SI2390255T1 - Novi aminoglikozidi in njihove uporabe pri zdravljenju genetskih motenj - Google Patents
Novi aminoglikozidi in njihove uporabe pri zdravljenju genetskih motenjInfo
- Publication number
- SI2390255T1 SI2390255T1 SI200731844A SI200731844A SI2390255T1 SI 2390255 T1 SI2390255 T1 SI 2390255T1 SI 200731844 A SI200731844 A SI 200731844A SI 200731844 A SI200731844 A SI 200731844A SI 2390255 T1 SI2390255 T1 SI 2390255T1
- Authority
- SI
- Slovenia
- Prior art keywords
- treatment
- genetic disorders
- novel aminoglycosides
- aminoglycosides
- novel
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D25/00—Details of other kinds or types of rigid or semi-rigid containers
- B65D25/20—External fittings
- B65D25/205—Means for the attachment of labels, cards, coupons or the like
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
- C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
- C07H5/06—Aminosugars
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Mechanical Engineering (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US78807006P | 2006-04-03 | 2006-04-03 | |
EP11173958.7A EP2390255B1 (en) | 2006-04-03 | 2007-04-10 | Novel aminoglycosides and uses thereof in the treatment of genetic disorders |
Publications (1)
Publication Number | Publication Date |
---|---|
SI2390255T1 true SI2390255T1 (sl) | 2016-12-30 |
Family
ID=38353813
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI200731844A SI2390255T1 (sl) | 2006-04-03 | 2007-04-10 | Novi aminoglikozidi in njihove uporabe pri zdravljenju genetskih motenj |
Country Status (13)
Country | Link |
---|---|
US (4) | US9073958B2 (sl) |
EP (3) | EP2390255B1 (sl) |
JP (1) | JP5345928B2 (sl) |
CA (1) | CA2646407C (sl) |
CY (1) | CY1118065T1 (sl) |
DK (1) | DK2390255T3 (sl) |
ES (2) | ES2689539T3 (sl) |
HU (1) | HUE031643T2 (sl) |
LT (1) | LT2390255T (sl) |
PL (1) | PL2390255T3 (sl) |
PT (1) | PT2390255T (sl) |
SI (1) | SI2390255T1 (sl) |
WO (1) | WO2007113841A2 (sl) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL2390255T3 (pl) | 2006-04-03 | 2017-01-31 | Technion Research & Development Foundation Ltd. | Nowe aminoglikozydy i ich zastosowania w leczeniu zaburzeń genetycznych |
KR20120123509A (ko) * | 2010-02-03 | 2012-11-08 | 도꾜 다이가꾸 | 리드 스루 유도제 및 넌센스 돌연변이형 유전질환의 치료제 |
US8765698B2 (en) * | 2010-02-03 | 2014-07-01 | University Of Central Florida Research Foundation, Inc. | Methods and products for reawakening retrocyclins |
WO2012021707A2 (en) * | 2010-08-11 | 2012-02-16 | The Regents Of The University Of California | Premature-termination-codons readthrough compounds |
EP2640734B1 (en) | 2010-11-18 | 2017-10-18 | Technion Research & Development Foundation Ltd. | Aminoglycosides and uses thereof in treating genetic disorders |
CN103748103A (zh) * | 2011-01-05 | 2014-04-23 | 台湾大学 | 制备鞘糖脂的方法及其应用 |
MX363437B (es) | 2012-12-13 | 2019-03-22 | Novartis Ag | Pirimido-4,5-b]-quinolina-4,5 (3h,10h)-dionas como supresoras de mutacion sin sentido. |
EP3152207B1 (en) | 2014-06-03 | 2019-05-08 | Novartis AG | Pyridopyrimidinedione derivatives as suppressors of non-sens mutations |
PE20170086A1 (es) | 2014-06-03 | 2017-03-17 | Novartis Ag | Derivados de naftiridinadiona |
ES2743184T3 (es) | 2014-06-03 | 2020-02-18 | Novartis Ag | Derivados de pirimido[4,5-b]quinolin-4,5(3H,10H)-diona como supresores de mutaciones finalizadoras |
