DOP2017000080A - Triazolopirazinonas como inhibidores de pde1 - Google Patents
Triazolopirazinonas como inhibidores de pde1Info
- Publication number
- DOP2017000080A DOP2017000080A DO2017000080A DO2017000080A DOP2017000080A DO P2017000080 A DOP2017000080 A DO P2017000080A DO 2017000080 A DO2017000080 A DO 2017000080A DO 2017000080 A DO2017000080 A DO 2017000080A DO P2017000080 A DOP2017000080 A DO P2017000080A
- Authority
- DO
- Dominican Republic
- Prior art keywords
- triazolopirazinonas
- pde1 inhibitors
- pde1
- inhibitors
- triazolopyrazinones
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La presente invención proporciona triazolopirazinonas como inhibidores de PDE1 y su uso como un medicamento, en particular para el tratamiento de trastornos neurodegenerativos y trastornos psiquiátricos.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA201400582 | 2014-10-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
DOP2017000080A true DOP2017000080A (es) | 2017-05-15 |
Family
ID=58698606
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DO2017000080A DOP2017000080A (es) | 2014-10-10 | 2017-03-21 | Triazolopirazinonas como inhibidores de pde1 |
Country Status (25)
Country | Link |
---|---|
US (1) | US10150771B2 (es) |
EP (1) | EP3204387B1 (es) |
JP (1) | JP6596489B2 (es) |
KR (1) | KR20170066417A (es) |
CN (1) | CN106715438B (es) |
AR (1) | AR102227A1 (es) |
AU (1) | AU2015329898A1 (es) |
BR (1) | BR112017006940A2 (es) |
CA (1) | CA2961986A1 (es) |
CL (1) | CL2017000817A1 (es) |
CO (1) | CO2017002708A2 (es) |
DO (1) | DOP2017000080A (es) |
EA (1) | EA201790575A1 (es) |
EC (1) | ECSP17018120A (es) |
ES (1) | ES2735733T3 (es) |
IL (1) | IL251420A0 (es) |
MX (1) | MX2017004510A (es) |
PE (1) | PE20180024A1 (es) |
PH (1) | PH12017500621A1 (es) |
RU (1) | RU2017111888A (es) |
SG (1) | SG11201702874YA (es) |
SV (1) | SV2017005419A (es) |
TN (1) | TN2017000099A1 (es) |
TW (1) | TW201629064A (es) |
WO (1) | WO2016055618A1 (es) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW201629064A (zh) | 2014-10-10 | 2016-08-16 | H 朗德貝克公司 | 作爲pde1抑制劑之三唑並吡酮 |
TW201643167A (zh) * | 2015-04-22 | 2016-12-16 | H 朗德貝克公司 | 作爲pde1抑制劑之咪唑並三酮 |
JO3627B1 (ar) | 2015-04-30 | 2020-08-27 | H Lundbeck As | إيميدازو بيرازينونات على هيئة مثبطات pde1 |
TWI729109B (zh) | 2016-04-12 | 2021-06-01 | 丹麥商H 朗德貝克公司 | 作爲PDE1抑制劑的1,5-二氫-4H-吡唑并[3,4-d]嘧啶-4-酮和1,5-二氫-4H-吡唑并[4,3-c]吡啶-4-酮 |
US10034861B2 (en) | 2016-07-04 | 2018-07-31 | H. Lundbeck A/S | 1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors |
JOP20170164A1 (ar) * | 2016-08-25 | 2019-01-30 | Lilly Co Eli | مشتق ترايازولو بيرازينون مفيد كمثبط لـ pde1 بشري |
ES2967489T3 (es) * | 2016-10-18 | 2024-04-30 | H Lundbeck As | Imidazopirazinonas, pirazolopirimidinonas y pirazolopiridinonas como inhibidores de PDE1 |
EP3532053A1 (en) | 2016-10-28 | 2019-09-04 | H. Lundbeck A/S | Combination treatments comprising administration of imidazopyrazinones |
