AR057772A1 - Derivados de imidazol como inhibidores de sintasa de aldosterona y aromatasa. composiciones farmaceuticas - Google Patents
Derivados de imidazol como inhibidores de sintasa de aldosterona y aromatasa. composiciones farmaceuticasInfo
- Publication number
- AR057772A1 AR057772A1 ARP060103664A ARP060103664A AR057772A1 AR 057772 A1 AR057772 A1 AR 057772A1 AR P060103664 A ARP060103664 A AR P060103664A AR P060103664 A ARP060103664 A AR P060103664A AR 057772 A1 AR057772 A1 AR 057772A1
- Authority
- AR
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- Prior art keywords
- alkyl
- alkoxy
- hydrogen
- aryl
- group
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/32—Antioestrogens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Abstract
Este compuesto es inhibidor de la sintasa de aldosterona y de la aromatasa, y por lo tanto, se puede emplear para el tratamiento de un trastorno y de una enfermedad mediada por la sintasa de aldosterona o por la aromatasa. De conformidad con lo anterior, se puede utilizar en el tratamiento de hipocalemia, hipertension, insuficiencia cardíaca congestiva, fibrilacion auricular, insuficiencia renal, en particular insuficiencia renal cronica, restenosis, ateroesclerosis, síndrome X, obesidad, nefropatía, infarto post-miocardial, enfermedades cardíacas coronarias, inflamacion, mayor formacion de colágeno, fibrosis, tales como fibrosis cardíaca o miocardíaca, y remodelacion en seguida de hipertension y disfuncion endotelial, ginecomastia, osteoporosis, cáncer de prostata, endometriosis, fibroides uterinos, hemorragia uterina disfuncional, hiperplasia endometrial, enfermedad de ovario poliquístico, infertilidad, enfermedad de mama fibroquística, cáncer de mama, y mastopatía fibroquística. Finalmente, la presente también proporciona una composicion farmacéutica. Reivindicacion 1: Un compuesto de formula (1), en donde: n es 1, o 2, o 3; R es hidrogeno, alquilo C1-7, o alquenilo C1-7, estando el alquilo C1-7 y el alquenilo C1-7 opcionalmente sustituidos por 1 a 5 sustituyentes independientemente seleccionados a partir del grupo que consiste en -O-R8 y -N(R8)(R9), en donde R8 y R9 se seleccionan independientemente a partir del grupo que consiste en hidrogeno, alquilo C1-7, acilo, arilo y heteroarilo, cada uno de los cuales está además opcionalmente sustituido por 1 a 4 sustituyentes independientemente seleccionados a partir del grupo que consiste en halogeno, alcoxilo C1-7 y alquilo C1-7; o R es -C(O)O- R10, o -C(O)N(R11)(R12), en donde R10, R11 y R12 se seleccionan independientemente a partir del grupo que consiste en hidrogeno, alquilo C1-7, cicloalquilo C3-8, arilo, aril-alquilo C1-7, haloalquilo C1-7 y heteroarilo, cada uno de los cuales está además opcionalmente sustituido por 1 a 4 sustituyentes independientemente seleccionados a partir del grupo que consiste en halogeno, hidroxilo, alcoxilo C1-7, alquilo C1-7, y arilo, en donde R11 y R12, tomados junto con el átomo de nitrogeno con el que están unidos, forman opcionalmente un anillo de 3 a 8 miembros; R1, R2, R3, R4, y R5 se seleccionan independientemente a partir del grupo que consiste en hidrogeno, alquenilo C1-7, alquilo C1-7, cicloalquilo C3-8, halogeno, ciano, nitro, H2N-, haloalquilo C1-7, alcoxilo C1-7, cicloalcoxilo C3-8, ariloxilo, arilo, heteroarilo, -C(O)OR10, y -N(R13)(R14), estando el alquilo