CA2949754A1 (en) | 2014-06-05 | 2015-12-10 | Eloxx Pharmaceuticals Ltd. | Use of aminoglycoside analogs in the treatment of rett syndrome |
WO2016196927A1 (en) * | 2015-06-05 | 2016-12-08 | Ptc Therapeutics, Inc. | Use of an aminoglycoside for nonsense mutation suppression and the treatment of disease |
JP6862428B6 (ja) * | 2015-09-02 | 2021-06-02 | エロックス ファーマシューティカルズ リミテッド | アミノグリコシド誘導体および遺伝性疾患の治療におけるその使用 |
US11306115B2 (en) | 2015-09-02 | 2022-04-19 | Eloxx Pharmaceuticals Ltd. | Aminoglycoside derivatives and uses thereof in treating genetic disorders |
EP3350194A4 (en) | 2015-09-02 | 2019-04-24 | Eloxx Pharmaceuticals Ltd. | AMINO-LIKES DERIVATIVES AND USES THEREOF FOR THE TREATMENT OF GENETIC DISEASES |
US20190016746A1 (en) * | 2016-01-05 | 2019-01-17 | Eloxx Pharmaceuticals Ltd. | Aminoglycoside derivatives and uses thereof in treating genetic disorders |
WO2017118967A1 (en) * | 2016-01-05 | 2017-07-13 | Technion Research & Development Foundation Limited | Aminoglycoside derivatives and uses thereof in treating microbial infections |
US10960018B2 (en) | 2016-04-15 | 2021-03-30 | The Uab Research Foundation | Methods and compounds for stimulating read-through of premature termination codons |
EP3609902A4 (en) * | 2017-03-15 | 2021-01-06 | Eloxx Pharmaceuticals Ltd. | LARGE-SCALE PREPARATION OF PSEUDO-TRISACCHARIDE AMINOGLYCOSIDES AND INTERMEDIARIES THEREOF |
EP3618835A4 (en) | 2017-05-01 | 2021-03-17 | Wayne State University | APRAMYCIN DERIVATIVES |
CN108358983A (zh) * | 2018-04-11 | 2018-08-03 | 常州方圆制药有限公司 | 一种侧链酰胺衍生化合成阿贝卡星的方法 |
CN108358982A (zh) * | 2018-04-11 | 2018-08-03 | 常州方圆制药有限公司 | 一种硫酸阿贝卡星游离碱的分离提纯方法 |
WO2023120658A1 (ja) | 2021-12-24 | 2023-06-29 | 国立大学法人北陸先端科学技術大学院大学 | 酵素、複合体、組換えベクター、遺伝性疾患治療薬及びポリヌクレオチド |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3897412A (en) * | 1972-05-04 | 1975-07-29 | Bristol Myers Co | Paromomycin antibiotic derivatives |
NL7407483A (sl) * | 1973-06-05 | 1974-12-09 | ||
US4029882A (en) * | 1974-03-19 | 1977-06-14 | Schering Corporation | Selective acylation of the C-1 amino group of aminoglycoside antibiotics |
AR207582A1 (es) | 1974-03-19 | 1976-10-15 | Scherico Ltd | Procedimiento para preparar derivados de diaminociclitole |
ES433990A1 (es) * | 1974-03-19 | 1977-03-01 | Scherico Ltd | Procedimiento para la preparacion de derivados de diaminoci-clitoles. |
US3996205A (en) * | 1975-09-08 | 1976-12-07 | The Upjohn Company | Aminoglycoside antibiotics and intermediates |
FR2427341A1 (fr) * | 1978-06-02 | 1979-12-28 | Delalande Sa | Nouveaux derives aminoglycosidiques hemisynthetiques, leur procede de preparation et leur application en therapeutique |
JPH0446189A (ja) * | 1990-06-08 | 1992-02-17 | Meiji Seika Kaisha Ltd | 新規なリボスタマイシン誘導体 |
US5840702A (en) * | 1996-03-22 | 1998-11-24 | Uab Research Foundation | Cystic fibrosis treatment |
AU5821998A (en) * | 1997-01-13 | 1998-08-03 | Scripps Research Institute, The | Nucleic acid binders having an hydroxyamine motif |
US6403777B1 (en) * | 1999-07-06 | 2002-06-11 | The Ohio State University Research Foundation | Metalloligands for cleaving nucleic acids |
JP4629192B2 (ja) | 2000-07-07 | 2011-02-09 | 富士通セミコンダクター株式会社 | トリミング回路、調整回路及び半導体装置 |
EP1368039A4 (en) * | 2001-02-20 | 2006-03-29 | Uab Research Foundation | AMINOGLYCOSIDE TREATMENT FOR LYSOSOMAL STORAGE DISEASES |
