EA201490419A1 - Соединения для лечения и профилактики респираторного синцитиального вирусного заболевания - Google Patents

Соединения для лечения и профилактики респираторного синцитиального вирусного заболевания

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Publication number
EA201490419A1
EA201490419A1 EA201490419A EA201490419A EA201490419A1 EA 201490419 A1 EA201490419 A1 EA 201490419A1 EA 201490419 A EA201490419 A EA 201490419A EA 201490419 A EA201490419 A EA 201490419A EA 201490419 A1 EA201490419 A1 EA 201490419A1
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EA
Eurasian Patent Office
Prior art keywords
syncial
respiratory
prevention
compounds
treatment
Prior art date
Application number
EA201490419A
Other languages
English (en)
Other versions
EA023262B1 (ru
Inventor
Ли Чэнь
Личунь Фэн
Сун Фэн
Лу Гао
Тао Го
Мэнвэй Хуан
Чуньгэнь Лян
Юнфу Лю
Лиша Ван
Джейсон Кристофер Вон
Джим Чжэнь У
Сихань Ву
Хунин Юнь
Сюфан Чжэн
Original Assignee
Ф.Хоффманн-Ля Рош Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ф.Хоффманн-Ля Рош Аг filed Critical Ф.Хоффманн-Ля Рош Аг
Publication of EA201490419A1 publication Critical patent/EA201490419A1/ru
Publication of EA023262B1 publication Critical patent/EA023262B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

Abstract

Соединение формулы (I)и его фармацевтически приемлемая соль, где R-R, A, Q, X и Y являются такими, как определено в описании и формуле изобретения, могут применяться в качестве лекарственного средства.
EA201490419A 2011-08-11 2012-08-08 Соединения для лечения и профилактики респираторного синцитиального вирусного заболевания EA023262B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2011078258 2011-08-11
CN2012078439 2012-07-10
PCT/EP2012/065499 WO2013020993A1 (en) 2011-08-11 2012-08-08 Compounds for the treatment and prophylaxis of respiratory syncytial virus disease

Publications (2)

Publication Number Publication Date
EA201490419A1 true EA201490419A1 (ru) 2014-05-30
EA023262B1 EA023262B1 (ru) 2016-05-31

Family

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EA201490419A EA023262B1 (ru) 2011-08-11 2012-08-08 Соединения для лечения и профилактики респираторного синцитиального вирусного заболевания

Country Status (21)

Country Link
US (2) US8871756B2 (ru)
EP (1) EP2742039B1 (ru)
JP (1) JP5746793B2 (ru)
KR (1) KR101570627B1 (ru)
CN (1) CN103717589B (ru)
AU (1) AU2012293644B2 (ru)
BR (1) BR112014003198B1 (ru)
CA (1) CA2842123C (ru)
CL (1) CL2014000311A1 (ru)
CO (1) CO6852080A2 (ru)
CR (1) CR20140026A (ru)
EA (1) EA023262B1 (ru)
EC (1) ECSP14013199A (ru)
ES (1) ES2552016T3 (ru)
HK (1) HK1196131A1 (ru)
IL (1) IL230458A (ru)
MA (1) MA35432B1 (ru)
MX (1) MX349881B (ru)
MY (1) MY184306A (ru)
PE (1) PE20142148A1 (ru)
WO (1) WO2013020993A1 (ru)

