ES2161714T3 - Derivados de 1h-bencimidazol sustituidos por pirroloimidazolilo e imidazopiridinilo como inhibidores de aromatasa. - Google Patents

Derivados de 1h-bencimidazol sustituidos por pirroloimidazolilo e imidazopiridinilo como inhibidores de aromatasa.

Info

Publication number
ES2161714T3
ES2161714T3 ES93903211T ES93903211T ES2161714T3 ES 2161714 T3 ES2161714 T3 ES 2161714T3 ES 93903211 T ES93903211 T ES 93903211T ES 93903211 T ES93903211 T ES 93903211T ES 2161714 T3 ES2161714 T3 ES 2161714T3
Authority
ES
Spain
Prior art keywords
substituted
phenyl
amino
6alkyl
6alkyloxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93903211T
Other languages
English (en)
Inventor
Marcel August Constant Janssen
Alfons Herman Marg Raeymaekers
Eddy Jean Edgard Freyne
Michael Nicholas Greco
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Application granted granted Critical
Publication of ES2161714T3 publication Critical patent/ES2161714T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/10—Biofuels, e.g. bio-diesel

Abstract

DERIVADOS DE 1H-BENZIMIDAZOL SUSTITUIDOS POR PIRROLOIMIDAZOLIL E IMIDAZOPIRIDINILO CON FORMULA (I) DONDE N ES 0 O 1; R1 ES HIDROGENO, NITRO, AMINO, MONOO, (C1-6) ALQUILO, HIDROXI O (C1-6) ALQUILOXI; R2 ES HIDROGENO; (C1-10) ALQUIL; (C3-6) ALQUENIL; (C3-6) ALQUINILO; (C3-7) CICLOALQUILO; FENILO; FENILO SUSTITUIDO; (C1-4) ALQUILO SUSTITUIDO POR FENILO, SUSTITUTO DE FENILO, NAFTALENILO, TIENILO, FURANILO, (C1-4) ALQUILFURANILO, (C3-7) CICLOALQUILO; Y R3 ES HIDROGENO, (C1-8) ALQUILO, (C3-7) CICLOALQUILO; HIDROXI, AMINO; (C1-6) ALQUILOXI; (C1-6) ALGUILOXICARBONILAMINO; FENILO; (C1-4) ALQUILO SUSTITUIDO POR FENILO, PIPERACINILO, 4-(C14)ALQUILO)PIPERACINILO O MORFOLINILO; CADA FENILO SUSTITUIDO INDEPENDIENTEMENTE ES FENILO SUSTITUIDO CON UN SUSTITUYENTE INDEPENDIENTEMENTE SELECCIONADO ENTRE HALOGENO, HIDROXI, HIDROXIMETILO, TRIFLUOROMETILO, (C1-6) ALQUILO, (C1-6) ALQUILOXI, (C1-6) ALQUILOXICARBONILO, CARBOXILO, FORMILO, (HIDROXIIMINO)METILO, CIANO, AMINO, MONO- Y DI(C1-6ALQUIL)AMINO Y NITRO, QUE TIENE PROPIEDADES INIHIBIDORAS DE LA SINTESIS DE LA HORMONA SEXUAL. COMPOSICIONES QUE CONTIENEN TALES COMPONENTES DE FORMULA (I). PREPARACIONES DE TALES COMPONENTES Y COMPOSICIONES Y SU USO PARA TRATAR MAMIFEROS QUE SUFREN DESORDENES DE HORMONA SEXUAL.
ES93903211T 1992-01-27 1993-01-20 Derivados de 1h-bencimidazol sustituidos por pirroloimidazolilo e imidazopiridinilo como inhibidores de aromatasa. Expired - Lifetime ES2161714T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US82656492A 1992-01-27 1992-01-27

Publications (1)

Publication Number Publication Date
ES2161714T3 true ES2161714T3 (es) 2001-12-16

Family

ID=25246906

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93903211T Expired - Lifetime ES2161714T3 (es) 1992-01-27 1993-01-20 Derivados de 1h-bencimidazol sustituidos por pirroloimidazolilo e imidazopiridinilo como inhibidores de aromatasa.

