CL2017000817A1 - Triazolopirazinonas como inhibidores de pde1 - Google Patents
Triazolopirazinonas como inhibidores de pde1Info
- Publication number
- CL2017000817A1 CL2017000817A1 CL2017000817A CL2017000817A CL2017000817A1 CL 2017000817 A1 CL2017000817 A1 CL 2017000817A1 CL 2017000817 A CL2017000817 A CL 2017000817A CL 2017000817 A CL2017000817 A CL 2017000817A CL 2017000817 A1 CL2017000817 A1 CL 2017000817A1
- Authority
- CL
- Chile
- Prior art keywords
- triazolopyrazinones
- pde1 inhibitors
- pde1
- inhibitors
- triazoioprazinonas
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
<p>LA PRESENTE INVENCIÓN PROPORCIONA TRIAZOIOPRAZINONAS COMA INHIBIDORES DE PDE1 Y SU USO COMA UN MEDICAMENTO, EN PARTICULAR PARA EL TRATAMIENTO DE TRASTORNOS NEURODEGENERATIVOS Y TRASTORNOS PSIQUIÁTRICAS.</p>
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA201400582 | 2014-10-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2017000817A1 true CL2017000817A1 (es) | 2017-11-03 |
Family
ID=58698606
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2017000817A CL2017000817A1 (es) | 2014-10-10 | 2017-04-04 | Triazolopirazinonas como inhibidores de pde1 |
Country Status (25)
Country | Link |
---|---|
US (1) | US10150771B2 (es) |
EP (1) | EP3204387B1 (es) |
JP (1) | JP6596489B2 (es) |
KR (1) | KR20170066417A (es) |
CN (1) | CN106715438B (es) |
AR (1) | AR102227A1 (es) |
AU (1) | AU2015329898A1 (es) |
BR (1) | BR112017006940A2 (es) |
CA (1) | CA2961986A1 (es) |
CL (1) | CL2017000817A1 (es) |
CO (1) | CO2017002708A2 (es) |
DO (1) | DOP2017000080A (es) |
EA (1) | EA201790575A1 (es) |
EC (1) | ECSP17018120A (es) |
ES (1) | ES2735733T3 (es) |
IL (1) | IL251420A0 (es) |
MX (1) | MX2017004510A (es) |
PE (1) | PE20180024A1 (es) |
PH (1) | PH12017500621A1 (es) |
RU (1) | RU2017111888A (es) |
SG (1) | SG11201702874YA (es) |
SV (1) | SV2017005419A (es) |
TN (1) | TN2017000099A1 (es) |
TW (1) | TW201629064A (es) |
WO (1) | WO2016055618A1 (es) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW201629064A (zh) | 2014-10-10 | 2016-08-16 | H 朗德貝克公司 | 作爲pde1抑制劑之三唑並吡酮 |
US20160311831A1 (en) * | 2015-04-22 | 2016-10-27 | H. Lundbeck A/S | Imidazotriazinones as PDE1 Inhibitors |
JO3627B1 (ar) | 2015-04-30 | 2020-08-27 | H Lundbeck As | إيميدازو بيرازينونات على هيئة مثبطات pde1 |
TWI729109B (zh) | 2016-04-12 | 2021-06-01 | 丹麥商H 朗德貝克公司 | 作爲PDE1抑制劑的1,5-二氫-4H-吡唑并[3,4-d]嘧啶-4-酮和1,5-二氫-4H-吡唑并[4,3-c]吡啶-4-酮 |
US10034861B2 (en) | 2016-07-04 | 2018-07-31 | H. Lundbeck A/S | 1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors |
JOP20170164A1 (ar) | 2016-08-25 | 2019-01-30 | Lilly Co Eli | مشتق ترايازولو بيرازينون مفيد كمثبط لـ pde1 بشري |
WO2018073251A1 (en) | 2016-10-18 | 2018-04-26 | H. Lundbeck A/S | Imidazopyrazinones, pyrazolopyrimidinones and pyrazolopyridinones as pde1 inhibitors |
