JO3089B1 - مشتقات ايميدازول كمثبطات لانزيمات pde10a - Google Patents

مشتقات ايميدازول كمثبطات لانزيمات pde10a

Info

Publication number
JO3089B1
JO3089B1 JOP/2011/0339A JOP20110339A JO3089B1 JO 3089 B1 JO3089 B1 JO 3089B1 JO P20110339 A JOP20110339 A JO P20110339A JO 3089 B1 JO3089 B1 JO 3089B1
Authority
JO
Jordan
Prior art keywords
present
inhibitors
provides
compound
formula
Prior art date
Application number
JOP/2011/0339A
Other languages
English (en)
Inventor
Nielsen Jacob
Kehler Jan
Paul Kilburn John
Marigo Mauro
Langgard Morten
Original Assignee
H Lundbeck As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H Lundbeck As filed Critical H Lundbeck As
Application granted granted Critical
Publication of JO3089B1 publication Critical patent/JO3089B1/ar

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

يتعلق الاختراع الحالي بمركبات، تعتبر مثبطات لإنزيم PDE10A. يوفر الاختراع تركيبة صيدلانية تشتمل على كمية فعالة علاجياً من مركب الاختراع وحامل مقبول صيدلانياً. كما يوفر الاختراع الحالي عمليات لتحضير مركبات لها الصيغة I. كما يوفر الاختراع الحالي طريقة لعلاج حالة تعاني من اضطراب تنكسي عصبي تشتمل على إعطاء الحالة كمية فعالة علاجياً من مركب له الصيغة I. كما يوفر الاختراع الحالي طريقة لعلاج حالة تعاني من إدمان المخدرات تشتمل على إعطاء الحالة كمية فعالة علاجياً من مركب له الصيغة I. كما يوفر الاختراع الحالي طريقة لعلاج حالة تعاني من اضطراب نفسي تشتمل على إعطاء الحالة كمية فعالة علاجياً من مركب له الصيغة I.
JOP/2011/0339A 2010-11-19 2011-11-14 مشتقات ايميدازول كمثبطات لانزيمات pde10a JO3089B1 (ar)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DKPA201001045 2010-11-19

Publications (1)

Publication Number Publication Date
JO3089B1 true JO3089B1 (ar) 2017-03-15

Family

ID=45217102

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2011/0339A JO3089B1 (ar) 2010-11-19 2011-11-14 مشتقات ايميدازول كمثبطات لانزيمات pde10a

Country Status (32)

Country Link
EP (1) EP2640731B9 (ar)
JP (1) JP5937608B2 (ar)
KR (1) KR101916487B1 (ar)
CN (1) CN103328487B (ar)
AP (1) AP3342A (ar)
AR (1) AR083926A1 (ar)
AU (1) AU2011331607B2 (ar)
BR (1) BR112013012378A2 (ar)
CA (1) CA2817663C (ar)
CR (1) CR20130226A (ar)
DK (1) DK2640731T3 (ar)
EA (1) EA027082B1 (ar)
EC (1) ECSP13012698A (ar)
ES (1) ES2547090T3 (ar)
GE (1) GEP20156346B (ar)
GT (1) GT201300130A (ar)
HU (1) HUE025596T2 (ar)
JO (1) JO3089B1 (ar)
ME (1) ME02193B (ar)
MY (1) MY163327A (ar)
NZ (1) NZ610353A (ar)
PE (1) PE20141534A1 (ar)
PH (1) PH12013500968A1 (ar)
PL (1) PL2640731T3 (ar)
PT (1) PT2640731E (ar)
RS (1) RS54210B1 (ar)
SG (1) SG190282A1 (ar)
SI (1) SI2640731T1 (ar)
TW (1) TWI541245B (ar)
UA (1) UA112065C2 (ar)
WO (1) WO2012065612A1 (ar)
ZA (1) ZA201303607B (ar)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8552045B2 (en) 2010-11-19 2013-10-08 H. Lundbeck A/S Tricyclic imidazole compounds as PDE10 inhibitors
WO2012096929A2 (en) 2011-01-11 2012-07-19 Sunovion Pharmaceuticals Inc. Heteroaryl compounds and methods of use thereof
WO2013045607A1 (en) * 2011-09-30 2013-04-04 H. Lundbeck A/S Quinazoline linked heteroaromatic tricycle derivatives as pde10a enzyme inhibitors
WO2013107856A1 (en) * 2012-01-20 2013-07-25 H. Lundbeck A/S Imidazole derivatives as pde10a enzyme inhibitors
NZ702239A (en) * 2012-06-19 2017-01-27 Sunovion Pharmaceuticals Inc Heteroaryl compounds and methods of use thereof
CN103435617B (zh) * 2013-08-22 2016-04-27 南京华安药业有限公司 一种6,7-二氢-5H-吡咯并[1,2-a]咪唑-2-甲醛的合成方法
JO3627B1 (ar) 2015-04-30 2020-08-27 H Lundbeck As إيميدازو بيرازينونات على هيئة مثبطات pde1
TWI729109B (zh) 2016-04-12 2021-06-01 丹麥商Ｈ 朗德貝克公司 作爲PDE1抑制劑的1,5-二氫-4H-吡唑并[3,4-d]嘧啶-4-酮和1,5-二氫-4H-吡唑并[4,3-c]吡啶-4-酮
CN109843884B (zh) 2016-10-18 2022-03-04 H.隆德贝克有限公司 作为pde1抑制剂的咪唑并吡嗪酮、吡唑并嘧啶酮和吡唑并吡啶酮
EP3532064B1 (en) 2016-10-28 2020-07-29 H. Lundbeck A/S Combination treatments comprising imidazopyrazinones for the treatment of psychiatric and/or cognitive disorders
KR20190077349A (ko) 2016-10-28 2019-07-03 하. 룬드벡 아크티에셀스카브 이미다조피라지논의 투여를 포함하는 병용 치료
WO2020094591A1 (en) 2018-11-06 2020-05-14 H. Lundbeck A/S Pde10a inhibitors for treating negative symptoms and cognitive impairments in a patient suffering from schizophrenia
CN109776527A (zh) * 2019-02-21 2019-05-21 药雅科技(上海)有限公司 一种5-溴-7-氮杂吲哚的合成方法

