HK1222395A1 - 用於治療和預防呼吸道合胞病毒感染的氮雜-氧代-吲哚 - Google Patents
用於治療和預防呼吸道合胞病毒感染的氮雜-氧代-吲哚Info
- Publication number
- HK1222395A1 HK1222395A1 HK16110598.7A HK16110598A HK1222395A1 HK 1222395 A1 HK1222395 A1 HK 1222395A1 HK 16110598 A HK16110598 A HK 16110598A HK 1222395 A1 HK1222395 A1 HK 1222395A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- indoles
- aza
- prophylaxis
- oxo
- treatment
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pulmonology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2013075594 | 2013-05-14 | ||
PCT/EP2014/059699 WO2014184163A1 (en) | 2013-05-14 | 2014-05-13 | Aza-oxo-indoles for the treatment and prophylaxis of respiratory syncytial virus infection |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1222395A1 true HK1222395A1 (zh) | 2017-06-30 |
Family
ID=50721785
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK16110598.7A HK1222395A1 (zh) | 2013-05-14 | 2016-09-06 | 用於治療和預防呼吸道合胞病毒感染的氮雜-氧代-吲哚 |
Country Status (9)
Country | Link |
---|---|
US (1) | US10189838B2 (zh) |
EP (1) | EP2997028A1 (zh) |
JP (1) | JP2016518421A (zh) |
BR (1) | BR112015028475A2 (zh) |
CA (1) | CA2910508A1 (zh) |
HK (1) | HK1222395A1 (zh) |
MX (1) | MX2015015691A (zh) |
RU (1) | RU2015148926A (zh) |
WO (1) | WO2014184163A1 (zh) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2015022263A1 (en) * | 2013-08-12 | 2015-02-19 | F. Hoffmann-La Roche Ag | Novel aza-oxo-indoles for the treatment and prophylaxis of respiratory syncytial virus infection |
RU2016105969A (ru) * | 2013-08-15 | 2017-09-20 | Ф. Хоффманн-Ля Рош Аг | Новые азаоксоиндолы для лечения и профилактики респираторно-синцитиальной вирусной инфекции |
AR099134A1 (es) | 2014-01-24 | 2016-06-29 | Hoffmann La Roche | Procedimiento para la preparación de n-[(3-aminooxetán-3-il)metil]-2-(1,1-dioxo-3,5-dihidro-1,4-benzotiazepín-4-il)-6-metil-quinazolín-4-amina |
GB201417707D0 (en) * | 2014-10-07 | 2014-11-19 | Viral Ltd | Pharmaceutical compounds |
EP3298017B1 (en) | 2015-05-20 | 2019-08-14 | H. Hoffnabb-La Roche Ag | Compounds for treating spinal muscular atrophy |
JP6779972B2 (ja) | 2015-07-16 | 2020-11-04 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 呼吸器合胞体ウイルス(rsv)感染症の処置のためのn−[(3−アミノ−3−オキセタニル)メチル]−2−(2,3−ジヒドロ−1,1−ジオキシド−1,4−ベンゾチアゼピン−4(5h)−イル)−6−メチル−4−キナゾリンアミンの結晶形 |
RU2601749C1 (ru) * | 2015-09-08 | 2016-11-10 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Волгоградский государственный технический университет" (ВолгГТУ) | Способ получения 4'-фторспиро[циклопропан-1,3'-индол]-2'(1'н)-она |
WO2017080967A1 (en) | 2015-11-12 | 2017-05-18 | F. Hoffmann-La Roche Ag | Compositions for treating spinal muscular atrophy |
WO2017100726A1 (en) | 2015-12-10 | 2017-06-15 | Ptc Therapeutics, Inc. | Methods for treatng huntington's disease |
WO2017097728A1 (en) | 2015-12-10 | 2017-06-15 | F. Hoffmann-La Roche Ag | Bridged piperidine derivatives |
