TW200846344A - Chemical compounds - Google Patents

Chemical compounds Download PDF

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Publication number
TW200846344A
TW200846344A TW097115128A TW97115128A TW200846344A TW 200846344 A TW200846344 A TW 200846344A TW 097115128 A TW097115128 A TW 097115128A TW 97115128 A TW97115128 A TW 97115128A TW 200846344 A TW200846344 A TW 200846344A
Authority
TW
Taiwan
Prior art keywords
group
alkyl
independently selected
alkynyl
carbocyclyl
Prior art date
Application number
TW097115128A
Other languages
English (en)
Chinese (zh)
Inventor
Hui-Ping Guan
Barry Raymond Hayter
Shan Huang
Stephanos Ioannidis
Jeffrey Johannes
Michelle Lamb
Bo Peng
Bin Yang
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of TW200846344A publication Critical patent/TW200846344A/zh

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
TW097115128A 2007-04-25 2008-04-24 Chemical compounds TW200846344A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US91401707P 2007-04-25 2007-04-25

Publications (1)

Publication Number Publication Date
TW200846344A true TW200846344A (en) 2008-12-01

Family

ID=39618922

Family Applications (1)

Application Number Title Priority Date Filing Date
TW097115128A TW200846344A (en) 2007-04-25 2008-04-24 Chemical compounds

Country Status (5)

Country Link
AR (1) AR066147A1 (es)
PE (1) PE20090210A1 (es)
TW (1) TW200846344A (es)
UY (1) UY31048A1 (es)
WO (1) WO2008132502A1 (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106565673A (zh) * 2015-10-08 2017-04-19 苏州云轩医药科技有限公司 具有Wnt信号通路抑制活性的5‑氟嘧啶杂环化合物及其应用

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101531448B1 (ko) 2010-06-04 2015-06-24 에프. 호프만-라 로슈 아게 Lrrk2 조절제로서의 아미노피리미딘 유도체
US8815882B2 (en) 2010-11-10 2014-08-26 Genentech, Inc. Pyrazole aminopyrimidine derivatives as LRRK2 modulators
ITMI20110472A1 (it) * 2011-03-24 2012-09-25 Erregierre Spa Procedimento per la preparazione di zileuton ad elevata purezza
KR20140047092A (ko) * 2011-07-28 2014-04-21 셀좀 리미티드 Jak 억제제로서의 헤테로시클릴 피리미딘 유사체
EP2554544A1 (en) * 2011-08-01 2013-02-06 Almirall, S.A. Pyridin-2(1h)-one derivatives as jak inhibitors
AU2012312303B2 (en) 2011-09-22 2016-09-15 Merck Sharp & Dohme Corp. Cyanomethylpyrazole carboxamides as janus kinase inhibitors
AU2013265307B2 (en) * 2012-05-24 2016-04-07 Cellzome Limited Heterocyclyl pyrimidine analogues as TYK2 inhibitors
NZ708909A (en) 2012-11-21 2019-11-29 Ptc Therapeutics Inc Substituted reverse pyrimidine bmi-1 inhibitors
EP3039015B1 (en) 2013-08-30 2019-10-30 PTC Therapeutics, Inc. Substituted pyrimidine bmi-1 inhibitors
WO2015076800A1 (en) 2013-11-21 2015-05-28 Ptc Therapeutics, Inc. Substituted pyridine and pyrazine bmi-1 inhibitors
JP6853819B2 (ja) * 2015-10-08 2021-03-31 スーチョウ ユンシュアン イーヤオ カジ ヨウシェン ゴンス Ｗｎｔシグナル伝達経路阻害剤およびその治療用途
WO2018112843A1 (en) * 2016-12-22 2018-06-28 Merck Sharp & Dohme Corp. Heteroaryl piperidine ether allosteric modulators of the m4 muscarinic acetylcholine receptor
US12030896B2 (en) 2018-07-05 2024-07-09 Mayo Foundation For Medical Education And Research PIKfyve inhibitors
CA3109386A1 (en) 2018-08-17 2020-03-19 Ptc Therapeutics, Inc. Use of 5-fluoro-2-(6-fluoro-2-methyl-1h-benzo(d)imidazol-1-yl)-n4-(4-(trifluoromethyl)phenyl)pyrimidine-4,6-diamine in the treatment of pancreatic cancer
CN111454214B (zh) * 2020-05-27 2023-04-07 龙曦宁（上海）医药科技有限公司 一种2-甲氧基1-嘧啶乙胺盐酸盐的合成方法
MX2024000273A (es) * 2021-07-01 2024-01-31 Aerie Pharmaceuticals Inc Azetidinil pirimidinas y usos de las mismas.
US20240002392A1 (en) * 2022-06-29 2024-01-04 Aerie Pharmaceuticals, Inc. Azetidinyl Pyrimidines and Uses Thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY141220A (en) * 2003-11-17 2010-03-31 Astrazeneca Ab Pyrazole derivatives as inhibitors of receptor tyrosine kinases
US20080194606A1 (en) * 2005-05-05 2008-08-14 Astrazeneca Pyrazolyl-Amino-Substituted Pyrimidines and Their Use in the Treatment of Cancer
MX2007014328A (es) * 2005-05-16 2008-02-12 Astrazeneca Ab Compuestos quimicos.

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106565673A (zh) * 2015-10-08 2017-04-19 苏州云轩医药科技有限公司 具有Wnt信号通路抑制活性的5‑氟嘧啶杂环化合物及其应用
CN106565673B (zh) * 2015-10-08 2019-12-06 苏州云轩医药科技有限公司 具有Wnt信号通路抑制活性的5-氟嘧啶杂环化合物及其应用

Also Published As

Publication number Publication date
WO2008132502A1 (en) 2008-11-06
AR066147A1 (es) 2009-07-29
UY31048A1 (es) 2008-11-28
PE20090210A1 (es) 2009-04-01

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