BR112012017205A2 - derivados de fenilimidazol heteroaromáticos como inibidores de enzima pde10a - Google Patents
derivados de fenilimidazol heteroaromáticos como inibidores de enzima pde10aInfo
- Publication number
- BR112012017205A2 BR112012017205A2 BR112012017205A BR112012017205A BR112012017205A2 BR 112012017205 A2 BR112012017205 A2 BR 112012017205A2 BR 112012017205 A BR112012017205 A BR 112012017205A BR 112012017205 A BR112012017205 A BR 112012017205A BR 112012017205 A2 BR112012017205 A2 BR 112012017205A2
- Authority
- BR
- Brazil
- Prior art keywords
- enzyme inhibitors
- actuating
- valve
- pde10a enzyme
- phenylimidazole derivatives
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Valve Device For Special Equipments (AREA)
Abstract
patente de invenção para: "sistema mecânico de atuação variável de válvula para operações de motor de 2 tempos e de 4 tempos". a invenção se refere a um sistema mecânico de atuação variável de válvula (vva) para o controle e a atuação das válvulas de um motor de combustão interna. o sistema de acordo com a presente invenção realiza o controle de elevador de válvula por meio de uma parte pivó fixo para um balancim oscilante adequado para atuar a válvula, o balancim oscilante sendo atuado por meio de um elemento de controle de excêntrico.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA200901339 | 2009-12-17 | ||
PCT/DK2010/050341 WO2011072694A1 (en) | 2009-12-17 | 2010-12-15 | Heteroaromatic phenylimidazole derivatives as pde10a enzyme inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112012017205A2 true BR112012017205A2 (pt) | 2018-08-14 |
Family
ID=44246808
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112012017205A BR112012017205A2 (pt) | 2009-12-17 | 2010-12-15 | derivados de fenilimidazol heteroaromáticos como inibidores de enzima pde10a |
Country Status (36)
Country | Link |
---|---|
US (2) | US9096589B2 (pt) |
EP (1) | EP2513107B1 (pt) |
JP (1) | JP5901535B2 (pt) |
KR (1) | KR101803984B1 (pt) |
CN (1) | CN102741250B (pt) |
AR (1) | AR079495A1 (pt) |
AU (1) | AU2010333435B2 (pt) |
BR (1) | BR112012017205A2 (pt) |
CA (1) | CA2783726A1 (pt) |
CO (1) | CO6612245A2 (pt) |
CR (1) | CR20120319A (pt) |
CY (1) | CY1115843T1 (pt) |
DK (1) | DK2513107T3 (pt) |
DO (1) | DOP2012000165A (pt) |
EA (1) | EA023663B1 (pt) |
ES (1) | ES2514647T3 (pt) |
GE (1) | GEP20156241B (pt) |
GT (1) | GT201200171A (pt) |
HK (1) | HK1177208A1 (pt) |
HR (1) | HRP20140898T1 (pt) |
IL (1) | IL220327A (pt) |
MA (1) | MA33922B1 (pt) |
MX (1) | MX2012006969A (pt) |
MY (1) | MY158197A (pt) |
NZ (1) | NZ600260A (pt) |
PL (1) | PL2513107T3 (pt) |
PT (1) | PT2513107E (pt) |
RS (1) | RS53579B1 (pt) |
SG (1) | SG181674A1 (pt) |
SI (1) | SI2513107T1 (pt) |
SM (1) | SMT201400158B (pt) |
TN (1) | TN2012000271A1 (pt) |
TW (1) | TWI485151B (pt) |
UA (1) | UA108487C2 (pt) |
WO (1) | WO2011072694A1 (pt) |
ZA (1) | ZA201204419B (pt) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI485151B (zh) | 2009-12-17 | 2015-05-21 | Lundbeck & Co As H | 作為pde10a酵素抑制劑之雜芳香族苯基咪唑衍生物 |
TWI487705B (zh) | 2009-12-17 | 2015-06-11 | Lundbeck & Co As H | 作為pde10a酵素抑制劑之雜芳香族芳基三唑衍生物 |
TWI481607B (zh) | 2009-12-17 | 2015-04-21 | Lundbeck & Co As H | 作為pde10a酵素抑制劑的2-芳基咪唑衍生物 |
WO2011150156A2 (en) * | 2010-05-26 | 2011-12-01 | Sunovion Pharmaceuticals Inc. | Heteroaryl compounds and methods of use thereof |
JO3089B1 (ar) * | 2010-11-19 | 2017-03-15 | H Lundbeck As | مشتقات ايميدازول كمثبطات لانزيمات pde10a |
US8552045B2 (en) | 2010-11-19 | 2013-10-08 | H. Lundbeck A/S | Tricyclic imidazole compounds as PDE10 inhibitors |
WO2012096929A2 (en) | 2011-01-11 | 2012-07-19 | Sunovion Pharmaceuticals Inc. | Heteroaryl compounds and methods of use thereof |