ES2878058T3 (es) * | 2016-08-04 | 2021-11-18 | Reviral Ltd | Derivados de pirimidina y su uso en el tratamiento y la prevención de una infección por virus respiratorio sincitial |
US11407753B2 (en) | 2017-06-05 | 2022-08-09 | Ptc Therapeutics, Inc. | Compounds for treating Huntington's disease |
US11395822B2 (en) | 2017-06-28 | 2022-07-26 | Ptc Therapeutics, Inc. | Methods for treating Huntington's disease |
EP3644996B1 (en) | 2017-06-28 | 2023-07-26 | PTC Therapeutics, Inc. | Methods for treating huntington's disease |
GB201711704D0 (en) * | 2017-07-20 | 2017-09-06 | Reviral Ltd | Pharmaceutical compounds |
GB201721812D0 (en) | 2017-12-22 | 2018-02-07 | Reviral Ltd | Pharmaceutical compounds |
WO2019191092A1 (en) | 2018-03-27 | 2019-10-03 | Ptc Therapeutics, Inc. | Compounds for treating huntington's disease |
EP3814360B1 (en) | 2018-06-27 | 2024-10-02 | PTC Therapeutics, Inc. | Heteroaryl compounds for treating huntington's disease |
LT3814357T (lt) | 2018-06-27 | 2024-06-25 | Ptc Therapeutics, Inc. | Heterocikliniai ir heteroarilų junginiai, skirti hantingtono ligos gydymui |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6774134B2 (en) * | 2000-12-20 | 2004-08-10 | Bristol-Myers Squibb Company | Heterocyclic substituted 2-methyl-benzimidazole antiviral agents |
TWI501967B (zh) | 2010-12-16 | 2015-10-01 | Janssen R&D Ireland | 作為呼吸道融合病毒抗病毒劑之氮雜吲哚類 |
TWI530495B (zh) | 2010-12-16 | 2016-04-21 | 健生科學愛爾蘭無限公司 | 苯并咪唑呼吸道融合病毒抑制劑 |
TWI527814B (zh) | 2010-12-16 | 2016-04-01 | 健生科學愛爾蘭無限公司 | 作為呼吸道融合病毒抗病毒劑之氮雜苯并咪唑類 |
GB201119538D0 (en) * | 2011-11-10 | 2011-12-21 | Viral Ltd | Pharmaceutical compounds |
TWI598351B (zh) * | 2012-10-16 | 2017-09-11 | 健生科學愛爾蘭無限公司 | Rsv抗病毒化合物 |
CN104693211A (zh) * | 2013-12-10 | 2015-06-10 | 南京明德新药研发股份有限公司 | 作为抗病毒剂的咪唑衍生物及其制药用途 |
JP6118470B2 (ja) * | 2013-12-10 | 2017-04-19 | 南京明徳新薬研発股▲分▼有限公司 | 抗ウイルス剤として使用されるイミダゾール誘導体及び該イミダゾール誘導体の薬剤の製造における使用 |
-
2014
- 2014-05-13 EP EP14723783.8A patent/EP2997028A1/en not_active Withdrawn
- 2014-05-13 RU RU2015148926A patent/RU2015148926A/ru unknown
- 2014-05-13 JP JP2016513325A patent/JP2016518421A/ja not_active Ceased
- 2014-05-13 BR BR112015028475A patent/BR112015028475A2/pt not_active IP Right Cessation
- 2014-05-13 CA CA2910508A patent/CA2910508A1/en not_active Abandoned
- 2014-05-13 MX MX2015015691A patent/MX2015015691A/es unknown
- 2014-05-13 WO PCT/EP2014/059699 patent/WO2014184163A1/en active Application Filing
-
2015
- 2015-11-16 US US14/942,725 patent/US10189838B2/en not_active Expired - Fee Related
-
2016
- 2016-09-06 HK HK16110598.7A patent/HK1222395A1/zh not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
JP2016518421A (ja) | 2016-06-23 |
CA2910508A1 (en) | 2014-11-20 |
BR112015028475A2 (pt) | 2017-07-25 |
RU2015148926A (ru) | 2017-06-15 |
EP2997028A1 (en) | 2016-03-23 |
MX2015015691A (es) | 2016-03-04 |
US20180072726A9 (en) | 2018-03-15 |
US10189838B2 (en) | 2019-01-29 |
US20160068531A1 (en) | 2016-03-10 |
WO2014184163A1 (en) | 2014-11-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20220511 |