HK1196131A1 - 用於治療或預防呼吸道合胞病毒疾病的化合物 - Google Patents
用於治療或預防呼吸道合胞病毒疾病的化合物Info
- Publication number
- HK1196131A1 HK1196131A1 HK14109553.4A HK14109553A HK1196131A1 HK 1196131 A1 HK1196131 A1 HK 1196131A1 HK 14109553 A HK14109553 A HK 14109553A HK 1196131 A1 HK1196131 A1 HK 1196131A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- prophylaxis
- compounds
- treatment
- respiratory syncytial
- syncytial virus
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011078258 | 2011-08-11 | ||
| CN2012078439 | 2012-07-10 | ||
| PCT/EP2012/065499 WO2013020993A1 (en) | 2011-08-11 | 2012-08-08 | Compounds for the treatment and prophylaxis of respiratory syncytial virus disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1196131A1 true HK1196131A1 (zh) | 2014-12-05 |
Family
ID=46651492
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK14109553.4A HK1196131A1 (zh) | 2011-08-11 | 2014-09-23 | 用於治療或預防呼吸道合胞病毒疾病的化合物 |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US8871756B2 (zh) |
| EP (1) | EP2742039B1 (zh) |
| JP (1) | JP5746793B2 (zh) |
| KR (1) | KR101570627B1 (zh) |
| CN (1) | CN103717589B (zh) |
| AU (1) | AU2012293644B2 (zh) |
| BR (1) | BR112014003198B1 (zh) |
| CA (1) | CA2842123C (zh) |
| CL (1) | CL2014000311A1 (zh) |
| CO (1) | CO6852080A2 (zh) |
| CR (1) | CR20140026A (zh) |
| EA (1) | EA023262B1 (zh) |
| EC (1) | ECSP14013199A (zh) |
| ES (1) | ES2552016T3 (zh) |
| HK (1) | HK1196131A1 (zh) |
| IL (1) | IL230458A (zh) |
| MA (1) | MA35432B1 (zh) |
| MX (1) | MX349881B (zh) |
| MY (1) | MY184306A (zh) |
| PE (1) | PE20142148A1 (zh) |
| WO (1) | WO2013020993A1 (zh) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR099134A1 (es) | 2014-01-24 | 2016-06-29 | Hoffmann La Roche | Procedimiento para la preparación de n-[(3-aminooxetán-3-il)metil]-2-(1,1-dioxo-3,5-dihidro-1,4-benzotiazepín-4-il)-6-metil-quinazolín-4-amina |
| US9266835B2 (en) * | 2014-02-27 | 2016-02-23 | Janssen Pharmaceutica Nv | Quinoline derivatives useful as CB-1 inverse agonists |
| WO2015130445A1 (en) * | 2014-02-27 | 2015-09-03 | Janssen Pharmaceutica Nv | Quinoline derivatives useful as cb-1 inverse agonists |
| CN105726488B (zh) * | 2014-12-08 | 2020-10-20 | 上海爱科百发生物医药技术有限公司 | 含有呼吸道合胞病毒抑制剂的肠溶微丸及其制备方法 |
| CN104529802A (zh) * | 2014-12-13 | 2015-04-22 | 西安近代化学研究所 | 一种合成n,n′-双取代氟代丙二酰胺化合物的方法 |
| CN104860954B (zh) * | 2015-04-20 | 2018-05-04 | 南京天印健华医药科技有限公司 | 一种苯酯螺吡咯烷类化合物及其制备方法 |
| CN107635999B (zh) | 2015-05-20 | 2020-09-25 | 豪夫迈·罗氏有限公司 | 用于治疗脊髓性肌萎缩的化合物 |
| EP3322704B1 (en) * | 2015-07-16 | 2019-11-27 | H. Hoffnabb-La Roche Ag | Crystalline form of n-[(3-amino-3-oxetanyl)methyl]-2-(2,3-dihydro-1,1-dioxido-1,4-benzothiazepin-4(5h)-yl)-6-methyl-4-quinazolinamine for the treatment of respiratory syncytial virus (rsv) infections |
| CA3002494C (en) | 2015-11-12 | 2021-01-12 | F. Hoffmann-La Roche Ag | Compositions for treating spinal muscular atrophy |
| JP6872550B2 (ja) | 2015-12-10 | 2021-05-19 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 架橋されたピペリジン誘導体 |