BR112018013247A2 (pt) | 2016-10-28 | 2018-12-04 | H Lundbeck As | tratamentos de combinação compreendendo imidazopirazinonas para o tratamento de distúrbios psiquiátricos e/ou cognitivos |
EP3532053A1 (en) | 2016-10-28 | 2019-09-04 | H. Lundbeck A/S | Combination treatments comprising administration of imidazopyrazinones |
JOP20190126A1 (ar) | 2016-12-22 | 2019-05-28 | H Lundbeck As | بيرازولو [3، 4-b] بيريدينات وإيميدازو [1، 5-b] بيريدازينات على هيئة مثبطات PDE1 |
CN110337437B (zh) | 2016-12-28 | 2023-02-03 | 达特神经科学有限公司 | 作为pde2抑制剂的取代的吡唑并嘧啶酮化合物 |
AR112457A1 (es) * | 2017-08-02 | 2019-10-30 | Lilly Co Eli | Derivados de [1,2,4]triazolo[4,3-a]pirazin-6(5h)-ona |
JP7254078B2 (ja) | 2017-11-27 | 2023-04-07 | ダート・ニューロサイエンス・エルエルシー | Pde1阻害剤としての置換フラノピリミジン化合物 |
PL3723807T3 (pl) | 2017-12-14 | 2022-01-24 | H. Lundbeck A/S | Leczenie skojarzone obejmujące podawanie 1h-pirazolo[4,3-b]pirydyn |
AR113926A1 (es) * | 2017-12-14 | 2020-07-01 | H Lundbeck As | Derivados de 1h-pirazolo[4,3-b]piridinas |
WO2019121840A1 (en) | 2017-12-20 | 2019-06-27 | H. Lundbeck A/S | Pyrazolo[3,4-b]pyridines and imidazo[1,5-b]pyridazines as pde1 inhibitors |
TW201927784A (zh) * | 2017-12-20 | 2019-07-16 | 丹麥商H 朗德貝克公司 | 作為pde1抑制劑之大環 |
US10766893B2 (en) | 2017-12-20 | 2020-09-08 | H. Lundbeck A/S | 1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors |
US11453673B2 (en) * | 2018-02-06 | 2022-09-27 | Eli Lilly And Company | Substituted [1,2,4]triazolo[4,3-a]pyrazines as phosphodiesterase inhibitors |
Family Cites Families (35)
Publication number | Priority date | Publication date | Assignee | Title |
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GB973361A (en) | 1960-05-11 | 1964-10-28 | Ciba Ltd | Pyrazolo-pyrimidines and process for their manufacture |
DE10238722A1 (de) | 2002-08-23 | 2004-03-11 | Bayer Ag | Selektive Phosphodiesterase 9A-Inhibitoren als Arzneimittel zur Verbesserung kognitiver Prozesse |
DE10238723A1 (de) | 2002-08-23 | 2004-03-11 | Bayer Ag | Phenyl-substituierte Pyrazolyprimidine |
DE10238724A1 (de) | 2002-08-23 | 2004-03-04 | Bayer Ag | Alkyl-substituierte Pyrazolpyrimidine |
JP2006525966A (ja) | 2003-05-09 | 2006-11-16 | バイエル・ヘルスケア・アクチェンゲゼルシャフト | 6−シクリルメチル−および6−アルキルメチル置換ピラゾロピリミジン類 |
WO2006068978A2 (en) | 2004-12-21 | 2006-06-29 | Takeda Pharmaceutial Company Limited | Dipeptidyl peptidase inhibitors |
US20080194592A1 (en) | 2005-08-23 | 2008-08-14 | Intra-Cellular Therapies, Inc. | Organic Compounds |
US9006258B2 (en) | 2006-12-05 | 2015-04-14 | Intra-Cellular Therapies, Inc. | Method of treating female sexual dysfunction with a PDE1 inhibitor |
EP2152712B1 (en) | 2007-05-11 | 2012-01-11 | Pfizer Inc. | Amino-heterocyclic compounds |
UA105362C2 (en) | 2008-04-02 | 2014-05-12 | Бьорингер Ингельхайм Интернациональ Гмбх | 1-heterocyclyl-1, 5-dihydro-pyrazolo [3, 4-d] pyrimidin-4-one derivatives and their use as pde9a modulators |
