MX2016013689A - Compuestos 4-amino-imidazoquinolina. - Google Patents

Compuestos 4-amino-imidazoquinolina.

Info

Publication number
MX2016013689A
MX2016013689A MX2016013689A MX2016013689A MX2016013689A MX 2016013689 A MX2016013689 A MX 2016013689A MX 2016013689 A MX2016013689 A MX 2016013689A MX 2016013689 A MX2016013689 A MX 2016013689A MX 2016013689 A MX2016013689 A MX 2016013689A
Authority
MX
Mexico
Prior art keywords
amino
imidazoquinoline compounds
compounds
imidazoquinoline
diseases
Prior art date
Application number
MX2016013689A
Other languages
English (en)
Inventor
Ricklin Fabienne
Kuhn Bernd
Hoves Sabine
Roever Stephan
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2016013689A publication Critical patent/MX2016013689A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Transplantation (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

La presente invención se refiere a nuevos compuestos 4-amino-imidazoquinolina de la fórmula: (ver Fórmula) en la que R1 a R4 son tal como se define en la descripción y en las reivindicaciones, así como sales farmacéuticamente aceptables de los mismos. Estos compuestos son agonistas de RTT y, por lo tanto, pueden resultar útiles como medicamentos para el tratamiento de enfermedades tales como el cáncer o enfermedades infecciosas.
MX2016013689A 2014-04-22 2015-04-20 Compuestos 4-amino-imidazoquinolina. MX2016013689A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14165349 2014-04-22
PCT/EP2015/058465 WO2015162075A1 (en) 2014-04-22 2015-04-20 4-amino-imidazoquinoline compounds

Publications (1)

Publication Number Publication Date
MX2016013689A true MX2016013689A (es) 2017-01-20

Family

ID=50489008

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016013689A MX2016013689A (es) 2014-04-22 2015-04-20 Compuestos 4-amino-imidazoquinolina.

Country Status (22)

Country Link
US (2) US9334268B2 (es)
EP (1) EP3134402B1 (es)
JP (1) JP6367366B2 (es)
KR (1) KR101905292B1 (es)
CN (1) CN106232599B (es)
AR (1) AR100137A1 (es)
BR (1) BR112016017261B1 (es)
CA (1) CA2938280C (es)
DK (1) DK3134402T3 (es)
ES (1) ES2804101T3 (es)
HR (1) HRP20201043T1 (es)
HU (1) HUE049656T2 (es)
LT (1) LT3134402T (es)
MA (1) MA39898B1 (es)
MX (1) MX2016013689A (es)
PL (1) PL3134402T3 (es)
PT (1) PT3134402T (es)
RS (1) RS60430B1 (es)
RU (1) RU2698902C2 (es)
SI (1) SI3134402T1 (es)
TW (1) TWI607007B (es)
WO (1) WO2015162075A1 (es)

