MA33922B1 - Dérivés hétéroaromatiques de phénylimidazole en tant qu'inhibiteurs de l'enzyme pde10a - Google Patents
Dérivés hétéroaromatiques de phénylimidazole en tant qu'inhibiteurs de l'enzyme pde10aInfo
- Publication number
- MA33922B1 MA33922B1 MA35063A MA35063A MA33922B1 MA 33922 B1 MA33922 B1 MA 33922B1 MA 35063 A MA35063 A MA 35063A MA 35063 A MA35063 A MA 35063A MA 33922 B1 MA33922 B1 MA 33922B1
- Authority
- MA
- Morocco
- Prior art keywords
- relates
- patient
- inhibitors
- heteraromatic
- formula
- Prior art date
Links
- 101001072037 Homo sapiens cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 150000004841 phenylimidazoles Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- 238000000034 method Methods 0.000 abstract 3
- 230000001225 therapeutic effect Effects 0.000 abstract 3
- 239000003937 drug carrier Substances 0.000 abstract 1
- 206010013663 drug dependence Diseases 0.000 abstract 1
- 239000002532 enzyme inhibitor Substances 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 208000011117 substance-related disease Diseases 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Valve Device For Special Equipments (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
La présente invention a pour objet des composés qui sont des inhibiteurs de l'enzyme PDE10A. La présente invention concerne une composition pharmaceutique comprenant une quantité thérapeutiquement efficace d'un composé selon l'invention et un véhicule pharmaceutiquement acceptable. La présente invention concerne également des procédés pour la préparation des composés de formule I. La présente invention concerne en outre une méthode de traitement d'un sujet souffrant d'un trouble neurodégénératif comprenant l'administration au sujet d'une quantité thérapeutiquement efficace d'un composé de formule I. La présente invention concerne également une méthode de traitement d'un sujet souffrant d'une pharmacodépendance comprenant l'administration au sujet d'une quantité thérapeutiquement efficace d'un composé de formule I. La présente invention concerne en outre une méthode de traitement d'un sujet souffrant d'un trouble psychiatrique comprenant l'administration au sujet d'une quantité thérapeutiquement efficace d'un composé de formule I.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28731509P | 2009-12-17 | 2009-12-17 | |
| DKPA200901339 | 2009-12-17 | ||
| PCT/DK2010/050341 WO2011072694A1 (fr) | 2009-12-17 | 2010-12-15 | Dérivés hétéroaromatiques de phénylimidazole en tant qu'inhibiteurs de l'enzyme pde10a |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA33922B1 true MA33922B1 (fr) | 2013-01-02 |
Family
ID=44246808
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA35063A MA33922B1 (fr) | 2009-12-17 | 2010-12-15 | Dérivés hétéroaromatiques de phénylimidazole en tant qu'inhibiteurs de l'enzyme pde10a |
Country Status (36)
| Country | Link |
|---|---|
| US (2) | US9096589B2 (fr) |
| EP (1) | EP2513107B1 (fr) |
| JP (1) | JP5901535B2 (fr) |
| KR (1) | KR101803984B1 (fr) |
| CN (1) | CN102741250B (fr) |
| AR (1) | AR079495A1 (fr) |
