EA201491548A1 - 2'-замещенные карбануклеозидные аналоги для противовирусного лечения - Google Patents

2'-замещенные карбануклеозидные аналоги для противовирусного лечения

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Publication number
EA201491548A1
EA201491548A1 EA201491548A EA201491548A EA201491548A1 EA 201491548 A1 EA201491548 A1 EA 201491548A1 EA 201491548 A EA201491548 A EA 201491548A EA 201491548 A EA201491548 A EA 201491548A EA 201491548 A1 EA201491548 A1 EA 201491548A1
Authority
EA
Eurasian Patent Office
Prior art keywords
carbaneculose
analogues
substituted
virus treatment
compounds
Prior art date
Application number
EA201491548A
Other languages
English (en)
Other versions
EA028928B9 (ru
EA028928B1 (ru
Inventor
Майкл О'Нил Ханрахан Кларк
Original Assignee
Джилид Сайэнс, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Джилид Сайэнс, Инк. filed Critical Джилид Сайэнс, Инк.
Publication of EA201491548A1 publication Critical patent/EA201491548A1/ru
Publication of EA028928B1 publication Critical patent/EA028928B1/ru
Publication of EA028928B9 publication Critical patent/EA028928B9/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/12—Triazine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/30—Vaccines

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Предложены соединения формулы Iа также фармацевтические композиции, содержащие соединения формулы I, и способы лечения ортомиксовирусных инфекций путем введения этих соединений. Предложенные соединения, композиции и способы являются особенно подходящими для лечения инфекций, вызванных вирусом гриппа человека.
EA201491548A 2012-03-13 2013-03-11 2'-замещенные карбануклеозидные аналоги для противовирусного лечения EA028928B9 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261610411P 2012-03-13 2012-03-13
PCT/US2013/030196 WO2013138236A1 (en) 2012-03-13 2013-03-11 2'- substituted carba-nucleoside analogs for antiviral treatment

Publications (3)

Publication Number Publication Date
EA201491548A1 true EA201491548A1 (ru) 2015-02-27
EA028928B1 EA028928B1 (ru) 2018-01-31
EA028928B9 EA028928B9 (ru) 2018-05-31

Family

ID=47997868

Family Applications (2)

Application Number Title Priority Date Filing Date
EA201791916A EA201791916A1 (ru) 2012-03-13 2013-03-11 2'-замещенные карбануклеозидные аналоги для противовирусного лечения
EA201491548A EA028928B9 (ru) 2012-03-13 2013-03-11 2'-замещенные карбануклеозидные аналоги для противовирусного лечения

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EA201791916A EA201791916A1 (ru) 2012-03-13 2013-03-11 2'-замещенные карбануклеозидные аналоги для противовирусного лечения

Country Status (19)

Country Link
US (4) US9481704B2 (ru)
EP (4) EP3932931A1 (ru)
JP (3) JP6242378B2 (ru)
KR (1) KR102068856B1 (ru)
CN (2) CN104185638A (ru)
AU (2) AU2013232378B2 (ru)
CA (1) CA2866381C (ru)
EA (2) EA201791916A1 (ru)
ES (3) ES2878087T3 (ru)
HK (2) HK1207083A1 (ru)
IL (2) IL234586A (ru)
IN (1) IN2014DN08505A (ru)
MD (1) MD4496C1 (ru)
MX (1) MX355267B (ru)
NZ (1) NZ629996A (ru)
PL (1) PL2834258T3 (ru)
PT (1) PT2834258T (ru)
SI (1) SI2834258T1 (ru)
WO (1) WO2013138236A1 (ru)

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Also Published As

Publication number Publication date
JP2017206528A (ja) 2017-11-24
AU2017279590A1 (en) 2018-01-18
JP2019069986A (ja) 2019-05-09
MD20140112A2 (ru) 2015-02-28
ES2878087T3 (es) 2021-11-18
EP3351552A1 (en) 2018-07-25
SI2834258T1 (sl) 2017-04-26
PT2834258T (pt) 2017-04-07
MD4496C1 (ru) 2018-02-28
US10941177B2 (en) 2021-03-09
IN2014DN08505A (ru) 2015-05-15
AU2013232378B2 (en) 2017-09-28
CN104185638A (zh) 2014-12-03
EP3210993B1 (en) 2018-12-12
EP3351552B1 (en) 2021-05-19
HK1207083A1 (en) 2016-01-22
EP3932931A1 (en) 2022-01-05
KR102068856B1 (ko) 2020-01-21
JP6525441B2 (ja) 2019-06-05
US20210253622A1 (en) 2021-08-19
US9481704B2 (en) 2016-11-01
KR20140135820A (ko) 2014-11-26
IL256397A (en) 2018-02-28
PL2834258T3 (pl) 2017-07-31
EP3210993A1 (en) 2017-08-30
MD4496B1 (ru) 2017-07-31
CN106749272B (zh) 2019-08-30
ES2621217T3 (es) 2017-07-03
EA201791916A1 (ru) 2018-07-31
NZ629996A (en) 2016-10-28
HK1256856A1 (zh) 2019-10-04
CN106749272A (zh) 2017-05-31
US20130243725A1 (en) 2013-09-19
JP6242378B2 (ja) 2017-12-06
JP2015509983A (ja) 2015-04-02
EA028928B9 (ru) 2018-05-31
WO2013138236A1 (en) 2013-09-19
EA028928B1 (ru) 2018-01-31
MX2014011009A (es) 2014-10-13
CA2866381C (en) 2020-03-24
EP2834258A1 (en) 2015-02-11
AU2013232378A1 (en) 2014-09-25
ES2709071T3 (es) 2019-04-15
CA2866381A1 (en) 2013-09-19
US11787832B2 (en) 2023-10-17
IL234586A (en) 2017-12-31
MX355267B (es) 2018-04-12
US20170114086A1 (en) 2017-04-27
US20190016749A1 (en) 2019-01-17
EP2834258B1 (en) 2017-01-04

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