PT2640734T - Aminoglicosideos e suas utlizações no tratamento de doenças genéticas - Google Patents
Aminoglicosideos e suas utlizações no tratamento de doenças genéticasInfo
- Publication number
- PT2640734T PT2640734T PT117995019T PT11799501T PT2640734T PT 2640734 T PT2640734 T PT 2640734T PT 117995019 T PT117995019 T PT 117995019T PT 11799501 T PT11799501 T PT 11799501T PT 2640734 T PT2640734 T PT 2640734T
- Authority
- PT
- Portugal
- Prior art keywords
- aminoglycosides
- genetic disorders
- treating genetic
- treating
- disorders
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D79/00—Kinds or details of packages, not otherwise provided for
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
- C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
- C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
- C07H15/228—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to adjacent ring-carbon atoms of the cyclohexane rings
- C07H15/23—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to adjacent ring-carbon atoms of the cyclohexane rings with only two saccharide radicals in the molecule, e.g. ambutyrosin, butyrosin, xylostatin, ribostamycin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
- C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
- C07H5/06—Aminosugars
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurology (AREA)
- Mechanical Engineering (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41495610P | 2010-11-18 | 2010-11-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT2640734T true PT2640734T (pt) | 2018-01-22 |
Family
ID=45390144
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT117995019T PT2640734T (pt) | 2010-11-18 | 2011-11-17 | Aminoglicosideos e suas utlizações no tratamento de doenças genéticas |
Country Status (18)
| Country | Link |
|---|---|
| US (7) | US8895519B2 (pt) |
| EP (2) | EP3296311B1 (pt) |
| JP (3) | JP5960712B2 (pt) |
| CA (1) | CA2816789C (pt) |
| CY (1) | CY1120082T1 (pt) |
| DK (1) | DK2640734T3 (pt) |
| ES (2) | ES2833938T3 (pt) |
| HK (1) | HK1248709A1 (pt) |
| HR (1) | HRP20180056T1 (pt) |
| HU (1) | HUE036248T2 (pt) |
| IL (3) | IL266495B (pt) |
| LT (1) | LT2640734T (pt) |
| NO (1) | NO2640734T3 (pt) |
| PL (1) | PL2640734T3 (pt) |
| PT (1) | PT2640734T (pt) |
| RS (1) | RS56739B1 (pt) |
| SI (1) | SI2640734T1 (pt) |
| WO (1) | WO2012066546A1 (pt) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3296311B1 (en) * | 2010-11-18 | 2020-09-30 | Technion Research & Development Foundation Ltd. | Aminoglycosides and uses thereof in treating genetic disorders |
| KR101703137B1 (ko) | 2014-05-30 | 2017-02-07 | 선문대학교 산학협력단 | 당 부가 아미노글리코사이드 화합물, 이의 제조방법 및 이를 유효성분으로 함유하는 약학적 조성물 |
| US20170360817A1 (en) | 2014-06-05 | 2017-12-21 | Eloxx Pharmaceuticals Ltd. | Use of aminoglycoside analogs in the treatment of rett syndrome |
| US10899785B2 (en) * | 2015-09-02 | 2021-01-26 | Eloxx Pharmaceuticals Ltd. | Aminoglycoside derivatives and uses thereof in treating genetic disorders |
| WO2017037718A1 (en) * | 2015-09-02 | 2017-03-09 | Eloxx Pharmaceuticals Ltd. | Aminoglycoside derivatives and uses thereof in treating genetic disorders |
| WO2017037717A1 (en) * | 2015-09-02 | 2017-03-09 | Eloxx Pharmaceuticals Ltd. | Aminoglycoside derivatives and uses thereof in treating genetic disorders |
| US20190016746A1 (en) * | 2016-01-05 | 2019-01-17 | Eloxx Pharmaceuticals Ltd. | Aminoglycoside derivatives and uses thereof in treating genetic disorders |
| US11136345B2 (en) * | 2017-03-15 | 2021-10-05 | Eloxx Pharmaceuticals Ltd. | Large scale preparation of pseudo-trisaccharide aminoglycosides and of intermediates thereof |
