 | 2023-01-10 | Bayer Ag | Uso de fenilacetamidas possuindo atividade antagonística de receptor de p2x4 para o tratamento de certos distúrbios oculares |
KR20230031307A (ko) | 2020-06-30 | 2023-03-07 | 바이엘 악티엔게젤샤프트 | P2x4 수용체 길항 활성을 갖는 치환된 n-페닐아세트아미드 |
CN111743864B (zh) * | 2020-08-05 | 2022-04-01 | 牡丹江医学院 | 一种体育外伤喷雾剂及其制备方法 |
WO2022049253A1 (en) | 2020-09-07 | 2022-03-10 | Bayer Aktiengesellschaft | Substituted n-heteroaryl-n-pyridinylacetamides as p2x4 modulators |
CN116635020A (zh) * | 2021-01-27 | 2023-08-22 | 武汉朗来科技发展有限公司 | 一种芳香化合物、其制备方法及应用 |
CN116917276A (zh) | 2021-03-01 | 2023-10-20 | 日本农药株式会社 | 具有磺酰胺基的缩合杂环化合物或其盐类及含有该化合物或其盐类的农业园艺用杀虫剂或者动物用的外部或内部寄生虫防除剂以及其使用方法 |
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WO2023190826A1 (ja) * | 2022-03-31 | 2023-10-05 | 学校法人 高崎健康福祉大学 | 偽アレルギー反応に伴う症状の予防若しくは抑制又は治療用の医薬組成物 |
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WO2016198374A1 (en) | 2015-06-10 | 2016-12-15 | Bayer Pharma Aktiengesellschaft | Aromatic sulfonamide derivatives |
MX2018013354A (es) | 2016-05-03 | 2019-02-20 | Galera Labs Llc | Terapia de combinacion para tratamiento de cancer. |
US9988367B2 (en) | 2016-05-03 | 2018-06-05 | Bayer Pharma Aktiengesellschaft | Amide-substituted pyridinyltriazole derivatives and uses thereof |
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WO2018104305A1 (en) * | 2016-12-09 | 2018-06-14 | Bayer Pharma Aktiengesellschaft | Field of application of the invention |
WO2018104307A1 (en) * | 2016-12-09 | 2018-06-14 | Bayer Pharma Aktiengesellschaft | Aromatic sulfonamide derivatives and their use as anatagon i sts or negative allosteric modulators of p2x4 |
WO2018210729A1 (en) * | 2017-05-18 | 2018-11-22 | Bayer Pharma Aktiengesellschaft | Aromatic sulfonamide derivatives as antagonists or negative allosteric modulators of p2x4 receptor |
MA50448A (fr) * | 2017-10-29 | 2020-09-02 | Bayer Ag | Dérivés sulfonamides aromatiques pour le traitement d'un accident cérébral ischémique |
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