JO3627B1 - إيميدازو بيرازينونات على هيئة مثبطات pde1 - Google Patents

إيميدازو بيرازينونات على هيئة مثبطات pde1

Info

Publication number
JO3627B1
JO3627B1 JOP/2016/0081A JOP20160081A JO3627B1 JO 3627 B1 JO3627 B1 JO 3627B1 JO P20160081 A JOP20160081 A JO P20160081A JO 3627 B1 JO3627 B1 JO 3627B1
Authority
JO
Jordan
Prior art keywords
imidazopyrazinones
pde1 inhibitors
pde1
inhibitors
medicament
Prior art date
Application number
JOP/2016/0081A
Other languages
English (en)
Inventor
Juhl Karsten
Kyhn Rasmussen Lars
Langgard Morten
Jessing Mikkel
Kehler Jan
Jorge Vieira Vital Paulo
Original Assignee
H Lundbeck As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H Lundbeck As filed Critical H Lundbeck As
Application granted granted Critical
Publication of JO3627B1 publication Critical patent/JO3627B1/ar

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

يتعلق الاختراع الحالي بتوفير إيميدازو بيرازينونات على هيئة مثبطات PDE1 واستخدامها على هيئة دواء، بالتحديد لمعالجة اضطرابات التنكسية العصبية واضطرابات نفسية.
JOP/2016/0081A 2015-04-30 2016-04-26 إيميدازو بيرازينونات على هيئة مثبطات pde1 JO3627B1 (ar)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA201500261 2015-04-30
DKPA201500666 2015-10-29
DKPA201600202 2016-04-04

Publications (1)

Publication Number Publication Date
JO3627B1 true JO3627B1 (ar) 2020-08-27

Family

ID=55910242

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2016/0081A JO3627B1 (ar) 2015-04-30 2016-04-26 إيميدازو بيرازينونات على هيئة مثبطات pde1

Country Status (41)

Country Link
US (4) US20160318939A1 (ar)
EP (1) EP3288944B1 (ar)
JP (1) JP6663930B2 (ar)
KR (1) KR102605759B1 (ar)
CN (1) CN107531714B (ar)
AU (1) AU2016256573B2 (ar)
BR (1) BR112017023182B1 (ar)
CA (1) CA2983563A1 (ar)
CL (1) CL2017002719A1 (ar)
CO (1) CO2017010399A2 (ar)
CY (1) CY1121806T1 (ar)
DK (1) DK3288944T3 (ar)
DO (1) DOP2017000254A (ar)
EA (1) EA031946B1 (ar)
EC (1) ECSP17072228A (ar)
ES (1) ES2735422T3 (ar)
GE (1) GEP20207058B (ar)
GT (1) GT201700223A (ar)
HK (1) HK1252098B (ar)
HR (1) HRP20191180T1 (ar)
HU (1) HUE044244T2 (ar)
IL (1) IL255316B (ar)
JO (1) JO3627B1 (ar)
LT (1) LT3288944T (ar)
MA (1) MA41977B1 (ar)
ME (1) ME03414B (ar)
MX (1) MX2017013785A (ar)
MY (1) MY182382A (ar)
PE (1) PE20180121A1 (ar)
PH (1) PH12017501990B1 (ar)
PL (1) PL3288944T3 (ar)
PT (1) PT3288944T (ar)
RS (1) RS59051B1 (ar)
RU (1) RU2712219C2 (ar)
SG (1) SG11201708822PA (ar)
SI (1) SI3288944T1 (ar)
TN (1) TN2017000428A1 (ar)
TW (1) TWI695838B (ar)
UA (1) UA123050C2 (ar)
WO (1) WO2016174188A1 (ar)
ZA (1) ZA201706847B (ar)

