AR084637A1 - Compuestos heterociclicos apropiados para el tratamiento de la dislipidemia - Google Patents

Compuestos heterociclicos apropiados para el tratamiento de la dislipidemia

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Publication number
AR084637A1
AR084637A1 ARP110104988A ARP110104988A AR084637A1 AR 084637 A1 AR084637 A1 AR 084637A1 AR P110104988 A ARP110104988 A AR P110104988A AR P110104988 A ARP110104988 A AR P110104988A AR 084637 A1 AR084637 A1 AR 084637A1
Authority
AR
Argentina
Prior art keywords
alkyl
heterocyclyl
compounds
groups
aryl
Prior art date
Application number
ARP110104988A
Other languages
English (en)
Inventor
Sairam Kalapatapu
Vrajesh Pandya
Lankaj Makadia
Harikishor Pingali
Original Assignee
Cadila Healthcare Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cadila Healthcare Ltd filed Critical Cadila Healthcare Ltd
Publication of AR084637A1 publication Critical patent/AR084637A1/es

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/04—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
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    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
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    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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  • Indole Compounds (AREA)
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  • Pyrane Compounds (AREA)

Abstract

La presente se relaciona con compuestos de la fórmula general (1), sus formas tautoméricas, esteroisómeros, sales farmacéuticamente aceptables, composiciones farmacéuticas que los contienen, métodos para su elaboración, uso de estos compuestos en medicina y los productos intermedios que se utilizan en su elaboración. La presente se dirige a los compuestos que pueden utilizarse para tratar enfermedades tales como la hiperlipidemia y también tienen un efecto benéfico sobre el colesterol.Reivindicación 1: Compuestos de la fórmula (1) caracterizado por sus formas tautoméricas, esteroisómeros, sales farmacéuticamente aceptables y composiciones farmacéuticamente aceptables que los contienen donde ‘A’ representa a un grupo opcionalmente sustituido simple o fusionado elegido de los grupos aril, heterociclil o cicloalquil; ‘Y’ representa los grupos alquil C1-6, alquenil C2-6 unidos, sustituidos o no sustituidos, lineares o con ramas, o los grupos representados por ‘-U(CH2)m-’, donde U representa a O, S(O)o, NR4; ‘m’ representa enteros de 2 a 4, ‘o’ representa enteros de 0 a 2 y R4 representa a H, alquil C1-6 sustituido o no sustituido, linear o con ramas alquil C1-6; ‘Z’ representa a un grupo único o fusionado opcionalmente sustituido de los grupos aril, heterociclil o cicloalquil; ‘X’ representa a una unión o puede seleccionarse de O, S(O)o ó NR4 donde R4 se definió anteriormente; ‘W’ representa a grupos alquil C1-6, alquenil C2-6 lineares o con ramas, sustituidos o no sustituidos; R1 representa al hidrógeno, a los grupos opcionalmente sustituidos alquil C1-6, cicloalquil C3-6, alcoxialquil, hidroxialquil, aminoalquil, aril, heterociclil, aralquil, heterociclilalquil; R2 representa al hidrógeno, o a los grupos seleccionados de alquil C1-6, aril, heterociclil, aralquil, heterociclilalquil, alcoxi C1-6, hidroxialquil, tioalquil C1-6, amino, aminoalquil, alquilamino, cada uno de los cuales puede ser opcionalmente sustituido; o R1 y R2, cuando sea posible, juntos pueden formar de 4 a 7 anillos provistos de miembros saturados o parcialmente saturados que contienen 0 - 2 heteroátomos adicionales seleccionados del grupo de N, O y S(O)o; R3 en cada ocurrencia independientemente representa al hidrógeno, halógeno, alquil C1-3, haloalquil C1-3, alcoxi C1-3, tioalquil C1-3, derivados de sulfenil, derivados de sulfonil; ‘n’ representa a enteros de 0 - 3.
ARP110104988A 2010-12-28 2011-12-28 Compuestos heterociclicos apropiados para el tratamiento de la dislipidemia AR084637A1 (es)

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