Families Citing this family (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2848648T3 (es) * 2015-12-14 2021-08-11 Glaxosmithkline Biologicals Sa Imidazoquinolinas pegiladas como agonistas de TLR7 y TLR8
EP3889145B1 (en) 2015-12-17 2024-02-21 Merck Patent GmbH 8-cyano-5-piperidino-quinolines as tlr7/8 antagonists and their uses for treating immune disorders
EP3464245B1 (en) 2016-05-23 2020-10-14 H. Hoffnabb-La Roche Ag Benzazepine dicarboxamide compounds with tertiary amide function
WO2017202703A1 (en) 2016-05-23 2017-11-30 F. Hoffmann-La Roche Ag Benzazepine dicarboxamide compounds with secondary amide function
JP7012668B2 (ja) 2016-06-12 2022-02-14 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト ジヒドロピリミジニルベンズアゼピンジカルボキサミド化合物
KR20230149857A (ko) 2016-07-07 2023-10-27 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 항체-애쥬번트 접합체
MX2019001096A (es) 2016-08-08 2019-07-04 Merck Patent Gmbh Antagonistas del receptor 7/8 tipo toll (tlr7/8) y uso de los mismos.
DK3526323T3 (da) 2016-10-14 2023-06-26 Prec Biosciences Inc Modificerede meganucleaser der er specifikke for en genkendelsessekvens i hepatitis b virusgenomet
PT3546457T (pt) * 2016-11-28 2021-08-06 Jiangsu Hengrui Medicine Co Derivado de pirazolo-heteroarílico, método de preparação e a utilização médica do mesmo
US10757485B2 (en) * 2017-08-25 2020-08-25 Honda Motor Co., Ltd. System and method for synchronized vehicle sensor data acquisition processing using vehicular communication
WO2019084060A1 (en) 2017-10-24 2019-05-02 Silverback Therapeutics, Inc. CONJUGATES AND METHODS OF USE FOR THE SELECTIVE DELIVERY OF IMMUNOMODULATORY AGENTS
CA3084667A1 (en) 2017-12-15 2019-06-20 Silverback Therapeutics, Inc. Antibody construct-drug conjugate for the treatment of hepatitis
AU2018392212B9 (en) 2017-12-20 2021-03-18 Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. 2'3' cyclic dinucleotides with phosphonate bond activating the STING adaptor protein
EP3728283B1 (en) 2017-12-20 2023-11-22 Institute of Organic Chemistry and Biochemistry ASCR, V.V.I. 3'3' cyclic dinucleotides with phosphonate bond activating the sting adaptor protein
EP3728255B1 (en) 2017-12-20 2022-01-26 3M Innovative Properties Company Amide substituted imidazo[4,5-c]quinoline compounds with a branched chain linking group for use as an immune response modifier
CN108299421B (zh) * 2018-01-30 2020-09-29 中国医学科学院药用植物研究所 一种瑞喹莫德的酰化衍生物及制备方法与应用
CN111788204B (zh) 2018-02-26 2023-05-05 吉利德科学公司 作为hbv复制抑制剂的取代吡咯嗪化合物
EP3759107A1 (en) 2018-02-28 2021-01-06 3M Innovative Properties Company Substituted imidazo[4,5-c]quinoline compounds with an n-1 branched group
US10870691B2 (en) 2018-04-05 2020-12-22 Gilead Sciences, Inc. Antibodies and fragments thereof that bind hepatitis B virus protein X
TW202005654A (zh) 2018-04-06 2020-02-01 捷克科學院有機化學與生物化學研究所 ２，２，─環二核苷酸
TWI833744B (zh) 2018-04-06 2024-03-01 捷克科學院有機化學與生物化學研究所 3'3'-環二核苷酸
TWI818007B (zh) 2018-04-06 2023-10-11 捷克科學院有機化學與生物化學研究所 2'3'-環二核苷酸
TW201945388A (zh) 2018-04-12 2019-12-01 美商精密生物科學公司 對b型肝炎病毒基因體中之識別序列具有特異性之最佳化之經工程化巨核酸酶
WO2019211799A1 (en) 2018-05-03 2019-11-07 Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. 2'3'-cyclic dinucleotide analogue comprising a cyclopentanyl modified nucleotide
EP3802536B1 (en) 2018-05-24 2022-07-13 3M Innovative Properties Company N-1 branched cycloalkyl substituted imidazo[4,5-c]quinoline compounds, compositions, and methods
CN110526917B (zh) * 2018-05-25 2021-09-03 江苏恒瑞医药股份有限公司 一种吡唑并杂芳基类衍生物的可药用盐、晶型及其制备方法
TWI704916B (zh) * 2018-05-25 2020-09-21 大陸商江蘇恒瑞醫藥股份有限公司 一種吡唑并雜芳基類衍生物鹽酸鹽的晶型及製備方法
CN110526918B (zh) * 2018-05-25 2021-09-03 江苏恒瑞医药股份有限公司 一种吡唑并杂芳基类衍生物的晶型及制备方法
WO2020028097A1 (en) 2018-08-01 2020-02-06 Gilead Sciences, Inc. Solid forms of (r)-11-(methoxymethyl)-12-(3-methoxypropoxy)-3,3-dimethyl-8-0x0-2,3,8,13b-tetrahydro-1h-pyrido[2,1-a]pyrrolo[1,2-c] phthalazine-7-c arboxylic acid
US11572360B2 (en) 2018-08-16 2023-02-07 Innate Tumor Immunity, Inc. Substituted 4-amino-1H-imidazo[4,5-c]quinoline compounds and improved methods for their preparation
CA3111786A1 (en) * 2018-09-07 2020-03-12 Birdie Biopharmaceuticals, Inc. Imidazoquinoline compounds and uses thereof
US20220323596A1 (en) * 2018-09-12 2022-10-13 Silverback Therapeutics, Inc. Antibody conjugates of toll-like receptor agonists
