GT201300130A - Derivados de imidazol como inhibidores de la enzima pde10a - Google Patents

Derivados de imidazol como inhibidores de la enzima pde10a

Info

Publication number
GT201300130A
GT201300130A GT201300130A GT201300130A GT201300130A GT 201300130 A GT201300130 A GT 201300130A GT 201300130 A GT201300130 A GT 201300130A GT 201300130 A GT201300130 A GT 201300130A GT 201300130 A GT201300130 A GT 201300130A
Authority
GT
Guatemala
Prior art keywords
inhibitors
enzyme
imidazol derivatives
imidazol
pde10a
Prior art date
Application number
GT201300130A
Other languages
English (en)
Inventor
Kehler Jan
Nielsen Jacob
Marigo Mauro
Kilburn John Paul
Langgard Morten
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GT201300130A publication Critical patent/GT201300130A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

LA PRESENTE INVENCIÓN PROPORCIONA COMPUESTOS DERIVADOS DE IMIDAZOL LOS CUALES SON DE UTILIDAD COMO INHIBIDORES DE LA ENZIMA PDE 10A POR LO QUE SON DE UTILIDAD EN TRASTORNOS NEURODEGENERATIVOS Y PSIQUIÁTRICOS. ADICIONALMENTE LA INVENCIÓN PROPORCIONA COMPUESTOS QUE SON ALTAMENTE SELECTIVOS DE LA ENZIMA PDE 10A CON RESPECTO A OTROS SUBTIPOS DE PDE
GT201300130A 2010-11-19 2013-05-16 Derivados de imidazol como inhibidores de la enzima pde10a GT201300130A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DKPA201001045 2010-11-19

Publications (1)

Publication Number Publication Date
GT201300130A true GT201300130A (es) 2015-01-16

Family

ID=45217102

Family Applications (1)

Application Number Title Priority Date Filing Date
GT201300130A GT201300130A (es) 2010-11-19 2013-05-16 Derivados de imidazol como inhibidores de la enzima pde10a

Country Status (31)

