PE20120120A1 - DERIVADOS DE 2H-PIRAZOLO[3,4-d]PIRIMIDINA-4,6(5H,7H)-DIONA, COMO INHIBIDORES DE PDE1 - Google Patents
DERIVADOS DE 2H-PIRAZOLO[3,4-d]PIRIMIDINA-4,6(5H,7H)-DIONA, COMO INHIBIDORES DE PDE1Info
- Publication number
- PE20120120A1 PE20120120A1 PE2011001171A PE2011001171A PE20120120A1 PE 20120120 A1 PE20120120 A1 PE 20120120A1 PE 2011001171 A PE2011001171 A PE 2011001171A PE 2011001171 A PE2011001171 A PE 2011001171A PE 20120120 A1 PE20120120 A1 PE 20120120A1
- Authority
- PE
- Peru
- Prior art keywords
- diona
- benzyl
- pyrazolo
- substituted
- alkyl
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/164—Amides, e.g. hydroxamic acids of a carboxylic acid with an aminoalcohol, e.g. ceramides
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
Abstract
SE REFIERE A UN COMPUESTO DE FORMULA (II) DONDE: L ES S, SO Y SO2; R1 ES H, ALQUILO C1-C6; R2 ES H, ALQUILO C1-C6 NO SUSTITUIDO O SUSTITUIDO CON HALO O HIDROXI, ALQUILO C1-C4, CICLOALQUILO C3-C8 NO SUSTITUIDO O SUSTITUIDO CON UNO O MAS AMINO; R3 ESTA UNIDO A UNO DE LOS NITROGENOS EN LA PORCION DEL PIRAZOLO DE LA FORMULA (II) Y ES DE PREFERENCIA 4-TRIFLUOROMETIL-BENCIL, 4-METOXIBENCIL, (1,2,4-TRIAZOL-1-IL)BENCIL, 4-METILSULFONIL-BENCIL, ENTRE OTROS; R4 ES H, ALQUILO C1-C6, CICLOALQUILO C3-C8, HETEROCICLOALQUILO C3-C8, ARILO O HETEROARILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 2-(4-(1H-1,2,4-TRIAZOL-1-IL)BENCIL)-5-METIL-3-(METILTIO)-7-NEOPENTIL-2H-PIRAZOL[3,4-d]PIRIMIDIN-4,6(5H,7H)-DIONA; 2-(4-METOXIBENCIL)-5-METIL-7-NEOPENTIL-3-(FENILTIO)-2H-PIRAZOLO[3,4-d]PIRIMIDIN-4,6(5H,7H)-DIONA; 5-METIL-3-(METILTIO)-7-NEOPENTIL-2-(4-(TRIFLUOROMETIL)BENCIL)-2H-PIRAZOLO[3,4-d]PIRIMIDIN-4,6(5H,7H)-DIONA; ENTRE OTROS. REFERIDA TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHO COMPUESTO ES UN INHIBIDOR DE LA FOSFODIESTERASA 1 (PDE1) UTIL EN EL TRATAMIENTO DE ENFERMEDADES NEURODEGENERATIVAS, TRANSTORNOS MENTALES, CIRCULATORIOS Y CARIDOVASCULARES
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12044408P | 2008-12-06 | 2008-12-06 |
Publications (1)
Publication Number | Publication Date |
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PE20120120A1 true PE20120120A1 (es) | 2012-03-03 |
Family
ID=42233536
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2011001171A PE20120120A1 (es) | 2008-12-06 | 2009-12-07 | DERIVADOS DE 2H-PIRAZOLO[3,4-d]PIRIMIDINA-4,6(5H,7H)-DIONA, COMO INHIBIDORES DE PDE1 |
Country Status (22)
Country | Link |
---|---|
US (2) | US8859564B2 (es) |
EP (1) | EP2367430B1 (es) |
JP (1) | JP5813511B2 (es) |
KR (1) | KR20110098731A (es) |
CN (1) | CN102227167A (es) |
AU (1) | AU2009322904A1 (es) |
BR (1) | BRPI0922351A2 (es) |
CA (1) | CA2740396A1 (es) |
CL (1) | CL2011001265A1 (es) |