| CA3007412C (en) | 2015-12-10 | 2021-08-24 | Ptc Therapeutics, Inc. | The use of 1,4-disubstituted pyridazine compounds to treat huntington's disease |
| MX2019000588A (es) | 2016-07-14 | 2019-09-09 | Crinetics Pharmaceuticals Inc | Moduladores de la somatostatina y usos de los mismos. |
| CN111065626A (zh) | 2017-06-05 | 2020-04-24 | Ptc医疗公司 | 用于治疗亨廷顿氏舞蹈病的化合物 |
| US11382918B2 (en) | 2017-06-28 | 2022-07-12 | Ptc Therapeutics, Inc. | Methods for treating Huntington's Disease |
| EP3645121A4 (en) | 2017-06-28 | 2021-03-17 | PTC Therapeutics, Inc. | HUNTINGTON'S DISEASE TREATMENT METHODS |
| JP7399870B2 (ja) | 2018-03-27 | 2023-12-18 | ピーティーシー セラピューティクス， インコーポレイテッド | ハンチントン病を処置するための化合物 |
| EA202092896A1 (ru) | 2018-06-27 | 2021-04-13 | ПиТиСи ТЕРАПЬЮТИКС, ИНК. | Гетероциклические и гетероарильные соединения для лечения болезни гентингтона |
| WO2020005882A1 (en) | 2018-06-27 | 2020-01-02 | Ptc Therapeutics, Inc. | Heteroaryl compounds for treating huntington's disease |
| CR20210166A (es) | 2018-09-06 | 2021-07-27 | Cidara Therapeutics Inc | Composiciones y métodos para el tratamiento de infecciones virales |
| CN116023365A (zh) * | 2019-01-29 | 2023-04-28 | 轩竹生物科技股份有限公司 | 己酮糖激酶抑制剂及其用途 |
| JP2022547538A (ja) * | 2019-09-09 | 2022-11-14 | シダラ セラピューティクス インコーポレーテッド | 呼吸器合胞体ウイルス感染症の処置のための組成物及び方法 |
| GB201915273D0 (en) * | 2019-10-22 | 2019-12-04 | Reviral Ltd | Pharmaceutical compounds |
| US20220387443A1 (en) * | 2019-10-31 | 2022-12-08 | Shanghai Ark Biopharmaceutical Co., Ltd. | Respiratory syncytial virus fusion protein inhibitor compositions and methods for the treatment and prophylaxis of rsv diseases using the same |
| GB201915932D0 (en) * | 2019-11-01 | 2019-12-18 | Reviral Ltd | Pharmaceutical compounds |
| CN113149977A (zh) * | 2020-01-22 | 2021-07-23 | 苏州爱科百发生物医药技术有限公司 | 一类呼吸道合胞病毒抑制剂的合成与用途 |
| CN111548325A (zh) * | 2020-05-16 | 2020-08-18 | 西安都创医药科技有限公司 | 一种卤代苯并硫氮杂卓化合物的制备方法及其制备的产品及其应用 |
| CN111620838A (zh) * | 2020-05-16 | 2020-09-04 | 西安都创医药科技有限公司 | 一种氯代苯并硫氮杂卓化合物的制备方法及其制备的产品及其应用 |
| CN111518055A (zh) * | 2020-05-16 | 2020-08-11 | 西安都创医药科技有限公司 | 一种苯并硫氮杂卓氧化物的制备方法及其制备的产品及其应用 |
| CN111574475B (zh) * | 2020-06-03 | 2022-09-20 | 西安都创医药科技有限公司 | 卤代苯并硫杂卓氧化物的制备方法及其制备的产品及其应用 |
| MX2023002761A (es) | 2020-09-09 | 2023-04-03 | Crinetics Pharmaceuticals Inc | Formulaciones de un modulador de somatostatina. |
| CN113234085A (zh) * | 2021-04-26 | 2021-08-10 | 无锡合全药业有限公司 | 一种2-氧杂-6-氮杂螺[3.4]辛烷-8-基氨基甲酸叔丁酯的合成方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1383409A (en) * | 1972-09-09 | 1974-02-12 | Pfizer Ltd | Derivatives of 2-amino- and 4-amino-quinazoline and pharmaceutical compositions containing them |
| US4044136A (en) * | 1972-09-09 | 1977-08-23 | Pfizer Inc. | Aminoquinazoline therapeutic agents |
| US5874438A (en) * | 1996-10-11 | 1999-02-23 | Bayer Aktiengesellschaft | 2,2'-bridged bis-2,4-diaminoquinazolines |
| US6774134B2 (en) * | 2000-12-20 | 2004-08-10 | Bristol-Myers Squibb Company | Heterocyclic substituted 2-methyl-benzimidazole antiviral agents |
| KR20060118547A (ko) * | 2003-12-12 | 2006-11-23 | 큐티엘 바이오시스템즈 엘엘씨 | 금속 이온-매개된 형광 수퍼켄칭 검정, 키트 및 시약 |
