PE20141534A1 - Derivados de imidazol como inhibidores de la enzima pde10a - Google Patents
Derivados de imidazol como inhibidores de la enzima pde10aInfo
- Publication number
- PE20141534A1 PE20141534A1 PE2013001212A PE2013001212A PE20141534A1 PE 20141534 A1 PE20141534 A1 PE 20141534A1 PE 2013001212 A PE2013001212 A PE 2013001212A PE 2013001212 A PE2013001212 A PE 2013001212A PE 20141534 A1 PE20141534 A1 PE 20141534A1
- Authority
- PE
- Peru
- Prior art keywords
- inhibitors
- compounds
- imidazole derivatives
- isoindol
- triazolo
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
SE REFIERE A COMPUESTOS DE FORMULA I, EN DONDE n ES 0 O 1; X ES SELECCIONADO DE CH, CF, COCH3, COH Y N, CON LA LIMITACION DE NO MAS DE UNA X ES N; R1 Y R2 SON INDEPENDIENTEMENTE H, ALQUILO C1-C6, HIDROXIALQUILO C1-C6, ALCOXI C1-C6, CH2CN, ENTRE OTROS; R3 Y R4 SON INDEPENDIENTEMENTE H, OH, F, CH3 Y OCH3; L ES UN CONECTOR SELECCIONADO DE -CH2-CH2-, -CH=CH-, -CH2-S- Y -S-CH2-; HET ES UN GRUPO HETEROAROMATICO DE FORMULA II QUE CONTIENE DE 2 A 4 ATOMOS DE N, EN DONDE Y ES N O CH; Z ES N O C; "*" INDICA EL PUNTO DE UNION. SON COMPUESTOS PREFERIDOS: 2-[2-(5,8-DIMETIL-[1,2,4]TRIAZOLO[1,5-a]PIRAZIN-2-IL)-ETIL]-5H-IMIDAZO[2,1-a]ISOINDOL; {2-[2-(5H-IMIDAZO[2,1-a]ISOINDOL-2-IL)-ETIL]-5-METIL-[1,2,4]TRIAZOLO[1,5-a]PIRAZIN-8-IL}-METANOL; ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON UTILES PARA EL TRATAMIENTO TRASTORNOS NEURODEGENERATIVOS O PSIQUIATRICOS
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US41535610P | 2010-11-19 | 2010-11-19 | |
DKPA201001045 | 2010-11-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20141534A1 true PE20141534A1 (es) | 2014-11-16 |
Family
ID=45217102
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2013001212A PE20141534A1 (es) | 2010-11-19 | 2011-11-18 | Derivados de imidazol como inhibidores de la enzima pde10a |
Country Status (31)
Country | Link |
---|---|
EP (1) | EP2640731B9 (es) |
JP (1) | JP5937608B2 (es) |
KR (1) | KR101916487B1 (es) |
CN (1) | CN103328487B (es) |
AP (1) | AP3342A (es) |
AR (1) | AR083926A1 (es) |
AU (1) | AU2011331607B2 (es) |
BR (1) | BR112013012378A2 (es) |
CA (1) | CA2817663C (es) |
CR (1) | CR20130226A (es) |
DK (1) | DK2640731T3 (es) |
EA (1) | EA027082B1 (es) |
EC (1) | ECSP13012698A (es) |
ES (1) | ES2547090T3 (es) |
GE (1) | GEP20156346B (es) |
GT (1) | GT201300130A (es) |
HU (1) | HUE025596T2 (es) |
JO (1) | JO3089B1 (es) |
ME (1) | ME02193B (es) |
MY (1) | MY163327A (es) |
NZ (1) | NZ610353A (es) |
PE (1) | PE20141534A1 (es) |
PL (1) | PL2640731T3 (es) |
PT (1) | PT2640731E (es) |
RS (1) | RS54210B1 (es) |
SG (1) | SG190282A1 (es) |
SI (1) | SI2640731T1 (es) |
TW (1) | TWI541245B (es) |
UA (1) | UA112065C2 (es) |
WO (1) | WO2012065612A1 (es) |
ZA (1) | ZA201303607B (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8552045B2 (en) | 2010-11-19 | 2013-10-08 | H. Lundbeck A/S | Tricyclic imidazole compounds as PDE10 inhibitors |
