EA201390984A1 - Гетероциклические соединения, подходящие для лечения дислипидемии - Google Patents

Гетероциклические соединения, подходящие для лечения дислипидемии

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Publication number
EA201390984A1
EA201390984A1 EA201390984A EA201390984A EA201390984A1 EA 201390984 A1 EA201390984 A1 EA 201390984A1 EA 201390984 A EA201390984 A EA 201390984A EA 201390984 A EA201390984 A EA 201390984A EA 201390984 A1 EA201390984 A1 EA 201390984A1
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EA
Eurasian Patent Office
Prior art keywords
dyslipidemia
treatment
compounds
heterocyclic compounds
compounds suitable
Prior art date
Application number
EA201390984A
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English (en)
Other versions
EA025199B1 (ru
Inventor
Харикишоре Пингали
Панкадж Макадия
Враджеш Пандия
В. В. М. Саирам Калапатапу
Мукул Р. Джаин
Original Assignee
Кадила Хелзкэр Лимитед
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Publication date
Application filed by Кадила Хелзкэр Лимитед filed Critical Кадила Хелзкэр Лимитед
Publication of EA201390984A1 publication Critical patent/EA201390984A1/ru
Publication of EA025199B1 publication Critical patent/EA025199B1/ru

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    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/04—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
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    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4433—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
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    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
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    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract

Изобретение относится к соединениям общей формулы (I), их таутомерным формам, их стереоизомерам, их фармацевтически приемлемым солям, содержащим их фармацевтическим композициям, способам их получения, применению этих соединений в медицине и промежуточным продуктам, используемым при их получении. Изобретение относится к соединениям, которые могут быть использованы для лечения заболеваний, таких как гиперлипидемия, и также оказывают полезное воздействие на холестерин.
EA201390984A 2010-12-28 2011-12-26 Гетероциклические соединения, подходящие для лечения дислипидемии EA025199B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN3556MU2010 2010-12-28
PCT/IN2011/000888 WO2012090220A1 (en) 2010-12-28 2011-12-26 Heterocyclic compounds suitable for the treatment of dyslipidemia

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EA201390984A1 true EA201390984A1 (ru) 2014-04-30
EA025199B1 EA025199B1 (ru) 2016-11-30

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EA201390984A EA025199B1 (ru) 2010-12-28 2011-12-26 Гетероциклические соединения, подходящие для лечения дислипидемии

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US (1) US8822414B2 (ru)
EP (1) EP2658851B1 (ru)
JP (1) JP5786034B2 (ru)
KR (1) KR101510975B1 (ru)
CN (1) CN103298799B (ru)
AP (1) AP2013006987A0 (ru)
AR (1) AR084637A1 (ru)
AU (1) AU2011350629C1 (ru)
CA (1) CA2820854C (ru)
DK (1) DK2658851T3 (ru)
EA (1) EA025199B1 (ru)
ES (1) ES2535244T3 (ru)
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MY (1) MY169485A (ru)
NZ (1) NZ612544A (ru)
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PT (1) PT2658851E (ru)
SG (1) SG191305A1 (ru)
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Publication number Priority date Publication date Assignee Title
AU2012372441B2 (en) * 2012-03-07 2015-11-05 Cadila Healthcare Limited Novel compounds for the treatment of dyslipidemia and related diseases
US20150051144A1 (en) * 2012-06-25 2015-02-19 Cadila Healthcare Limited Compounds for the treatment of dyslipidemia and other diseases
WO2014192023A1 (en) * 2013-05-22 2014-12-04 Cadila Healthcare Limited Novel compounds suitable for the treatment of dyslipidemia
CN106883141B (zh) * 2017-03-15 2018-08-10 何黎琴 一种丹皮酚肟醚类化合物、其制备方法及医药用途
CN108191845A (zh) * 2018-02-12 2018-06-22 李化绪 一种异恶唑亚氨基类化合物及其在降血脂药物中的应用
US11306125B2 (en) 2018-06-21 2022-04-19 Merck Sharp & Dohme Corp. PCSK9 antagonists bicyclo-compounds
EP3810196A4 (en) 2018-06-21 2022-05-04 Merck Sharp & Dohme Corp. CYCLIC POLYPEPTIDES FOR INHIBITION OF PCSK9
WO2019246387A1 (en) 2018-06-21 2019-12-26 Ra Pharmaceuticals, Inc. Cyclic peptides for pcsk9 inhibition
US11814444B2 (en) 2018-06-21 2023-11-14 Ra Pharmaceuticals, Inc. Cyclic polypeptides for PCSK9 inhibition
JOP20190150A1 (ar) 2018-06-21 2019-12-21 Merck Sharp & Dohme مركبات مناهضة لـ pcsk9
WO2020009805A2 (en) 2018-06-21 2020-01-09 Merck Sharp & Dohme Corp. Cyclic polypeptides for pcsk9 inhibition
TW202123960A (zh) 2019-08-30 2021-07-01 美商默沙東藥廠 Pcsk9拮抗劑化合物
US11932705B2 (en) 2020-12-18 2024-03-19 Merck Sharp & Dohme Llc Cyclic polypeptides for PCSK9 inhibition

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002014291A1 (en) * 2000-08-11 2002-02-21 Nippon Chemiphar Co.,Ltd. PPARδ ACTIVATORS
BRPI0408325A (pt) * 2003-03-13 2006-03-21 Ono Pharmaceutical Co compostos derivados de imino éter e medicamentos contendo os compostos como o ingrediente ativo
US7420083B2 (en) * 2003-09-25 2008-09-02 Wyeth Substituted aryloximes
WO2007003581A1 (en) * 2005-06-30 2007-01-11 Novo Nordisk A/S Phenoxy acetic acids as ppar delta activators
WO2008035359A2 (en) * 2006-06-12 2008-03-27 Cadila Healthcare Limited Oximinophenoxyalkanoic acid and phenylalkanoic acid derivatives
EP2179999A4 (en) 2007-12-18 2011-06-08 Univ Toyama Nat Univ Corp CONDENSED TRICYCLIC COMPOUND WITH ALDOSIS REDUCTASE HARMFUL EFFECT

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