PE20070517A1 - Derivados de imidazol como agentes inhibidores de la sintasa de aldosterona y aromatasa - Google Patents

Derivados de imidazol como agentes inhibidores de la sintasa de aldosterona y aromatasa

Info

Publication number
PE20070517A1
PE20070517A1 PE2006001030A PE2006001030A PE20070517A1 PE 20070517 A1 PE20070517 A1 PE 20070517A1 PE 2006001030 A PE2006001030 A PE 2006001030A PE 2006001030 A PE2006001030 A PE 2006001030A PE 20070517 A1 PE20070517 A1 PE 20070517A1
Authority
PE
Peru
Prior art keywords
alkyl
aromatase
aldosterone synthase
imidazol
dihydro
Prior art date
Application number
PE2006001030A
Other languages
English (en)
Inventor
Gary Michael Ksander
Erik Meredith
Julien Papillon
Qi-Ying Hu
Fariborz Firooznia
Lauren G Monovich
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37610275&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20070517(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PE20070517A1 publication Critical patent/PE20070517A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
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    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pregnancy & Childbirth (AREA)
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  • Hospice & Palliative Care (AREA)
  • Communicable Diseases (AREA)
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  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

REFERIDA A UN DEIRVADO DE IMIDAZOL DE FORMULA (I), DONDE n ES 1, 2 O 3; R ES H, ALQUILO C1-C7, ALQUENILO C1-C7, ENTRE OTROS; R1, R2, R3, R4 y R5 SON H, ALQUENILO C1-C7, ALQUILO C1-C7, HALOGENO, ENTRE OTROS, CON LA CONDICION DE QUE NO MAS DE TRES R1, R2, R3, R4 Y R5 SON SIMULTANEAMENTE H; R6 y R7 SON H, OH, ALQUILO C1-C7, FENILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: BUTIL-ESTER DEL ACIDO 5-(4-CIANO-2-METOXI-FENIL)-6,7-DIHIDRO-5H-PIRROLO-[1,2-c]-IMIDAZOL-5-CARBOXILICO, ETIL-ESTER DEL ACIDO 5-(2-CLORO-4-CIANO-FENIL)-6,7-DIHIDRO-5H-PIRROLO-[1,2-c]-IMIDAZOL-5-CARBOXILICO, 4-(6,7-DIHIDRO-5H-PIRROLO-[1,2-c]-IMIDAZOL-5-IL)-3-METOXI-BENZONITRILO, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS SON INHIBIDORES DE LA SINTASA DE LA ALDOSTERONA Y DE LA AROMATASA Y SON UTILES PARA EL TRATAMIENTO DE HIPOCALEMIA, HIPERTENSION, INSUFICIENCIA RENAL, OBESIDAD, ENTRE OTRAS
PE2006001030A 2005-08-25 2006-08-24 Derivados de imidazol como agentes inhibidores de la sintasa de aldosterona y aromatasa PE20070517A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US71144205P 2005-08-25 2005-08-25

Publications (1)

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PE20070517A1 true PE20070517A1 (es) 2007-06-21

Family

ID=37610275

Family Applications (2)

Application Number Title Priority Date Filing Date
PE2009001318A PE20100263A1 (es) 2005-08-25 2006-08-24 Derivados condensados de imidazol para la inhibicion de sintasa de aldosterona y aromatasa
PE2006001030A PE20070517A1 (es) 2005-08-25 2006-08-24 Derivados de imidazol como agentes inhibidores de la sintasa de aldosterona y aromatasa

Family Applications Before (1)

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PE2009001318A PE20100263A1 (es) 2005-08-25 2006-08-24 Derivados condensados de imidazol para la inhibicion de sintasa de aldosterona y aromatasa

Country Status (34)

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US (4) US8314097B2 (es)
EP (3) EP2256118B1 (es)
JP (2) JP5225086B2 (es)
KR (3) KR101549762B1 (es)
CN (2) CN101248078B (es)
AR (1) AR057772A1 (es)
AU (1) AU2006283105C1 (es)
BR (1) BRPI0615095B8 (es)
CA (1) CA2619660C (es)
DK (1) DK1919916T3 (es)
EA (1) EA014940B1 (es)
EC (1) ECSP088201A (es)
ES (2) ES2417498T3 (es)
GT (1) GT200600381A (es)
HK (1) HK1117518A1 (es)
HR (1) HRP20130797T1 (es)
IL (2) IL189024A (es)
JO (1) JO2882B1 (es)
MA (1) MA29771B1 (es)
MX (1) MX2008002545A (es)
MY (1) MY151601A (es)
NO (1) NO340854B1 (es)
NZ (1) NZ565476A (es)
PE (2) PE20100263A1 (es)
PH (1) PH12013502342A1 (es)
PL (1) PL1919916T3 (es)
PT (1) PT1919916E (es)
SG (1) SG165319A1 (es)
SI (1) SI1919916T1 (es)
TN (1) TNSN08082A1 (es)
TW (2) TWI382986B (es)
UA (1) UA96737C2 (es)
WO (1) WO2007024945A1 (es)
ZA (1) ZA200800589B (es)

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IL221869A (en) 2016-06-30
US20120277215A1 (en) 2012-11-01
JP5225086B2 (ja) 2013-07-03
MA29771B1 (fr) 2008-09-01
KR20130083470A (ko) 2013-07-22
EA200800488A1 (ru) 2008-08-29
AU2006283105A1 (en) 2007-03-01
EP1919916B8 (en) 2014-04-30
JO2882B1 (en) 2015-03-15
TNSN08082A1 (en) 2009-07-14
EP2270011A1 (en) 2011-01-05
KR101549762B1 (ko) 2015-09-04
EA014940B1 (ru) 2011-04-29
BRPI0615095B1 (pt) 2020-10-20
BRPI0615095A2 (pt) 2011-05-03
HK1117518A1 (en) 2009-01-16
CN101248078B (zh) 2012-01-04
US9278969B2 (en) 2016-03-08
MY151601A (en) 2014-06-13
TW201305175A (zh) 2013-02-01
ECSP088201A (es) 2008-03-26
KR20130018985A (ko) 2013-02-25
AU2006283105C1 (en) 2011-03-10
AR057772A1 (es) 2007-12-19
IL189024A (en) 2013-11-28
UA96737C2 (ru) 2011-12-12
ES2527209T3 (es) 2015-01-21
TWI487708B (zh) 2015-06-11
CN102408429A (zh) 2012-04-11
TW200740822A (en) 2007-11-01
US20070049616A1 (en) 2007-03-01
GT200600381A (es) 2007-03-28
EP1919916A1 (en) 2008-05-14
IL189024A0 (en) 2008-08-07
MX2008002545A (es) 2008-03-14
WO2007024945A1 (en) 2007-03-01
WO2007024945A8 (en) 2013-09-12
US8314097B2 (en) 2012-11-20
BRPI0615095B8 (pt) 2021-05-25
US8835646B2 (en) 2014-09-16
JP5658719B2 (ja) 2015-01-28
DK1919916T3 (da) 2013-07-01
NZ565476A (en) 2011-06-30
KR101324872B1 (ko) 2013-11-01
PL1919916T3 (pl) 2013-08-30
SI1919916T1 (sl) 2013-09-30
EP2256118B1 (en) 2014-10-29
CN102408429B (zh) 2014-07-30
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AU2006283105B2 (en) 2010-08-12
JP2009506048A (ja) 2009-02-12

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