EP3210984B1 (en) * | 2011-01-11 | 2019-06-19 | Sunovion Pharmaceuticals Inc. | Heteroaryl compounds and methods of use thereof |
WO2013045607A1 (en) * | 2011-09-30 | 2013-04-04 | H. Lundbeck A/S | Quinazoline linked heteroaromatic tricycle derivatives as pde10a enzyme inhibitors |
WO2013107856A1 (en) * | 2012-01-20 | 2013-07-25 | H. Lundbeck A/S | Imidazole derivatives as pde10a enzyme inhibitors |
IN2015DN00345A (es) * | 2012-06-19 | 2015-06-12 | Sunovion Pharmaceuticals Inc | |
CN103435617B (zh) * | 2013-08-22 | 2016-04-27 | 南京华安药业有限公司 | 一种6,7-二氢-5H-吡咯并[1,2-a]咪唑-2-甲醛的合成方法 |
JO3627B1 (ar) | 2015-04-30 | 2020-08-27 | H Lundbeck As | إيميدازو بيرازينونات على هيئة مثبطات pde1 |
TWI729109B (zh) | 2016-04-12 | 2021-06-01 | 丹麥商H 朗德貝克公司 | 作爲PDE1抑制劑的1,5-二氫-4H-吡唑并[3,4-d]嘧啶-4-酮和1,5-二氫-4H-吡唑并[4,3-c]吡啶-4-酮 |
WO2018073251A1 (en) | 2016-10-18 | 2018-04-26 | H. Lundbeck A/S | Imidazopyrazinones, pyrazolopyrimidinones and pyrazolopyridinones as pde1 inhibitors |
JP2020500841A (ja) | 2016-10-28 | 2020-01-16 | ハー・ルンドベック・アクチエゼルスカベット | イミダゾピラジノンの投与を含む併用療法 |
WO2018078038A1 (en) | 2016-10-28 | 2018-05-03 | H. Lundbeck A/S | Combination treatments comprising imidazopyrazinones for the treatment of psychiatric and/or cognitive disorders |
TW202031250A (zh) | 2018-11-06 | 2020-09-01 | 丹麥商H 朗德貝克公司 | 用於治療負性症狀和認知損傷之pde10a抑制劑 |
CN109776527A (zh) * | 2019-02-21 | 2019-05-21 | 药雅科技(上海)有限公司 | 一种5-溴-7-氮杂吲哚的合成方法 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8307865D0 (en) | 1983-03-22 | 1983-04-27 | Fujisawa Pharmaceutical Co | Benzimidazole derivatives |
US5571775A (en) | 1994-07-11 | 1996-11-05 | Dowelanco | N-aryl[1,2,4]triazolo[1,5-a]pyridine-2-sulfonamide herbicides |
IL149106A0 (en) | 2001-04-20 | 2002-11-10 | Pfizer Prod Inc | Therapeutic use of selective pde10 inhibitors |
US20030032579A1 (en) | 2001-04-20 | 2003-02-13 | Pfizer Inc. | Therapeutic use of selective PDE10 inhibitors |
ATE438398T1 (de) | 2003-06-30 | 2009-08-15 | Nycomed Gmbh | Pyrrolo-dihydroisochinolin-derivate als pde10- inhibitoren |
CA2530316A1 (en) | 2003-06-30 | 2005-01-13 | Altana Pharma Ag | Pyrrolodihydroisoquinolines as pde10 inhibitors |
EP1651251A4 (en) | 2003-07-31 | 2008-06-18 | Bayer Pharmaceuticals Corp | METHOD FOR THE TREATMENT OF DIABETES AND RELATED DISEASES USING PDE 10A INHIBITORS |
EP1723134A2 (en) | 2004-02-18 | 2006-11-22 | Pfizer Products Incorporated | Tetrahydroisoquinolinyl derivatives of quinazoline and isoquinoline |
US20090162286A1 (en) | 2004-06-07 | 2009-06-25 | Pfizer Inc. | Phosphodiesterase 10 Inhibition as Treatment for Obesity-Related and Metabolic Syndrome-Related Conditions |
US20060019975A1 (en) | 2004-07-23 | 2006-01-26 | Pfizer Inc | Novel piperidyl derivatives of quinazoline and isoquinoline |
EP1802585A1 (en) | 2004-09-03 | 2007-07-04 | Memory Pharmaceuticals Corporation | 4-substituted 4,6-dialkoxy-cinnoline derivatives as phospodiesterase 10 inhibitors for the treatment of psychiatric or neurological syndroms |
UA102693C2 (ru) * | 2008-06-20 | 2013-08-12 | Х. Луннбек А/С | Производные фенилимидазола как ингибиторы фермента pde10a |
