PT2390255T - Novos aminoglicosídeos e utilizações destes no tratamento de distúrbios genéticos - Google Patents

Novos aminoglicosídeos e utilizações destes no tratamento de distúrbios genéticos

Info

Publication number
PT2390255T
PT2390255T PT111739587T PT11173958T PT2390255T PT 2390255 T PT2390255 T PT 2390255T PT 111739587 T PT111739587 T PT 111739587T PT 11173958 T PT11173958 T PT 11173958T PT 2390255 T PT2390255 T PT 2390255T
Authority
PT
Portugal
Prior art keywords
treatment
genetic disorders
novel aminoglycosides
aminoglycosides
novel
Prior art date
Application number
PT111739587T
Other languages
English (en)
Inventor
Baasov Timor
Ben-Yosef Tamar
Nudelman Igor
Rebibo-Sabbah Annie
Shallom-Shezifi Dalia
Hainrichson Mariana
Original Assignee
Technion Res & Dev Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Technion Res & Dev Foundation filed Critical Technion Res & Dev Foundation
Publication of PT2390255T publication Critical patent/PT2390255T/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D25/00—Details of other kinds or types of rigid or semi-rigid containers
    • B65D25/20—External fittings
    • B65D25/205—Means for the attachment of labels, cards, coupons or the like
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
    • C07H5/06—Aminosugars

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Physiology (AREA)
  • Mechanical Engineering (AREA)
  • Nutrition Science (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PT111739587T 2006-04-03 2007-04-10 Novos aminoglicosídeos e utilizações destes no tratamento de distúrbios genéticos PT2390255T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US78807006P 2006-04-03 2006-04-03

Publications (1)

Publication Number Publication Date
PT2390255T true PT2390255T (pt) 2016-10-24

Family

ID=38353813

Family Applications (1)

Application Number Title Priority Date Filing Date
PT111739587T PT2390255T (pt) 2006-04-03 2007-04-10 Novos aminoglicosídeos e utilizações destes no tratamento de distúrbios genéticos

Country Status (13)

Country Link
US (4) US9073958B2 (pt)
EP (3) EP2390255B1 (pt)
JP (1) JP5345928B2 (pt)
CA (1) CA2646407C (pt)
CY (1) CY1118065T1 (pt)
DK (1) DK2390255T3 (pt)
ES (2) ES2689539T3 (pt)
HU (1) HUE031643T2 (pt)
LT (1) LT2390255T (pt)
PL (1) PL2390255T3 (pt)
PT (1) PT2390255T (pt)
SI (1) SI2390255T1 (pt)
WO (1) WO2007113841A2 (pt)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT2390255T (lt) 2006-04-03 2016-10-25 Technion Research & Development Foundation Ltd. Nauji aminoglikozidai ir jų panaudojimas genetinių sutrikimų gydyme
US8765698B2 (en) * 2010-02-03 2014-07-01 University Of Central Florida Research Foundation, Inc. Methods and products for reawakening retrocyclins
RU2571060C2 (ru) 2010-02-03 2015-12-20 Майкробайл Кемистри Рисерч Фаундейшн Индуктор считывания и терапевтический агент для генетических заболеваний, вызванных мутациями типа нонсенс-мутаций
WO2012021707A2 (en) * 2010-08-11 2012-02-16 The Regents Of The University Of California Premature-termination-codons readthrough compounds
ES2833938T3 (es) 2010-11-18 2021-06-16 Technion Res & Dev Foundation Aminoglucósidos y usos de los mismos en el tratamiento de trastornos genéticos
AU2012204336C1 (en) 2011-01-05 2017-08-03 National Taiwan University Methods for preparation of glycosphingolipids and uses thereof
AU2013358591B2 (en) 2012-12-13 2016-08-25 Novartis Ag Pyrimido [4,5-b]quinoline-4,5 (3H,10H)-diones as nonsense mutation suppressors
CN106459041B (zh) 2014-06-03 2018-10-16 诺华股份有限公司 嘧啶并[4,5-b]喹啉-4,5(3H,10H)-二酮衍生物
CN106414443B (zh) 2014-06-03 2018-10-26 诺华股份有限公司 吡啶并嘧啶二酮衍生物
JP6343034B2 (ja) 2014-06-03 2018-06-13 ノバルティス アーゲー ナフチリジンジオン誘導体
US20170360817A1 (en) * 2014-06-05 2017-12-21 Eloxx Pharmaceuticals Ltd. Use of aminoglycoside analogs in the treatment of rett syndrome
WO2016196927A1 (en) * 2015-06-05 2016-12-08 Ptc Therapeutics, Inc. Use of an aminoglycoside for nonsense mutation suppression and the treatment of disease
EP3344640A4 (en) * 2015-09-02 2019-05-01 Eloxx Pharmaceuticals Ltd. AMINO-LIKES DERIVATIVES AND USES THEREOF FOR THE TREATMENT OF GENETIC DISEASES
US10786520B2 (en) 2015-09-02 2020-09-29 Eloxx Pharmaceuticals Ltd. Aminoglycoside derivatives and uses thereof in treating genetic disorders
JP6862428B6 (ja) * 2015-09-02 2021-06-02 エロックス ファーマシューティカルズ リミテッド アミノグリコシド誘導体および遺伝性疾患の治療におけるその使用
EP3400231A4 (en) * 2016-01-05 2019-10-09 Technion Research & Development Foundation Limited AMINOGLYCOSIDE DERIVATIVES AND USES THEREOF IN THE TREATMENT OF MICROBIAL INFECTIONS
EP3400232A4 (en) * 2016-01-05 2019-10-16 Eloxx Pharmaceuticals Ltd. AMINO-L-KOSIDE DERIVATIVES AND USES THEREOF FOR THE TREATMENT OF GENETIC DISEASES
EP3442512A4 (en) * 2016-04-15 2020-07-22 The UAB Research Foundation METHODS AND COMPOUNDS FOR STIMULATING THE TRANSLECTURE OF PREMATURE TERMINATION CODONS
US11136345B2 (en) 2017-03-15 2021-10-05 Eloxx Pharmaceuticals Ltd. Large scale preparation of pseudo-trisaccharide aminoglycosides and of intermediates thereof
WO2018204358A1 (en) * 2017-05-01 2018-11-08 Wayne State University Apramycin derivatives
CN108358983A (zh) * 2018-04-11 2018-08-03 常州方圆制药有限公司 一种侧链酰胺衍生化合成阿贝卡星的方法
CN108358982A (zh) * 2018-04-11 2018-08-03 常州方圆制药有限公司 一种硫酸阿贝卡星游离碱的分离提纯方法