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US9266835B2 (en) * 2014-02-27 2016-02-23 Janssen Pharmaceutica Nv Quinoline derivatives useful as CB-1 inverse agonists
US9464055B2 (en) * 2014-02-27 2016-10-11 Janssen Pharmaceutica Nv Quinoline derivatives useful as CB-1 inverse agonists
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CN104529802A (zh) * 2014-12-13 2015-04-22 西安近代化学研究所 一种合成n,n′-双取代氟代丙二酰胺化合物的方法
CN104860954B (zh) * 2015-04-20 2018-05-04 南京天印健华医药科技有限公司 一种苯酯螺吡咯烷类化合物及其制备方法
WO2016184832A1 (en) 2015-05-20 2016-11-24 F. Hoffmann-La Roche Ag Compounds for treating spinal muscular atrophy
EP3322704B1 (en) * 2015-07-16 2019-11-27 H. Hoffnabb-La Roche Ag Crystalline form of n-[(3-amino-3-oxetanyl)methyl]-2-(2,3-dihydro-1,1-dioxido-1,4-benzothiazepin-4(5h)-yl)-6-methyl-4-quinazolinamine for the treatment of respiratory syncytial virus (rsv) infections
WO2017080967A1 (en) 2015-11-12 2017-05-18 F. Hoffmann-La Roche Ag Compositions for treating spinal muscular atrophy
EP3386978B1 (en) 2015-12-10 2021-01-27 H. Hoffnabb-La Roche Ag Bridged piperidine derivatives
LT3386511T (lt) 2015-12-10 2021-08-25 Ptc Therapeutics, Inc. Hantingtono ligos gydymo būdai
HRP20221279T1 (hr) 2016-07-14 2022-12-23 Crinetics Pharmaceuticals, Inc. Modulatori somatostatina i njihove uporabe
EP3634953B1 (en) 2017-06-05 2024-01-03 PTC Therapeutics, Inc. Compounds for treating huntington's disease
CN111182898B (zh) 2017-06-28 2024-04-16 Ptc医疗公司 用于治疗亨廷顿氏病的方法
EP3645121A4 (en) 2017-06-28 2021-03-17 PTC Therapeutics, Inc. HUNTINGTON'S DISEASE TREATMENT METHODS
US20210009590A1 (en) 2018-03-27 2021-01-14 Ptc Therapeutics, Inc. Compounds for treating huntington's disease
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EP3814360A1 (en) 2018-06-27 2021-05-05 PTC Therapeutics, Inc. Heteroaryl compounds for treating huntington's disease
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EP4028392A1 (en) * 2019-09-09 2022-07-20 Cidara Therapeutics, Inc. Compositions and methods for the treatment of respiratory syncytial virus
GB201915273D0 (en) * 2019-10-22 2019-12-04 Reviral Ltd Pharmaceutical compounds
US20220387443A1 (en) * 2019-10-31 2022-12-08 Shanghai Ark Biopharmaceutical Co., Ltd. Respiratory syncytial virus fusion protein inhibitor compositions and methods for the treatment and prophylaxis of rsv diseases using the same
GB201915932D0 (en) * 2019-11-01 2019-12-18 Reviral Ltd Pharmaceutical compounds
CN113149977A (zh) * 2020-01-22 2021-07-23 苏州爱科百发生物医药技术有限公司 一类呼吸道合胞病毒抑制剂的合成与用途
CN111518055A (zh) * 2020-05-16 2020-08-11 西安都创医药科技有限公司 一种苯并硫氮杂卓氧化物的制备方法及其制备的产品及其应用
CN111620838A (zh) * 2020-05-16 2020-09-04 西安都创医药科技有限公司 一种氯代苯并硫氮杂卓化合物的制备方法及其制备的产品及其应用
CN111548325A (zh) * 2020-05-16 2020-08-18 西安都创医药科技有限公司 一种卤代苯并硫氮杂卓化合物的制备方法及其制备的产品及其应用
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Also Published As

Publication number Publication date
CR20140026A (es) 2014-05-12
MY184306A (en) 2021-03-31
MA35432B1 (fr) 2014-09-01
MX2014001481A (es) 2014-04-30
US20130196974A1 (en) 2013-08-01
AU2012293644A1 (en) 2014-01-30
EP2742039B1 (en) 2015-09-16
CO6852080A2 (es) 2014-01-30
BR112014003198B1 (pt) 2020-10-13
CA2842123C (en) 2020-10-06
CA2842123A1 (en) 2013-02-14
PE20142148A1 (es) 2015-01-03
AU2012293644B2 (en) 2017-05-25
ECSP14013199A (es) 2014-03-31
IL230458A0 (en) 2014-03-31
HK1196131A1 (zh) 2014-12-05
CL2014000311A1 (es) 2014-10-17
US8871756B2 (en) 2014-10-28
CN103717589A (zh) 2014-04-09
BR112014003198A2 (pt) 2017-04-04
JP5746793B2 (ja) 2015-07-08
KR20140045590A (ko) 2014-04-16
KR101570627B1 (ko) 2015-11-19
EP2742039A1 (en) 2014-06-18
ES2552016T3 (es) 2015-11-25
CN103717589B (zh) 2016-08-17
EA023262B1 (ru) 2016-05-31
MX349881B (es) 2017-08-16
IL230458A (en) 2015-11-30
JP2014521709A (ja) 2014-08-28
NZ620079A (en) 2016-06-24
USRE49481E1 (en) 2023-04-04
WO2013020993A1 (en) 2013-02-14

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