US20140142689A1 - Device and method of treating heart valve malfunction - Google Patents

Device and method of treating heart valve malfunction Download PDF

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Publication number
US20140142689A1
US20140142689A1 US13/691,087 US201213691087A US2014142689A1 US 20140142689 A1 US20140142689 A1 US 20140142689A1 US 201213691087 A US201213691087 A US 201213691087A US 2014142689 A1 US2014142689 A1 US 2014142689A1
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Prior art keywords
chord
valve leaflet
heart
recited
anchor
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Abandoned
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US13/691,087
Inventor
Didier De Canniere
Christophe Moureaux
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CORQUEST MEDICAL Inc
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CORQUEST MEDICAL Inc
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Application filed by CORQUEST MEDICAL Inc filed Critical CORQUEST MEDICAL Inc
Priority to US13/691,087 priority patent/US20140142689A1/en
Assigned to CORQUEST MEDICAL, INC. reassignment CORQUEST MEDICAL, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: DE CANNIERE, Didier, MOUREAUX, CHRISTOPHE
Publication of US20140142689A1 publication Critical patent/US20140142689A1/en
Application status is Abandoned legal-status Critical

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/24Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices
    • A61F2/2442Annuloplasty rings or inserts for correcting the valve shape; Implants for improving the function of a native heart valve
    • A61F2/2466Delivery devices therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/04Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
    • A61B17/0401Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/064Surgical staples, i.e. penetrating the tissue
    • A61B17/0643Surgical staples, i.e. penetrating the tissue with separate closing member, e.g. for interlocking with staple
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/068Surgical staplers, e.g. containing multiple staples or clamps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/24Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices
    • A61F2/2442Annuloplasty rings or inserts for correcting the valve shape; Implants for improving the function of a native heart valve
    • A61F2/2454Means for preventing inversion of the valve leaflets, e.g. chordae tendineae prostheses
    • A61F2/2457Chordae tendineae prostheses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/04Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
    • A61B17/0482Needle or suture guides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/04Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
    • A61B17/0401Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors
    • A61B2017/0409Instruments for applying suture anchors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/04Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
    • A61B17/0401Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors
    • A61B2017/0427Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors having anchoring barbs or pins extending outwardly from the anchor body
    • A61B2017/0437Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors having anchoring barbs or pins extending outwardly from the anchor body the barbs being resilient or spring-like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/04Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
    • A61B17/0401Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors
    • A61B2017/0446Means for attaching and blocking the suture in the suture anchor
    • A61B2017/0448Additional elements on or within the anchor
    • A61B2017/045Additional elements on or within the anchor snug fit within the anchor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/04Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
    • A61B17/0401Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors
    • A61B2017/0464Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors for soft tissue

Abstract

An assembly and method for treating heart valve malfunction typically including treating of mitral regurgitation wherein an instrument assembly includes an elongated chord movably disposed within an introductory sheath and including an anchor secured to a distal end thereof. An attendant method includes concurrently introducing the sheath and the chord into the heart chamber through an exterior wall and penetrating and passing the sheath and the chord through the anterior mitral valve leaflet. The sheath and the chord are then extended transversely across the heart chamber and the distal end of the chord is anchored to an opposing portion of the heart wall. The sheath is then withdrawn back along the length of the anchored chord and through the anterior mitral valve leaflet and a securing member connects the proximal end of the chord to the valve leaflet. The chord is secured between the valve leaflet and the opposing heart wall under sufficient tension to maintain an intended positioning of the valve leaflet to overcome mitral regurgitation.

Description

    CLAIM OF PRIORITY
  • The present application is based on and a claim of priority is made under 35 U.S.C. Section 119(e) to a provisional patent application that is currently pending in the U.S. Patent and Trademark Office, namely, that having Ser. No. 61/729,152 and a filing date of Nov. 21, 2012, and which is incorporated herein by reference in its entirety.
  • BACKGROUND OF THE INVENTION
  • 1. Field of the Invention
  • The present invention is directed to an instrument assembly and method of use and application in the treatment of heart valve malfunction. In more specific terms the instrument assembly is specifically adapted to treat mitral regurgitation by means of a direct entry of the instrument through the atrial wall rather than through the vascular system, in order to apply sufficient tension to a prolapsing leaflet, including the anterior leaflet and/or the posterior leaflet of the mitral valve, in order to overcome mitral regurgitation.