WO2012112946A1 (en) | 2011-02-18 | 2012-08-23 | Allergan, Inc. | Substituted 6,7-dialkoxy-3-isoquinolinol derivatives as inhibitors of phosphodiesterase 10 (pde10a) |
US9938269B2 (en) * | 2011-06-30 | 2018-04-10 | Abbvie Inc. | Inhibitor compounds of phosphodiesterase type 10A |
AU2012311713A1 (en) * | 2011-09-19 | 2014-03-13 | F. Hoffmann-La Roche Ag | Triazolopyridine compounds as PDE10A inhibitors |
WO2013050527A1 (en) | 2011-10-05 | 2013-04-11 | H. Lundbeck A/S | Quinazoline derivatives as pde10a enzyme inhibitors |
AR089361A1 (es) | 2011-12-21 | 2014-08-20 | Lundbeck & Co As H | Derivados de quinolina como inhibidores de la enzima pde10a |
WO2013192273A1 (en) * | 2012-06-19 | 2013-12-27 | Sunovion Pharmaceuticals Inc. | Heteroaryl compounds and methods of use thereof |
WO2014071044A1 (en) | 2012-11-01 | 2014-05-08 | Allergan, Inc. | Substituted 6,7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (pde10a) |
US9790203B2 (en) * | 2012-11-26 | 2017-10-17 | Abbvie Inc. | Inhibitor compounds of phosphodiesterase type 10A |
US9200016B2 (en) | 2013-12-05 | 2015-12-01 | Allergan, Inc. | Substituted 6, 7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (PDE 10A) |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8307865D0 (en) | 1983-03-22 | 1983-04-27 | Fujisawa Pharmaceutical Co | Benzimidazole derivatives |
US5571775A (en) | 1994-07-11 | 1996-11-05 | Dowelanco | N-aryl[1,2,4]triazolo[1,5-a]pyridine-2-sulfonamide herbicides |
IL149106A0 (en) | 2001-04-20 | 2002-11-10 | Pfizer Prod Inc | Therapeutic use of selective pde10 inhibitors |
US20030032579A1 (en) | 2001-04-20 | 2003-02-13 | Pfizer Inc. | Therapeutic use of selective PDE10 inhibitors |
FR2824065A1 (fr) | 2001-04-26 | 2002-10-31 | Neuro3D | Composes inhibiteurs des phosphodiesterases des nucleotides cycliques, preparation et utilisations |
JP2006509832A (ja) | 2002-10-30 | 2006-03-23 | ニューロ3デー | サイクリックヌクレオチドホスホジエステラーゼ阻害剤、その調製及び使用 |
CA2530114A1 (en) | 2003-06-30 | 2005-01-13 | Altana Pharma Ag | Pyrrolo-dihydroisoquinoline derivatives as pde10 inhibitors |
MXPA05013822A (es) | 2003-06-30 | 2006-02-28 | Altana Pharma Ag | Pirrolodihidroisoquinolinas utiles en el tratamiento del cancer. |
US20070032404A1 (en) | 2003-07-31 | 2007-02-08 | Bayer Pharmaceuticals Corporation | Methods for treating diabetes and related disorders using pde10a inhibitors |
CA2556413A1 (en) | 2004-02-18 | 2005-09-09 | Pfizer Products Inc. | Tetrahydroisoquinolinyl derivatives of quinazoline and isoquinoline |
FR2870539B1 (fr) | 2004-05-19 | 2006-08-04 | Greenpharma Sa Sa | Nouvelles methodes et medicaments |
EP1755611A1 (en) | 2004-06-07 | 2007-02-28 | Pfizer Products Inc. | Phosphodiesterase 10 inhibition as treatment for obesity-related and metabolic syndrome-related conditions |
US20060019975A1 (en) | 2004-07-23 | 2006-01-26 | Pfizer Inc | Novel piperidyl derivatives of quinazoline and isoquinoline |
US20060160814A1 (en) | 2004-09-03 | 2006-07-20 | Arrington Mark P | Phosphodiesterase 10 inhibitors |
NL2000397C2 (nl) * | 2006-01-05 | 2007-10-30 | Pfizer Prod Inc | Bicyclische heteroarylverbindingen als PDE10 inhibitoren. |
US20080090834A1 (en) * | 2006-07-06 | 2008-04-17 | Pfizer Inc | Selective azole pde10a inhibitor compounds |
JP2009542732A (ja) * | 2006-07-10 | 2009-12-03 | ハー・ルンドベック・アクチエゼルスカベット | 6,7−ジアルコキシキナゾリン、6,7−ジアルコキシフタラジンおよび6,7−ジアルコキシイソキノリンの(3−アリール−ピペラジン−1−イル)、(2−アリール−モルホリン−4−イル)および(2−アリール−チオモルホリン−4−イル)誘導体 |
CA2692713A1 (en) | 2007-07-17 | 2009-01-22 | Amgen Inc. | Heterocyclic modulators of pkb |
UA102693C2 (ru) | 2008-06-20 | 2013-08-12 | Х. Луннбек А/С | Производные фенилимидазола как ингибиторы фермента pde10a |