CN113164618A (zh) 2018-09-12 2021-07-23 希沃尔拜克治疗公司 用免疫刺激性缀合物治疗疾病的方法和组合物
JP7460644B2 (ja) 2018-10-31 2024-04-02 ギリアード サイエンシーズ， インコーポレイテッド Ｈｐｋ１阻害剤としての置換６－アザベンゾイミダゾール化合物
WO2020092528A1 (en) 2018-10-31 2020-05-07 Gilead Sciences, Inc. Substituted 6-azabenzimidazole compounds having hpk1 inhibitory activity
EP3917926A4 (en) * 2019-02-01 2022-06-22 Canwell Biotech Limited IMIDAZOQUINOLINE AMINE DERIVATIVES, PHARMACEUTICAL COMPOSITION, USE THEREOF
AU2020231115A1 (en) 2019-03-07 2021-08-26 Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. 3'3'-cyclic dinucleotides and prodrugs thereof
EP3935065A1 (en) 2019-03-07 2022-01-12 Institute of Organic Chemistry and Biochemistry ASCR, V.V.I. 3'3'-cyclic dinucleotide analogue comprising a cyclopentanyl modified nucleotide as sting modulator
EP3934757B1 (en) 2019-03-07 2023-02-22 Institute of Organic Chemistry and Biochemistry ASCR, V.V.I. 2'3'-cyclic dinucleotides and prodrugs thereof
WO2020190725A1 (en) 2019-03-15 2020-09-24 Bolt Biotherapeutics, Inc. Immunoconjugates targeting her2
TW202210480A (zh) 2019-04-17 2022-03-16 美商基利科學股份有限公司 類鐸受體調節劑之固體形式
TW202212339A (zh) 2019-04-17 2022-04-01 美商基利科學股份有限公司 類鐸受體調節劑之固體形式
TWI826690B (zh) 2019-05-23 2023-12-21 美商基利科學股份有限公司 經取代之烯吲哚酮化物及其用途
MX2021015533A (es) 2019-06-19 2022-02-10 Silverback Therapeutics Inc Anticuerpos anti-mesotelina e inmunoconjugados de los mismos.
CN112174903B (zh) * 2019-07-01 2022-07-12 清华大学 Tlr8的小分子调节剂
US11339159B2 (en) * 2019-07-17 2022-05-24 Pfizer Inc. Toll-like receptor agonists
EP4017476A1 (en) 2019-08-19 2022-06-29 Gilead Sciences, Inc. Pharmaceutical formulations of tenofovir alafenamide
CA3149557A1 (en) 2019-09-30 2021-04-08 Scott J. Balsitis Hbv vaccines and methods treating hbv
WO2021067644A1 (en) 2019-10-01 2021-04-08 Silverback Therapeutics, Inc. Combination therapy with immune stimulatory conjugates
KR20220091528A (ko) * 2019-10-29 2022-06-30 프라임 리치 트레이딩 리미티드 4-아미노-이미다조퀴놀린 화합물 및 이의 용도
CN116057068A (zh) 2019-12-06 2023-05-02 精密生物科学公司 对乙型肝炎病毒基因组中的识别序列具有特异性的优化的工程化大范围核酸酶
WO2021168274A1 (en) 2020-02-21 2021-08-26 Silverback Therapeutics, Inc. Nectin-4 antibody conjugates and uses thereof
AU2021237718B2 (en) 2020-03-20 2023-09-21 Gilead Sciences, Inc. Prodrugs of 4'-C-substituted-2-halo-2'-deoxyadenosine nucleosides and methods of making and using the same
AU2021258392A1 (en) 2020-04-19 2022-12-15 Ludwig ENGLMEIER Prophylaxis and treatment of coronavirus infection
JP2023526304A (ja) * 2020-05-14 2023-06-21 メルク ヘルスケア コマンディトゲゼルシャフト アウフ アクティーン コロナウイルス感染症治療のためのｔｌｒ７／８拮抗薬
EP4153590A4 (en) * 2020-05-21 2024-06-19 Ohio State Innovation Foundation FUNCTIONAL LIPID DERIVATIVES AND THEIR USES
JP2023532304A (ja) 2020-07-01 2023-07-27 エーアールエス ファーマシューティカルズ オペレーションズ，インク． 抗ａｓｇｒ１抗体コンジュゲートおよびその使用
WO2022153157A1 (en) * 2021-01-13 2022-07-21 Pfizer Inc. A crystalline form of 2-((4-amino-2-(ethoxymethyl)-6,7-dimethyl-1 h-imidazo[4,5-c]pyridin-1-yl)methyl)-2-methylpropane-1,3-diol free base
KR20230152679A (ko) * 2021-02-03 2023-11-03 씨젠 인크. 면역자극 화합물 및 접합체
CA3215049A1 (en) 2021-04-10 2022-10-13 Baiteng ZHAO Folr1 binding agents, conjugates thereof and methods of using the same
TW202308699A (zh) 2021-04-23 2023-03-01 美商普方生物製藥美國公司 Ｃｄ７０結合劑、其結合物及其使用方法
AU2022274607A1 (en) 2021-05-13 2023-11-16 Gilead Sciences, Inc. COMBINATION OF A TLR8 MODULATING COMPOUND AND ANTI-HBV siRNA THERAPEUTICS
EP4359415A1 (en) 2021-06-23 2024-05-01 Gilead Sciences, Inc. Diacylglyercol kinase modulating compounds
WO2022271650A1 (en) 2021-06-23 2022-12-29 Gilead Sciences, Inc. Diacylglyercol kinase modulating compounds
CN117480155A (zh) 2021-06-23 2024-01-30 吉利德科学公司 二酰基甘油激酶调节化合物
CA3222439A1 (en) 2021-06-23 2022-12-29 Gilead Sciences, Inc. Diacylglyercol kinase modulating compounds
TW202320857A (zh) 2021-07-06 2023-06-01 美商普方生物製藥美國公司 連接子、藥物連接子及其結合物及其使用方法
WO2023081237A1 (en) * 2021-11-03 2023-05-11 Regents Of The University Of Minnesota Toll-like receptor agonists and antagonists and uses thereof
WO2024030577A1 (en) * 2022-08-03 2024-02-08 Seagen Inc. Immunostimulatory anti-pd-l1-drug conjugates
WO2024100093A1 (en) * 2022-11-09 2024-05-16 Merck Patent Gmbh Toll-like receptor 7 agonists as immune-stimulators to elicit the innate antitumor immunity
WO2024112932A1 (en) * 2022-11-23 2024-05-30 Regents Of The University Of Minnesota Immunomodulators and immunomodulator conjugates

