RU2012137245A - Индуктор считывания и терапевтический агент для генетических заболеваний, вызванных мутациями типа нонсенс-мутаций - Google Patents
Индуктор считывания и терапевтический агент для генетических заболеваний, вызванных мутациями типа нонсенс-мутаций Download PDFInfo
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- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
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- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
- C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
- C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
- C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
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Abstract
1. Индуктор считывания для индукции считывания преждевременного стоп-кодона, образовавшегося вследствие нонсенс-мутаций, где индуктор считывания включает:соединение, имеющее структуру, отображаемую следующей структурной формулой (A):2. Лекарственное средство для лечения генетического заболевания, вызванного нонсенс-мутациями, где лекарственное средство включаетиндуктор считывания по п.1.3. Лекарственное средство по п.2, где генетическое заболевание, вызванное нонсенс-мутациями, представляет собой мышечную дистрофию.
Claims (3)
1. Индуктор считывания для индукции считывания преждевременного стоп-кодона, образовавшегося вследствие нонсенс-мутаций, где индуктор считывания включает:
соединение, имеющее структуру, отображаемую следующей структурной формулой (A):
2. Лекарственное средство для лечения генетического заболевания, вызванного нонсенс-мутациями, где лекарственное средство включает
индуктор считывания по п.1.
3. Лекарственное средство по п.2, где генетическое заболевание, вызванное нонсенс-мутациями, представляет собой мышечную дистрофию.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010-021817 | 2010-02-03 | ||
| JP2010021817 | 2010-02-03 | ||
| PCT/JP2011/052263 WO2011096484A1 (ja) | 2010-02-03 | 2011-02-03 | リードスルー誘導剤、及びナンセンス変異型遺伝性疾患治療薬 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2012137245A true RU2012137245A (ru) | 2014-03-10 |
| RU2571060C2 RU2571060C2 (ru) | 2015-12-20 |
Family
ID=44355477
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2012137245/15A RU2571060C2 (ru) | 2010-02-03 | 2011-02-03 | Индуктор считывания и терапевтический агент для генетических заболеваний, вызванных мутациями типа нонсенс-мутаций |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US20130005953A1 (ru) |
| EP (1) | EP2535051B1 (ru) |
| JP (1) | JP5705136B2 (ru) |
| KR (1) | KR20120123509A (ru) |
| CN (1) | CN102740860B (ru) |
| AU (1) | AU2011211744B2 (ru) |
| BR (1) | BR112012019515A2 (ru) |
| CA (1) | CA2788730A1 (ru) |
| IL (1) | IL221251A0 (ru) |
| MX (1) | MX2012009028A (ru) |
| RU (1) | RU2571060C2 (ru) |
| WO (1) | WO2011096484A1 (ru) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101703137B1 (ko) | 2014-05-30 | 2017-02-07 | 선문대학교 산학협력단 | 당 부가 아미노글리코사이드 화합물, 이의 제조방법 및 이를 유효성분으로 함유하는 약학적 조성물 |
| CN108014110A (zh) * | 2016-11-03 | 2018-05-11 | 武汉科技大学 | 灭瘟素的无义突变通读活性用途 |
| US20180315708A1 (en) * | 2017-05-01 | 2018-11-01 | Globalfoundries Inc. | Power rail and mol constructs for fdsoi |
| EP3688837A4 (en) * | 2017-09-25 | 2021-06-02 | Antwave Intellectual Property Limited | SYSTEMS, DEVICES, AND METHODS FOR IMPROVING ANTENNA PERFORMANCE IN ELECTRONIC DEVICES |
| WO2021182517A1 (ja) | 2020-03-11 | 2021-09-16 | 隆光 矢野 | －１フレームシフトを誘導するための１本鎖核酸分子及び組成物 |
| KR102517522B1 (ko) | 2020-12-28 | 2023-04-03 | 고려대학교 산학협력단 | 2-데옥시-스킬로이노사민을 포함하는 아미노사이클리톨 화합물, 이의 제조방법 및 이를 함유하는 약학 조성물 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5488038A (en) * | 1992-11-27 | 1996-01-30 | Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai | Dibekacin derivatives and arbekacin derivatives active against resistant bacteria |