  • 2. Description of the Related Art
  • The human heart is a four chambered pump that moves blood efficiently through the vascular system. During normal operation, blood enters the heart through the vena cava and flows into the right atrium. Thereafter, blood flows from the right atrium through the tricuspid valve and into the right ventricle. Upon contraction of the right ventricle, blood is forced through the pulmonic valve and into the lungs for oxygenation. The oxygenated blood returns from the lungs and enters the heart through the left atrium and passes through the mitral valve into the left ventricle. Upon contraction of the left ventricle the blood therein flows through the aortic valve and into the aorta and throughout the vascular system.
  • The mitral valve is disposed in flow regulating communication between the left atrium and the left ventricle. It is composed of two valve leaflets, the mitral valve annulus, which forms a ring that supports the valve leaflets; papillary muscles, which tether the valve leaflets to the left ventricle wall, by preventing them from prolapsing back into the left atrium. Chordae tendineae serve to connect the mitral valve leaflets to the papillary muscles thereby further preventing the leaflets from prolapsing back into the left atrium. A dysfunction of any of these components of the mitral valve can cause “mitral regurgitation”. Mitral regurgitation is a disorder of the heart in which the mitral valve does not close properly when the heart pumps out blood. This abnormal leaking of blood from the left ventricle, through the mitral valve and, into the left atrium when the left ventricle contracts, results in the “regurgitation” of blood back into the left atrium. It is generally recognized in the medical profession that mitral regurgitation is the second most common form of valvular heart disease.
  • As generally set forth above, when properly functioning, the anterior and posterior valve leaflets of the mitral valve overlap during contraction of the left ventricle and prevent blood from flowing back into the left atrium. This overlap of the 2 leaflets leaning upon each other is called the coaptation and absorbs most of the strain on the mitral apparatus during the ventricular contraction. However, when the mitral valve malfunctions, due to various cardiac diseases, the leaflets are no longer coapting resulting in the mitral valve remaining partially open during ventricular contraction. In turn this allows the “regurgitation” of the blood back into the left atrium, as generally set forth above. When the mitral valve does not close hermetically during the ventricular contraction, the aforementioned back flow of blood to the atrium and the pulmonary vasculature, results in a deleterious condition. More specifically, this condition increases the work load to the heart and may lead to heart failure.
  • Methods of treating conditions relating to the malfunctioning of the heart valve specifically including valve incompetencies, mitral valve leakage and other heart failure conditions may be in various stages of development such as the extending of an elongate member transverse across a corresponding or affected heart chamber. Each end of the elongate member extends through a wall of the heart such as the septum wall and an oppositely disposed wall portion, wherein first and second anchoring members are connected to corresponding ends of the elongate member but are disposed external of the heart chamber. Connecting clips or the like are applied to the corresponding exterior ends of the elongate member, resulting in the papillary muscles within the chamber to be effectively repositioned. A predetermined force is applied to the heart itself and/or the affected portions of the heart chamber.
  • Other specific treatments associated with mitral regurgitation sometimes may include the replacement of the mitral valve, resulting in traumatic and frequently dangerous surgical procedures being performed on a patient.
  • Accordingly, there is a need in the medical arts for appropriate instrumentation and attendant methods of overcoming heart valve malfunctions, specifically including mitral regurgitation.
  • SUMMARY OF THE INVENTION
  • The present invention is directed to an instrument assembly and attendant method for treating heart valve malfunction. In more specific terms, the instrumentation and method are specifically, but not exclusively, adapted for the treatment of mitral regurgitation. However, for purposes of clarity and in order to emphasize the versatility of the various embodiments of the present invention, the subject instrument assembly and method will be described generically regarding treatment of a predetermined heart valve. In addition, the present invention will be more specifically described in regard to a procedure involving correction of a prolapsing mitral valve leaflet, which may include the anterior mitral valve leaflet and/or the posterior valve leaflet correcting of mitral regurgitation.
  • Accordingly, the instrument assembly of the present invention includes an introductory sheath formed of a material of sufficient rigidity to facilitate the penetration and passage through various portions of the heart and mitral valve. As such, the introductory sheath may be said to be formed of at least a “semi-rigid” material. However, this term is to be understood to include material having sufficient flexibility to be manipulated or “steered” through and/or along a predetermined path during the delivery of the sheath and associated components of the instrument assembly to predetermined portions of the heart. Moreover, in one preferred embodiment the sheath will be sufficiently maneuverable to pass through the atrial wall into interior portions of the heart such as the left atrium and left ventricle. In addition and as described in greater detail hereinafter, an introduction assembly and a delivery catheter will be used to facilitate the positioning the introductory sheath into the thoracic cavity and through the atrial wall or other preferred exterior locations of the heart wall.