| RU2422444C2 (ru) * | 2003-12-24 | 2011-06-27 | Байота Сайентифик Менеджмент Пти Лтд | Полициклические средства для лечения респираторно-синцитиальных вирусных инфекций |
| WO2008033466A2 (en) * | 2006-09-14 | 2008-03-20 | Combinatorx (Singapore) Pre. Ltd. | Compositions and methods for treatment of viral diseases |
-
2012
- 2012-07-30 US US13/561,366 patent/US8871756B2/en not_active Ceased
- 2012-08-08 JP JP2014524370A patent/JP5746793B2/ja active Active
- 2012-08-08 MX MX2014001481A patent/MX349881B/es active IP Right Grant
- 2012-08-08 EP EP12746320.6A patent/EP2742039B1/en active Active
- 2012-08-08 EA EA201490419A patent/EA023262B1/ru not_active IP Right Cessation
- 2012-08-08 CA CA2842123A patent/CA2842123C/en active Active
- 2012-08-08 KR KR1020147006355A patent/KR101570627B1/ko active IP Right Grant
- 2012-08-08 CN CN201280039193.0A patent/CN103717589B/zh active Active
- 2012-08-08 MY MYPI2014700267A patent/MY184306A/en unknown
- 2012-08-08 AU AU2012293644A patent/AU2012293644B2/en active Active
- 2012-08-08 BR BR112014003198-3A patent/BR112014003198B1/pt active IP Right Grant
- 2012-08-08 WO PCT/EP2012/065499 patent/WO2013020993A1/en active Application Filing
- 2012-08-08 ES ES12746320.6T patent/ES2552016T3/es active Active
- 2012-08-08 PE PE2014000187A patent/PE20142148A1/es active IP Right Grant
-
2014
- 2014-01-14 IL IL230458A patent/IL230458A/en active IP Right Grant
- 2014-01-17 CO CO14008865A patent/CO6852080A2/es active IP Right Grant
- 2014-01-20 CR CR20140026A patent/CR20140026A/es unknown
- 2014-02-07 CL CL2014000311A patent/CL2014000311A1/es unknown
- 2014-02-11 EC ECSP14013199 patent/ECSP14013199A/es unknown
- 2014-03-11 MA MA36815A patent/MA35432B1/fr unknown
- 2014-09-23 HK HK14109553.4A patent/HK1196131A1/zh unknown
-
2020
- 2020-10-21 US US17/075,948 patent/USRE49481E1/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EA023262B1 (ru) | 2016-05-31 |
| CA2842123C (en) | 2020-10-06 |
| IL230458A0 (en) | 2014-03-31 |
| CO6852080A2 (es) | 2014-01-30 |
| IL230458A (en) | 2015-11-30 |
| CR20140026A (es) | 2014-05-12 |
| BR112014003198B1 (pt) | 2020-10-13 |
| PE20142148A1 (es) | 2015-01-03 |
| BR112014003198A2 (pt) | 2017-04-04 |
| KR101570627B1 (ko) | 2015-11-19 |
| US20130196974A1 (en) | 2013-08-01 |
| CA2842123A1 (en) | 2013-02-14 |
| CN103717589A (zh) | 2014-04-09 |
| EP2742039A1 (en) | 2014-06-18 |
| MX2014001481A (es) | 2014-04-30 |
| NZ620079A (en) | 2016-06-24 |
| ECSP14013199A (es) | 2014-03-31 |
| EA201490419A1 (ru) | 2014-05-30 |
| AU2012293644B2 (en) | 2017-05-25 |
| US8871756B2 (en) | 2014-10-28 |
| KR20140045590A (ko) | 2014-04-16 |
| EP2742039B1 (en) | 2015-09-16 |
| JP2014521709A (ja) | 2014-08-28 |
| CL2014000311A1 (es) | 2014-10-17 |
| MX349881B (es) | 2017-08-16 |
| WO2013020993A1 (en) | 2013-02-14 |
| MY184306A (en) | 2021-03-31 |
| AU2012293644A1 (en) | 2014-01-30 |
| MA35432B1 (fr) | 2014-09-01 |
| USRE49481E1 (en) | 2023-04-04 |
| CN103717589B (zh) | 2016-08-17 |
| ES2552016T3 (es) | 2015-11-25 |
| JP5746793B2 (ja) | 2015-07-08 |
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