US8133897B2 (en) | 2008-06-20 | 2012-03-13 | H. Lundbeck A/S | Phenylimidazole derivatives as PDE10A enzyme inhibitors |
TWI501965B (zh) | 2008-06-20 | 2015-10-01 | Lundbeck & Co As H | 作為pde10a酵素抑制劑之新穎苯基咪唑衍生物 |
TWI485151B (zh) * | 2009-12-17 | 2015-05-21 | Lundbeck & Co As H | 作為pde10a酵素抑制劑之雜芳香族苯基咪唑衍生物 |
TW201200516A (en) * | 2009-12-17 | 2012-01-01 | Lundbeck & Co As H | Phenylimidazole derivatives comprising an ethynylene linker as PDE10A enzyme inhibitors |
TWI481607B (zh) * | 2009-12-17 | 2015-04-21 | Lundbeck & Co As H | 作為pde10a酵素抑制劑的2-芳基咪唑衍生物 |
-
2011
- 2011-11-14 JO JOP/2011/0339A patent/JO3089B1/ar active
- 2011-11-15 TW TW100141570A patent/TWI541245B/zh not_active IP Right Cessation
- 2011-11-18 PE PE2013001212A patent/PE20141534A1/es active IP Right Grant
- 2011-11-18 EP EP11793325.9A patent/EP2640731B9/en active Active
- 2011-11-18 HU HUE11793325A patent/HUE025596T2/en unknown
- 2011-11-18 UA UAA201307630A patent/UA112065C2/uk unknown
- 2011-11-18 NZ NZ610353A patent/NZ610353A/en not_active IP Right Cessation
- 2011-11-18 KR KR1020137012797A patent/KR101916487B1/ko active IP Right Grant
- 2011-11-18 DK DK11793325.9T patent/DK2640731T3/en active
- 2011-11-18 PT PT117933259T patent/PT2640731E/pt unknown
- 2011-11-18 BR BR112013012378A patent/BR112013012378A2/pt not_active Application Discontinuation
- 2011-11-18 RS RS20150574A patent/RS54210B1/en unknown
- 2011-11-18 SI SI201130586T patent/SI2640731T1/sl unknown
- 2011-11-18 WO PCT/DK2011/000136 patent/WO2012065612A1/en active Application Filing
- 2011-11-18 ME MEP-2015-130A patent/ME02193B/me unknown
- 2011-11-18 AR ARP110104313A patent/AR083926A1/es unknown
- 2011-11-18 PL PL11793325T patent/PL2640731T3/pl unknown
- 2011-11-18 CN CN201180065325.2A patent/CN103328487B/zh not_active Expired - Fee Related
- 2011-11-18 EA EA201390741A patent/EA027082B1/ru not_active IP Right Cessation
- 2011-11-18 SG SG2013037163A patent/SG190282A1/en unknown
- 2011-11-18 JP JP2013539140A patent/JP5937608B2/ja not_active Expired - Fee Related
- 2011-11-18 MY MYPI2013001727A patent/MY163327A/en unknown
- 2011-11-18 GE GEAP201113117A patent/GEP20156346B/en unknown
- 2011-11-18 AU AU2011331607A patent/AU2011331607B2/en not_active Ceased
- 2011-11-18 CA CA2817663A patent/CA2817663C/en not_active Expired - Fee Related
- 2011-11-18 ES ES11793325.9T patent/ES2547090T3/es active Active
- 2011-11-18 AP AP2013006928A patent/AP3342A/xx active
-
2013
- 2013-05-16 CR CR20130226A patent/CR20130226A/es unknown
- 2013-05-16 GT GT201300130A patent/GT201300130A/es unknown
- 2013-05-17 ZA ZA2013/03607A patent/ZA201303607B/en unknown
- 2013-06-18 EC ECSP13012698 patent/ECSP13012698A/es unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PE20141534A1 (es) | Derivados de imidazol como inhibidores de la enzima pde10a | |
EA201001017A1 (ru) | 3h-[1,2,3]триазоло[4,5-d]пиримидиновые соединения, их применение в качестве ингибиторов киназы mtor и киназы pi3 и их синтезы | |