AP2011005672A0 (en) | 2008-09-08 | 2011-04-30 | Boehringer Ingelheim Int | Pyrazolopyrimidines and their use for the treatment of CNS disorders. |
PE20120120A1 (es) | 2008-12-06 | 2012-03-03 | Intra Cellular Therapies Inc | DERIVADOS DE 2H-PIRAZOLO[3,4-d]PIRIMIDINA-4,6(5H,7H)-DIONA, COMO INHIBIDORES DE PDE1 |
TWI404721B (zh) | 2009-01-26 | 2013-08-11 | Pfizer | 胺基-雜環化合物 |
US9434730B2 (en) * | 2010-05-31 | 2016-09-06 | Intra-Cellular Therapies, Inc. | PDE1 inhibitor compounds |
MX2013003093A (es) | 2010-09-20 | 2013-10-28 | Envivo Pharmaceuticals Inc | Compuestos de imidazotriazinona. |
WO2012040048A2 (en) * | 2010-09-21 | 2012-03-29 | Schering Corporation | Triazolopyrazinones as p2x7 receptor antagonists |
WO2012171016A1 (en) * | 2011-06-10 | 2012-12-13 | Intra-Cellular Therapies, Inc. | Organic compounds |
MX370433B (es) | 2011-10-10 | 2019-12-13 | H Lundbeck As | Derivados de 7h-imidazo [1-5-a] pirazin-8-ona como inhibidores de la fosfodiasterasa 9(pde9); y el uso de los mismos en el tratamiento de trastornos neurodegenerativos. |
EP2807163B1 (en) | 2012-01-26 | 2017-03-22 | H. Lundbeck A/S | Pde9 inhibitors with imidazo triazinone backbone |
DK3489238T3 (da) | 2012-06-18 | 2022-01-10 | Dart Neuroscience Llc | Farmaceutiske sammensætninger af 6h-pyrido[3,2-e][1,2,4]triazolo[1,5-c]pyrimidin-5-on- og [1,2,4]triazolo[1,5-c]pteridin-5(6h)-on-derivater som pde1-inhibitorer til behandling af for eksempel neurologiske lidelser |
DK2970279T3 (da) | 2013-03-15 | 2020-11-30 | Intra Cellular Therapies Inc | Organiske forbindelser |
JP5783297B2 (ja) | 2013-08-06 | 2015-09-24 | 株式会社デンソー | 力学量センサ |
JP5797815B1 (ja) | 2014-06-27 | 2015-10-21 | 細田建設株式会社 | 後施工アンカー及びその施工方法 |
US20160083391A1 (en) | 2014-09-18 | 2016-03-24 | Sunovion Pharmaceuticals Inc. | Tricyclic piperazine derivative |
US20160083400A1 (en) | 2014-09-18 | 2016-03-24 | Sunovion Pharmaceuticals Inc. | Tricyclic guanidine derivative |
WO2016042775A1 (en) | 2014-09-18 | 2016-03-24 | Sunovion Pharmaceuticals Inc. | Tricyclic derivative |
TW201629064A (zh) | 2014-10-10 | 2016-08-16 | H 朗德貝克公司 | 作爲pde1抑制劑之三唑並吡酮 |
JP2018508555A (ja) | 2015-03-16 | 2018-03-29 | 大日本住友製薬株式会社 | 二環性イミダゾロ誘導体 |
US20160311831A1 (en) | 2015-04-22 | 2016-10-27 | H. Lundbeck A/S | Imidazotriazinones as PDE1 Inhibitors |
JO3627B1 (ar) | 2015-04-30 | 2020-08-27 | H Lundbeck As | إيميدازو بيرازينونات على هيئة مثبطات pde1 |
AR107456A1 (es) | 2016-02-12 | 2018-05-02 | Lilly Co Eli | Inhibidor de pde1 |
TWI729109B (zh) | 2016-04-12 | 2021-06-01 | 丹麥商H 朗德貝克公司 | 作爲PDE1抑制劑的1,5-二氫-4H-吡唑并[3,4-d]嘧啶-4-酮和1,5-二氫-4H-吡唑并[4,3-c]吡啶-4-酮 |
WO2018073251A1 (en) | 2016-10-18 | 2018-04-26 | H. Lundbeck A/S | Imidazopyrazinones, pyrazolopyrimidinones and pyrazolopyridinones as pde1 inhibitors |
BR112018013247A2 (pt) | 2016-10-28 | 2018-12-04 | H Lundbeck As | tratamentos de combinação compreendendo imidazopirazinonas para o tratamento de distúrbios psiquiátricos e/ou cognitivos |