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JO3627B1 (ar) 2015-04-30 2020-08-27 H Lundbeck As إيميدازو بيرازينونات على هيئة مثبطات pde1
TWI729109B (zh) 2016-04-12 2021-06-01 丹麥商Ｈ 朗德貝克公司 作爲PDE1抑制劑的1,5-二氫-4H-吡唑并[3,4-d]嘧啶-4-酮和1,5-二氫-4H-吡唑并[4,3-c]吡啶-4-酮
ES2967489T3 (es) 2016-10-18 2024-04-30 H Lundbeck As Imidazopirazinonas, pirazolopirimidinonas y pirazolopiridinonas como inhibidores de PDE1
JP2020500841A (ja) 2016-10-28 2020-01-16 ハー・ルンドベック・アクチエゼルスカベット イミダゾピラジノンの投与を含む併用療法
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CN117447475A (zh) 2017-12-20 2024-01-26 H.隆德贝克有限公司 作为PDE1抑制剂的吡唑并[4,3-b]吡啶和咪唑并[1,5-a]嘧啶
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ES2967489T3 (es) 2016-10-18 2024-04-30 H Lundbeck As Imidazopirazinonas, pirazolopirimidinonas y pirazolopiridinonas como inhibidores de PDE1
SI3532064T1 (sl) 2016-10-28 2020-10-30 H. Lundbeck A/S Kombinirana zdravljenja, ki obsegajo imidazopirazinone za zdravljenje psihiatričnih in/ali kognitivnih motenj
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Publication number Publication date
RU2017137514A3 (ar) 2019-07-17
TW201700477A (zh) 2017-01-01
PT3288944T (pt) 2019-07-19
CY1121806T1 (el) 2020-07-31
IL255316B (en) 2021-10-31
US11472810B2 (en) 2022-10-18
PL3288944T3 (pl) 2019-11-29
HK1252098B (zh) 2020-02-07
WO2016174188A1 (en) 2016-11-03
CO2017010399A2 (es) 2018-01-05
PH12017501990A1 (en) 2018-03-26
RS59051B1 (sr) 2019-08-30
JP6663930B2 (ja) 2020-03-13
US20160318939A1 (en) 2016-11-03
DOP2017000254A (es) 2018-01-15
MA41977B1 (fr) 2019-08-30
CL2017002719A1 (es) 2018-04-20
ES2735422T3 (es) 2019-12-18
PE20180121A1 (es) 2018-01-18
ZA201706847B (en) 2019-01-30
HUE044244T2 (hu) 2019-10-28
US10011606B2 (en) 2018-07-03
CN107531714B (zh) 2019-07-19
US20170291903A1 (en) 2017-10-12
AU2016256573B2 (en) 2019-11-21
KR102605759B1 (ko) 2023-11-23
US10858362B2 (en) 2020-12-08
UA123050C2 (uk) 2021-02-10
US20190062335A1 (en) 2019-02-28
CN107531714A (zh) 2018-01-02
EP3288944B1 (en) 2019-06-12
SG11201708822PA (en) 2017-11-29
ECSP17072228A (es) 2018-02-28
CA2983563A1 (en) 2016-11-03
SI3288944T1 (sl) 2019-08-30
GT201700223A (es) 2018-12-19
EP3288944A1 (en) 2018-03-07
GEP20207058B (en) 2020-01-27
PH12017501990B1 (en) 2018-03-26
HRP20191180T1 (hr) 2019-10-04
TN2017000428A1 (en) 2019-04-12
BR112017023182B1 (pt) 2023-10-31
MY182382A (en) 2021-01-22
KR20170140216A (ko) 2017-12-20
US20210238182A1 (en) 2021-08-05
RU2017137514A (ru) 2019-05-31
IL255316A0 (en) 2017-12-31
DK3288944T3 (da) 2019-07-22
EA031946B1 (ru) 2019-03-29
ME03414B (me) 2020-01-20
MA41977A (fr) 2018-07-23
RU2712219C2 (ru) 2020-01-27
AU2016256573A1 (en) 2017-12-14
EA201792157A1 (ru) 2018-03-30
HK1252098A1 (zh) 2019-05-17
TWI695838B (zh) 2020-06-11
JP2018514552A (ja) 2018-06-07
BR112017023182A2 (ar) 2018-10-02
LT3288944T (lt) 2019-07-25
MX2017013785A (es) 2018-03-27

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