EA201100446A1 - Пиразолопиримидины и их применение для лечения нарушений цнс - Google Patents

Пиразолопиримидины и их применение для лечения нарушений цнс

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Publication number
EA201100446A1
EA201100446A1 EA201100446A EA201100446A EA201100446A1 EA 201100446 A1 EA201100446 A1 EA 201100446A1 EA 201100446 A EA201100446 A EA 201100446A EA 201100446 A EA201100446 A EA 201100446A EA 201100446 A1 EA201100446 A1 EA 201100446A1
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Prior art keywords
group
cycloalkyl
cycloalkenyl
compounds
representatives
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EA201100446A
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English (en)
Inventor
Клаус Фукс
Корнелиа Дорнер-Циоссек
Кристиан Айкмайер
Деннис Фиген
Томас Фокс
Риккардо Джованнини
Никлас Хайне
Мартин Хендрикс
Хольгер Розенброк
Герхард Шэнцле
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Бёрингер Ингельхайм Интернациональ Гмбх
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Application filed by Бёрингер Ингельхайм Интернациональ Гмбх filed Critical Бёрингер Ингельхайм Интернациональ Гмбх
Publication of EA201100446A1 publication Critical patent/EA201100446A1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
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  • Psychology (AREA)
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  • Gynecology & Obstetrics (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Vascular Medicine (AREA)
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  • Pregnancy & Childbirth (AREA)
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Abstract

В заявке описаны новые циклоалкил- или циклоалкенилзамещенные пиразолопиримидиноны формулы (I)в которой А выбран из группы А, включающей С-С-циклоалкильную группу или С-С-циклоалкенильную группу, где представители С-С-циклоалкильной группы выбраны из группы, включающей циклопропил, циклобутил, циклопентил, циклогексил, циклогептанил и циклооктанил; и представители С-С-циклоалкенильной группы выбраны из группы, включающей циклобутенил, циклопентенил, циклогексенил, циклогептенил, циклооктенил, циклопентадиенил, циклогексадиенил, циклогептадиенил, циклооктадиенил, циклогептатриенил, циклооктатриенил, циклооктатетраенил. Эти новые соединения можно использовать для приготовления лекарственных средств, в частности лекарственных средств, предназначенных для улучшения восприятия, сосредоточенности, способности к обучению и/или памяти у нуждающихся в нем пациентов. С химической точки зрения эти соединения представляют собой пиразолопиримидиноны с циклоалкильным фрагментом, присоединенным в положении 1 пиразолопиримидинона, и вторым заместителем, находящимся в положении 6, который присоединен с помощью необязательно замещенного метиленового мостика. Другими объектами настоящего изобретения являются способ получения соединений и их применение для приготовления лекарственных средств.
EA201100446A 2008-09-08 2009-09-04 Пиразолопиримидины и их применение для лечения нарушений цнс EA201100446A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08163879 2008-09-08
EP09167675 2009-08-12
PCT/EP2009/061455 WO2010026214A1 (en) 2008-09-08 2009-09-04 Pyrazolopyrimidines and their use for the treatment of cns disorders

Publications (1)

Publication Number Publication Date
EA201100446A1 true EA201100446A1 (ru) 2011-10-31

Family

ID=41651170

Family Applications (1)

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EA201100446A EA201100446A1 (ru) 2008-09-08 2009-09-04 Пиразолопиримидины и их применение для лечения нарушений цнс

Country Status (23)

Country Link
US (1) US9079905B2 (ru)
EP (1) EP2334684B1 (ru)
JP (1) JP5453431B2 (ru)
KR (1) KR20110063447A (ru)
CN (1) CN102143965A (ru)
AP (1) AP2011005672A0 (ru)
AR (1) AR073500A1 (ru)
AU (1) AU2009289240A1 (ru)
BR (1) BRPI0918527A2 (ru)
CA (1) CA2736304A1 (ru)
CL (1) CL2011000488A1 (ru)
CO (1) CO6351731A2 (ru)
EA (1) EA201100446A1 (ru)
EC (1) ECSP11010866A (ru)
IL (1) IL210854A0 (ru)
MA (1) MA32620B1 (ru)
MX (1) MX2011002340A (ru)
NZ (1) NZ590788A (ru)
PE (1) PE20110383A1 (ru)
TW (1) TW201014859A (ru)
UY (1) UY32092A (ru)
WO (1) WO2010026214A1 (ru)
ZA (1) ZA201100482B (ru)

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