LT3532064T (lt) * | 2016-10-28 | 2020-09-25 | H. Lundbeck A/S | Kompleksiniai gydymai, apimantys imidazopirazonus, skirti psichiatrinių ir (arba) kognityvinių sutrikimų gydymui |
JOP20190126A1 (ar) | 2016-12-22 | 2019-05-28 | H Lundbeck As | بيرازولو [3، 4-b] بيريدينات وإيميدازو [1، 5-b] بيريدازينات على هيئة مثبطات PDE1 |
AU2017388054B2 (en) | 2016-12-28 | 2022-03-24 | Dart Neuroscience, Llc | Substituted pyrazolopyrimidinone compounds as PDE2 inhibitors |
AR112457A1 (es) * | 2017-08-02 | 2019-10-30 | Lilly Co Eli | Derivados de [1,2,4]triazolo[4,3-a]pirazin-6(5h)-ona |
WO2019104285A1 (en) | 2017-11-27 | 2019-05-31 | Dart Neuroscience, Llc | Substituted furanopyrimidine compounds as pde1 inhibitors |
RU2020118913A (ru) | 2017-12-14 | 2022-01-14 | Х. Лундбекк А/С (H. Lundbeck A/S) | Виды комбинированного лечения, предусматривающего введение 1h-пиразолo[4,3-b]пиридинов |
AR113926A1 (es) | 2017-12-14 | 2020-07-01 | H Lundbeck As | Derivados de 1h-pirazolo[4,3-b]piridinas |
US10766893B2 (en) * | 2017-12-20 | 2020-09-08 | H. Lundbeck A/S | 1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors |
JP7194738B2 (ja) | 2017-12-20 | 2022-12-22 | ハー・ルンドベック・アクチエゼルスカベット | PDE1阻害剤としてのピラゾロ[3,4-b]ピリジン及びイミダゾ[1,5-b]ピリダジン |
TW201927784A (zh) * | 2017-12-20 | 2019-07-16 | 丹麥商H 朗德貝克公司 | 作為pde1抑制劑之大環 |
US11453673B2 (en) | 2018-02-06 | 2022-09-27 | Eli Lilly And Company | Substituted [1,2,4]triazolo[4,3-a]pyrazines as phosphodiesterase inhibitors |
Family Cites Families (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB973361A (en) | 1960-05-11 | 1964-10-28 | Ciba Ltd | Pyrazolo-pyrimidines and process for their manufacture |
DE10238723A1 (de) | 2002-08-23 | 2004-03-11 | Bayer Ag | Phenyl-substituierte Pyrazolyprimidine |
DE10238724A1 (de) | 2002-08-23 | 2004-03-04 | Bayer Ag | Alkyl-substituierte Pyrazolpyrimidine |
DE10238722A1 (de) | 2002-08-23 | 2004-03-11 | Bayer Ag | Selektive Phosphodiesterase 9A-Inhibitoren als Arzneimittel zur Verbesserung kognitiver Prozesse |
WO2004099211A1 (de) | 2003-05-09 | 2004-11-18 | Bayer Healthcare Ag | 6-cyclylmethyl- und 6-alkylmethyl-substituierte pyrazolopyrimidine |
JP2008524331A (ja) | 2004-12-21 | 2008-07-10 | 武田薬品工業株式会社 | ジペプチジルペプチダーゼ阻害剤 |
WO2007025103A2 (en) | 2005-08-23 | 2007-03-01 | Intra-Cellular Therapies, Inc. | Organic compounds for treating reduced dopamine receptor signalling activity |
JP5837278B2 (ja) | 2006-12-05 | 2015-12-24 | イントラ−セルラー・セラピーズ・インコーポレイテッドIntra−Cellular Therapies, Inc. | 新規使用 |
JP4579346B2 (ja) | 2007-05-11 | 2010-11-10 | ファイザー・インク | アミノ複素環式化合物 |
UA105362C2 (en) | 2008-04-02 | 2014-05-12 | Бьорингер Ингельхайм Интернациональ Гмбх | 1-heterocyclyl-1, 5-dihydro-pyrazolo [3, 4-d] pyrimidin-4-one derivatives and their use as pde9a modulators |
NZ590788A (en) | 2008-09-08 | 2012-11-30 | Boehringer Ingelheim Int | Pyrazolopyrimidines and their use for the treatment of cns disorders |
