EA201590358A1 - Ингибиторы репликации вируса иммунодефицита человека - Google Patents

Ингибиторы репликации вируса иммунодефицита человека

Info

Publication number
EA201590358A1
EA201590358A1 EA201590358A EA201590358A EA201590358A1 EA 201590358 A1 EA201590358 A1 EA 201590358A1 EA 201590358 A EA201590358 A EA 201590358A EA 201590358 A EA201590358 A EA 201590358A EA 201590358 A1 EA201590358 A1 EA 201590358A1
Authority
EA
Eurasian Patent Office
Prior art keywords
inhibitors
immunodeficiency virus
human immunodeficiency
virus replication
compounds
Prior art date
Application number
EA201590358A
Other languages
English (en)
Inventor
Б. Нарасимхулу Наиду
Манодж Пател
Стенли Д'Андреа
Чжичжэн Барбара Чжэн
Тимоти П. Коннолли
Давид Р. Ланглей
Кевин Пис
Чжунюй Ван
Майкл А. Уокер
Джон Ф. Кадов
Original Assignee
Бристол-Майерс Сквибб Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Бристол-Майерс Сквибб Компани filed Critical Бристол-Майерс Сквибб Компани
Publication of EA201590358A1 publication Critical patent/EA201590358A1/ru

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/16—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/16—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • AIDS & HIV (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Изобретение, в общем, относится к соединениям формулы I, включая композиции, и к способам лечения заболевания, вызванного вирусом иммунодефицита человека (ВИЧ). Изобретение относится к новым ингибиторам ВИЧ, фармацевтическим композициям, содержащим такие соединения, и способам применения этих соединений для лечения ВИЧ-инфекции.
EA201590358A 2012-08-16 2013-08-12 Ингибиторы репликации вируса иммунодефицита человека EA201590358A1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201261683772P 2012-08-16 2012-08-16
US201361818572P 2013-05-02 2013-05-02
US13/959,268 US8906929B2 (en) 2012-08-16 2013-08-05 Inhibitors of human immunodeficiency virus replication
PCT/US2013/054532 WO2014028384A1 (en) 2012-08-16 2013-08-12 Inhibitors of human immunodeficiency virus replication

Publications (1)

Publication Number Publication Date
EA201590358A1 true EA201590358A1 (ru) 2015-05-29

Family

ID=50100460

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201590358A EA201590358A1 (ru) 2012-08-16 2013-08-12 Ингибиторы репликации вируса иммунодефицита человека

Country Status (15)

Country Link
US (1) US8906929B2 (ru)
EP (1) EP2888266B1 (ru)
JP (1) JP6214657B2 (ru)
KR (1) KR20150042830A (ru)
CN (1) CN104583214B (ru)
AU (1) AU2013302873B2 (ru)
BR (1) BR112015003175A2 (ru)
CA (1) CA2882077A1 (ru)
EA (1) EA201590358A1 (ru)
ES (1) ES2619960T3 (ru)
IL (1) IL237154A (ru)
MX (1) MX2015001899A (ru)
SG (1) SG11201500887QA (ru)
TW (1) TW201412750A (ru)
WO (1) WO2014028384A1 (ru)

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US8906929B2 (en) 2012-08-16 2014-12-09 Bristol-Myers Squibb Company Inhibitors of human immunodeficiency virus replication

Also Published As

Publication number Publication date
CN104583214B (zh) 2017-06-09
WO2014028384A1 (en) 2014-02-20
US20140051692A1 (en) 2014-02-20
KR20150042830A (ko) 2015-04-21
IL237154A (en) 2017-03-30
JP6214657B2 (ja) 2017-10-18
CN104583214A (zh) 2015-04-29
JP2015524841A (ja) 2015-08-27
MX2015001899A (es) 2015-05-07
US8906929B2 (en) 2014-12-09
BR112015003175A2 (pt) 2017-08-08
ES2619960T3 (es) 2017-06-27
IL237154A0 (en) 2015-04-30
AU2013302873B2 (en) 2017-02-02
EP2888266B1 (en) 2017-01-11
SG11201500887QA (en) 2015-03-30
AU2013302873A1 (en) 2015-04-02
CA2882077A1 (en) 2014-02-20
EP2888266A1 (en) 2015-07-01
TW201412750A (zh) 2014-04-01

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