| AU (1) | AU2010333435B2 (fr) |
| BR (1) | BR112012017205A2 (fr) |
| CA (1) | CA2783726A1 (fr) |
| CO (1) | CO6612245A2 (fr) |
| CR (1) | CR20120319A (fr) |
| CY (1) | CY1115843T1 (fr) |
| DK (1) | DK2513107T3 (fr) |
| DO (1) | DOP2012000165A (fr) |
| EA (1) | EA023663B1 (fr) |
| ES (1) | ES2514647T3 (fr) |
| GE (1) | GEP20156241B (fr) |
| GT (1) | GT201200171A (fr) |
| HR (1) | HRP20140898T1 (fr) |
| IL (1) | IL220327A (fr) |
| MA (1) | MA33922B1 (fr) |
| MX (1) | MX2012006969A (fr) |
| MY (1) | MY158197A (fr) |
| NZ (1) | NZ600260A (fr) |
| PH (1) | PH12012501201A1 (fr) |
| PL (1) | PL2513107T3 (fr) |
| PT (1) | PT2513107E (fr) |
| RS (1) | RS53579B1 (fr) |
| SG (1) | SG181674A1 (fr) |
| SI (1) | SI2513107T1 (fr) |
| SM (1) | SMT201400158B (fr) |
| TN (1) | TN2012000271A1 (fr) |
| TW (1) | TWI485151B (fr) |
| UA (1) | UA108487C2 (fr) |
| WO (1) | WO2011072694A1 (fr) |
| ZA (1) | ZA201204419B (fr) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI487705B (zh) | 2009-12-17 | 2015-06-11 | Lundbeck & Co As H | 作為ｐｄｅ１０ａ酵素抑制劑之雜芳香族芳基三唑衍生物 |
| TWI485151B (zh) | 2009-12-17 | 2015-05-21 | Lundbeck & Co As H | 作為ｐｄｅ１０ａ酵素抑制劑之雜芳香族苯基咪唑衍生物 |
| TWI481607B (zh) | 2009-12-17 | 2015-04-21 | Lundbeck & Co As H | 作為ｐｄｅ１０ａ酵素抑制劑的２－芳基咪唑衍生物 |
| NZ603789A (en) | 2010-05-26 | 2015-03-27 | Sunovion Pharmaceuticals Inc | Heteroaryl compounds and methods of use thereof |
| JO3089B1 (ar) * | 2010-11-19 | 2017-03-15 | H Lundbeck As | مشتقات ايميدازول كمثبطات لانزيمات pde10a |
| US8552045B2 (en) | 2010-11-19 | 2013-10-08 | H. Lundbeck A/S | Tricyclic imidazole compounds as PDE10 inhibitors |
| US8765760B2 (en) | 2011-01-11 | 2014-07-01 | Sunovion Pharmaceuticals, Inc. | [1,2,4] triazol [1,5-a] pyrazines useful as inhibitors of phosphodiesterases |
| MX2013009575A (es) | 2011-02-18 | 2014-10-14 | Exonhit Therapeutics Sa | Derivados de 6, 7-dialcoxi-3-isoquinolinol sustituidos como inhibidores de fosfodiesterasa 10 (pdei0a). |
| US9938269B2 (en) * | 2011-06-30 | 2018-04-10 | Abbvie Inc. | Inhibitor compounds of phosphodiesterase type 10A |
| SG11201400759RA (en) * | 2011-09-19 | 2014-07-30 | Hoffmann La Roche | Triazolopyridine compounds as pde10a inhibitors |
| WO2013050527A1 (fr) | 2011-10-05 | 2013-04-11 | H. Lundbeck A/S | Dérivés de quinazoline en tant qu'inhibiteurs de l'enzyme pde10a |
| AR089361A1 (es) | 2011-12-21 | 2014-08-20 | Lundbeck & Co As H | Derivados de quinolina como inhibidores de la enzima pde10a |
| NZ702239A (en) * | 2012-06-19 | 2017-01-27 | Sunovion Pharmaceuticals Inc | Heteroaryl compounds and methods of use thereof |
| WO2014071044A1 (fr) | 2012-11-01 | 2014-05-08 | Allergan, Inc. | Dérivés de 6,7-dialcoxy-3-isoquinoline substitués à titre d'inhibiteurs de phosphodiestérase 10 (pde10a) |
| US9790203B2 (en) * | 2012-11-26 | 2017-10-17 | Abbvie Inc. | Inhibitor compounds of phosphodiesterase type 10A |
| US9200016B2 (en) | 2013-12-05 | 2015-12-01 | Allergan, Inc. | Substituted 6, 7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (PDE 10A) |