EP2367430B1 (en) * | 2008-12-06 | 2014-08-13 | Intra-Cellular Therapies, Inc. | Organic compounds |
TWI404721B (zh) | 2009-01-26 | 2013-08-11 | Pfizer | 胺基-雜環化合物 |
EP2575817A4 (en) * | 2010-05-31 | 2014-01-08 | Intra Cellular Therapies Inc | ORGANIC CONNECTIONS |
EP2619208B1 (en) | 2010-09-20 | 2016-11-09 | Ironwood Pharmaceuticals, Inc. | Imidazotriazinone compounds |
WO2012040048A2 (en) | 2010-09-21 | 2012-03-29 | Schering Corporation | Triazolopyrazinones as p2x7 receptor antagonists |
JP6051210B2 (ja) * | 2011-06-10 | 2016-12-27 | イントラ−セルラー・セラピーズ・インコーポレイテッドIntra−Cellular Therapies, Inc. | 有機化合物 |
JP2015531401A (ja) | 2011-10-10 | 2015-11-02 | ハー・ルンドベック・アクチエゼルスカベット | イミダゾピラジノン骨格を有するpde9i |
CN107082783B (zh) | 2012-01-26 | 2019-03-22 | H.隆德贝克有限公司 | 具有咪唑并三嗪酮骨架的pde9抑制剂 |
JP6129960B2 (ja) | 2012-06-18 | 2017-05-17 | ダート・ニューロサイエンス・(ケイマン)・リミテッド | 置換ピリジンアゾロピリミジン−5−(6h)−オン化合物 |
DK2970279T3 (da) | 2013-03-15 | 2020-11-30 | Intra Cellular Therapies Inc | Organiske forbindelser |
JP5783297B2 (ja) | 2013-08-06 | 2015-09-24 | 株式会社デンソー | 力学量センサ |
JP5797815B1 (ja) | 2014-06-27 | 2015-10-21 | 細田建設株式会社 | 後施工アンカー及びその施工方法 |
US20160083391A1 (en) | 2014-09-18 | 2016-03-24 | Sunovion Pharmaceuticals Inc. | Tricyclic piperazine derivative |
JP2017527606A (ja) | 2014-09-18 | 2017-09-21 | サノビオン ファーマシューティカルズ インクSunovion Pharmaceuticals Inc. | 三環系誘導体 |
US20160083400A1 (en) | 2014-09-18 | 2016-03-24 | Sunovion Pharmaceuticals Inc. | Tricyclic guanidine derivative |
TW201629064A (zh) | 2014-10-10 | 2016-08-16 | H 朗德貝克公司 | 作爲pde1抑制劑之三唑並吡酮 |
JP2018508555A (ja) | 2015-03-16 | 2018-03-29 | 大日本住友製薬株式会社 | 二環性イミダゾロ誘導体 |
TW201643167A (zh) | 2015-04-22 | 2016-12-16 | H 朗德貝克公司 | 作爲pde1抑制劑之咪唑並三酮 |
JO3627B1 (ar) | 2015-04-30 | 2020-08-27 | H Lundbeck As | إيميدازو بيرازينونات على هيئة مثبطات pde1 |
AR107456A1 (es) | 2016-02-12 | 2018-05-02 | Lilly Co Eli | Inhibidor de pde1 |
TWI729109B (zh) | 2016-04-12 | 2021-06-01 | 丹麥商H 朗德貝克公司 | 作爲PDE1抑制劑的1,5-二氫-4H-吡唑并[3,4-d]嘧啶-4-酮和1,5-二氫-4H-吡唑并[4,3-c]吡啶-4-酮 |
ES2967489T3 (es) | 2016-10-18 | 2024-04-30 | H Lundbeck As | Imidazopirazinonas, pirazolopirimidinonas y pirazolopiridinonas como inhibidores de PDE1 |
LT3532064T (lt) | 2016-10-28 | 2020-09-25 | H. Lundbeck A/S | Kompleksiniai gydymai, apimantys imidazopirazonus, skirti psichiatrinių ir (arba) kognityvinių sutrikimų gydymui |
EP3532053A1 (en) | 2016-10-28 | 2019-09-04 | H. Lundbeck A/S | Combination treatments comprising administration of imidazopyrazinones |
-
2015
- 2015-10-08 TW TW104133183A patent/TW201629064A/zh unknown
- 2015-10-09 BR BR112017006940A patent/BR112017006940A2/pt not_active Application Discontinuation
- 2015-10-09 PE PE2017000481A patent/PE20180024A1/es not_active Application Discontinuation
- 2015-10-09 AR ARP150103269A patent/AR102227A1/es unknown
- 2015-10-09 US US15/517,348 patent/US10150771B2/en active Active
- 2015-10-09 CA CA2961986A patent/CA2961986A1/en not_active Abandoned