CO (1) | CO6390081A2 (es) |
CR (1) | CR20110309A (es) |
DO (1) | DOP2011000172A (es) |
EA (1) | EA201170772A1 (es) |
EC (1) | ECSP11011183A (es) |
GE (1) | GEP20146046B (es) |
IL (1) | IL213315A0 (es) |
MA (1) | MA32941B1 (es) |
MX (1) | MX2011005934A (es) |
PE (1) | PE20120120A1 (es) |
SG (1) | SG171777A1 (es) |
WO (1) | WO2010065152A1 (es) |
ZA (1) | ZA201103629B (es) |
Families Citing this family (63)
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CN101248050B (zh) | 2005-06-06 | 2013-07-17 | 武田药品工业株式会社 | 有机化合物 |
WO2007143705A2 (en) | 2006-06-06 | 2007-12-13 | Intra-Cellular Therapies, Inc. | Organic compounds |
ES2411604T3 (es) * | 2006-11-13 | 2013-07-05 | Intra-Cellular Therapies, Inc. | Compuestos orgánicos |
US9006258B2 (en) | 2006-12-05 | 2015-04-14 | Intra-Cellular Therapies, Inc. | Method of treating female sexual dysfunction with a PDE1 inhibitor |
CA2845454C (en) | 2007-12-06 | 2017-02-07 | Takeda Pharmaceutical Company Limited | Organic compounds useful as inhibitors of phosphodiesterase 1 |
JP5701608B2 (ja) * | 2007-12-06 | 2015-04-15 | イントラ−セルラー・セラピーズ・インコーポレイテッドIntra−Cellular Therapies, Inc. | 有機化合物 |
MX2011005934A (es) | 2008-12-06 | 2011-12-16 | Intra Cellular Therapies Inc | Compuestos organicos. |
SG171774A1 (en) * | 2008-12-06 | 2011-07-28 | Intra Cellular Therapies Inc | Organic compounds |
JP5710493B2 (ja) | 2008-12-06 | 2015-04-30 | イントラ−セルラー・セラピーズ・インコーポレイテッドIntra−Cellular Therapies, Inc. | 有機化合物 |
MX2011005935A (es) | 2008-12-06 | 2011-12-16 | Intra Cellular Therapies Inc | Compuestos organicos. |
EA201170771A1 (ru) | 2008-12-06 | 2012-01-30 | Интра-Селлулар Терапиз, Инк. | Органические соединения |
WO2010065149A1 (en) | 2008-12-06 | 2010-06-10 | Intra-Cellular Therapies, Inc. | Organic compounds |
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BRPI0922351A2 (pt) | 2018-06-05 |
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US20150119370A1 (en) | 2015-04-30 |
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ECSP11011183A (es) | 2011-10-31 |
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SG171777A1 (en) | 2011-07-28 |
IL213315A0 (en) | 2011-07-31 |
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GEP20146046B (en) | 2014-02-25 |
MX2011005934A (es) | 2011-12-16 |
US9487527B2 (en) | 2016-11-08 |
CN102227167A (zh) | 2011-10-26 |
CR20110309A (es) | 2011-10-28 |
AU2009322904A1 (en) | 2010-06-10 |
JP5813511B2 (ja) | 2015-11-17 |
ZA201103629B (en) | 2013-02-27 |
EP2367430B1 (en) | 2014-08-13 |
EA201170772A1 (ru) | 2012-03-30 |
US8859564B2 (en) | 2014-10-14 |
EP2367430A1 (en) | 2011-09-28 |
MA32941B1 (fr) | 2012-01-02 |
WO2010065152A1 (en) | 2010-06-10 |
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