PE20090210A1 - Compuestos derivados de pirazolo pirimidina como inhibidores de jak quinasa - Google Patents
Compuestos derivados de pirazolo pirimidina como inhibidores de jak quinasaInfo
- Publication number
- PE20090210A1 PE20090210A1 PE2008000710A PE2008000710A PE20090210A1 PE 20090210 A1 PE20090210 A1 PE 20090210A1 PE 2008000710 A PE2008000710 A PE 2008000710A PE 2008000710 A PE2008000710 A PE 2008000710A PE 20090210 A1 PE20090210 A1 PE 20090210A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- carbocyclyl
- jak
- pyrimidin
- fluoro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
SE REFIERE A COMPUESTOS DE FORMULA I, DONDE; EL ANILLO A ES FENILO Y HETEROCICLILO DE 6 MIEMBROS; X ES -NH-, -O-, -S-; R1 ES H, -CN, (C1-C6)ALQUILO, CARBOCICLILO DE 3 A 5 MIEMBROS, -N(R1a)C(O)R1b, ENTRE OTROS; R1a ES (C1-C6)ALQUILO, CARBOCICLILO DE 3 A 5 MIEMBROS, ENTRE OTROS; R1b ES (C2-C6)ALQUENILO, HETEROCICLILO DE 5 MIEMBROS, (C1-C6)ALQUILO, ENTRE OTROS; R2 ES HALO, (C2-C6)ALQUENILO, -OC(O)N(R2a)2, ENTRE OTROS; R2a ES H, (C1-C6)ALQUILO, CARBOCICLILO, ENTRE OTROS; R2 ES-CN, -OR2a, -N(R2a)N(R2a)2, ENTRE OTROS; R3 ES HALO, (C1-C6)ALQUILO, C(R3a)=N(OR3a), ENTRE OTROS; R3a ES H, (C1-C6)ALQUILO, CARBOCICLILO, ENTRE OTROS; R4 ES (C1-C6)ALQUILO, -NO2, -N(R4a)C(O)N(R4a)2; R4a ES (C1-C6)ALQUILO, CARBOCICLILO, H, ENTRE OTROS. SON SELECCIONADOS 5-FLUORO-N4-[(S)-1-(5-FLUORO-PIRIMIDIN-2-IL)-ETIL]-N2-(5-METOXI-1H-PIRAZOL-3-IL)-6-MORFOLIN-4-IL-PIRIMIDIN-2,4-DIAMINA, 1-(5-FLUORO-6-(1-(5-FLUOROPIRIMIDIN-2-IL)ETOXI)-2-(5-METIL-1H-PIRAZOL-3-ILAMINO)PIRIMIDIN-4-IL)PIPERIDIN-4-CARBONITRILO, ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCESO DE PREPARACION Y COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS TIENEN ACTIVIDAD INHIBIDORA JAK QUINASA Y SON UTILES EN EL TRATAMIENTO DE DESORDENES MIELOPROLIFERATIVOS Y CANCER
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US91401707P | 2007-04-25 | 2007-04-25 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20090210A1 true PE20090210A1 (es) | 2009-04-01 |
Family
ID=39618922
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2008000710A PE20090210A1 (es) | 2007-04-25 | 2008-04-25 | Compuestos derivados de pirazolo pirimidina como inhibidores de jak quinasa |
Country Status (5)
Country | Link |
---|---|
AR (1) | AR066147A1 (es) |
PE (1) | PE20090210A1 (es) |
TW (1) | TW200846344A (es) |
UY (1) | UY31048A1 (es) |
WO (1) | WO2008132502A1 (es) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL2576541T3 (pl) | 2010-06-04 | 2016-10-31 | Pochodne aminopirymidyny jako modulatory lrrk2 | |
PL2638031T3 (pl) | 2010-11-10 | 2018-03-30 | Genentech, Inc. | Pirazolowo-aminopirymidynowe pochodne jako modulatory LRRK2 |
ITMI20110472A1 (it) * | 2011-03-24 | 2012-09-25 | Erregierre Spa | Procedimento per la preparazione di zileuton ad elevata purezza |
