CY1118065T1 - Καινοτομες αμινογλυκοσιδες και χρησεις αυτων στη θεραπεια γενετικων διαταραχων - Google Patents

Καινοτομες αμινογλυκοσιδες και χρησεις αυτων στη θεραπεια γενετικων διαταραχων

Info

Publication number
CY1118065T1
CY1118065T1 CY20161100992T CY161100992T CY1118065T1 CY 1118065 T1 CY1118065 T1 CY 1118065T1 CY 20161100992 T CY20161100992 T CY 20161100992T CY 161100992 T CY161100992 T CY 161100992T CY 1118065 T1 CY1118065 T1 CY 1118065T1
Authority
CY
Cyprus
Prior art keywords
treatment
genetic disorders
aminoglycosides
innovative
paromomycin
Prior art date
Application number
CY20161100992T
Other languages
English (en)
Inventor
Timor Baasov
Tamar Ben-Yosef
Igor Nudelman
Annie Rebibo-Sabbah
Dalia Shallom-Shezifi
Mariana Hainrichson
Original Assignee
Technion Research & Development Foundation Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Technion Research & Development Foundation Ltd. filed Critical Technion Research & Development Foundation Ltd.
Publication of CY1118065T1 publication Critical patent/CY1118065T1/el

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D25/00—Details of other kinds or types of rigid or semi-rigid containers
    • B65D25/20—External fittings
    • B65D25/205—Means for the attachment of labels, cards, coupons or the like
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
    • C07H5/06—Aminosugars

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Mechanical Engineering (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Cardiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Παρέχεται μια νέα κατηγορία αμινογλυκοσιδών παραγώγων παρομομυκίνης (Τύπος I), οι οποίες εμφανίζουν αποτελεσματική δραστικότητα καταστολής μεταλλάξεων κωδικονίου τερματισμού, χαμηλή κυτταροτοξικότητα και επιλεκτικότητα έναντι των ευκαρυωτικών κυττάρων. Επίσης παρέχονται διαδικασίες παρασκευής αυτών των αμινογλυκοσιδών παραγώγων παρομομυκίνης και των ενδιαμέσων αυτών, καθώς και οι φαρμακευτικές συνθέσεις που περιέχουν τις ίδιες, και οι χρήσεις αυτών στην θεραπεία γενετικών διαταραχών.
CY20161100992T 2006-04-03 2016-10-05 Καινοτομες αμινογλυκοσιδες και χρησεις αυτων στη θεραπεια γενετικων διαταραχων CY1118065T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78807006P 2006-04-03 2006-04-03
EP07736203.6A EP2007783B1 (en) 2006-04-03 2007-04-10 Novel aminoglycosides and uses thereof in the treatment of genetic disorders

Publications (1)

Publication Number Publication Date
CY1118065T1 true CY1118065T1 (el) 2017-06-28

Family

ID=38353813

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20161100992T CY1118065T1 (el) 2006-04-03 2016-10-05 Καινοτομες αμινογλυκοσιδες και χρησεις αυτων στη θεραπεια γενετικων διαταραχων

Country Status (13)

Country Link
US (4) US9073958B2 (el)
EP (3) EP3421481A1 (el)
JP (1) JP5345928B2 (el)
CA (1) CA2646407C (el)
CY (1) CY1118065T1 (el)
DK (1) DK2390255T3 (el)
ES (2) ES2594343T3 (el)
HU (1) HUE031643T2 (el)
LT (1) LT2390255T (el)
PL (1) PL2390255T3 (el)
PT (1) PT2390255T (el)
SI (1) SI2390255T1 (el)
WO (1) WO2007113841A2 (el)