Country Link
EP (1) EP2640731B9 (es)
JP (1) JP5937608B2 (es)
KR (1) KR101916487B1 (es)
CN (1) CN103328487B (es)
AP (1) AP3342A (es)
AR (1) AR083926A1 (es)
AU (1) AU2011331607B2 (es)
BR (1) BR112013012378A2 (es)
CA (1) CA2817663C (es)
CR (1) CR20130226A (es)
DK (1) DK2640731T3 (es)
EA (1) EA027082B1 (es)
EC (1) ECSP13012698A (es)
ES (1) ES2547090T3 (es)
GE (1) GEP20156346B (es)
GT (1) GT201300130A (es)
HU (1) HUE025596T2 (es)
JO (1) JO3089B1 (es)
ME (1) ME02193B (es)
MY (1) MY163327A (es)
NZ (1) NZ610353A (es)
PE (1) PE20141534A1 (es)
PL (1) PL2640731T3 (es)
PT (1) PT2640731E (es)
RS (1) RS54210B1 (es)
SG (1) SG190282A1 (es)
SI (1) SI2640731T1 (es)
TW (1) TWI541245B (es)
UA (1) UA112065C2 (es)
WO (1) WO2012065612A1 (es)
ZA (1) ZA201303607B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8552045B2 (en) 2010-11-19 2013-10-08 H. Lundbeck A/S Tricyclic imidazole compounds as PDE10 inhibitors
WO2012096929A2 (en) 2011-01-11 2012-07-19 Sunovion Pharmaceuticals Inc. Heteroaryl compounds and methods of use thereof
WO2013045607A1 (en) * 2011-09-30 2013-04-04 H. Lundbeck A/S Quinazoline linked heteroaromatic tricycle derivatives as pde10a enzyme inhibitors
WO2013107856A1 (en) * 2012-01-20 2013-07-25 H. Lundbeck A/S Imidazole derivatives as pde10a enzyme inhibitors
WO2013192273A1 (en) * 2012-06-19 2013-12-27 Sunovion Pharmaceuticals Inc. Heteroaryl compounds and methods of use thereof
CN103435617B (zh) * 2013-08-22 2016-04-27 南京华安药业有限公司 一种6,7-二氢-5H-吡咯并[1,2-a]咪唑-2-甲醛的合成方法
JO3627B1 (ar) 2015-04-30 2020-08-27 H Lundbeck As إيميدازو بيرازينونات على هيئة مثبطات pde1
TWI729109B (zh) 2016-04-12 2021-06-01 丹麥商Ｈ 朗德貝克公司 作爲PDE1抑制劑的1,5-二氫-4H-吡唑并[3,4-d]嘧啶-4-酮和1,5-二氫-4H-吡唑并[4,3-c]吡啶-4-酮
EP3529250B1 (en) 2016-10-18 2023-12-06 H. Lundbeck A/S Imidazopyrazinones, pyrazolopyrimidinones and pyrazolopyridinones as pde1 inhibitors
BR112018013247A2 (pt) 2016-10-28 2018-12-04 H Lundbeck As tratamentos de combinação compreendendo imidazopirazinonas para o tratamento de distúrbios psiquiátricos e/ou cognitivos
US10912773B2 (en) 2016-10-28 2021-02-09 H. Lundbeck A/S Combinations comprising substituted imidazo[1,5-a]pyrazinones as PDE1 inhibitors
TW202031250A (zh) 2018-11-06 2020-09-01 丹麥商Ｈ 朗德貝克公司 用於治療負性症狀和認知損傷之pde10a抑制劑
CN109776527A (zh) * 2019-02-21 2019-05-21 药雅科技(上海)有限公司 一种5-溴-7-氮杂吲哚的合成方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8307865D0 (en) 1983-03-22 1983-04-27 Fujisawa Pharmaceutical Co Benzimidazole derivatives
US5571775A (en) 1994-07-11 1996-11-05 Dowelanco N-aryl[1,2,4]triazolo[1,5-a]pyridine-2-sulfonamide herbicides
US20030032579A1 (en) 2001-04-20 2003-02-13 Pfizer Inc. Therapeutic use of selective PDE10 inhibitors
IL149106A0 (en) 2001-04-20 2002-11-10 Pfizer Prod Inc Therapeutic use of selective pde10 inhibitors
CA2530114A1 (en) 2003-06-30 2005-01-13 Altana Pharma Ag Pyrrolo-dihydroisoquinoline derivatives as pde10 inhibitors
MXPA05013822A (es) 2003-06-30 2006-02-28 Altana Pharma Ag Pirrolodihidroisoquinolinas utiles en el tratamiento del cancer.
US20070032404A1 (en) 2003-07-31 2007-02-08 Bayer Pharmaceuticals Corporation Methods for treating diabetes and related disorders using pde10a inhibitors
CA2556413A1 (en) 2004-02-18 2005-09-09 Pfizer Products Inc. Tetrahydroisoquinolinyl derivatives of quinazoline and isoquinoline
EP1755611A1 (en) 2004-06-07 2007-02-28 Pfizer Products Inc. Phosphodiesterase 10 inhibition as treatment for obesity-related and metabolic syndrome-related conditions
US20060019975A1 (en) 2004-07-23 2006-01-26 Pfizer Inc Novel piperidyl derivatives of quinazoline and isoquinoline
US20060160814A1 (en) 2004-09-03 2006-07-20 Arrington Mark P Phosphodiesterase 10 inhibitors
UA102693C2 (ru) * 2008-06-20 2013-08-12 Х. Луннбек А/С Производные фенилимидазола как ингибиторы фермента pde10a
US8133897B2 (en) * 2008-06-20 2012-03-13 H. Lundbeck A/S Phenylimidazole derivatives as PDE10A enzyme inhibitors
TWI501965B (zh) * 2008-06-20 2015-10-01 Lundbeck & Co As H 作為ｐｄｅ１０ａ酵素抑制劑之新穎苯基咪唑衍生物
TW201200516A (en) * 2009-12-17 2012-01-01 Lundbeck & Co As H Phenylimidazole derivatives comprising an ethynylene linker as PDE10A enzyme inhibitors
TWI485151B (zh) * 2009-12-17 2015-05-21 Lundbeck & Co As H 作為ｐｄｅ１０ａ酵素抑制劑之雜芳香族苯基咪唑衍生物
TWI481607B (zh) * 2009-12-17 2015-04-21 Lundbeck & Co As H 作為ｐｄｅ１０ａ酵素抑制劑的２－芳基咪唑衍生物

Also Published As

Publication number Publication date
AU2011331607B2 (en) 2016-05-19
PL2640731T3 (pl) 2015-11-30
AP2013006928A0 (en) 2013-06-30
AP3342A (en) 2015-07-31
ES2547090T3 (es) 2015-10-01
PE20141534A1 (es) 2014-11-16
JO3089B1 (ar) 2017-03-15
CA2817663C (en) 2020-04-28
TWI541245B (zh) 2016-07-11
JP2013542963A (ja) 2013-11-28
EP2640731A1 (en) 2013-09-25
EA201390741A1 (ru) 2013-11-29
GEP20156346B (en) 2015-08-10
HUE025596T2 (en) 2016-03-29
WO2012065612A1 (en) 2012-05-24
CN103328487B (zh) 2015-11-25
EA027082B1 (ru) 2017-06-30
EP2640731B9 (en) 2015-11-25
KR101916487B1 (ko) 2018-11-07
CA2817663A1 (en) 2012-05-24
EP2640731B1 (en) 2015-07-08
SG190282A1 (en) 2013-06-28
CN103328487A (zh) 2013-09-25
CR20130226A (es) 2013-09-03
JP5937608B2 (ja) 2016-06-22
SI2640731T1 (sl) 2015-10-30
DK2640731T3 (en) 2015-08-31
KR20140009192A (ko) 2014-01-22
ZA201303607B (en) 2014-07-30
ME02193B (me) 2016-02-20
UA112065C2 (uk) 2016-07-25
BR112013012378A2 (pt) 2016-08-30
NZ610353A (en) 2015-01-30
TW201300391A (zh) 2013-01-01
AR083926A1 (es) 2013-04-10
AU2011331607A1 (en) 2013-05-30
RS54210B1 (en) 2015-12-31
MY163327A (en) 2017-09-15
PT2640731E (pt) 2015-10-13
ECSP13012698A (es) 2013-08-30

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