  • Additional structural operative features of the instrument assembly include the provision and utilization of at least one, or under required circumstances, more than one elongated chord formed of a biocompatible material and being at least partially flexible. The material from which the chord is formed should have sufficient and/or predetermined tensile strength to exert a predetermined tension on the predetermined, prolapsing valve leaflet as the chord extends between a corresponding portion of the heart wall, such as the ventricular wall, as also more fully described hereinafter. The chord is initially housed concentrically within the interior of the introductory sheath, wherein the sheath and the chord are concurrently movable relative to the heart as well as throughout a portion of the interior thereof. As set forth above, the introductory sheath is formed of a material having physical characteristics that allow it to be accurately manipulated so as to be steerable in such a manner that its tip can aim towards the different designated portions of the anterior or posterior mitral valve leaflets that are in the siege of the prolapse.
  • Also, the exteriorly concentric introductory sheath is movable relative to and along the length of the chord so as to accommodate proper and intended placement and anchoring of the chord within the heart chamber. Therefore, the sheath is movable with the chord into and through predetermined portions of the heart chamber and movable relative to the chord after proper anchoring, securing and/or intended placement of the chord within the heart chamber. Accordingly, the instrument assembly of the present invention also includes an anchor secured to an outer or distal end of the chord. The anchor may also be sufficiently sharpened, pointed or otherwise configured to penetrate an intended heart valve leaflet, such as a prolapsing leaflet of the mitral valve. Further, the penetration and passage of the anchor, the chord, and the introductory sheath substantially through the predetermined valve leaflet may thereby be facilitated.
  • When properly positioned, the anchor is structured to be secured to a substantially opposing portion of the heart wall, such as the ventricular wall associated with the left ventricle and/or the papillary muscles associated therewith. In order to assure secure anchoring of the distal end of the chord with the corresponding ventricular wall, a gripping structure may be operatively attached to a remainder of the anchor and disposable into an outwardly and/or radially extending orientation. When so disposed, the gripping structure, in combination with the remainder of the anchor, eliminates or significantly restricts the inadvertent detachment of the anchor, and the distal end of the chord attached thereto, from the corresponding ventricular wall portion. In at least one preferred embodiment of the present invention, the anchor and the gripping structure are disposed and applied so as to penetrate the corresponding portion of the ventricular wall but not extend there through. Therefore, the anchored relation of the gripping structure, anchor and the connected distal end of the chord may be defined by a penetration into the interior of the ventricular wall rather than a passage completely there through. Complications associated with sealing and exterior attachment of the chord to the exterior of the ventricular wall are thereby eliminated.
  • As provided, the present invention further comprises a method of treating heart and valve malfunction utilizing the instrument as generally set forth above. Accordingly, the attendant method comprises, at least in more generic terms, the passing of a portion of the instrument assembly into an intended heart chamber and into penetrating relation to a predetermined valve leaflet, such as a prolapsing leaflet. The sheath, with the chord concentrically disposed on the interior thereof, is passed through the predetermined valve leaflet. Therefore, by virtue of the enclosed disposition of the chord, the chord and sheath will concurrently enter and extend through the predetermined valve leaflet. By manipulation and the application of a positioning force on the sheath, the sheath and the chord will extend across a corresponding heart chamber and into an anchored relation with a substantially opposing portion of the heart wall.
  • Once the anchor and the connected distal end of the chord are secured to the opposing heart wall portion, the sheath, still concentrically mounted exteriorly of and in enclosing relation to the chord, is withdrawn from heart chamber in which the chord is anchored. More specifically, the sheath is withdrawn by moving relative to and back along the length of the anchored chord in a direction away from the anchor and connected distal end of the chord. The introductory sheath is further withdrawn back through the predetermined valve leaflet while the proximal portion of the chord remains within the valve leaflet. Once the sheath is disposed exteriorly of the valve leaflet and possibly on the exterior of the heart itself, a securing assembly is operatively disposed within the heart chamber in interconnecting relation between a proximal extremity of the chord and the predetermined valve leaflet.
  • In more specific terms, the securing assembly may include a securing member, which will be mounted on or connected to a proximal portion of the chord and moved along the length thereof into a predetermined, interconnecting position relative to the prolapsing valve leaflet. The position of the securing member will be tailored to and disposed at the exact position needed to achieve correction of the mitral regurgitation, which may be determined by preoperative transoesopageal echography or other preoperative manner, to quantify the occurring mitral regurgitation preoperatively. The securing member then securely interconnects the proximal extremity of the chord to the predetermined valve leaflet and any excess length of the chord will be severed or detached from the proximal extremity of the chord, which is secured to the surface of the leaflet associated with the atrium. The chord is thereby properly tensioned between the opposing, interior corresponding wall portion of the heart and the predetermined valve leaflet so as to overcome the malfunction of the predetermined valve leaflet as explained in more specific details hereinafter.
