EA200801773A1 - Глюкопиранозилзамещенные производные бензонитрила, фармацевтические композиции, содержащие такие соединения, их применение и способ их получения - Google Patents

Глюкопиранозилзамещенные производные бензонитрила, фармацевтические композиции, содержащие такие соединения, их применение и способ их получения

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EA200801773A1
EA200801773A1 EA200801773A EA200801773A EA200801773A1 EA 200801773 A1 EA200801773 A1 EA 200801773A1 EA 200801773 A EA200801773 A EA 200801773A EA 200801773 A EA200801773 A EA 200801773A EA 200801773 A1 EA200801773 A1 EA 200801773A1
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EA
Eurasian Patent Office
Prior art keywords
hydroxy
group
yloxy
butyl
alkyl
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EA200801773A
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English (en)
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Маттиас Эккхардт
Петер Айкельманн
Франк Химмельсбах
Ахим Зауер
Лео Томас
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Бёрингер Ингельхайм Интернациональ Гмбх
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Publication of EA200801773A1 publication Critical patent/EA200801773A1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/04—Carbocyclic radicals

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

В заявке описаны глюкопиранозилзамещенные производные бензонитрила формулы (I), в которой Rобозначает водород, фтор, хлор, бром, йод, метил, этил, пропил, изопропил, бутил, втор-бутил, изобутил, трет-бутил, 3-метилбут-1-ил, циклопропил, циклобутил, циклопентил, циклогексил, дифторметил, трифторметил, пентафторэтил, 2-гидроксиэтил, гидроксиметил, 3-гидроксипропил, 2-гидрокси-2-метилпроп-1-ил, 3-гидрокси-3-метилбут-1-ил, 1-гидрокси-1-метилэтил, 2,2,2-трифтор-1-гидрокси-1-метилэтил, 2,2,2-трифтор-1-гидрокси-1-трифторметилэтил, 2-метоксиэтил, 2-этоксиэтил, гидроксигруппу, метилоксигруппу, этилоксигруппу, изопропилоксигруппу, дифторметилоксигруппу, трифторметилоксигруппу, циклобутилоксигруппу, циклопентилоксигруппу, циклогексилоксигруппу, (S)-тетрагидрофуран-3-илоксигруппу, (R)-тетрагидрофуран-3-илоксигруппу, тетрагидропиран-4-илоксигруппу, 1-ацетилпиперидин-4-илоксигруппу, 2-метилоксиэтилоксигруппу, метилсульфанил, метилсульфинил, метилсульфонил, этилсульфинил, этилсульфонил, триметилсилил или цианогруппу, или его производное, в котором одна или большее количество гидроксигрупп β-D-глюкопиранозильной группы ацилированы группами, выбранными из группы, включающей (С-С-алкил)карбонил, (С-С-алкил)оксикарбонил, фенилкарбонил и фенил-(С-С-алкил)карбонил; включая их таутомеры, стереоизомеры и их смеси; и их физиологически приемлемые соли. Соединения, предлагаемые в настоящем изобретении, применимы для лечения или предупреждения метаболических нарушений.
EA200801773A 2006-02-15 2007-02-14 Глюкопиранозилзамещенные производные бензонитрила, фармацевтические композиции, содержащие такие соединения, их применение и способ их получения EA200801773A1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP06101711 2006-02-15
EP06113412 2006-05-03
EP06124833 2006-11-27
PCT/EP2007/051411 WO2007093610A1 (en) 2006-02-15 2007-02-14 Glucopyranosyl-substituted benzonitrile derivatives, pharmaceutical compositions containing such compounds, their use and process for their manufacture

Publications (1)

Publication Number Publication Date
EA200801773A1 true EA200801773A1 (ru) 2009-02-27

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Family Applications (1)

Application Number Title Priority Date Filing Date
EA200801773A EA200801773A1 (ru) 2006-02-15 2007-02-14 Глюкопиранозилзамещенные производные бензонитрила, фармацевтические композиции, содержащие такие соединения, их применение и способ их получения

Country Status (15)

Country Link
US (1) US7745414B2 (ru)
EP (1) EP1989191B1 (ru)
JP (1) JP2009531291A (ru)
KR (1) KR20080102395A (ru)
AR (1) AR059489A1 (ru)
AT (1) ATE517099T1 (ru)
AU (1) AU2007216452A1 (ru)
BR (1) BRPI0707849A2 (ru)
CA (1) CA2635838A1 (ru)
EA (1) EA200801773A1 (ru)
EC (1) ECSP088605A (ru)
IL (1) IL193385A0 (ru)
NO (1) NO20082649L (ru)
TW (1) TW200801029A (ru)
WO (1) WO2007093610A1 (ru)

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KR20080102395A (ko) 2008-11-25
ATE517099T1 (de) 2011-08-15
NO20082649L (no) 2008-09-09
AU2007216452A1 (en) 2007-08-23
US20080058379A1 (en) 2008-03-06
CA2635838A1 (en) 2007-08-23
TW200801029A (en) 2008-01-01
US7745414B2 (en) 2010-06-29
EP1989191B1 (en) 2011-07-20
JP2009531291A (ja) 2009-09-03
BRPI0707849A2 (pt) 2011-05-10
IL193385A0 (en) 2009-05-04
WO2007093610A1 (en) 2007-08-23
ECSP088605A (es) 2008-08-29
AR059489A1 (es) 2008-04-09

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