GT201200171A - Derivados de fenilimidazol heteroaromáticos como inhibidores de enzima pde10a - Google Patents
Derivados de fenilimidazol heteroaromáticos como inhibidores de enzima pde10aInfo
- Publication number
- GT201200171A GT201200171A GT201200171A GT201200171A GT201200171A GT 201200171 A GT201200171 A GT 201200171A GT 201200171 A GT201200171 A GT 201200171A GT 201200171 A GT201200171 A GT 201200171A GT 201200171 A GT201200171 A GT 201200171A
- Authority
- GT
- Guatemala
- Prior art keywords
- heteroaromatic
- phenylimidazol
- derivatives
- pde10a inhibitors
- enzyme
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Abstract
LA PRESENTE INVENCIÓN PROPORCIONA COMPUESTOS HETEROAROMÁTICOS QUE SON INHIBIDORES DE ENZIMA PDE 10A, Y COMO TALES SON ÚTILES PARA TRATAR LOS TRASTORNOS NEURODEGENERATIVOS Y PSIQUIÁTRICOS. LA PRESENTE INVENCIÓN TAMBIÉN PROPORCIONA COMPOSICIONES FARMACÉUTICAS QUE COMPRENDEN COMPUESTOS DE LA INVENCIÓN Y MÉTODOS PARA TRATAR TRASTORNOS UTILIZANDO COMPUESTOS DE LA INVENCIÓN
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA200901339 | 2009-12-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
GT201200171A true GT201200171A (es) | 2015-01-16 |
Family
ID=44246808
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GT201200171A GT201200171A (es) | 2009-12-17 | 2012-05-31 | Derivados de fenilimidazol heteroaromáticos como inhibidores de enzima pde10a |
Country Status (36)
Country | Link |
---|---|
US (2) | US9096589B2 (es) |
EP (1) | EP2513107B1 (es) |
JP (1) | JP5901535B2 (es) |
KR (1) | KR101803984B1 (es) |
CN (1) | CN102741250B (es) |
AR (1) | AR079495A1 (es) |
AU (1) | AU2010333435B2 (es) |
BR (1) | BR112012017205A2 (es) |
CA (1) | CA2783726A1 (es) |
CO (1) | CO6612245A2 (es) |
CR (1) | CR20120319A (es) |
CY (1) | CY1115843T1 (es) |
DK (1) | DK2513107T3 (es) |
DO (1) | DOP2012000165A (es) |
EA (1) | EA023663B1 (es) |
ES (1) | ES2514647T3 (es) |
GE (1) | GEP20156241B (es) |
GT (1) | GT201200171A (es) |
HK (1) | HK1177208A1 (es) |
HR (1) | HRP20140898T1 (es) |
IL (1) | IL220327A (es) |
MA (1) | MA33922B1 (es) |
MX (1) | MX2012006969A (es) |
MY (1) | MY158197A (es) |
NZ (1) | NZ600260A (es) |
PL (1) | PL2513107T3 (es) |
PT (1) | PT2513107E (es) |
RS (1) | RS53579B1 (es) |
SG (1) | SG181674A1 (es) |
SI (1) | SI2513107T1 (es) |
SM (1) | SMT201400158B (es) |
TN (1) | TN2012000271A1 (es) |
TW (1) | TWI485151B (es) |
UA (1) | UA108487C2 (es) |
WO (1) | WO2011072694A1 (es) |
ZA (1) | ZA201204419B (es) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI487705B (zh) | 2009-12-17 | 2015-06-11 | Lundbeck & Co As H | 作為pde10a酵素抑制劑之雜芳香族芳基三唑衍生物 |
TWI481607B (zh) | 2009-12-17 | 2015-04-21 | Lundbeck & Co As H | 作為pde10a酵素抑制劑的2-芳基咪唑衍生物 |
TWI485151B (zh) | 2009-12-17 | 2015-05-21 | Lundbeck & Co As H | 作為pde10a酵素抑制劑之雜芳香族苯基咪唑衍生物 |
CA2800618C (en) | 2010-05-26 | 2018-08-28 | Sunovion Pharmaceuticals Inc. | Heteroaryl compounds and methods of use thereof |
JO3089B1 (ar) * | 2010-11-19 | 2017-03-15 | H Lundbeck As | مشتقات ايميدازول كمثبطات لانزيمات pde10a |
US8552045B2 (en) | 2010-11-19 | 2013-10-08 | H. Lundbeck A/S | Tricyclic imidazole compounds as PDE10 inhibitors |
CA2824047C (en) | 2011-01-11 | 2019-06-18 | Sunovion Pharmaceuticals Inc. | Heteroaryl compounds and methods of use thereof |
CN103476757A (zh) | 2011-02-18 | 2013-12-25 | 阿勒根公司 | 作为磷酸二酯酶10(pde10a)的抑制剂的取代的6,7-二烷氧基-3-异喹啉醇衍生物 |