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG70625A1 (en) * 1991-03-01 2000-02-22 Minnesota Mining & Mfg 1-Substituted 2-substituted 1H-imidazo(4, 5-c) quinolin-4-amines
US6451810B1 (en) * 1999-06-10 2002-09-17 3M Innovative Properties Company Amide substituted imidazoquinolines
US6664265B2 (en) * 2000-12-08 2003-12-16 3M Innovative Properties Company Amido ether substituted imidazoquinolines
US6861440B2 (en) * 2001-10-26 2005-03-01 Hoffmann-La Roche Inc. DPP IV inhibitors
JP2005513021A (ja) * 2001-11-16 2005-05-12 スリーエム イノベイティブ プロパティズ カンパニー Ｉｒｍ化合物およびトール様受容体経路に関する方法および組成物
BRPI0414045A (pt) * 2003-09-05 2006-10-24 Anadys Pharmaceuticals Inc administração de ligantes de tlr7 e pró-medicamentos dos mesmos para tratamento de infecção por vìrus de hepatite c
WO2005076783A2 (en) 2003-12-04 2005-08-25 3M Innovative Properties Company Sulfone substituted imidazo ring ethers
TW201402124A (zh) 2005-08-19 2014-01-16 Array Biopharma Inc 作為類鐸受體（ｔｏｌｌ-ｌｉｋｅ ｒｅｃｅｐｔｏｒ）調節劑之８-經取代苯并氮雜呯
US8466167B2 (en) 2008-03-03 2013-06-18 Irm Llc Compounds and compositions as TLR activity modulators
EP2940009B1 (en) 2008-11-06 2018-10-17 VentiRx Pharmaceuticals, Inc. Methods of synthesis of benzazepine derivatives
CN102439011B (zh) 2009-02-11 2016-05-04 加利福尼亚大学校务委员会 Toll样受体调节剂和疾病的治疗
EP2461690A4 (en) 2009-08-07 2013-03-27 Glaxosmithkline Biolog Sa LIPIDED OXOADENINE DERIVATIVES
JP2013512859A (ja) 2009-12-03 2013-04-18 大日本住友製薬株式会社 トール様受容体（ｔｌｒ）を介して作用するイミダゾキノリン
CN103118682A (zh) 2010-04-30 2013-05-22 加利福尼亚大学校务委员会 合成tlr7激动剂的磷脂缀合物的用途
ES2616449T3 (es) 2010-10-01 2017-06-13 Ventirx Pharmaceuticals, Inc. Uso terapéutico de un agonista de TLR y terapia de combinación
WO2012066336A1 (en) 2010-11-19 2012-05-24 Astrazeneca Ab Benzylamine compounds as toll -like receptor 7 agonists
MX355623B (es) 2011-06-03 2018-04-25 3M Innovative Properties Co Hidrazino-1h-imidazoquinolin-4-aminas y conjugados elaborados a partir de las mismas.
WO2012167801A1 (ru) 2011-06-07 2012-12-13 Uglovsky Sergey Evgenievich Импульсная установка для преобразования низкопотенциальной тепловой энергии в электрическую
WO2013033345A1 (en) 2011-08-30 2013-03-07 Regents Of The University Of Minnesota Immunomodulators and immunomodulator conjugates
JP2014532799A (ja) * 2011-11-09 2014-12-08 アセンド・バイオファーマシューティカルズ・リミテッド 免疫調節結合体
WO2013166110A1 (en) 2012-05-02 2013-11-07 Yale University Tlr-agonist-conjugated antibody recruiting molecules (tlr_arms)