| WO2019237076A1 (en) * | 2018-06-07 | 2019-12-12 | Eloxx Pharmaceuticals, Inc. | Methods, compositions, and kits for inducing readthrough |
| KR102067477B1 (ko) * | 2018-06-20 | 2020-01-17 | 고려대학교 산학협력단 | 스킬로이노사민을 포함하는 아미노사이클리톨 화합물, 이의 제조방법 및 이를 함유하는 약학 조성물 |
| MX2021006146A (es) * | 2018-11-29 | 2021-09-28 | Eloxx Pharmaceuticals | Metodos, composiciones y kits para tratar enfermedades oculares. |
| WO2021061873A1 (en) * | 2019-09-23 | 2021-04-01 | Eloxx Pharmaceuticals, Inc. | Methods, compositions, and kits for treating polycystic kidney disease |
| EP4230196A1 (en) | 2022-02-21 | 2023-08-23 | Som Innovation Biotech, S.A. | Compounds for use in the treatment of dystrophinopathies |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5960712A (ja) | 1982-09-30 | 1984-04-06 | Toshiba Corp | デ−タ判別装置 |
| JP5830213B2 (ja) | 2004-02-17 | 2015-12-09 | ザ ホスピタル フォー シック チルドレン | Ｍｅｃｐ２ｅ１遺伝子 |
| WO2007113841A2 (en) * | 2006-04-03 | 2007-10-11 | Technion Research & Development Foundation Ltd. | Novel aminoglycosides and uses thereof in the treatment of genetic disorders |
| EP3296311B1 (en) | 2010-11-18 | 2020-09-30 | Technion Research & Development Foundation Ltd. | Aminoglycosides and uses thereof in treating genetic disorders |
| US20170360817A1 (en) | 2014-06-05 | 2017-12-21 | Eloxx Pharmaceuticals Ltd. | Use of aminoglycoside analogs in the treatment of rett syndrome |
-
2011
- 2011-11-17 EP EP17192028.3A patent/EP3296311B1/en active Active
- 2011-11-17 LT LTEP11799501.9T patent/LT2640734T/lt unknown
- 2011-11-17 EP EP11799501.9A patent/EP2640734B1/en active Active
- 2011-11-17 NO NO11799501A patent/NO2640734T3/no unknown
- 2011-11-17 DK DK11799501.9T patent/DK2640734T3/en active
- 2011-11-17 JP JP2013539397A patent/JP5960712B2/ja active Active
- 2011-11-17 CA CA2816789A patent/CA2816789C/en active Active
- 2011-11-17 RS RS20180029A patent/RS56739B1/sr unknown
- 2011-11-17 PT PT117995019T patent/PT2640734T/pt unknown
- 2011-11-17 ES ES17192028T patent/ES2833938T3/es active Active
- 2011-11-17 WO PCT/IL2011/000889 patent/WO2012066546A1/en active Application Filing
- 2011-11-17 HU HUE11799501A patent/HUE036248T2/hu unknown
- 2011-11-17 PL PL11799501T patent/PL2640734T3/pl unknown
- 2011-11-17 SI SI201131387T patent/SI2640734T1/en unknown
- 2011-11-17 ES ES11799501.9T patent/ES2655916T3/es active Active
- 2011-11-17 US US13/885,715 patent/US8895519B2/en active Active
-
2014
- 2014-08-18 US US14/461,477 patent/US9175029B2/en active Active
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2015
- 2015-09-27 US US14/866,960 patent/US9616079B2/en active Active
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2016
- 2016-01-22 JP JP2016011038A patent/JP2016121168A/ja active Pending
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2017
- 2017-03-09 US US15/453,990 patent/US9943533B2/en active Active
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2018
- 2018-01-12 HR HRP20180056TT patent/HRP20180056T1/hr unknown
- 2018-01-15 CY CY20181100039T patent/CY1120082T1/el unknown
- 2018-03-01 JP JP2018036281A patent/JP6758338B2/ja active Active
- 2018-03-07 US US15/914,045 patent/US10398718B2/en active Active
- 2018-06-25 HK HK18108109.1A patent/HK1248709A1/zh unknown
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2019
- 2019-05-07 IL IL266495A patent/IL266495B/en active IP Right Grant
- 2019-08-23 US US16/550,121 patent/US10973839B2/en active Active
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2020
- 2020-09-01 IL IL277063A patent/IL277063B/en unknown
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2021
- 2021-04-08 US US17/226,050 patent/US11865128B2/en active Active
- 2021-06-16 IL IL284067A patent/IL284067B/en unknown
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