US9938269B2 (en) * | 2011-06-30 | 2018-04-10 | Abbvie Inc. | Inhibitor compounds of phosphodiesterase type 10A |
AU2012311713A1 (en) * | 2011-09-19 | 2014-03-13 | F. Hoffmann-La Roche Ag | Triazolopyridine compounds as PDE10A inhibitors |
WO2013050527A1 (en) | 2011-10-05 | 2013-04-11 | H. Lundbeck A/S | Quinazoline derivatives as pde10a enzyme inhibitors |
TWI570124B (zh) | 2011-12-21 | 2017-02-11 | H 朗德貝克公司 | 作為pde10a酵素抑制劑的喹啉衍生物 |
EP2861596B1 (en) | 2012-06-19 | 2019-03-20 | Sunovion Pharmaceuticals Inc. | Heteroaryl compounds and methods of use thereof |
WO2014071044A1 (en) | 2012-11-01 | 2014-05-08 | Allergan, Inc. | Substituted 6,7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (pde10a) |
US9790203B2 (en) * | 2012-11-26 | 2017-10-17 | Abbvie Inc. | Inhibitor compounds of phosphodiesterase type 10A |
US9200016B2 (en) | 2013-12-05 | 2015-12-01 | Allergan, Inc. | Substituted 6, 7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (PDE 10A) |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8307865D0 (en) | 1983-03-22 | 1983-04-27 | Fujisawa Pharmaceutical Co | Benzimidazole derivatives |
US5571775A (en) | 1994-07-11 | 1996-11-05 | Dowelanco | N-aryl[1,2,4]triazolo[1,5-a]pyridine-2-sulfonamide herbicides |
US20030032579A1 (en) | 2001-04-20 | 2003-02-13 | Pfizer Inc. | Therapeutic use of selective PDE10 inhibitors |
IL149106A0 (en) | 2001-04-20 | 2002-11-10 | Pfizer Prod Inc | Therapeutic use of selective pde10 inhibitors |
FR2824065A1 (fr) | 2001-04-26 | 2002-10-31 | Neuro3D | Composes inhibiteurs des phosphodiesterases des nucleotides cycliques, preparation et utilisations |
JP2006509832A (ja) | 2002-10-30 | 2006-03-23 | ニューロ3デー | サイクリックヌクレオチドホスホジエステラーゼ阻害剤、その調製及び使用 |
RS20050945A (en) | 2003-06-30 | 2008-06-05 | Altana Pharma Ag., | Novel pyrrolodihydroisoquinolines useful in the treatment of cancer |
EP1641457B1 (en) | 2003-06-30 | 2009-08-05 | Nycomed GmbH | Pyrrolo-dihydroisoquinoline derivatives as pde10 inhibitors |
CA2534432A1 (en) | 2003-07-31 | 2005-02-10 | Bayer Pharmaceuticals Corporation | Methods for treating diabetes and related disorders using pde10a inhibitors |
JP2007523152A (ja) | 2004-02-18 | 2007-08-16 | ファイザー・プロダクツ・インク | キナゾリンおよびイソキノリンのテトラヒドロイソキノリニル誘導体 |
FR2870539B1 (fr) | 2004-05-19 | 2006-08-04 | Greenpharma Sa Sa | Nouvelles methodes et medicaments |
EP1755611A1 (en) | 2004-06-07 | 2007-02-28 | Pfizer Products Inc. | Phosphodiesterase 10 inhibition as treatment for obesity-related and metabolic syndrome-related conditions |
US20060019975A1 (en) | 2004-07-23 | 2006-01-26 | Pfizer Inc | Novel piperidyl derivatives of quinazoline and isoquinoline |
EP1802585A1 (en) | 2004-09-03 | 2007-07-04 | Memory Pharmaceuticals Corporation | 4-substituted 4,6-dialkoxy-cinnoline derivatives as phospodiesterase 10 inhibitors for the treatment of psychiatric or neurological syndroms |
NL2000397C2 (nl) | 2006-01-05 | 2007-10-30 | Pfizer Prod Inc | Bicyclische heteroarylverbindingen als PDE10 inhibitoren. |
US20080090834A1 (en) * | 2006-07-06 | 2008-04-17 | Pfizer Inc | Selective azole pde10a inhibitor compounds |
ES2392553T3 (es) * | 2006-07-10 | 2012-12-11 | H. Lundbeck A/S | Derivados (3-aril-piperazina-1-ilo) de 6,7-dialcoxiquinazolina, 6,7-dialcoxiftalazina y 6,7-dialcoxiisoquinolina |
EP2173728A2 (en) | 2007-07-17 | 2010-04-14 | Amgen Inc. | Heterocyclic modulators of pkb |