| US7749971B2 (en) | 2001-02-20 | 2010-07-06 | Bedwell David M | Aminoglycoside treatment for lysosomal storage diseases |
| EP1402889A1 (en) | 2001-06-13 | 2004-03-31 | Masayuki Arakawa | Remedies for diseases caused by nonsense mutation |
| GB0600948D0 (en) | 2006-01-18 | 2006-02-22 | Univ Dundee | Prevention/Treatment Of Ichthyosis Vulgaris, Atopy And Other Disorders |
| PT2390255T (pt) * | 2006-04-03 | 2016-10-24 | Technion Res & Dev Foundation | Novos aminoglicosídeos e utilizações destes no tratamento de distúrbios genéticos |
| CN1843330A (zh) * | 2006-05-24 | 2006-10-11 | 山东蓝金生物工程有限公司 | 一种含氨基糖苷类抗菌素的缓释剂及其应用 |
| RU2316590C1 (ru) * | 2006-06-16 | 2008-02-10 | Институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова Российской академии наук | РЕКОМБИНАНТНАЯ ПЛАЗМИДНАЯ ДНК pE-His8-TrxL-Ar2, КОДИРУЮЩАЯ ГИБРИДНЫЙ БЕЛОК, СОДЕРЖАЩИЙ АНТИМИКРОБНЫЙ ПЕПТИД АРЕНИЦИН МОРСКОГО КОЛЬЧАТОГО ЧЕРВЯ Arenicola marina, И ШТАММ Escherichia coli BL21(DE3)/pE-His8-TrxL-Ar2 - ПРОДУЦЕНТ ГИБРИДНОГО БЕЛКА, СОДЕРЖАЩЕГО АРЕНИЦИН |
| WO2008004610A1 (fr) * | 2006-07-05 | 2008-01-10 | The University Of Tokyo | Méthode de traitement de maladie génétique provoquée par une mutation non sens |
| CA2661195A1 (en) * | 2006-08-21 | 2008-02-28 | Next21 K.K. | Bone model, bone filler and process for producing bone filler |
| CN101129383B (zh) * | 2006-08-25 | 2014-04-02 | 天津和美生物技术有限公司 | 含氨基糖苷类抗生素的抗生素复方 |
| JP5061345B2 (ja) * | 2006-09-26 | 2012-10-31 | 国立大学法人山口大学 | 薬剤耐性病原性微生物の薬剤感受性増強方法、および高度薬剤耐性菌の出現予防方法 |
| JP2008161075A (ja) * | 2006-12-27 | 2008-07-17 | Shizuoka Prefecture | タカアシガニ幼体の飼育方法及びその方法により飼育されたタカアシガニ幼体 |
| CA2685540C (en) * | 2007-08-03 | 2018-10-16 | Graham Michael Wynne | Drug combinations for the treatment of duchenne muscular dystrophy |
| JP2009095436A (ja) * | 2007-10-16 | 2009-05-07 | Toray Ind Inc | 血液製剤浄化用材料および該材料を用いた浄化方法および浄化物 |
| JP5059045B2 (ja) * | 2008-03-28 | 2012-10-24 | 三井造船株式会社 | βラクタム系抗生物質含有水の処理方法 |
-
2011
- 2011-02-03 KR KR1020127022832A patent/KR20120123509A/ko not_active Application Discontinuation
- 2011-02-03 CA CA2788730A patent/CA2788730A1/en not_active Abandoned
- 2011-02-03 RU RU2012137245/15A patent/RU2571060C2/ru not_active IP Right Cessation
- 2011-02-03 WO PCT/JP2011/052263 patent/WO2011096484A1/ja active Application Filing
- 2011-02-03 MX MX2012009028A patent/MX2012009028A/es not_active Application Discontinuation
- 2011-02-03 BR BR112012019515-8A patent/BR112012019515A2/pt not_active IP Right Cessation
- 2011-02-03 CN CN201180008253.8A patent/CN102740860B/zh not_active Expired - Fee Related
- 2011-02-03 AU AU2011211744A patent/AU2011211744B2/en not_active Ceased
- 2011-02-03 JP JP2011552822A patent/JP5705136B2/ja not_active Expired - Fee Related
- 2011-02-03 EP EP11739832.1A patent/EP2535051B1/en not_active Not-in-force
-
2012
- 2012-08-01 US US13/563,872 patent/US20130005953A1/en not_active Abandoned
- 2012-08-01 IL IL221251A patent/IL221251A0/en unknown
-
2014
- 2014-09-15 US US14/486,321 patent/US9358246B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US9358246B2 (en) | 2016-06-07 |
| KR20120123509A (ko) | 2012-11-08 |
| CN102740860B (zh) | 2014-11-19 |
| JP5705136B2 (ja) | 2015-04-22 |
| RU2571060C2 (ru) | 2015-12-20 |
| AU2011211744B2 (en) | 2015-06-18 |
| CN102740860A (zh) | 2012-10-17 |
| EP2535051A4 (en) | 2013-09-11 |
| BR112012019515A2 (pt) | 2018-03-13 |
| AU2011211744A1 (en) | 2012-08-23 |
| IL221251A0 (en) | 2012-10-31 |
| US20130005953A1 (en) | 2013-01-03 |
| MX2012009028A (es) | 2012-10-15 |
| EP2535051B1 (en) | 2016-04-20 |
| EP2535051A1 (en) | 2012-12-19 |
| US20150005249A1 (en) | 2015-01-01 |
| WO2011096484A1 (ja) | 2011-08-11 |
| CA2788730A1 (en) | 2011-08-11 |
| JPWO2011096484A1 (ja) | 2013-06-13 |
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