  • As emphasized throughout this description, the instrument assembly and attendant method of the present invention is specifically adapted for the treatment of mitral regurgitation. As such, the introductory sheath and the chord, substantially concurrently enter the atrial wall of the left atrium and pass into the interior thereof. Further, the sheath and the chord penetrate and are passed, substantially concurrently, through a prolapsing (flail) anterior or posterior leaflet of the mitral valve into the left ventricle of the heart chamber. Thereafter the sheath and chord are concurrently extended transversely across the left ventricle, wherein the anchor penetrates and is thereby secured in an anchored relation with a substantially opposing portion of the ventricular wall and/or corresponding papillary muscles. The distal end of the chord is connected to the anchor and is thereby secured in an anchored relation to the ventricular wall, by virtue of the penetrating anchor.
  • Once the distal end of the chord and anchor are in the anchored relation to the ventricular wall, the sheath is withdrawn back along the length of the chord, away from the anchor and the ventricular wall to which the distal portion of the chord is secured. Moreover, the introductory sheath continues to travel back along the length of the chord through the prolapsing anterior or posterior mitral valve leaflet to a location at least exterior to the leaflet, such as within the left atrium and possibly exteriorly of the heart itself.
  • A securing assembly is then operatively associated with the instrument and is movably disposed along the length of a proximal portion of the chord. In even more specific terms, the movement of the securing assembly and its associated securing member are disposed into an interconnecting position between a proximal extremity of the chord and the mitral valve leaflet penetrated by the chord. As indicated above, proper tensioning is thereby placed on the prolapsing mitral valve leaflet in order to restore a sufficient surface of coaptation between its counterpart, opposing leaflet and maintain the suppressed leaflet in an operative position sufficient to overcome the mitral regurgitation.
  • These and other objects, features and advantages of the present invention will become clearer when the drawings as well as the detailed description are taken into consideration.
  • BRIEF DESCRIPTION OF THE DRAWINGS
  • For a fuller understanding of the nature of the present invention, reference should be had to the following detailed description taken in connection with the accompanying drawings in which:
  • FIG. 1 is a perspective view of one preferred embodiment of the instrument assembly of the present invention used in the treatment of heart valve malfunction.
  • FIG. 1A is a perspective view of the instrument assembly of the embodiment of FIG. 1 in an initially introductory position.
  • FIGS. 2 through 9 are schematic representations of successive steps in the attendant method of utilizing and applying the instrument assembly of the embodiment of FIGS. 1 and 1A specifically for the treatment and correction of mitral regurgitation.
  • Like reference numerals refer to like parts throughout the several views of the drawings.
  • DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENT
  • As represented in the accompanying drawings and with specific reference to FIGS. 1 and 1A, the instrument assembly of the present invention is schematically and generally indicated as 10 and is used for the treatment of heart valve malfunction generally and more specifically for the treatment of mitral regurgitation. As such, the instrument assembly 10 includes an elongated delivery catheter or tube 12 having a hollow interior and structured to deliver operative portions of the instrument assembly 10 to the treatment site within the heart of a patient. As such, the elongated delivery catheter or tube 12 is dimensioned and configured to enter the chest cavity through appropriate introduction instrumentation. The delivery tube 12 is formed of a material and/or includes positioning structure or linkage incorporated therein which facilitates the maneuvering or steering thereof to a point at least generally exterior the heart and more specifically the atrial wall of the left atrium. However, the at least semi-rigid material of the delivery tube 12 should be sufficient to also facilitate proper manipulation so as to position or “steer” the remainder of the instrument assembly 10 to the intended location within the interior thereof, as well as facilitate penetration of and anchoring to intended tissue portions.
  • The instrument assembly 10 also includes an introductory sheath 14 movable within the delivery tube 12 and an elongated flexible material chord 16. The introductory sheath 14 is concentrically and movably enclosed within the delivery tube 12 and the sheath 14 is movably disposed concentrically about the chord 16. It is emphasized that FIG. 1 represents a completely assembled instrument assembly 10. However, as will be described in detail with the schematic representations of FIGS. 1 through 9, the various portions of the instrument assembly 10 are used in successive steps to accomplish installation relative to the affected portions of the heart valve being treated.