- 2015-10-09 AU AU2015329898A patent/AU2015329898A1/en not_active Abandoned
- 2015-10-09 WO PCT/EP2015/073417 patent/WO2016055618A1/en active Application Filing
- 2015-10-09 MX MX2017004510A patent/MX2017004510A/es unknown
- 2015-10-09 JP JP2017518482A patent/JP6596489B2/ja active Active
- 2015-10-09 CN CN201580052980.2A patent/CN106715438B/zh active Active
- 2015-10-09 RU RU2017111888A patent/RU2017111888A/ru unknown
- 2015-10-09 ES ES15787486T patent/ES2735733T3/es active Active
- 2015-10-09 TN TN2017000099A patent/TN2017000099A1/en unknown
- 2015-10-09 EA EA201790575A patent/EA201790575A1/ru unknown
- 2015-10-09 KR KR1020177009566A patent/KR20170066417A/ko unknown
- 2015-10-09 SG SG11201702874YA patent/SG11201702874YA/en unknown
- 2015-10-09 EP EP15787486.8A patent/EP3204387B1/en active Active
-
2017
- 2017-03-21 DO DO2017000080A patent/DOP2017000080A/es unknown
- 2017-03-22 CO CONC2017/0002708A patent/CO2017002708A2/es unknown
- 2017-03-24 EC ECIEPI201718120A patent/ECSP17018120A/es unknown
- 2017-03-27 IL IL251420A patent/IL251420A0/en unknown
- 2017-03-31 SV SV2017005419A patent/SV2017005419A/es unknown
- 2017-04-04 CL CL2017000817A patent/CL2017000817A1/es unknown
- 2017-04-04 PH PH12017500621A patent/PH12017500621A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
US20170298072A1 (en) | 2017-10-19 |
KR20170066417A (ko) | 2017-06-14 |
JP2017530173A (ja) | 2017-10-12 |
TN2017000099A1 (en) | 2018-07-04 |
RU2017111888A (ru) | 2018-11-12 |
SV2017005419A (es) | 2017-06-07 |
JP6596489B2 (ja) | 2019-10-23 |
SG11201702874YA (en) | 2017-05-30 |
EP3204387A1 (en) | 2017-08-16 |
CA2961986A1 (en) | 2016-04-14 |
TW201629064A (zh) | 2016-08-16 |
IL251420A0 (en) | 2017-05-29 |
EA201790575A1 (ru) | 2017-07-31 |
CN106715438B (zh) | 2019-04-12 |
MX2017004510A (es) | 2017-06-28 |
CL2017000817A1 (es) | 2017-11-03 |
CN106715438A (zh) | 2017-05-24 |
AU2015329898A1 (en) | 2017-03-30 |
ES2735733T3 (es) | 2019-12-20 |
ECSP17018120A (es) | 2017-08-31 |
PH12017500621A1 (en) | 2017-09-25 |
US10150771B2 (en) | 2018-12-11 |
WO2016055618A1 (en) | 2016-04-14 |
AR102227A1 (es) | 2017-02-15 |
CO2017002708A2 (es) | 2017-06-30 |
PE20180024A1 (es) | 2018-01-09 |
BR112017006940A2 (pt) | 2018-01-09 |
EP3204387B1 (en) | 2019-06-12 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ECSP17018120A (es) | Triazolopirazinonas como inhibidores de pde1 | |
DOP2017000254A (es) | Imidazopirazinonas como inhibidores de pde1 | |
ECSP16061208A (es) | Quinazolin-thf-aminas como inhibidores de pde1 | |
BR112017009000A2 (pt) | apilimod para uso no tratamento de melanoma | |
PH12017500602A1 (en) | Methods for treating ocular conditions | |
ECSP16082599A (es) | Quinazolin-thf-aminas halogenadas como inhibidores de pde1 | |
ECSP16071574A (es) | Hexahidrofuropirroles como inhibidores de pde1 | |
DK3903774T3 (da) | N,n-bis-2-mercaptoethyl isophthalamide for the treatment of neurodegenerative diseases |