| GB202319181D0 (en) * | 2023-12-14 | 2024-01-31 | Imperial College Innovations Ltd | Nora Inhibitors |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8307865D0 (en) | 1983-03-22 | 1983-04-27 | Fujisawa Pharmaceutical Co | Benzimidazole derivatives |
| US5571775A (en) | 1994-07-11 | 1996-11-05 | Dowelanco | N-aryl[1,2,4]triazolo[1,5-a]pyridine-2-sulfonamide herbicides |
| IL149106A0 (en) | 2001-04-20 | 2002-11-10 | Pfizer Prod Inc | Therapeutic use of selective pde10 inhibitors |
| US20030032579A1 (en) | 2001-04-20 | 2003-02-13 | Pfizer Inc. | Therapeutic use of selective PDE10 inhibitors |
| FR2824065A1 (fr) | 2001-04-26 | 2002-10-31 | Neuro3D | Composes inhibiteurs des phosphodiesterases des nucleotides cycliques, preparation et utilisations |
| WO2004041258A2 (fr) | 2002-10-30 | 2004-05-21 | Neuro3D | Utilisation d’inhibiteurs des phosphodiesterases des nucleotides cycliques, ayant une structure benzodiazepinique en therapie |
| ES2331519T3 (es) | 2003-06-30 | 2010-01-07 | Nycomed Gmbh | Derivados de pirrolo-dihidroisoquinolina como inhibidores de pde10. |
| MXPA05013822A (es) | 2003-06-30 | 2006-02-28 | Altana Pharma Ag | Pirrolodihidroisoquinolinas utiles en el tratamiento del cancer. |
| JP2007508241A (ja) | 2003-07-31 | 2007-04-05 | バイエル・フアーマシユーチカルズ・コーポレーシヨン | Ｐｄｅ１０ａ阻害剤を用いる糖尿病および関連障害の処置方法 |
| WO2005082883A2 (fr) | 2004-02-18 | 2005-09-09 | Pfizer Products Inc. | Derives tetrahydroisoquinolinyliques de quinazoline et d'isoquinoline |
| FR2870539B1 (fr) | 2004-05-19 | 2006-08-04 | Greenpharma Sa Sa | Nouvelles methodes et medicaments |
| CA2568929A1 (fr) | 2004-06-07 | 2005-12-22 | Pfizer Products Inc. | Inhibition de la phosphodiesterase 10 dans le traitement des etats pathologiques associes a l'obesite et au syndrome metabolique |
| US20060019975A1 (en) | 2004-07-23 | 2006-01-26 | Pfizer Inc | Novel piperidyl derivatives of quinazoline and isoquinoline |
| WO2006028957A1 (fr) | 2004-09-03 | 2006-03-16 | Memory Pharmaceuticals Corporation | Derives de 4, 6-dialkoxy-cinnoline substitues en position 4 en tant qu'inhibiteurs de phospodiesterase 10 pour le traitement de syndromes psychiatriques ou neurologiques |
| NL2000397C2 (nl) * | 2006-01-05 | 2007-10-30 | Pfizer Prod Inc | Bicyclische heteroarylverbindingen als PDE10 inhibitoren. |
| US20080090834A1 (en) * | 2006-07-06 | 2008-04-17 | Pfizer Inc | Selective azole pde10a inhibitor compounds |
| PT2057153E (pt) * | 2006-07-10 | 2012-11-14 | Lundbeck & Co As H | Derivados (3-aril-piperazin-1-il) de 6,7- dialcoxiquinazolina, 6,7-dialcoxiftalazina e 6,7-dialcoxiisoquinolina |
| AU2008276521B2 (en) | 2007-07-17 | 2011-11-03 | Amgen Inc. | Heterocyclic modulators of PKB |
| TWI501965B (zh) | 2008-06-20 | 2015-10-01 | Lundbeck & Co As H | 作為ｐｄｅ１０ａ酵素抑制劑之新穎苯基咪唑衍生物 |
| US8133897B2 (en) | 2008-06-20 | 2012-03-13 | H. Lundbeck A/S | Phenylimidazole derivatives as PDE10A enzyme inhibitors |
| UA102693C2 (ru) | 2008-06-20 | 2013-08-12 | Х. Луннбек А/С | Производные фенилимидазола как ингибиторы фермента pde10a |
| TWI481607B (zh) | 2009-12-17 | 2015-04-21 | Lundbeck & Co As H | 作為ｐｄｅ１０ａ酵素抑制劑的２－芳基咪唑衍生物 |