  • Accordingly, the instrument assembly 10 further includes the elongated flexible material chord 16 which may be formed of a synthetic, biocompatible material. An anchor 18 is fixedly secured to the outer or distal end of the chord 16 and is movable therewith relative to the introductory sheath 14. As clearly represented in FIG. 1A chord 16 is at least initially enclosed concentrically within the interior of the introductory sheath 14, wherein the sheath 14 is movable along the length of the chord 16. Further, the sheath includes an open distal end 14′ serving to at least partially encloses or be registered alignment with the anchor 18. Therefore, FIG. 1A represents cooperative portions of the instrument assembly 10 at least upon initial entry of the introductory sheath 14 and anchor 18 into the interior of the heart 30, as specifically described in detail in FIGS. 2 through 9, hereinafter described.
  • Therefore, with further regard to FIG. 1A, the positioning of the anchor 18, the introductory sheath 14 and the chord 16 is such that the chord 16 is disposed within the interior of the introductory sheath 14. Further, the anchor 18 is disposed at least partially within and/or in an exposed relation to the open distal end 14′ of the sheath 14. In addition, the anchor 18 has a sharpened, pointed or other appropriate configuration for penetrating portions of the heart. The anchor 18 may also include a gripping structure 20 which may be initially disposed in a collapsed position when the anchor 18 is in registry with the distal opening 14′ of the sheath 14. However, upon removal or exposure of the anchor 18 and a length of the chord 16 from an interior of the sheath 14, the gripping structure 20 may include an inherent bias causing it to expand outwardly and/or radially from the remainder of the anchor 18. This gripping structure 20 is provided to facilitate a secure engagement of the anchor 18 with predetermined heart wall portions, when the instrument assembly 10 is properly applied in the treatment of the heart valve malfunction.
  • With further reference to FIG. 1 the assembled representation of the instrument assembly 10 further includes the provision of a securing member 22 which may travel along the length of the chord 16. The securing member may be forcibly positioned into an intended interconnecting location relative to a heart valve leaflet in order to accomplish a secure attachment of the chord 16 to the leaflet as will be explained in greater detail hereinafter. Such an interconnecting placement of the securing member 22 relative to both the chord 16 and the affected valve leaflet serves to establish and maintain a sufficient tension and/or positioning force on the predetermined valve leaflet to suppress movement thereof, as explained hereinafter with regard to FIGS. 2 through 9.
  • As schematically represented in FIGS. 2 through 9, the heart is generally indicated as 30 and includes the representative portions including the left atrium 32, the left ventricle 34 and the mitral valve 36, including the anterior and posterior mitral valve leaflets 38 and 38′, respectively. As additionally represented, the left ventricle 34 is at least partially bordered or surrounded by ventricular wall 40 which may be directly associated with corresponding papillary muscles (not shown) facilitating the proper positioning of the mitral valve leaflets 38 and 38′ through organic tissue tethering, as generally outlined above.
  • For purposes of clarity, FIGS. 2-9 schematically represent the instrument assembly 10 used on the anterior leaflet 38 of the mitral valve 30 in order to treat and correct mitral regurgitation. However, it is emphasized the instrument assembly 10 and the attendant method of the present invention may be applied to an anterior and/or the posterior prolapsing leaflet in the manner described herein, in correcting a mitral regurgitation condition of the heart. Moreover, while the various embodiments of the present invention are described using a single chord 16, a plurality of chords 16 may be used with the cooperative instrument components of the instrument assembly 10.
  • With initial reference to FIGS. 2 and 3, the instrument assembly 10 is introduced into the interior of the heart 30 and more specifically into the left atrium 32, through the atrium wall 33, using an appropriate introduction assembly 42. Therefore, the introductory sheath 14 and the chord 16 located concentrically within the sheath 14 will concurrently pass through the atrial wall 33 of the heart into the left atrium 32, as it is directed towards the anterior leaflet 38 of the mitral valve 36. It should be further noted that the anchor 18 is at least initially in the position generally represented in FIG. 1A. Due to its predetermined configuration the anchor 18 will serve to approach and penetrate the anterior leaflet 38 of the mitral valve 36 as clearly represented in FIG. 3.
