PE20110223A1 - DERIVADOS DE PIRROLO[2,3-e][1,2,4]TRIAZOLO[4,3-a]PIRAZIN, COMO INHIBIDORES DE QUINASA - Google Patents
DERIVADOS DE PIRROLO[2,3-e][1,2,4]TRIAZOLO[4,3-a]PIRAZIN, COMO INHIBIDORES DE QUINASAInfo
- Publication number
- PE20110223A1 PE20110223A1 PE2010001126A PE2010001126A PE20110223A1 PE 20110223 A1 PE20110223 A1 PE 20110223A1 PE 2010001126 A PE2010001126 A PE 2010001126A PE 2010001126 A PE2010001126 A PE 2010001126A PE 20110223 A1 PE20110223 A1 PE 20110223A1
- Authority
- PE
- Peru
- Prior art keywords
- triazolo
- pirrolo
- pirazin
- cycloalkyl
- derivatives
- Prior art date
Links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/08—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis for Pneumocystis carinii
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/14—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
- C07D513/14—Ortho-condensed systems
Abstract
REFERIDA A UN COMPUESTO HETEROCICLICO DE FORMULA (I), DONDE T ES N, O, S, CR6; U ES N O CR4; X ES CR3 O NR3; Y ES N O C; R1, R2 Y R5 SON H, -CN, HALOGENO, -CF3, ENTRE OTROS; R3 ES H, CICLOALQUILO C5-C12, CICLOALQUILO C3-C10, ENTRE OTROS; R4 Y R6 SON H, HALOGENO, CICLOALQUILO C5-C12, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 1-(2-METILCICLOHEXIL)-6H-PIRROLO[2,3-e][1,2,4]TRIAZOLO[4,3-a]PIRAZINA, cis-4-(6H-PIRROLO[2,3-e][1,2,4]TRIAZOLO[4,3-a]PIRAZIN-1-IL)CICLOHEXAMINA, N-(4-(6H-PIRROLO[2,3-e][1,2,4]TRIAZOLO[4,3-a]PIRAZIN-1-IL)BICICLO[2,2,2]OCTAN-1-IL)-3-CLOROBECENSULFONAMIDA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE QUINASAS Y SON UTILES EN EL TRATAMIENTO DEL CANCER, TRASTORNOS CARDIOVASCULARES, MELANOMA, ARTERIOSCLEROSIS, ENTRE OTROS
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13160208P | 2008-06-10 | 2008-06-10 | |
US13159908P | 2008-06-10 | 2008-06-10 | |
US19015908P | 2008-08-26 | 2008-08-26 | |
US20106408P | 2008-12-05 | 2008-12-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20110223A1 true PE20110223A1 (es) | 2011-05-07 |
Family
ID=41415363
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2013001090A PE20140407A1 (es) | 2008-06-10 | 2009-06-09 | Nuevos compuestos triciclicos |
PE2010001126A PE20110223A1 (es) | 2008-06-10 | 2009-06-09 | DERIVADOS DE PIRROLO[2,3-e][1,2,4]TRIAZOLO[4,3-a]PIRAZIN, COMO INHIBIDORES DE QUINASA |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2013001090A PE20140407A1 (es) | 2008-06-10 | 2009-06-09 | Nuevos compuestos triciclicos |
Country Status (37)
Country | Link |
---|---|
US (5) | US8962629B2 (es) |
EP (2) | EP3031324A3 (es) |
JP (2) | JP5748659B2 (es) |
KR (2) | KR101718384B1 (es) |
CN (2) | CN102118968A (es) |
AR (1) | AR072086A1 (es) |
AU (1) | AU2009257602B2 (es) |
BR (1) | BRPI0915374B1 (es) |
CA (2) | CA3000973A1 (es) |
CL (1) | CL2010001426A1 (es) |
CO (1) | CO6382083A2 (es) |
CR (1) | CR20160007A (es) |
CY (1) | CY1117165T1 (es) |
DK (1) | DK2299821T3 (es) |
DO (2) | DOP2010000382A (es) |
EC (1) | ECSP10010657A (es) |
ES (1) | ES2559403T3 (es) |
HK (1) | HK1155617A1 (es) |
HR (1) | HRP20160098T1 (es) |
HU (1) | HUE028347T2 (es) |
IL (1) | IL209434A0 (es) |
ME (1) | ME02340B (es) |
MX (1) | MX2010013557A (es) |
MY (1) | MY161369A (es) |
NO (1) | NO20101688A1 (es) |
NZ (1) | NZ623922A (es) |
PE (2) | PE20140407A1 (es) |
PL (1) | PL2299821T3 (es) |
PT (1) | PT2299821E (es) |
RS (1) | RS54560B1 (es) |
RU (2) | RU2015105591A (es) |
SI (1) | SI2299821T1 (es) |
TW (3) | TWI527819B (es) |
UA (1) | UA106045C2 (es) |
UY (1) | UY31881A (es) |
WO (1) | WO2009152133A1 (es) |
ZA (1) | ZA201008562B (es) |
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PE20140407A1 (es) | 2008-06-10 | 2014-04-25 | Abbott Lab | Nuevos compuestos triciclicos |
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CA2759026C (en) | 2009-04-20 | 2019-01-15 | Auspex Pharmaceuticals, Inc. | Piperidine inhibitors of janus kinase 3 |
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US8361962B2 (en) * | 2009-07-27 | 2013-01-29 | Roche Palo Alto Llc | Tricyclic inhibitors of JAK |
JP5658756B2 (ja) | 2009-09-10 | 2015-01-28 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | Jakの阻害剤 |
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