AR112412A1 - Formas de sal de colina de un inhibidor de la cápside del vih - Google Patents

Formas de sal de colina de un inhibidor de la cápside del vih

Info

Publication number
AR112412A1
AR112412A1 ARP180102326A AR112412A1 AR 112412 A1 AR112412 A1 AR 112412A1 AR P180102326 A ARP180102326 A AR P180102326A AR 112412 A1 AR112412 A1 AR 112412A1
Authority
AR
Argentina
Prior art keywords
salt forms
choline salt
hiv capsid
capsid inhibitor
hiv
Prior art date
Application number
Other languages
English (en)
Inventor
Bing Shi
Travis Lee Houston
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of AR112412A1 publication Critical patent/AR112412A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Abstract

La presente descripción se refiere a sales de colina, y formas cristalinas de las mismas, de un compuesto que es N-((S)-1-(3-(4-cloro-3-(metilsulfonamido)-1-(2,2,2-trifluoroetil)-1H-indazol-7-il)-6-(3-metil-3-(metilsulfoni1)but-1-in-1-il)piridin-2-il)-2-(3,5-difluorofenil)etil)-2-((3bS,4aR)-5,5-difluoro-3-(trifluorometil)-3b,4,4a,5-tetrahidro-1H-ciclopropa[3,4]ciclopenta[1,2-c]pirazol-1-il)acetamida, que es útil en el tratamiento y la prevención de una infección viral por Retroviridae, incluida una infección causada por el virus VIH.
ARP180102326 2017-08-17 2018-08-15 Formas de sal de colina de un inhibidor de la cápside del vih AR112412A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201762546974P 2017-08-17 2017-08-17

Publications (1)

Publication Number Publication Date
AR112412A1 true AR112412A1 (es) 2019-10-23

Family

ID=63684411

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP180102326 AR112412A1 (es) 2017-08-17 2018-08-15 Formas de sal de colina de un inhibidor de la cápside del vih

Country Status (14)

Country Link
US (3) US10849892B2 (es)
EP (2) EP4046994B1 (es)
JP (2) JP6933770B2 (es)
KR (2) KR102389850B1 (es)
CN (2) CN111051297A (es)
AR (1) AR112412A1 (es)
AU (1) AU2018317304B2 (es)
CA (1) CA3070154A1 (es)
ES (1) ES2906385T3 (es)
PL (1) PL3668860T3 (es)
PT (1) PT3668860T (es)
SI (1) SI3668860T1 (es)
TW (2) TWI693219B (es)
WO (1) WO2019035973A1 (es)

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