JP2014521623A (ja) * | 2011-07-28 | 2014-08-28 | セルゾーム リミティッド | Jak阻害剤としてのヘテロシクリルピリミジンアナログ |
EP2554544A1 (en) * | 2011-08-01 | 2013-02-06 | Almirall, S.A. | Pyridin-2(1h)-one derivatives as jak inhibitors |
EP2758389B1 (en) * | 2011-09-22 | 2017-06-07 | Merck Sharp & Dohme Corp. | Pyrazole carboxamides as janus kinase inhibitors |
JP6197031B2 (ja) * | 2012-05-24 | 2017-09-13 | セルゾーム リミティッド | Tyk2阻害剤としてのヘテロシクリルピリミジン類似体 |
KR102455889B1 (ko) | 2012-11-21 | 2022-10-17 | 피티씨 테라퓨틱스, 인크. | 치환된 리버스 피리미딘 bmi-1 저해제 |
CN105683166B (zh) | 2013-08-30 | 2020-06-16 | Ptc医疗公司 | 取代的嘧啶Bmi-1抑制剂 |
EP3071553A4 (en) | 2013-11-21 | 2017-08-02 | PTC Therapeutics, Inc. | Substituted pyridine and pyrazine bmi-1 inhibitors |
CN105254613A (zh) * | 2015-10-08 | 2016-01-20 | 苏州云轩医药科技有限公司 | 具有Wnt信号通路抑制活性的杂环化合物及其应用 |
KR20180061363A (ko) | 2015-10-08 | 2018-06-07 | 쑤저우 운씨엔 이야오 커지 요씨엔 공시 | Wnt 신호 전달 경로 억제제 및 이의 치료적 적용 |
WO2018112843A1 (en) | 2016-12-22 | 2018-06-28 | Merck Sharp & Dohme Corp. | Heteroaryl piperidine ether allosteric modulators of the m4 muscarinic acetylcholine receptor |
CA3104521A1 (en) | 2018-07-05 | 2020-01-09 | Mayo Foundation For Medical Education And Research | Pikfyve inhibitors |
CN113164479A (zh) | 2018-08-17 | 2021-07-23 | Ptc医疗公司 | 用于治疗胰腺癌的方法 |
CN111454214B (zh) * | 2020-05-27 | 2023-04-07 | 龙曦宁(上海)医药科技有限公司 | 一种2-甲氧基1-嘧啶乙胺盐酸盐的合成方法 |
EP4363058A1 (en) * | 2021-07-01 | 2024-05-08 | Aerie Pharmaceuticals, Inc. | Azetidinyl pyrimidines and uses thereof |
WO2024006916A1 (en) * | 2022-06-29 | 2024-01-04 | Aerie Pharmaceuticals, Inc. | Azetidinyl pyrimidines and uses thereof as jak inhibitors |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MY141220A (en) * | 2003-11-17 | 2010-03-31 | Astrazeneca Ab | Pyrazole derivatives as inhibitors of receptor tyrosine kinases |
JP2008540391A (ja) * | 2005-05-05 | 2008-11-20 | アストラゼネカ アクチボラグ | ピラゾリルアミノ置換ピリミジン、および癌の処置におけるそれらの使用 |
WO2006123113A2 (en) * | 2005-05-16 | 2006-11-23 | Astrazeneca Ab | Pyrazolylaminopyrimidine derivatives useful as tyrosine kinase inhibitors |
-
2008
- 2008-04-24 UY UY31048A patent/UY31048A1/es unknown
- 2008-04-24 TW TW097115128A patent/TW200846344A/zh unknown
- 2008-04-24 WO PCT/GB2008/050290 patent/WO2008132502A1/en active Application Filing
- 2008-04-25 AR ARP080101763A patent/AR066147A1/es unknown
- 2008-04-25 PE PE2008000710A patent/PE20090210A1/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
AR066147A1 (es) | 2009-07-29 |
WO2008132502A1 (en) | 2008-11-06 |
TW200846344A (en) | 2008-12-01 |
UY31048A1 (es) | 2008-11-28 |
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Legal Events
Date | Code | Title | Description |
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FA | Abandonment or withdrawal |