HK1222855A1 - 新的用於治療和預防呼吸道合胞病毒感染的氮雜-氧代-吲哚 - Google Patents

新的用於治療和預防呼吸道合胞病毒感染的氮雜-氧代-吲哚

Info

Publication number
HK1222855A1
HK1222855A1 HK16111080.0A HK16111080A HK1222855A1 HK 1222855 A1 HK1222855 A1 HK 1222855A1 HK 16111080 A HK16111080 A HK 16111080A HK 1222855 A1 HK1222855 A1 HK 1222855A1
Authority
HK
Hong Kong
Prior art keywords
indoles
prophylaxis
oxo
treatment
virus infection
Prior art date
Application number
HK16111080.0A
Other languages
English (en)
Inventor
Lisha Wang
Hongying Yun
Weixing Zhang
Xiufang Zheng
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of HK1222855A1 publication Critical patent/HK1222855A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HK16111080.0A 2013-08-15 2016-09-21 新的用於治療和預防呼吸道合胞病毒感染的氮雜-氧代-吲哚 HK1222855A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2013081563 2013-08-15
PCT/EP2014/067197 WO2015022301A1 (en) 2013-08-15 2014-08-12 Novel aza-oxo-indoles for the treatment and prophylaxis of respiratory syncytial virus infection

Publications (1)

Publication Number Publication Date
HK1222855A1 true HK1222855A1 (zh) 2017-07-14

Family

ID=51302721

Family Applications (1)

Application Number Title Priority Date Filing Date
HK16111080.0A HK1222855A1 (zh) 2013-08-15 2016-09-21 新的用於治療和預防呼吸道合胞病毒感染的氮雜-氧代-吲哚

Country Status (8)

Country Link
US (2) US9890155B2 (zh)
EP (1) EP3033333A1 (zh)
JP (1) JP6262347B2 (zh)
CA (1) CA2914541A1 (zh)
HK (1) HK1222855A1 (zh)
MX (1) MX2016001858A (zh)
RU (1) RU2016105969A (zh)
WO (1) WO2015022301A1 (zh)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201417707D0 (en) * 2014-10-07 2014-11-19 Viral Ltd Pharmaceutical compounds
GB201721812D0 (en) * 2017-12-22 2018-02-07 Reviral Ltd Pharmaceutical compounds

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6774134B2 (en) * 2000-12-20 2004-08-10 Bristol-Myers Squibb Company Heterocyclic substituted 2-methyl-benzimidazole antiviral agents
TWI530495B (zh) * 2010-12-16 2016-04-21 健生科學愛爾蘭無限公司 苯并咪唑呼吸道融合病毒抑制劑
GB201119538D0 (en) * 2011-11-10 2011-12-21 Viral Ltd Pharmaceutical compounds
US9617289B2 (en) * 2012-10-16 2017-04-11 Janssen Sciences Ireland Uc RSV antiviral compounds
MX2015015691A (es) * 2013-05-14 2016-03-04 Hoffmann La Roche Aza-oxo-indoles novedosos para el tratamiento y profilaxis de la infeccion del virus sincital respiratorio.
EP3033341B1 (en) * 2013-08-12 2017-05-03 F. Hoffmann-La Roche AG Novel aza-oxo-indoles for the treatment and prophylaxis of respiratory syncytial virus infection
WO2015085844A1 (zh) * 2013-12-10 2015-06-18 南京明德新药研发股份有限公司 作为抗病毒剂的咪唑衍生物及其制药用途
TWI671299B (zh) * 2014-04-14 2019-09-11 愛爾蘭商健生科學愛爾蘭無限公司 作為ｒｓｖ抗病毒化合物之螺脲化合物

Also Published As

Publication number Publication date
US9890155B2 (en) 2018-02-13
CA2914541A1 (en) 2015-02-19
US20180072725A1 (en) 2018-03-15
WO2015022301A1 (en) 2015-02-19
JP6262347B2 (ja) 2018-01-17
JP2016527323A (ja) 2016-09-08
MX2016001858A (es) 2016-05-24
RU2016105969A (ru) 2017-09-20
US20160159794A1 (en) 2016-06-09
EP3033333A1 (en) 2016-06-22

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