AR072199A1 (es) | Derivados de fenilimidazol como inhibidores de la enzima pde10a | |
AR079497A1 (es) | Derivados fenilimidazol que comprenden un enlazante de etinileno como inhibidores de enzima pde10a | |
ME01269B (me) | Jedinjenja pirolo (2,3-d) pirimidina | |
PE20070517A1 (es) | Derivados de imidazol como agentes inhibidores de la sintasa de aldosterona y aromatasa | |
CL2011001360A1 (es) | Compuestos derivados de imidazol[1,2-a]pirazin-8-amina, inhibidores de tirosina quinasa esplenica; composicion farmaceutica que comprende un compuesto; uso de los compuestos en la preparacion de medicamentos para el tratamiento de trastornos alergicos, enfermedades autoinmunes y enfermedades inflamatorias; y metodo in vitro. | |
AR079495A1 (es) | Derivados de fenilimidazol heteroaromaticos como inhibidores de enzima pde10a | |
AR048642A1 (es) | Compuestos de metil-aril o heteroaril-amida sustituida utiles como antagonistas del receptor de prostaglandinas e2; composiciones farmaceuticas que los contienen y su uso en la fabricacion de un medicamento | |
PE20081135A1 (es) | Derivados que contienen sulfamoilo y sus usos | |
CL2012000059A1 (es) | Compuestos derivados de pirazolo[1,5-a]pirimidina; proceso de preparacion; composicion farmaceutica que los comprende; y su uso como inhbidores de trk-quinasa para el tratamiento de enfermedades o trastornos tales como dolor, cancer, inflamacion; entre otras. | |
HN2011000699A (es) | El compuesto (s)-1-({4-metil-5-[2-(2,2,2-trifluoro-1,1-dimetil-etil)-piridin-4-il]-tiazol-2-il}-amida) de 2-amida del acido pirrolidin-1,2-dicarboxilico en forma libre o de sal y composiciones y composicion farmaceutica que lo contiene. | |
UY29339A1 (es) | Derivados de triazol sustituidos como antagonistas de oxitocina | |
NZ596488A (en) | 1, 3-disubstituted imidazolidin-2-one derivatives as inhibitors of cyp 17 | |
CO6351787A2 (es) | Derivados de pirimidina como inhibidores de cinasa | |
EA201170832A1 (ru) | Пуриновые соединения | |
EA201071339A1 (ru) | Фосфорсодержащие производные в качестве ингибиторов киназы | |
CO6620050A2 (es) | Derivados de aminopirimidina como moduladores de la lrrk2 | |
GEP20156285B (en) | Compounds and compositions as trk inhibitors | |
EA201101341A1 (ru) | Соединения, ингибирующие киназы, и фармацевтическая композиция на их основе | |
EA201100079A1 (ru) | Производные триазоло[4,5-d]пирамидина и их применение в качестве антагонистов пуринового рецептора | |
ECSP088906A (es) | PIRAZOLO 1,5-a PIRIMIDINAS | |
CL2009001152A1 (es) | Compuestos derivados de n-(4-(cicloalquilo nitrogenado-1-il)-1h-pirrolo[2,3-b]piridin-3-il)amida, inhibidores de cinasa; proceso de preparacion; composicion farmaceutica; y su uso para el tratamiento de una enfermedad proliferativa. | |
MX2011013325A (es) | 2-(lh-pirazol-4-ilamino)-pirimidina como inhibidores de cinasa. | |
PE20090210A1 (es) | Compuestos derivados de pirazolo pirimidina como inhibidores de jak quinasa |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant, registration |