EP3532053A1 (en) | 2016-10-28 | 2019-09-04 | H. Lundbeck A/S | Combination treatments comprising administration of imidazopyrazinones |
-
2015
- 2015-10-08 TW TW104133183A patent/TW201629064A/zh unknown
- 2015-10-09 WO PCT/EP2015/073417 patent/WO2016055618A1/en active Application Filing
- 2015-10-09 KR KR1020177009566A patent/KR20170066417A/ko unknown
- 2015-10-09 US US15/517,348 patent/US10150771B2/en active Active
- 2015-10-09 AR ARP150103269A patent/AR102227A1/es unknown
- 2015-10-09 JP JP2017518482A patent/JP6596489B2/ja active Active
- 2015-10-09 MX MX2017004510A patent/MX2017004510A/es unknown
- 2015-10-09 CA CA2961986A patent/CA2961986A1/en not_active Abandoned
- 2015-10-09 ES ES15787486T patent/ES2735733T3/es active Active
- 2015-10-09 BR BR112017006940A patent/BR112017006940A2/pt not_active Application Discontinuation
- 2015-10-09 CN CN201580052980.2A patent/CN106715438B/zh active Active
- 2015-10-09 AU AU2015329898A patent/AU2015329898A1/en not_active Abandoned
- 2015-10-09 PE PE2017000481A patent/PE20180024A1/es not_active Application Discontinuation
- 2015-10-09 TN TN2017000099A patent/TN2017000099A1/en unknown
- 2015-10-09 RU RU2017111888A patent/RU2017111888A/ru unknown
- 2015-10-09 EP EP15787486.8A patent/EP3204387B1/en active Active
- 2015-10-09 SG SG11201702874YA patent/SG11201702874YA/en unknown
- 2015-10-09 EA EA201790575A patent/EA201790575A1/ru unknown
-
2017
- 2017-03-21 DO DO2017000080A patent/DOP2017000080A/es unknown
- 2017-03-22 CO CONC2017/0002708A patent/CO2017002708A2/es unknown
- 2017-03-24 EC ECIEPI201718120A patent/ECSP17018120A/es unknown
- 2017-03-27 IL IL251420A patent/IL251420A0/en unknown
- 2017-03-31 SV SV2017005419A patent/SV2017005419A/es unknown
- 2017-04-04 PH PH12017500621A patent/PH12017500621A1/en unknown
- 2017-04-04 CL CL2017000817A patent/CL2017000817A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
TW201629064A (zh) | 2016-08-16 |
TN2017000099A1 (en) | 2018-07-04 |
BR112017006940A2 (pt) | 2018-01-09 |
JP6596489B2 (ja) | 2019-10-23 |
CN106715438B (zh) | 2019-04-12 |
CN106715438A (zh) | 2017-05-24 |
SG11201702874YA (en) | 2017-05-30 |
US20170298072A1 (en) | 2017-10-19 |
EP3204387A1 (en) | 2017-08-16 |
CO2017002708A2 (es) | 2017-06-30 |
MX2017004510A (es) | 2017-06-28 |
EP3204387B1 (en) | 2019-06-12 |
SV2017005419A (es) | 2017-06-07 |
KR20170066417A (ko) | 2017-06-14 |
WO2016055618A1 (en) | 2016-04-14 |
AU2015329898A1 (en) | 2017-03-30 |
ECSP17018120A (es) | 2017-08-31 |
PH12017500621A1 (en) | 2017-09-25 |
IL251420A0 (en) | 2017-05-29 |
ES2735733T3 (es) | 2019-12-20 |
CA2961986A1 (en) | 2016-04-14 |
PE20180024A1 (es) | 2018-01-09 |
DOP2017000080A (es) | 2017-05-15 |
JP2017530173A (ja) | 2017-10-12 |
AR102227A1 (es) | 2017-02-15 |
US10150771B2 (en) | 2018-12-11 |
EA201790575A1 (ru) | 2017-07-31 |
RU2017111888A (ru) | 2018-11-12 |
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