Country Status (20)

Country Link
EP (1) EP0625155B1 (es)
JP (1) JPH07503242A (es)
KR (1) KR100263412B1 (es)
CN (2) CN1036007C (es)
AT (1) ATE203992T1 (es)
AU (1) AU668708B2 (es)
CA (1) CA2127689A1 (es)
DE (1) DE69330557T2 (es)
DK (1) DK0625155T3 (es)
ES (1) ES2161714T3 (es)
FI (1) FI106462B (es)
GR (1) GR3036545T3 (es)
HU (1) HU222117B1 (es)
IL (1) IL104498A (es)
MX (1) MX9300412A (es)
NO (1) NO301118B1 (es)
PT (1) PT625155E (es)
TW (1) TW221690B (es)
WO (1) WO1993015079A1 (es)
ZA (1) ZA93561B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6015796A (en) * 1995-06-14 1997-01-15 Yamanouchi Pharmaceutical Co., Ltd. Fused imidazole derivatives and medicinal composition thereof
JP3753971B2 (ja) 2000-11-17 2006-03-08 武田薬品工業株式会社 新規イミダゾール誘導体、その製造法および用途
EP1654221A2 (en) * 2003-06-10 2006-05-10 Smithkline Beecham Corporation Aniline derivatived androgen-, glucocorticoid-, mineralcorticoid- and progesterone- receptor modulators
CN100496525C (zh) * 2004-04-02 2009-06-10 李嫦梅 从洋蓟根、茎、叶中提取活性成份的方法及其应用
JP2008500999A (ja) * 2004-05-28 2008-01-17 シュペーデル・エクスペリメンタ・アーゲー 複素環式化合物およびアルドステロンシンターゼ阻害薬としてのそれらの使用
CA2568165A1 (en) * 2004-05-28 2005-12-15 Speedel Experimenta Ag Heterocyclic compounds and their use as aldosterone synthase inhibitors
CN1960991A (zh) * 2004-05-28 2007-05-09 斯皮德尔实验股份公司 用作醛固酮合酶抑制剂的四氢咪唑并[1,5－a]吡啶衍生物
WO2006005725A2 (en) * 2004-07-09 2006-01-19 Speedel Experimenta Ag N containing condensed heterocycles with antitumor effects
EP1854463A4 (en) * 2005-03-03 2011-03-23 Takeda Pharmaceutical COMPOSITION WITH CONTROLLED RELEASE
GT200600381A (es) * 2005-08-25 2007-03-28 Compuestos organicos
CN101250559B (zh) * 2008-03-14 2010-12-29 厦门大学 一种利用天然抗菌剂防治酒精发酵染菌的方法
ES2564143T3 (es) 2012-01-17 2016-03-18 Novartis Ag Nuevas formas y sales de un inhibidor dihidropirrolo[1,2-c]imidazolilo de aldosterona sintasa o aromatasa
CN106665636A (zh) * 2015-11-07 2017-05-17 郑州明德生物科技有限公司 采用月桂酰精氨酸乙酯抑制酒精发酵污染微生物的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4426450A (en) * 1981-08-24 1984-01-17 Fermentec Corporation Fermentation process and apparatus
GB8820730D0 (en) * 1988-09-02 1988-10-05 Erba Carlo Spa Substituted 5 6 7 8-tetrahydroimidazo/1.5-a/pyridines & process for their preparation
CA2026792A1 (en) * 1989-11-01 1991-05-02 Michael N. Greco (6,7-dihydro-5h-pyrrolo[1,2-c]imidazol-5-yl)- and (5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl) substituted 1h-benzotriazole derivatives
US5059431A (en) * 1990-12-07 1991-10-22 State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University Process for deacidifying wine

Also Published As

Publication number Publication date
ZA93561B (en) 1994-07-26
TW221690B (es) 1994-03-11
NO301118B1 (no) 1997-09-15
IL104498A (en) 1996-07-23
CN1074907A (zh) 1993-08-04
IL104498A0 (en) 1993-05-13
EP0625155B1 (en) 2001-08-08
WO1993015079A1 (en) 1993-08-05
HU9402208D0 (en) 1994-09-28
FI106462B (fi) 2001-02-15
DE69330557D1 (de) 2001-09-13
GR3036545T3 (en) 2001-12-31
FI943511A0 (fi) 1994-07-26
FI943511A (fi) 1994-07-26
HU222117B1 (hu) 2003-04-28
ATE203992T1 (de) 2001-08-15
DE69330557T2 (de) 2002-06-20
CN1036007C (zh) 1997-10-01
NO942748L (no) 1994-09-26
CN1095415A (zh) 1994-11-23
EP0625155A1 (en) 1994-11-23
CN1049687C (zh) 2000-02-23
AU668708B2 (en) 1996-05-16
HUT70853A (en) 1995-11-28
JPH07503242A (ja) 1995-04-06
PT625155E (pt) 2002-01-30
KR100263412B1 (ko) 2000-08-01
AU3450593A (en) 1993-09-01
CA2127689A1 (en) 1993-08-05
DK0625155T3 (da) 2001-11-12
MX9300412A (es) 1993-07-01
NO942748D0 (no) 1994-07-22

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