C1-7, alquenilo C1-7, alcoxilo C1-7, arilo y heteroarilo además opcionalmente sustituidos por 1 a 3 sustituyentes seleccionados a partir de alquilo C1-7, hidroxilo, halogeno, alcoxilo C1-7, nitro, ciano, dialquilo C1-7-amino, alcoxilo C1-7-alquilo C1-7-, y haloalquilo C1-7, teniendo el R10 el mismo significado que se define anteriormente, y R13 y R14 se seleccionan independientemente a partir del grupo que consiste en hidrogeno, alquilo C1-7, cicloalquilo C3-8, haloalquilo C1-7, haloalcoxilo C1-7, arilo y ciano, con la condicion de que no más de tres de R1, R2, R3, R4, y R5 son simultáneamente hidrogeno; R13 y R14, tomados junto con el átomo de nitrogeno con el que están unidos, forman opcionalmente un anillo de 3-8 miembros; R y R1, tomados juntos, forman opcionalmente un anillo de 5 a 6 miembros que contiene 0 o 1 heteroátomo seleccionado a partir de O, N, o S; R6 y R7 son independientemente hidrogeno, hidroxilo, alquilo C1-7, alcoxilo C1-7, fenilo, o bencilo, en donde fenilo y bencilo están opcionalmente sustituidos por 1 a 4 sustituyentes independientemente seleccionados a partir del grupo que consiste en halogeno, alcoxilo C1-7 y alquilo C1-7; cuando R6 y R7 están unidos al mismo átomo de carbono, opcionalmente forman una fraccion formula (2), en donde Ra y Rb son independientemente hidrogeno, alquilo C1-7, alcoxilo C1-7, acilo, -COOR15 o -COR15, siendo el R15 hidrogeno, alquilo C1-7, haloalquilo C1-7, arilo, o -NH2; o cuando R6 y R7 están unidos al mismo átomo de carbono, tomados junto con ese átomo de carbono, forman opcionalmente un anillo de 3 a 8 miembros; o una sal farmacéuticamente aceptable del mismo; o un isomero optico del mismo, o una mezcla de isomeros opticos.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US71144205P | 2005-08-25 | 2005-08-25 |
Publications (1)
Publication Number | Publication Date |
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AR057772A1 true AR057772A1 (es) | 2007-12-19 |
Family
ID=37610275
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP060103664A AR057772A1 (es) | 2005-08-25 | 2006-08-23 | Derivados de imidazol como inhibidores de sintasa de aldosterona y aromatasa. composiciones farmaceuticas |
Country Status (34)
Country | Link |
---|---|
US (4) | US8314097B2 (es) |
EP (3) | EP2256118B1 (es) |
JP (2) | JP5225086B2 (es) |
KR (3) | KR101549762B1 (es) |
CN (2) | CN102408429B (es) |
AR (1) | AR057772A1 (es) |
AU (1) | AU2006283105C1 (es) |
BR (1) | BRPI0615095B8 (es) |
CA (1) | CA2619660C (es) |
DK (1) | DK1919916T3 (es) |
EA (1) | EA014940B1 (es) |
EC (1) | ECSP088201A (es) |
ES (2) | ES2417498T3 (es) |
GT (1) | GT200600381A (es) |
HK (1) | HK1117518A1 (es) |
HR (1) | HRP20130797T1 (es) |
IL (2) | IL189024A (es) |
JO (1) | JO2882B1 (es) |
MA (1) | MA29771B1 (es) |
MX (1) | MX2008002545A (es) |
MY (1) | MY151601A (es) |
NO (1) | NO340854B1 (es) |
NZ (1) | NZ565476A (es) |
PE (2) | PE20070517A1 (es) |
PH (1) | PH12013502342A1 (es) |
PL (1) | PL1919916T3 (es) |
PT (1) | PT1919916E (es) |
SG (1) | SG165319A1 (es) |
SI (1) | SI1919916T1 (es) |
TN (1) | TNSN08082A1 (es) |
TW (2) | TWI487708B (es) |
UA (1) | UA96737C2 (es) |
WO (1) | WO2007024945A1 (es) |
ZA (1) | ZA200800589B (es) |
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TW200716105A (en) * | 2005-05-31 | 2007-05-01 | Speedel Experimenta Ag | Imidazole compounds |