UA102693C2 (ru) | 2008-06-20 | 2013-08-12 | Х. Луннбек А/С | Производные фенилимидазола как ингибиторы фермента pde10a |
TWI501965B (zh) * | 2008-06-20 | 2015-10-01 | Lundbeck & Co As H | 作為pde10a酵素抑制劑之新穎苯基咪唑衍生物 |
US8133897B2 (en) * | 2008-06-20 | 2012-03-13 | H. Lundbeck A/S | Phenylimidazole derivatives as PDE10A enzyme inhibitors |
TWI481607B (zh) | 2009-12-17 | 2015-04-21 | Lundbeck & Co As H | 作為pde10a酵素抑制劑的2-芳基咪唑衍生物 |
TWI485151B (zh) | 2009-12-17 | 2015-05-21 | Lundbeck & Co As H | 作為pde10a酵素抑制劑之雜芳香族苯基咪唑衍生物 |
TWI487705B (zh) | 2009-12-17 | 2015-06-11 | Lundbeck & Co As H | 作為pde10a酵素抑制劑之雜芳香族芳基三唑衍生物 |
TW201200516A (en) | 2009-12-17 | 2012-01-01 | Lundbeck & Co As H | Phenylimidazole derivatives comprising an ethynylene linker as PDE10A enzyme inhibitors |
-
2010
- 2010-12-10 TW TW099143184A patent/TWI485151B/zh not_active IP Right Cessation
- 2010-12-15 CA CA2783726A patent/CA2783726A1/en not_active Abandoned
- 2010-12-15 BR BR112012017205A patent/BR112012017205A2/pt not_active Application Discontinuation
- 2010-12-15 WO PCT/DK2010/050341 patent/WO2011072694A1/en active Application Filing
- 2010-12-15 MY MYPI2012002598A patent/MY158197A/en unknown
- 2010-12-15 CN CN201080063808.4A patent/CN102741250B/zh not_active Expired - Fee Related
- 2010-12-15 EP EP10798255.5A patent/EP2513107B1/en active Active
- 2010-12-15 JP JP2012543475A patent/JP5901535B2/ja not_active Expired - Fee Related
- 2010-12-15 KR KR1020127015655A patent/KR101803984B1/ko active IP Right Grant
- 2010-12-15 NZ NZ600260A patent/NZ600260A/en not_active IP Right Cessation
- 2010-12-15 EA EA201290516A patent/EA023663B1/ru not_active IP Right Cessation
- 2010-12-15 SI SI201030765T patent/SI2513107T1/sl unknown
- 2010-12-15 RS RSP20140527 patent/RS53579B1/en unknown
- 2010-12-15 UA UAA201207960A patent/UA108487C2/uk unknown
- 2010-12-15 ES ES10798255.5T patent/ES2514647T3/es active Active
- 2010-12-15 DK DK10798255.5T patent/DK2513107T3/da active
- 2010-12-15 AU AU2010333435A patent/AU2010333435B2/en not_active Ceased
- 2010-12-15 US US13/513,867 patent/US9096589B2/en not_active Expired - Fee Related
- 2010-12-15 PT PT107982555T patent/PT2513107E/pt unknown
- 2010-12-15 SG SG2012043519A patent/SG181674A1/en unknown
- 2010-12-15 PL PL10798255T patent/PL2513107T3/pl unknown
- 2010-12-15 GE GEAP201012785A patent/GEP20156241B/en unknown
- 2010-12-15 MX MX2012006969A patent/MX2012006969A/es active IP Right Grant
- 2010-12-15 MA MA35063A patent/MA33922B1/fr unknown
- 2010-12-16 AR ARP100104668A patent/AR079495A1/es unknown
-
2012
- 2012-05-29 TN TNP2012000271A patent/TN2012000271A1/en unknown
- 2012-05-31 GT GT201200171A patent/GT201200171A/es unknown
- 2012-06-12 IL IL220327A patent/IL220327A/en not_active IP Right Cessation
- 2012-06-12 CR CR20120319A patent/CR20120319A/es unknown
- 2012-06-13 CO CO12099152A patent/CO6612245A2/es active IP Right Grant
- 2012-06-14 DO DO2012000165A patent/DOP2012000165A/es unknown
- 2012-06-15 ZA ZA2012/04419A patent/ZA201204419B/en unknown
-
2013
- 2013-04-15 HK HK13104532.2A patent/HK1177208A1/xx not_active IP Right Cessation
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2014
- 2014-09-19 HR HRP20140898AT patent/HRP20140898T1/hr unknown
- 2014-09-26 CY CY20141100789T patent/CY1115843T1/el unknown
- 2014-10-29 SM SM201400158T patent/SMT201400158B/xx unknown
-
2015
- 2015-06-25 US US14/749,754 patent/US9669029B2/en active Active
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