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US3897412A (en) * 1972-05-04 1975-07-29 Bristol Myers Co Paromomycin antibiotic derivatives
LU70223A1 (pt) * 1973-06-05 1976-04-13
US4029882A (en) * 1974-03-19 1977-06-14 Schering Corporation Selective acylation of the C-1 amino group of aminoglycoside antibiotics
AR207582A1 (es) 1974-03-19 1976-10-15 Scherico Ltd Procedimiento para preparar derivados de diaminociclitole
NO140426C (no) * 1974-03-19 1979-08-29 Scherico Ltd Analogifremgangsmaate ved fremstilling av antibiotisk aktive derivater av aminocyclitoler
US3996205A (en) * 1975-09-08 1976-12-07 The Upjohn Company Aminoglycoside antibiotics and intermediates
FR2427341A1 (fr) * 1978-06-02 1979-12-28 Delalande Sa Nouveaux derives aminoglycosidiques hemisynthetiques, leur procede de preparation et leur application en therapeutique
JPH0446189A (ja) * 1990-06-08 1992-02-17 Meiji Seika Kaisha Ltd 新規なリボスタマイシン誘導体
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JP4629192B2 (ja) * 2000-07-07 2011-02-09 富士通セミコンダクター株式会社 トリミング回路、調整回路及び半導体装置
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KR100450864B1 (ko) * 2001-11-23 2004-10-01 한국과학기술연구원 Ｒｎａ 표적 분자에 대해 특이성이 향상된네오마이신-클로람페니콜 헤테로 이합체 및 그의 제조방법
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WO2005002498A2 (en) * 2003-07-01 2005-01-13 Yissum Research Development Company Of The Hebrew University Of Jerusalem Methods of treating disorders caused by formation of transcripts carrying nonsense mutations
US20050004052A1 (en) * 2003-07-03 2005-01-06 Technion Research & Development Foundation Ltd. Bifunctional antibiotics for targeting rRNA and resistance-causing enzymes
AU2005288519A1 (en) * 2004-09-27 2006-04-06 Technion Research & Development Foundation Ltd. Fatty acid modified polylysines as antimicrobial agents
LT2390255T (lt) 2006-04-03 2016-10-25 Technion Research & Development Foundation Ltd. Nauji aminoglikozidai ir jų panaudojimas genetinių sutrikimų gydyme

Also Published As

Publication number Publication date
US20180064743A1 (en) 2018-03-08
WO2007113841A2 (en) 2007-10-11
CA2646407C (en) 2015-08-18
JP2009532461A (ja) 2009-09-10
US9821001B2 (en) 2017-11-21
US20090093418A1 (en) 2009-04-09
HUE031643T2 (en) 2017-07-28
ES2689539T3 (es) 2018-11-14
US20150352136A1 (en) 2015-12-10
EP3421481A1 (en) 2019-01-02
US20190060340A1 (en) 2019-02-28
LT2390255T (lt) 2016-10-25
EP2007783A2 (en) 2008-12-31
US10159689B2 (en) 2018-12-25
SI2390255T1 (sl) 2016-12-30
US9073958B2 (en) 2015-07-07
EP2390255A1 (en) 2011-11-30
DK2390255T3 (en) 2016-11-07
EP2390255B1 (en) 2016-07-13
PL2390255T3 (pl) 2017-01-31
ES2594343T3 (es) 2016-12-19
WO2007113841A3 (en) 2007-11-29
JP5345928B2 (ja) 2013-11-20
EP2007783B1 (en) 2018-07-11
CY1118065T1 (el) 2017-06-28
CA2646407A1 (en) 2007-10-11

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