EA201490647A1 - Производные бензотиазол-6-илуксусной кислоты и их применение для лечения вич-инфекции - Google Patents

Производные бензотиазол-6-илуксусной кислоты и их применение для лечения вич-инфекции

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Publication number
EA201490647A1
EA201490647A1 EA201490647A EA201490647A EA201490647A1 EA 201490647 A1 EA201490647 A1 EA 201490647A1 EA 201490647 A EA201490647 A EA 201490647A EA 201490647 A EA201490647 A EA 201490647A EA 201490647 A1 EA201490647 A1 EA 201490647A1
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EA
Eurasian Patent Office
Prior art keywords
application
hiv infection
lucus
benzothiazol
derivatives
Prior art date
Application number
EA201490647A
Other languages
English (en)
Inventor
Керим Бабаоглу
Гедиминас Брызгис
Джейк Ча
Сяову Чэн
Хунянь Го
Рэндэл Л. Халькомб
Сяочунь Хань
Ричард Хуан
Хунтао Лю
Райан Макфадден
Майкл Л. Митчелл
Инмэй Ци
Пол А. Роусл
Лянхун Сюй
Хун Ян
Original Assignee
Джилид Сайэнс, Инк.
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48225146&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201490647(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Джилид Сайэнс, Инк. filed Critical Джилид Сайэнс, Инк.
Publication of EA201490647A1 publication Critical patent/EA201490647A1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
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    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4741—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having oxygen as a ring hetero atom, e.g. tubocuraran derivatives, noscapine, bicuculline
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

Abstract

Предложены соединения, описанные в настоящей заявке, включая соединения формулы I':и соли указанных соединений. Также предложены фармацевтические композиции, содержащие соединения, описанные в настоящей заявке, способы получения соединений, описанных в настоящей заявке, промежуточные соединения, подходящие для получения соединений, описанных в настоящей заявке, и терапевтические способы лечения ВИЧ-инфекции с применением соединений, описанных в настоящей заявке.
EA201490647A 2012-04-20 2013-04-19 Производные бензотиазол-6-илуксусной кислоты и их применение для лечения вич-инфекции EA201490647A1 (ru)

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