| TW201200516A (en) | 2009-12-17 | 2012-01-01 | Lundbeck & Co As H | Phenylimidazole derivatives comprising an ethynylene linker as PDE10A enzyme inhibitors |
| TWI485151B (zh) | 2009-12-17 | 2015-05-21 | Lundbeck & Co As H | 作為ｐｄｅ１０ａ酵素抑制劑之雜芳香族苯基咪唑衍生物 |
| TWI487705B (zh) | 2009-12-17 | 2015-06-11 | Lundbeck & Co As H | 作為ｐｄｅ１０ａ酵素抑制劑之雜芳香族芳基三唑衍生物 |
-
2010
- 2010-12-10 TW TW099143184A patent/TWI485151B/zh not_active IP Right Cessation
- 2010-12-15 UA UAA201207960A patent/UA108487C2/uk unknown
- 2010-12-15 BR BR112012017205A patent/BR112012017205A2/pt not_active Application Discontinuation
- 2010-12-15 SG SG2012043519A patent/SG181674A1/en unknown
- 2010-12-15 WO PCT/DK2010/050341 patent/WO2011072694A1/fr not_active Ceased
- 2010-12-15 HR HRP20140898AT patent/HRP20140898T1/hr unknown
- 2010-12-15 RS RSP20140527 patent/RS53579B1/sr unknown
- 2010-12-15 AU AU2010333435A patent/AU2010333435B2/en not_active Ceased
- 2010-12-15 MX MX2012006969A patent/MX2012006969A/es active IP Right Grant
- 2010-12-15 CA CA2783726A patent/CA2783726A1/fr not_active Abandoned
- 2010-12-15 EA EA201290516A patent/EA023663B1/ru not_active IP Right Cessation
- 2010-12-15 PL PL10798255T patent/PL2513107T3/pl unknown
- 2010-12-15 PT PT107982555T patent/PT2513107E/pt unknown
- 2010-12-15 KR KR1020127015655A patent/KR101803984B1/ko not_active Expired - Fee Related
- 2010-12-15 DK DK10798255.5T patent/DK2513107T3/da active
- 2010-12-15 MA MA35063A patent/MA33922B1/fr unknown
- 2010-12-15 GE GEAP201012785A patent/GEP20156241B/en unknown
- 2010-12-15 CN CN201080063808.4A patent/CN102741250B/zh not_active Expired - Fee Related
- 2010-12-15 NZ NZ600260A patent/NZ600260A/en not_active IP Right Cessation
- 2010-12-15 EP EP10798255.5A patent/EP2513107B1/fr active Active
- 2010-12-15 ES ES10798255.5T patent/ES2514647T3/es active Active
- 2010-12-15 MY MYPI2012002598A patent/MY158197A/en unknown
- 2010-12-15 PH PH1/2012/501201A patent/PH12012501201A1/en unknown
- 2010-12-15 JP JP2012543475A patent/JP5901535B2/ja not_active Expired - Fee Related
- 2010-12-15 SI SI201030765T patent/SI2513107T1/sl unknown
- 2010-12-15 US US13/513,867 patent/US9096589B2/en not_active Expired - Fee Related
- 2010-12-16 AR ARP100104668A patent/AR079495A1/es unknown
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2012
- 2012-05-29 TN TNP2012000271A patent/TN2012000271A1/en unknown
- 2012-05-31 GT GT201200171A patent/GT201200171A/es unknown
- 2012-06-12 IL IL220327A patent/IL220327A/en not_active IP Right Cessation
- 2012-06-12 CR CR20120319A patent/CR20120319A/es unknown
- 2012-06-13 CO CO12099152A patent/CO6612245A2/es active IP Right Grant
- 2012-06-14 DO DO2012000165A patent/DOP2012000165A/es unknown
- 2012-06-15 ZA ZA2012/04419A patent/ZA201204419B/en unknown
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2014
- 2014-09-26 CY CY20141100789T patent/CY1115843T1/el unknown
- 2014-10-29 SM SM201400158T patent/SMT201400158B/xx unknown
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2015
- 2015-06-25 US US14/749,754 patent/US9669029B2/en not_active Expired - Fee Related
Also Published As
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