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ES2594343T3 (es) 2006-04-03 2016-12-19 Technion Research & Development Foundation Limited Aminoglucósidos novedosos y usos de los mismos en el tratamiento de trastornos genéticos
EP2535051B1 (en) * 2010-02-03 2016-04-20 Microbial Chemistry Research Foundation Read through inducer, and therapeutic agent for nonsense-mutation-type genetic diseases
US8765698B2 (en) * 2010-02-03 2014-07-01 University Of Central Florida Research Foundation, Inc. Methods and products for reawakening retrocyclins
WO2012021707A2 (en) * 2010-08-11 2012-02-16 The Regents Of The University Of California Premature-termination-codons readthrough compounds
PT2640734T (pt) 2010-11-18 2018-01-22 Technion Res & Dev Foundation Aminoglicosideos e suas utlizações no tratamento de doenças genéticas
JP6057300B2 (ja) 2011-01-05 2017-01-11 ナショナル タイワン ユニバーシティ グリコスフィンゴ脂質の調製及びその使用の方法
IN2015DN03998A (el) 2012-12-13 2015-10-02 Novartis Ag
JP6526064B2 (ja) 2014-06-03 2019-06-05 ノバルティス アーゲー ピリドピリミジンジオン誘導体
JP6560257B2 (ja) 2014-06-03 2019-08-14 ノバルティス アーゲー ピリミド［４，５−ｂ］キノリン−４，５（３Ｈ，１０Ｈ）−ジオン誘導体
CA2950724A1 (en) 2014-06-03 2015-12-10 Novartis Ag Naphthyridinedione derivatives
JP2017516835A (ja) * 2014-06-05 2017-06-22 エロックス ファーマシューティカルズ リミテッド レット症候群治療におけるアミノグリコシド類縁体の使用
EP3303358A4 (en) * 2015-06-05 2018-12-26 PTC Therapeutics, Inc. Use of an aminoglycoside for nonsense mutation suppression and the treatment of disease
WO2017037718A1 (en) 2015-09-02 2017-03-09 Eloxx Pharmaceuticals Ltd. Aminoglycoside derivatives and uses thereof in treating genetic disorders
US11306115B2 (en) * 2015-09-02 2022-04-19 Eloxx Pharmaceuticals Ltd. Aminoglycoside derivatives and uses thereof in treating genetic disorders
IL295474A (en) * 2015-09-02 2022-10-01 Eloxx Pharmaceuticals Ltd Aminoglycosides for the treatment of genetic diseases
WO2017118968A1 (en) * 2016-01-05 2017-07-13 Eloxx Pharmaceuticals Ltd. Aminoglycoside derivatives and uses thereof in treating genetic disorders
EP3400231A4 (en) * 2016-01-05 2019-10-09 Technion Research & Development Foundation Limited AMINOGLYCOSIDE DERIVATIVES AND USES THEREOF IN THE TREATMENT OF MICROBIAL INFECTIONS
EP3442512A4 (en) * 2016-04-15 2020-07-22 The UAB Research Foundation METHODS AND COMPOUNDS FOR STIMULATING THE TRANSLECTURE OF PREMATURE TERMINATION CODONS
AU2018235441B2 (en) 2017-03-15 2022-07-21 Eloxx Pharmaceuticals Ltd. Large scale preparation of pseudo-trisaccharide aminoglycosides and of intermediates thereof
WO2018204358A1 (en) * 2017-05-01 2018-11-08 Wayne State University Apramycin derivatives
CN108358982A (zh) * 2018-04-11 2018-08-03 常州方圆制药有限公司 一种硫酸阿贝卡星游离碱的分离提纯方法
CN108358983A (zh) * 2018-04-11 2018-08-03 常州方圆制药有限公司 一种侧链酰胺衍生化合成阿贝卡星的方法

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Also Published As

Publication number Publication date
HUE031643T2 (en) 2017-07-28
US20150352136A1 (en) 2015-12-10
US10159689B2 (en) 2018-12-25
PL2390255T3 (pl) 2017-01-31
US20090093418A1 (en) 2009-04-09
EP3421481A1 (en) 2019-01-02
DK2390255T3 (en) 2016-11-07
ES2594343T3 (es) 2016-12-19
SI2390255T1 (sl) 2016-12-30
EP2007783A2 (en) 2008-12-31
EP2390255B1 (en) 2016-07-13
US20180064743A1 (en) 2018-03-08
LT2390255T (lt) 2016-10-25
WO2007113841A2 (en) 2007-10-11
PT2390255T (pt) 2016-10-24
US9821001B2 (en) 2017-11-21
EP2390255A1 (en) 2011-11-30
JP5345928B2 (ja) 2013-11-20
US9073958B2 (en) 2015-07-07
US20190060340A1 (en) 2019-02-28
EP2007783B1 (en) 2018-07-11
JP2009532461A (ja) 2009-09-10
WO2007113841A3 (en) 2007-11-29
CA2646407A1 (en) 2007-10-11
CA2646407C (en) 2015-08-18
ES2689539T3 (es) 2018-11-14

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