  • In addition, the penetration of the anterior leaflet 38 initially by the anchor 18 will facilitate the penetration and passage, substantially concurrently, of the chord 16 and the introductory sheath 14 through the anterior leaflet 38 as schematically represented. As further represented in FIG. 3, a continued force will be applied to the introductory sheath 14 causing the sheath 14 and interiorly disposed chord 16, as well as the anchor 18 to continue concurrent passage through the anterior valve leaflet 38 until the anchor 18 reaches, penetrates and is secured to the ventricular wall 40 and/or correspondingly disposed papillary muscles associated therewith.
  • As best represented in FIGS. 4 and 5, once the anchor 18 is secured to the ventricular wall 40 and/or the corresponding papillary muscles, the distal end of the chord 16 will be affixed to the ventricular wall 40 and remain in place as the introductory sheath 14 is withdrawn back along the length of the chord 16, as indicated by the directional arrows. As the introductory sheath 14 is withdrawn back along the length of the chord 16, the aforementioned gripping structure 20 will have been expanded into a gripping orientation. When the gripping structure 20 is so oriented, the anchor 18 and the distal end of the chord 16 connected thereto will be reliably anchored or connected to the ventricular wall 40. Continued withdrawal of the introductory sheath 14 will result in its passage back through the initially penetrated and suppressed mitral valve leaflet 38, as clearly represented in FIG. 5. As such, the majority of the length of the chord 16 will thereby be exposed and maintained in the represented position within the left ventricle and between the ventricular wall 40 and the penetrated (suppressed) leaflet 38, while the introductory sheath 14 passes back through the introduction assembly 42 and out of the interior of the left atrium 32, through the atrium wall 33. Therefore, the proximal portion 16′ of the chord 16 remains in place, within the left atrium 32, and may serve effectively as a guide or otherwise facilitate the placement of the securing member 22, as represented in FIGS. 6 through 9.
  • More specifically, once the introductory sheath 14 is removed from the left atrium 32, through the introduction assembly 42, the securing assembly, including securing member 22, will move along the length of the chord 16 as it is introduced into the left atrium 32 such as through the atrium wall via, the introduction assembly 42. As schematically represented, the securing member 22 will be forced, moved, positioned, etc. along the proximal portion or length 16′ of the chord 16 by any appropriate technique and/or appropriate positioning instrument/device, which may be incorporated or operatively associated with the chord 16. Positioning of the securing member 22 will continue until it is disposed in engaging, interconnecting and at least partially protective or sealing engagement with an exterior surface portion of the suppressed anterior mitral valve leaflet 38 located within the left atrium 32. The position of the securing member 22 will be disposed in the exact position, on and along the length of the chord 16 needed to position and or suppress movement of the leaflet 38 to achieve correction of the mitral regurgitation. Such exact positioning may be determined by preoperative transoesopageal echography or other preoperative manner to quantify online mitral regurgitation preoperatively.
  • With further regard to the positioning of the securing member 22 into the interconnecting relation between the proximal extremity of chord 16 and the anterior leaflet 38. One embodiment may also include a guiding element or sleeve 25, as represented in FIG. 1. When utilized, the element 25 will be disposed at a predetermined position along the length on the artificial chord 16 and be mounted concentrically about and/or along a portion of the chord 16. As applied, the guiding element 25 may assume and or be at least partially defined by a variety of different structures, devices and/or mechanisms other than, but possibly including, the schematically represented sleeve. Accordingly, the guiding element is operative to accurately center or otherwise dispose the securing member 22 in sealing and/or covering relation to the aperture or area where the chord 16 remains in its extended position through the anterior leaflet 38. Further, the securing member 22 securely connects the proximal extremity 16″ of the chord 16 to the valve leaflet 38 and any excess length of the proximal portion 16′ of the chord 16 will be severed or detached from the extremity 16″ of the chord 16 and the securing member 22, which interconnects the proximal extremity 16″ to the “exterior” surface of the leaflet 38 exposed to the left atrium 32.
  • With continued reference to FIGS. 5 through 8, manipulation of the instrument of the assembly 10, such as by medical personnel manipulating the delivery catheter 12 causes a severing of the proximal extremity from a remainder of the chord 16. As a result, the securing member 22 serves to securely connect and fasten the chord 16 to the exterior of the anterior leaflet 38, disposed within the left atrium 32. Upon a secure connection of the securing member 22 to the exterior side or surface of the anterior leaflet 38, the introductory sheath 14 passes back through the introduction assembly 42 so as to exit the left atrium 32 and the remainder of the heart. Thereafter, the introduction assembly 42 is also removed from its initial operative position.
  • Therefore, as represented in FIG. 9 the heart 30 is represented with the synthetic chord 16 properly anchored between the ventricular wall 40 and the penetrated anterior leaflet 38. In this position, proper tensioning or positioning forces are applied to the anterior leaflet 38 causing it to be positioned in a manner which effectively overcomes mitral regurgitation, as set forth above.