US8133897B2 (en) * | 2008-06-20 | 2012-03-13 | H. Lundbeck A/S | Phenylimidazole derivatives as PDE10A enzyme inhibitors |
TWI501965B (zh) * | 2008-06-20 | 2015-10-01 | Lundbeck & Co As H | 作為pde10a酵素抑制劑之新穎苯基咪唑衍生物 |
TWI485151B (zh) | 2009-12-17 | 2015-05-21 | Lundbeck & Co As H | 作為pde10a酵素抑制劑之雜芳香族苯基咪唑衍生物 |
TWI487705B (zh) | 2009-12-17 | 2015-06-11 | Lundbeck & Co As H | 作為pde10a酵素抑制劑之雜芳香族芳基三唑衍生物 |
TWI481607B (zh) * | 2009-12-17 | 2015-04-21 | Lundbeck & Co As H | 作為pde10a酵素抑制劑的2-芳基咪唑衍生物 |
TW201200516A (en) | 2009-12-17 | 2012-01-01 | Lundbeck & Co As H | Phenylimidazole derivatives comprising an ethynylene linker as PDE10A enzyme inhibitors |
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2010
- 2010-12-10 TW TW099143184A patent/TWI485151B/zh not_active IP Right Cessation
- 2010-12-15 CN CN201080063808.4A patent/CN102741250B/zh not_active Expired - Fee Related
- 2010-12-15 US US13/513,867 patent/US9096589B2/en not_active Expired - Fee Related
- 2010-12-15 JP JP2012543475A patent/JP5901535B2/ja not_active Expired - Fee Related
- 2010-12-15 ES ES10798255.5T patent/ES2514647T3/es active Active
- 2010-12-15 AU AU2010333435A patent/AU2010333435B2/en not_active Ceased
- 2010-12-15 BR BR112012017205A patent/BR112012017205A2/pt not_active Application Discontinuation
- 2010-12-15 KR KR1020127015655A patent/KR101803984B1/ko active IP Right Grant
- 2010-12-15 NZ NZ600260A patent/NZ600260A/en not_active IP Right Cessation
- 2010-12-15 PT PT107982555T patent/PT2513107E/pt unknown
- 2010-12-15 UA UAA201207960A patent/UA108487C2/uk unknown
- 2010-12-15 MA MA35063A patent/MA33922B1/fr unknown
- 2010-12-15 WO PCT/DK2010/050341 patent/WO2011072694A1/en active Application Filing
- 2010-12-15 EP EP10798255.5A patent/EP2513107B1/en active Active
- 2010-12-15 MY MYPI2012002598A patent/MY158197A/en unknown
- 2010-12-15 GE GEAP201012785A patent/GEP20156241B/en unknown
- 2010-12-15 CA CA2783726A patent/CA2783726A1/en not_active Abandoned
- 2010-12-15 SI SI201030765T patent/SI2513107T1/sl unknown
- 2010-12-15 SG SG2012043519A patent/SG181674A1/en unknown
- 2010-12-15 RS RSP20140527 patent/RS53579B1/en unknown
- 2010-12-15 PL PL10798255T patent/PL2513107T3/pl unknown
- 2010-12-15 MX MX2012006969A patent/MX2012006969A/es active IP Right Grant
- 2010-12-15 EA EA201290516A patent/EA023663B1/ru not_active IP Right Cessation
- 2010-12-15 DK DK10798255.5T patent/DK2513107T3/da active
- 2010-12-16 AR ARP100104668A patent/AR079495A1/es unknown
-
2012
- 2012-05-29 TN TNP2012000271A patent/TN2012000271A1/en unknown
- 2012-05-31 GT GT201200171A patent/GT201200171A/es unknown
- 2012-06-12 IL IL220327A patent/IL220327A/en not_active IP Right Cessation
- 2012-06-12 CR CR20120319A patent/CR20120319A/es unknown
- 2012-06-13 CO CO12099152A patent/CO6612245A2/es active IP Right Grant
- 2012-06-14 DO DO2012000165A patent/DOP2012000165A/es unknown
- 2012-06-15 ZA ZA2012/04419A patent/ZA201204419B/en unknown
-
2013
- 2013-04-15 HK HK13104532.2A patent/HK1177208A1/xx not_active IP Right Cessation
-
2014
- 2014-09-19 HR HRP20140898AT patent/HRP20140898T1/hr unknown
- 2014-09-26 CY CY20141100789T patent/CY1115843T1/el unknown
- 2014-10-29 SM SM201400158T patent/SMT201400158B/xx unknown
-
2015
- 2015-06-25 US US14/749,754 patent/US9669029B2/en active Active
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B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B06T | Formal requirements before examination [chapter 6.20 patent gazette] | ||
B11E | Dismissal acc. art. 34 of ipl - requirements for examination incomplete | ||
B11T | Dismissal of application maintained [chapter 11.20 patent gazette] | ||
B350 | Update of information on the portal [chapter 15.35 patent gazette] |