DK3903774T3 - N,n-bis-2-mercaptoethyl isophthalamide for the treatment of neurodegenerative diseases - Google Patents

N,n-bis-2-mercaptoethyl isophthalamide for the treatment of neurodegenerative diseases Download PDF

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Publication number
DK3903774T3
DK3903774T3 DK21180847.2T DK21180847T DK3903774T3 DK 3903774 T3 DK3903774 T3 DK 3903774T3 DK 21180847 T DK21180847 T DK 21180847T DK 3903774 T3 DK3903774 T3 DK 3903774T3
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DK
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Prior art keywords
bis
treatment
neurodegenerative diseases
mercaptoethyl isophthalamide
isophthalamide
Prior art date
Application number
DK21180847.2T
Other languages
English (en)
Inventor
Boyd Eugene Haley
Ragnar Axel Theodor Klingberg
Original Assignee
Emeramed Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Emeramed Ltd filed Critical Emeramed Ltd
Application granted granted Critical
Publication of DK3903774T3 publication Critical patent/DK3903774T3/da

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK21180847.2T 2014-05-30 2015-05-29 N,n-bis-2-mercaptoethyl isophthalamide for the treatment of neurodegenerative diseases DK3903774T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB1409662.2A GB2526623A (en) 2014-05-30 2014-05-30 New pharmaceutical use
EP15733860.9A EP3148588B1 (en) 2014-05-30 2015-05-29 N,n-bis-2-mercaptoethyl isophthalamide for the treatment of parkinson's disease

Publications (1)

Publication Number Publication Date
DK3903774T3 true DK3903774T3 (da) 2023-01-16

Family

ID=51214502

Family Applications (2)

Application Number Title Priority Date Filing Date
DK15733860.9T DK3148588T3 (en) 2014-05-30 2015-05-29 N,n-bis-2-mercaptoethyl isophthalamide for the treatment of parkinson's disease
DK21180847.2T DK3903774T3 (da) 2014-05-30 2015-05-29 N,n-bis-2-mercaptoethyl isophthalamide for the treatment of neurodegenerative diseases

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK15733860.9T DK3148588T3 (en) 2014-05-30 2015-05-29 N,n-bis-2-mercaptoethyl isophthalamide for the treatment of parkinson's disease

Country Status (16)

Country Link
US (4) US20170202791A1 (da)
EP (2) EP3903774B1 (da)
CY (1) CY1124509T1 (da)
DK (2) DK3148588T3 (da)
ES (2) ES2882977T3 (da)
FI (1) FI3903774T3 (da)
GB (1) GB2526623A (da)
HR (2) HRP20230105T1 (da)
HU (2) HUE055575T2 (da)
LT (2) LT3903774T (da)
MA (2) MA40065B1 (da)
PL (2) PL3148588T3 (da)
PT (2) PT3148588T (da)
RS (2) RS63859B1 (da)
SI (2) SI3903774T1 (da)
WO (1) WO2015181567A1 (da)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB202005057D0 (en) 2020-04-06 2020-05-20 Emeramed Ltd New Use

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6586600B2 (en) 2000-12-06 2003-07-01 University Of Kentucky Research Foundation Multidentate sulfur-containing ligands
US8349359B2 (en) * 2004-11-07 2013-01-08 Your Energy Systems, LLC Liposomal formulation for oral administration of glutathione (reduced)
US8950583B2 (en) 2008-12-06 2015-02-10 Ermes Medical Company Limited Method to remove heavy metals from a mammal
US20110076246A1 (en) 2009-09-28 2011-03-31 Haley Boyd E Thiol-containing compounds for the removal of elements from contaminated milieu and methods of use
US8575218B2 (en) 2009-09-28 2013-11-05 The University Of Kentucky Research Foundation Thiol-containing compounds for the removal of elements from tissues and formulations therefor
US8426368B2 (en) 2010-03-25 2013-04-23 The University Of Kentucky Research Foundation Method of ameliorating oxidative stress and supplementing the diet
US20110237776A1 (en) 2010-03-25 2011-09-29 Haley Boyd E Aromatic compounds with sulfur containing ligands

Also Published As

Publication number Publication date
MA54630B1 (fr) 2023-01-31
MA40065A (fr) 2021-05-19
WO2015181567A1 (en) 2015-12-03
MA40065B1 (fr) 2021-09-30
LT3148588T (lt) 2021-08-10
EP3148588B1 (en) 2021-06-23
SI3903774T1 (sl) 2023-03-31
GB2526623A (en) 2015-12-02
HUE060927T2 (hu) 2023-04-28
LT3903774T (lt) 2023-01-10
EP3148588A1 (en) 2017-04-05
HRP20230105T1 (hr) 2023-03-17
PT3148588T (pt) 2021-07-15
SI3148588T1 (sl) 2022-01-31
ES2882977T3 (es) 2021-12-03
US20170202791A1 (en) 2017-07-20
PL3903774T3 (pl) 2023-03-13
US20220287994A1 (en) 2022-09-15
US11628151B2 (en) 2023-04-18
RS63859B1 (sr) 2023-01-31
PL3148588T3 (pl) 2021-12-13
RS62095B1 (sr) 2021-08-31
EP3903774B1 (en) 2022-11-09
MA54630A (fr) 2021-11-03
US20230013704A1 (en) 2023-01-19
HRP20211309T1 (hr) 2021-11-26
GB201409662D0 (en) 2014-07-16
FI3903774T3 (fi) 2023-04-12
CY1124509T1 (el) 2022-07-22
US20180250247A1 (en) 2018-09-06
DK3148588T3 (en) 2021-07-26
HUE055575T2 (hu) 2021-12-28
PT3903774T (pt) 2022-12-23
EP3903774A1 (en) 2021-11-03
ES2938080T3 (es) 2023-04-04

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