Also Published As

Publication number Publication date
KR20160138317A (ko) 2016-12-02
PL3134402T3 (pl) 2020-11-02
SI3134402T1 (sl) 2020-08-31
RU2016144386A (ru) 2018-05-22
ES2804101T3 (es) 2021-02-03
EP3134402A1 (en) 2017-03-01
EP3134402B1 (en) 2020-05-06
US20150299194A1 (en) 2015-10-22
CN106232599A (zh) 2016-12-14
WO2015162075A1 (en) 2015-10-29
CA2938280C (en) 2022-07-12
BR112016017261A8 (pt) 2020-06-16
BR112016017261B1 (pt) 2022-04-19
US20160222010A1 (en) 2016-08-04
PT3134402T (pt) 2020-07-02
JP6367366B2 (ja) 2018-08-01
RU2016144386A3 (es) 2018-11-27
US9447097B2 (en) 2016-09-20
RS60430B1 (sr) 2020-07-31
HUE049656T2 (hu) 2020-10-28
CA2938280A1 (en) 2015-10-29
AR100137A1 (es) 2016-09-14
DK3134402T3 (da) 2020-07-20
TWI607007B (zh) 2017-12-01
LT3134402T (lt) 2020-07-10
RU2698902C2 (ru) 2019-09-02
CN106232599B (zh) 2018-11-16
HRP20201043T1 (hr) 2020-10-16
MA39898B1 (fr) 2020-08-31
TW201544505A (zh) 2015-12-01
KR101905292B1 (ko) 2018-11-21
US9334268B2 (en) 2016-05-10
JP2017513883A (ja) 2017-06-01

Similar Documents

Publication Publication Date Title
MX2016013689A (es) Compuestos 4-amino-imidazoquinolina.
PH12018501084A1 (en) Heterocyclic compounds as immunomodulators
PH12016502378A1 (en) Substituted dihydroisoquinolinone compounds
MD20170016A2 (ro) Compuşi aminopirimidinici ca inhibitori JAK
IN2015DN01156A (es)
MX2016002544A (es) Compuestos utiles como inmunomoduladores.
UA116648C2 (uk) Фумарати як проліки та їх застосування при лікуванні різних захворювань
MX2015011984A (es) Inhibidores de bromodominio de dihidro-pirrolopiridinona.
MY197698A (en) Oxysterols and methods of use thereof
MX2017008518A (es) Compuestos de isoquinolina para el tratamiento de virus de inmunodeficiencia humana (vih).
TW201613864A (en) Novel compounds
MX2017000312A (es) Derivados de isoindolina para usarse en el tratamiento de una infeccion viral.
JO3372B1 (ar) مشتقات 5-بنزيل إيزوكينولين لعلاج أمراض القلب والأوعية الدموية
MY180844A (en) Solid pharmaceutical compositions comprising biopterin derivatives and uses of such compositions
PH12018501709A1 (en) Naphthridinedione derivatives
MX2018005987A (es) Compuestos heterociclicos para el tratamiento de enfermedades.
PH12016501997B1 (en) Cycloalkyl-linked diheterocycle derivatives
CL2015003431A1 (es) Derivados de piridona para el tratamiento de infecciones virales y enfermedades adicionales
MX2018004696A (es) Analogos de epotilona, metodos de sintesis, metodos de tratamiento y conjugados con farmacos de los mismos.
MX2017002544A (es) Derivados de isoquinolinona utiles en el tratamiento contra el cancer.
PH12016502480A1 (en) Compounds, pharmaceutical composition and their use in treating neurodegenerative diseases
PH12015502703A1 (en) Pharmaceutical compositions
PH12017501147A1 (en) Total synthesis of trioxacarcin dc-45-a2 and preparation of trioxacarcin analogs
EA201792502A1 (ru) Кабазитаксел и его применение для лечения рака
SG10201903630UA (en) Iminosugars useful for the treatment of viral diseases