Family Cites Families (17)

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GB8307865D0 (en) 1983-03-22 1983-04-27 Fujisawa Pharmaceutical Co Benzimidazole derivatives
US5571775A (en) 1994-07-11 1996-11-05 Dowelanco N-aryl[1,2,4]triazolo[1,5-a]pyridine-2-sulfonamide herbicides
US20030032579A1 (en) 2001-04-20 2003-02-13 Pfizer Inc. Therapeutic use of selective PDE10 inhibitors
IL149106A0 (en) 2001-04-20 2002-11-10 Pfizer Prod Inc Therapeutic use of selective pde10 inhibitors
ATE438398T1 (de) 2003-06-30 2009-08-15 Nycomed Gmbh Pyrrolo-dihydroisochinolin-derivate als pde10- inhibitoren
TW200510407A (en) 2003-06-30 2005-03-16 Altana Pharma Ag Novel pyrrolodihydroisoquinolines as PDE 10 inhibitors
WO2005012485A2 (en) 2003-07-31 2005-02-10 Bayer Pharmaceuticals Corporation Methods for treating diabetes and related disorders using pde10a inhibitors
JP2007523152A (ja) 2004-02-18 2007-08-16 ファイザー・プロダクツ・インク キナゾリンおよびイソキノリンのテトラヒドロイソキノリニル誘導体
EP1755611A1 (en) 2004-06-07 2007-02-28 Pfizer Products Inc. Phosphodiesterase 10 inhibition as treatment for obesity-related and metabolic syndrome-related conditions
US20060019975A1 (en) 2004-07-23 2006-01-26 Pfizer Inc Novel piperidyl derivatives of quinazoline and isoquinoline
JP2008512375A (ja) 2004-09-03 2008-04-24 メモリ ファーマセチカル コーポレーション 精神医学的又は神経学的症候群の治療用のホスホジエステラーゼ１０阻害剤としての４−置換４，６−ジアルコキシ−シンノリン誘導体
TWI501965B (zh) * 2008-06-20 2015-10-01 Lundbeck & Co As H 作為ｐｄｅ１０ａ酵素抑制劑之新穎苯基咪唑衍生物
US8133897B2 (en) 2008-06-20 2012-03-13 H. Lundbeck A/S Phenylimidazole derivatives as PDE10A enzyme inhibitors
UA102693C2 (ru) * 2008-06-20 2013-08-12 Х. Луннбек А/С Производные фенилимидазола как ингибиторы фермента pde10a
TWI481607B (zh) * 2009-12-17 2015-04-21 Lundbeck & Co As H 作為ｐｄｅ１０ａ酵素抑制劑的２－芳基咪唑衍生物
TW201200516A (en) * 2009-12-17 2012-01-01 Lundbeck & Co As H Phenylimidazole derivatives comprising an ethynylene linker as PDE10A enzyme inhibitors
TWI485151B (zh) * 2009-12-17 2015-05-21 Lundbeck & Co As H 作為ｐｄｅ１０ａ酵素抑制劑之雜芳香族苯基咪唑衍生物

Also Published As

Publication number Publication date
CR20130226A (es) 2013-09-03
NZ610353A (en) 2015-01-30
DK2640731T3 (en) 2015-08-31
EP2640731B1 (en) 2015-07-08
WO2012065612A1 (en) 2012-05-24
PL2640731T3 (pl) 2015-11-30
HUE025596T2 (en) 2016-03-29
CA2817663A1 (en) 2012-05-24
BR112013012378A2 (pt) 2016-08-30
RS54210B1 (sr) 2015-12-31
AU2011331607B2 (en) 2016-05-19
CN103328487A (zh) 2013-09-25
JP5937608B2 (ja) 2016-06-22
ME02193B (me) 2016-02-20
SG190282A1 (en) 2013-06-28
GEP20156346B (en) 2015-08-10
KR101916487B1 (ko) 2018-11-07
AR083926A1 (es) 2013-04-10
TW201300391A (zh) 2013-01-01
KR20140009192A (ko) 2014-01-22
AP2013006928A0 (en) 2013-06-30
ES2547090T3 (es) 2015-10-01
SI2640731T1 (sl) 2015-10-30
PE20141534A1 (es) 2014-11-16
EA027082B1 (ru) 2017-06-30
AP3342A (en) 2015-07-31
EP2640731A1 (en) 2013-09-25
EA201390741A1 (ru) 2013-11-29
MY163327A (en) 2017-09-15
GT201300130A (es) 2015-01-16
EP2640731B9 (en) 2015-11-25
ZA201303607B (en) 2014-07-30
CN103328487B (zh) 2015-11-25
AU2011331607A1 (en) 2013-05-30
TWI541245B (zh) 2016-07-11
UA112065C2 (uk) 2016-07-25
PH12013500968A1 (en) 2022-10-24
PT2640731E (pt) 2015-10-13
ECSP13012698A (es) 2013-08-30
CA2817663C (en) 2020-04-28
JP2013542963A (ja) 2013-11-28

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