KR100450864B1 (ko) * | 2001-11-23 | 2004-10-01 | 한국과학기술연구원 | Rna 표적 분자에 대해 특이성이 향상된네오마이신-클로람페니콜 헤테로 이합체 및 그의 제조방법 |
US7364905B2 (en) | 2001-11-29 | 2008-04-29 | Techelan, Llc | Apparatus and method for high throughput analysis of compound-membrane interactions |
WO2005000249A2 (en) | 2003-06-27 | 2005-01-06 | Smithkline Beecham Corporation | Preparation of chemical compounds |
WO2005002498A2 (en) * | 2003-07-01 | 2005-01-13 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Methods of treating disorders caused by formation of transcripts carrying nonsense mutations |
US20050004052A1 (en) * | 2003-07-03 | 2005-01-06 | Technion Research & Development Foundation Ltd. | Bifunctional antibiotics for targeting rRNA and resistance-causing enzymes |
EP1793837A2 (en) * | 2004-09-27 | 2007-06-13 | Technion Research & Development Foundation Limited | Fatty acid modified polylysines as antimicrobial agents |
PL2390255T3 (pl) | 2006-04-03 | 2017-01-31 | Technion Research & Development Foundation Ltd. | Nowe aminoglikozydy i ich zastosowania w leczeniu zaburzeń genetycznych |
-
2007
- 2007-04-10 PL PL11173958T patent/PL2390255T3/pl unknown
- 2007-04-10 DK DK11173958.7T patent/DK2390255T3/en active
- 2007-04-10 ES ES07736203.6T patent/ES2689539T3/es active Active
- 2007-04-10 LT LTEP11173958.7T patent/LT2390255T/lt unknown
- 2007-04-10 SI SI200731844A patent/SI2390255T1/sl unknown
- 2007-04-10 HU HUE11173958A patent/HUE031643T2/en unknown
- 2007-04-10 EP EP11173958.7A patent/EP2390255B1/en active Active
- 2007-04-10 CA CA2646407A patent/CA2646407C/en active Active
- 2007-04-10 EP EP07736203.6A patent/EP2007783B1/en active Active
- 2007-04-10 JP JP2009503741A patent/JP5345928B2/ja active Active
- 2007-04-10 WO PCT/IL2007/000463 patent/WO2007113841A2/en active Application Filing
- 2007-04-10 EP EP18182780.9A patent/EP3421481A1/en not_active Withdrawn
- 2007-04-10 PT PT111739587T patent/PT2390255T/pt unknown
- 2007-04-10 ES ES11173958.7T patent/ES2594343T3/es active Active
-
2008
- 2008-10-01 US US12/285,299 patent/US9073958B2/en active Active
-
2015
- 2015-06-14 US US14/738,892 patent/US9821001B2/en active Active
-
2016
- 2016-10-05 CY CY20161100992T patent/CY1118065T1/el unknown
-
2017
- 2017-11-20 US US15/817,412 patent/US10159689B2/en active Active
-
2018
- 2018-11-14 US US16/190,312 patent/US20190060340A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
CA2646407C (en) | 2015-08-18 |
LT2390255T (lt) | 2016-10-25 |
CY1118065T1 (el) | 2017-06-28 |
ES2594343T3 (es) | 2016-12-19 |
DK2390255T3 (en) | 2016-11-07 |
PL2390255T3 (pl) | 2017-01-31 |
CA2646407A1 (en) | 2007-10-11 |
US20180064743A1 (en) | 2018-03-08 |
JP2009532461A (ja) | 2009-09-10 |
HUE031643T2 (en) | 2017-07-28 |
EP2007783A2 (en) | 2008-12-31 |
EP2007783B1 (en) | 2018-07-11 |
WO2007113841A3 (en) | 2007-11-29 |
US20190060340A1 (en) | 2019-02-28 |
US20150352136A1 (en) | 2015-12-10 |
US10159689B2 (en) | 2018-12-25 |
EP2390255A1 (en) | 2011-11-30 |
US9073958B2 (en) | 2015-07-07 |
EP2390255B1 (en) | 2016-07-13 |
PT2390255T (pt) | 2016-10-24 |
JP5345928B2 (ja) | 2013-11-20 |
EP3421481A1 (en) | 2019-01-02 |
WO2007113841A2 (en) | 2007-10-11 |
US20090093418A1 (en) | 2009-04-09 |
ES2689539T3 (es) | 2018-11-14 |
US9821001B2 (en) | 2017-11-21 |
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