  • Since many modifications, variations and changes in detail can be made to the described preferred embodiment of the invention, it is intended that all matters in the foregoing description and shown in the accompanying drawings be interpreted as illustrative and not in a limiting sense. Thus, the scope of the invention should be determined by the appended claims and their legal equivalents.
  • Now that the invention has been described,

Claims (28)

1. An instrument assembly for treating heart valve malfunction, said instrument assembly comprising:
at least one elongated chord and an introductory sheath, said sheath at least initially disposed in enclosing relation to said one chord and movable with said chord and along the length thereof,
said sheath and said one chord cooperatively structured to concurrently enter the heart chamber through the heart wall and penetrate and pass through a predetermined heart valve leaflet,
an anchor connected to a distal end of said one chord and disposable into an anchored relation with the heart wall substantially oppositely disposed to the predetermined valve leaflet,
a securing assembly connectable to a proximal extremity of said one chord in an interconnecting position between said one chord and the predetermined valve leaflet, and
said anchored relation of said anchor and said interconnecting position of said securing assembly collectively defining an operative length of one said chord within the heart chamber and a tensioning of the predetermined valve leaflet sufficient to restrict prolapsing of the predetermined valve leaflet, by said one chord.
2. An instrument assembly as recited in claim 1 wherein said interconnecting position comprises said securing assembly disposed in securing relation between said proximal extremity of said one chord and an exterior surface exposed to the left atrium of the predetermined valve leaflet.
3. An instrument assembly as recited in claim 1 wherein the predetermined valve leaflet comprises a prolapsing one of the anterior mitral valve leaflet and posterior mitral valve leaflet.
4. An instrument assembly as recited in claim 1 wherein said securing assembly comprises a securing member movably mounted on and extendable along the length of said one chord into said interconnecting position.
5. An instrument assembly as recited in claim 4 wherein said securing assembly further comprises a sleeve connected to said securing member, said sleeve concentrically mounted on and positionable along the length of said one chord with said securing member into said interconnecting position.
6. An instrument assembly as recited in claim 5 wherein said interconnecting position further comprises said sleeve disposed through the predetermined valve leaflet concurrently to said securing member being disposed in securing relation between said proximal extremity of said one chord and the predetermined valve leaflet.
7. An instrument assembly as recited in claim 1 wherein said anchor comprises an outer extremity comprising a configuration sufficient to penetrate the opposing heart wall portion.
8. An instrument assembly as recited in claim 7 wherein said outer extremity is disposable in penetrating relation to the predetermined valve leaflet prior to a chord securing relation with the opposing heart wall portion.
9. An instrument assembly as recited in claim 7 wherein said sheath comprises an open distal end dimensioned to facilitate disposition of said anchor into a penetrating orientation to the predetermined valve leaflet and subsequently, the opposing heart wall portion.
10. An instrument assembly as recited in claim wherein said anchor comprises a gripping structure disposed laterally outward from said outer extremity of said anchor; said gripping structure structured to define a secure connection of said anchor with the opposing heart wall portion.
11. An instrument assembly as recited in claim 10 wherein said gripping structure is expandable radially outward from said outer extremity of said anchor.
12. An instrument assembly as recited in claim wherein said anchor comprises a gripping structure disposed laterally outward from said outer extremity of said anchor; said gripping structure structured to define a secure connection of said anchor with the opposing heart wall.
13. A method of treating mitral valve regurgitation using the instrument assembly as recited in claim 1, the method comprising:
introducing the sheath and at least one chord into the chamber of the heart through the atrium wall thereof;
passing the sheath and one chord substantially concurrently through at least one mitral valve leaflet in the siege of prolapse and there from into the left ventricle of the heart chamber,
extending the sheath and one chord transversely across the left ventricle and securing the anchor into an anchored relation with a substantially opposing portion of the ventricular wall of the heart,
withdrawing the sheath back along the length of the anchored one chord from the ventricular wall and back through the one mitral valve leaflet, and
securing the securing assembly along the length of the one chord into an interconnecting position between a proximal extremity of the one chord and the one mitral valve leaflet.
14. A method as recited in claim 13 disposing the securing assembly along the length of the one chord into the interconnecting position with an exterior of the one mitral valve leaflet which is exposed to the left atrium.
15. A method as recited in claim 13 comprising passing the sheath and one chord substantially concurrently through the anterior mitral valve leaflet in the siege of prolapse and there from into the left ventricle of the heart chamber.