GT200600381A (es) | 2005-08-25 | 2007-03-28 | Compuestos organicos | |
US9884031B2 (en) * | 2007-05-09 | 2018-02-06 | The Trustees Of The University Of Pennsylvania | Use of HDAC inhibitors for treatment of cardiac rhythm disorders |
EP2095819A1 (en) | 2008-02-28 | 2009-09-02 | Maastricht University | N-benzyl imidazole derivatives and their use as aldosterone synthase inhibitors |
AR076707A1 (es) | 2009-05-28 | 2011-06-29 | Novartis Ag | Derivados amino-propionicos sustituidos como inhibidores de neprilisina |
EP2435402B1 (en) | 2009-05-28 | 2016-04-13 | Novartis AG | Substituted aminobutyric derivatives as neprilysin inhibitors |
WO2011019882A1 (en) * | 2009-08-12 | 2011-02-17 | William Marsh Rice University | Nanostructure-beta-blocker conjugates |
JO2967B1 (en) | 2009-11-20 | 2016-03-15 | نوفارتس ايه جي | Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors |
EP2507234B1 (en) | 2009-11-30 | 2014-03-12 | Novartis AG | Imidazole derivatives as aldosterone synthase inhibitors |
AU2011205290C1 (en) * | 2010-01-14 | 2014-11-06 | Recordati Ag | Use of an adrenal hormone-modifying agent |
US8080568B1 (en) | 2010-06-29 | 2011-12-20 | Ewha University - Industry Collaboration Foundation | 2-pyridyl substituted imidazoles as therapeutic ALK5 and/or ALK4 inhibitors |
US8877815B2 (en) | 2010-11-16 | 2014-11-04 | Novartis Ag | Substituted carbamoylcycloalkyl acetic acid derivatives as NEP |
US8673974B2 (en) | 2010-11-16 | 2014-03-18 | Novartis Ag | Substituted amino bisphenyl pentanoic acid derivatives as NEP inhibitors |
AR086665A1 (es) * | 2011-06-14 | 2014-01-15 | Lilly Co Eli | Inhibidor de aldosterona sintasa y composiciones farmaceuticas |
TWI627167B (zh) | 2011-07-08 | 2018-06-21 | 諾華公司 | 用於高三酸甘油酯個體治療動脈粥狀硬化之方法 |
US10813630B2 (en) | 2011-08-09 | 2020-10-27 | Corquest Medical, Inc. | Closure system for atrial wall |
US10307167B2 (en) | 2012-12-14 | 2019-06-04 | Corquest Medical, Inc. | Assembly and method for left atrial appendage occlusion |
US10314594B2 (en) | 2012-12-14 | 2019-06-11 | Corquest Medical, Inc. | Assembly and method for left atrial appendage occlusion |
AP2014007762A0 (en) | 2012-01-17 | 2014-07-31 | Novartis Ag | New forms and salts of a dihydropyrrolo[1,2C]imidazolyl aldosterone synthase or aromatase inhibitor |
KR102093526B1 (ko) | 2012-03-01 | 2020-03-25 | 어레이 바이오파마 인크. | 세린/트레오닌 키나제 억제제 |
WO2013131879A1 (en) | 2012-03-07 | 2013-09-12 | Novartis Ag | New application for pasireotide |
RU2663455C2 (ru) * | 2012-04-12 | 2018-08-06 | Новартис Аг | КОМБИНАЦИЯ АНАЛОГОВ СОМАТОСТАТИНА С ИНГИБИТОРАМИ 11β- ГИДРОКСИЛАЗЫ |
UY35144A (es) | 2012-11-20 | 2014-06-30 | Novartis Ag | Miméticos lineales sintéticos de apelina para el tratamiento de insuficiencia cardiaca |
US20140142689A1 (en) | 2012-11-21 | 2014-05-22 | Didier De Canniere | Device and method of treating heart valve malfunction |
PT2956464T (pt) | 2013-02-14 | 2018-07-04 | Novartis Ag | Derivados de ácido bisfenil butanóico fosfónico substituído como inibidores de nep (endopeptidase neutra |
EP2815749A1 (en) | 2013-06-20 | 2014-12-24 | IP Gesellschaft für Management mbH | Solid form of 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione having specified X-ray diffraction pattern |
SG11201600208RA (en) | 2013-07-25 | 2016-02-26 | Novartis Ag | Bioconjugates of synthetic apelin polypeptides |
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