16. A method as recited in claim 13 comprising passing the sheath and one chord substantially concurrently through the posterior mitral valve leaflet in the siege of prolapse and there from into the left ventricle of the heart chamber.
17. A method as recited in claim 13 comprising disconnecting a remaining distal portion of the one chord, extending between the securing assembly and the atrium wall, subsequently to securing the securing assembly in the interconnecting position.
18. A method of treating heart valve malfunction comprising:
passing an instrument into the heart chamber and into penetrating relation to a predetermined valve leaflet under the siege of prolapse,
passing the instrument through the predetermined valve leaflet,
extending at least one chord of the instrument from the predetermined valve leaflet across the heart chamber into anchored relation with a portion of the heart wall substantially opposing the predetermined valve leaflet,
withdrawing a sheath of the instrument back along a length of the anchored one chord from the opposing portion of the heart wall and back through the predetermined valve leaflet, and
securing a corresponding proximal extremity of the one chord to the predetermined valve leaflet.
19. A method as recited in claim 18 comprising disposing an anchor of the instrument into a griping orientation when in the anchored relation with the opposing portion of the heart wall.
20. A method as recited in claim 19 further comprising expanding the anchor into the gripping orientation with the opposing portion of the heart wall.
21. A method as recited in claim 19 further comprising defining the gripping orientation of the anchor portion as a penetrating engagement with an interior portion of the ventricular wall.
22. A method as recited in claim 21 further comprising tensioning the one chord between the ventricular wall and the predetermined valve leaflet by securing the corresponding proximal extremity of the one chord to an exterior of the predetermined valve leaflet.
23. A method as recited in claim 18 further comprising establishing an operative length of said one chord between the predetermined valve leaflet and the opposing portion of the heart wall to define a tensioning of the predetermined valve leaflet sufficient to restrict prolapsing of the predetermined valve leaflet, by the one chord.
24. A method as recited in claim 18 comprising treating mitral valve regurgitation by entering the heart through the atrial wall into the left atrium and penetrating the predetermined mitral valve leaflet under the siege of prolapse with a distal portion of the one chord and passing the one chord through the mitral valve leaflet and transversely across the left ventricle and disposing an anchor, secured to the distal end of the one chord, into anchored relation with an oppositely disposed portion of the ventricular wall.
25. A method as recited in claim 24 comprising positioning the anchor into a gripping orientation on the interior of the heart chamber by penetrating interior portions of the ventricular wall.
26. A method as recited in claim 25 further defining the gripping orientation by expanding the anchor into penetrating engagement with the interior portions of the papillary muscle of the ventricular wall.
27. A method as recited in claim 24 further comprising tensioning the one chord between the penetrated portion of the ventricular wall and the one mitral valve leaflet by securing a proximal extremity of the one chord to the one mitral valve leaflet.
28. A method as recited in claim 27 further comprising establishing an operative length of said one chord between the predetermined mitral valve leaflet and penetrated portion of the ventricular wall to define a tensioning of the predetermine valve leaflet sufficient to restrict prolapsing of the predetermined mitral valve leaflet, by the one chord.
US13/691,087 2012-11-21 2012-11-30 Device and method of treating heart valve malfunction Abandoned US20140142689A1 (en)

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US13/691,087 US20140142689A1 (en) 2012-11-21 2012-11-30 Device and method of treating heart valve malfunction
US13/967,647 US10159571B2 (en) 2012-11-21 2013-08-15 Device and method of treating heart valve malfunction
JP2015544111A JP2015535465A (en) 2012-11-21 2013-11-20 Therapeutic devices and treatment methods of the cardiac valve insufficiency
PCT/US2013/070972 WO2014081809A2 (en) 2012-11-21 2013-11-20 Device and method of treating heart valve malfunction
EP13856513.0A EP2922502B1 (en) 2012-11-21 2013-11-20 Device for treating heart valve malfunction
CA2891356A CA2891356A1 (en) 2012-11-21 2013-11-20 Device and method of treating heart valve malfunction
AU2013348100A AU2013348100C1 (en) 2012-11-21 2013-11-20 Device and method of treating heart valve malfunction
IL238933A IL238933D0 (en) 2012-11-21 2015-05-20 Device and method of treating heart valve malfunction
JP2018005752A JP2018061855A (en) 2012-11-21 2018-01-17 Device and method of treating heart valve malfunction

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CA2891356A1 (en) 2014-05-30
WO2014081809A2 (en) 2014-05-30

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